Multiple Myeloma Diagnostic Criteria

Identifies early indicators and "CRAB" features of Multiple Myeloma.

Major Diagnostic Criteria

Plasmacytoma on tissue biopsy

Bone marrow plasmacytosis of > 30%

M Protein: IgG > 3.5 g/L; IgA > 2.0 g/L

Urinary kappa or lambda chain excretion of > 1g / 24 hours in absence of amyloidosis

Minor Diagnostic Criteria

Marrow plasmacytosis of 10-30%

Lytic bone lesions

Evidence of a monoclonal protein but lessor amounts than above

Hypoglobulinemia of normal proteins: IgM < 500 mg/L, IgA < 1 g/L or IgG < 6g/L


Source: Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12):e538-48.