Temp >38°C (100.4°F) or < 36°C (96.8°F)
Heart Rate > 90
Respiratory Rate > 20 or PaCO2 < 32 mm Hg
WBC > 12,000/mm3, < 4,000/mm3, or > 10% bands
Suspected or Present Source of Infection
Lactic Acidosis, SBP <90 or SBP Drop ≥ 40 mm Hg of normal
Severe Sepsis with Hypotension, despite adequate fluid resuscitation
Evidence of ≥ 2 Organs Failing