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Plasmacytoma on tissue biopsy
Bone marrow plasmacytosis of > 30%
M Protein: IgG > 3.5 g/L; IgA > 2.0 g/L
Urinary kappa or lambda chain excretion of > 1g / 24 hours in absence of amyloidosis
Marrow plasmacytosis of 10-30%
Lytic bone lesions
Evidence of a monoclonal protein but lessor amounts than above
Hypoglobulinemia of normal proteins: IgM < 500 mg/L, IgA < 1 g/L or IgG < 6g/L