IMDC Risk Model for Metastatic Renal Cell Carcinoma

Predicts survival in patients with metastatic renal cell carcinoma treated with systemic therapy (also known as Heng criteria).


<1 year from time of diagnosis to systemic therapy

Karnofsky Performance Status <80%

Hemoglobin < lower limit of normal

  • Usually ~120 g/L or 12 g/dL

Corrected calcium > upper limit of normal

  • Usually ~120 g/L or 12 g/dL

Neutrophils > upper limit of normal

  • Usually ~2.0-7.0ₓ109/L

Platelets > upper limit of normal

  • Usually ~150,000-400,000 cells/µL

Interpretation