Lenalidomide and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Multiple Myeloma

Recruitment Status: ACTIVE, NOT RECRUITING - HAS RESULTS
(See Contacts and Locations)Verified March 2026 by National Cancer Institute (NCI)
Sponsor: National Cancer Institute (NCI)
Information Provided by (Responsible Party): National Cancer Institute (NCI)

Clinicaltrials.gov Identifier: NCT00644228
Other Study ID Numbers:: NCI-2009-00798

First Submitted: March 21, 2008
First Posted: March 25, 2008
Results First Posted: April 19, 2017
Last Update Posted: June 10, 2026
Last Verified: March 2026

ClinicalTrials.gov processed this data on June 2026. Link to the current ClinicalTrials.gov record .

Study Details

Study Description

PRIMARY OBJECTIVES:

I. To compare progression-free survival (PFS) in patients with newly diagnosed myeloma treated with lenalidomide plus low dose dexamethasone versus bortezomib plus lenalidomide and low dose dexamethasone.

SECONDARY OBJECTIVES:

I. Assess response using the new international response criteria. II. To bank specimens for future translational medicine research. III. Follow patients to assess overall survival and other long-term outcomes stratified by intent to transplant at progression.

TERTIARY OBJECTIVES:

I. To evaluate custom and genome-wide single nucleotide polymorphisms in correlation with biology, prognosis and outcome for both treatment regimens combined; to verify the findings recently obtained with the custom Bank on a Cure program (BOAC) single nucleotide polymorphism (SNP) chip on Total Therapy 2 (TT2) data with respect to bone disease in the cooperative group setting.

II. To use baseline gene expression profiling as a tool to evaluate the biology, prognostic and risk factors, and response to therapy for both treatment regimens combined. To validate John Shaughnessy's 70 gene risk model developed for Total Therapy 2 (TT2) in the cooperative group setting.

OUTLINE:

INDUCTION THERAPY: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive dexamethasone orally (PO) once daily (QD) on days 1, 8, 15, and 22 and lenalidomide PO QD on days 1-21. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive dexamethasone PO QD on days 1, 2, 4, 5, 8, 9, 11, and 12; lenalidomide PO QD on days 1-14; and bortezomib intravenously (IV) over 3-5 seconds on days 1, 4, 8, and 11. Treatment repeats every 21 days for 8 courses in the absence of disease progression or unacceptable toxicity.

In both arms, patients who intend to undergo transplantation at relapse undergo peripheral blood stem cell collection, preferably after course 2.

MAINTENANCE THERAPY: After the completion of at least 4 courses (Arm I) or at least 6 courses (Arm II) of induction therapy, patients receive maintenance therapy comprising dexamethasone PO QD on days 1, 8, 15, and 22 and lenalidomide PO QD on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up periodically for up to 6 years.

Condition or Disease	Intervention/Treatment
DS Stage I Multiple MyelomaDS Stage II Multiple MyelomaDS Stage III Multiple Myeloma	Drug: DexamethasoneDrug: Bortezomib

Study Design

Study Type	Interventional
Actual Enrollment	525 participants
Design Allocation	Randomized
Interventional Model	Parallel Assignment
Masking	None (Open Label)
Primary Purpose	Treatment
Official Title	A Randomized Phase III Trial of CC-5013 (Lenalidomide, NSC-703813) and Low Dose Dexamethasone (LLD) Versus Bortezomib (PS-341, NSC-681239), Lenalidomide And Low Dose Dexamethasone (BLLD) for Induction, in Patients With Previously Untreated Multiple Myeloma Without an Intent for Immediate Autologous Stem Cell Transplant
Study Start Date	July 27, 2008
Actual Primary Completion Date	November 4, 2015
Actual Study Completion Date	2mos 6d from now

Groups and Cohorts

Group/Cohort	Intervention/Treatment
Arm I (dexamethasone and lenalidomide) Patients receive dexamethasone PO QD on days 1, 8, 15, and 22 and lenalidomide PO QD on days 1-21. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity.	Drug: Dexamethasone Given PO
Arm II (dexamethasone, lenalidomide, bortezomib) Patients receive dexamethasone PO QD on days 1, 2, 4, 5, 8, 9, 11, and 12; lenalidomide PO QD on days 1-14; and bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11. Treatment repeats every 21 days for 8 courses in the absence of disease progression or unacceptable toxicity.	Drug: Bortezomib Given IV

Outcome Measures

Primary Outcome Measures

Progression-free Survival
Unstratified median progression-free survival in months.

Secondary Outcome Measures

Overall Survival
Unstratified median overall survival in months.
Response Rates ()
The response rate was calculated as the number of patients with documented confirmed partial response (PR) or better, which includes confirmed/unconfirmed stringent complete response (sCR), confirmed/unconfirmed complete response (CR), confirmed/unconfirmed very good partial response (VGPR), or confirmed partial response (PR), as best response divided by the total number of evaluable patients, in each arm. Patients with measurable disease, as defined in the protocol, are evaluable. Response rates were compared between the two treatment arms using a stratified Cochran-Mantel-Haenszel test. Response designations were based on the International Uniform Response Criteria for Multiple Myeloma. Due to the complexity of these criteria, the details of these criteria have been omitted.

Eligibility Criteria

Ages Eligible for Study	(Adult, Older Adult)
Sexes Eligible for Study	All
Accepts Healthy Volunteers	No
Inclusion Criteria	Patients must have newly diagnosed multiple myeloma with measurable disease; patients with non-secretory multiple myeloma (MM) based upon standard M-component criteria (i.e., measurable serum/urine M-component) are not eligible for this study; exception: patients with non-secretory MM will be eligible only if the baseline serum Freelite is elevated (Note that serum Freelite must be drawn; serum light chains are not acceptable); all tests for establishing baseline disease status must be completed within 28 days prior to registration and documented on the baseline and follow-up tumor assessment form for multiple myeloma Patients must have received no prior chemotherapy for this disease; patients must have received no prior radiotherapy to a large area of the pelvis (more than half of the pelvis); prior steroid treatment is allowed provided treatment was not more than 2 weeks in duration; patients must not have received any prior treatment with bortezomib or lenalidomide Patients must have a Zubrod performance status (PS) of 0 - 3; NOTE: patients with PS 3 are eligible only if it is documented by the treating physician that the patient's multiple myeloma is the central cause of his/her disability; patients who have a PS of 3 due to other concurrent medical conditions are not eligible for this trial Platelet count \>= 80 x 10\^3/mcL; must be obtained within 28 days prior to registration; exception: patients with biopsy-proven heavy-marrow involvement, as defined by having at least 30% marrow cellularity, with \> 50% of the cells being malignant plasma cells (documented marrow results required); in this case, although there are no required lower limits of normal for the blood counts, the treating physician must use his/her medical judgment as to the appropriateness of this study therapy for these patients Absolute neutrophil count (ANC) \>= 1 x 10\^3/mcL; must be obtained within 28 days prior to registration; exception: patients with biopsy-proven heavy-marrow involvement, as defined by having at least 30% marrow cellularity, with \> 50% of the cells being malignant plasma cells (documented marrow results required); in this case, although there are no required lower limits of normal for the blood counts, the treating physician must use his/her medical judgment as to the appropriateness of this study therapy for these patients Hemoglobin (including patients who have been either transfused or treated with erythropoietin \[EPO\]) \>= 9 g/dL; must be obtained within 28 days prior to registration; exception: patients with biopsy-proven heavy-marrow involvement, as defined by having at least 30% marrow cellularity, with \> 50% of the cells being malignant plasma cells (documented marrow results required); in this case, although there are no required lower limits of normal for the blood counts, the treating physician must use his/her medical judgment as to the appropriateness of this study therapy for these patients Patients must be offered participation in the Myeloma Specimen Repository for banking and future research; with the patient's consent, bone marrow aspirates and serum specimens will be submitted to the Myeloma Specimen Repository for additional testing and banking (including SNP testing); patient consent must be obtained before specimens may be submitted Patients must have baseline skeletal survey to include lateral skull, anterior-posterior (AP) pelvis and posterior-anterior (PA) chest within 28 days prior to registration Institutions must submit a local cytogenetics report and fluorescence in situ hybridization (FISH) analysis report obtained prior to enrollment to S0777; for FISH analysis two probes will be utilized: LSI 13 (RBI) 13q14 SpectrumOrange Probe for detection of chromosome 13 deletion and LSI p53 (17p13.1) SpectrumOrange probe for detection of tumor protein (p)53 locus on chromosome 17; if these exact probes are not available locally, it is acceptable to submit results using local protocol; this must be noted on the prestudy form; NOTE: it is not required that the results of the FISH analysis be known prior to registration, only that pre-registration specimens be drawn and sent for analysis prior to registration, and the FISH analysis report be submitted Patients with pathologic fractures, pneumonia at diagnosis or symptomatic hyperviscosity must have these conditions attended to prior to registration (i.e., intramedullary rod, I.V. antibiotics, plasmapheresis) Patients must have a calculated or measured creatinine clearance \> 30 cc/min; measured creatinine clearance or serum creatinine used in calculation must be obtained within 28 days prior to registration Patients must not have uncontrolled, active infection requiring intravenous antibiotics, New York Heart Association (NYHA) class III or class IV heart failure, myocardial infarction within the last 6 months, history of treatment for clinically significant ventricular cardiac arrhythmias, poorly controlled hypertension, or poorly controlled diabetes mellitus; patients must have undergone an electrocardiogram (EKG) within 28 days prior to registration Patients must not have any psychiatric illness that could potentially interfere with the completion of treatment according to this protocol Patients must not be hepatitis B, hepatitis C or human immunodeficiency virus (HIV) positive; patients must have a negative hepatitis B and HIV test performed within 28 days prior to registration; exception: treatment-sensitive HIV infection patients will be eligible provided that immunological and virologic indices are indicative of favorable long-term survival prospects on the basis of HIV infection, but whose life expectancy is limited predominantly by multiple myeloma rather than HIV infection in the judgment of the treating physician Patients must not have a history of cerebral vascular accident with persistent neurologic deficits Patients must be able to take aspirin 325 mg daily (or enoxaparin 40 mg subcutaneously \[SQ\] daily if patient is unable to take aspirin) as prophylactic anticoagulation; exception: patients receiving anticoagulation therapy such as Coumadin or heparin will NOT receive aspirin, and therefore need not be able to take it Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days and again within 24 hours prior to starting cycle 1 of lenalidomide; further, they must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy; a FCBP is a sexually mature woman who: has not undergone a hysterectomy or bilateral oophorectomy; or has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); all patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure No prior malignancy is allowed except for adequately treated basal cell (or squamous cell) skin cancer, in situ cervical cancer or other cancer for which the patient has been disease-free for five years Patients must be offered participation in gene expression profiling (GEP) molecular studies for the evaluation of genetic polymorphisms All patients must be informed of the investigational nature of this study and must sign and give written consent in accordance with institutional federal guidelines At the time of patient registration, the treating institution's name and identification (ID) number must be provided to the statistical center in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered into the data base
Exclusion Criteria	Inclusion Criteria: Patients must have newly diagnosed multiple myeloma with measurable disease; patients with non-secretory multiple myeloma (MM) based upon standard M-component criteria (i.e., measurable serum/urine M-component) are not eligible for this study; exception: patients with non-secretory MM will be eligible only if the baseline serum Freelite is elevated (Note that serum Freelite must be drawn; serum light chains are not acceptable); all tests for establishing baseline disease status must be completed within 28 days prior to registration and documented on the baseline and follow-up tumor assessment form for multiple myeloma Patients must have received no prior chemotherapy for this disease; patients must have received no prior radiotherapy to a large area of the pelvis (more than half of the pelvis); prior steroid treatment is allowed provided treatment was not more than 2 weeks in duration; patients must not have received any prior treatment with bortezomib or lenalidomide Patients must have a Zubrod performance status (PS) of 0 - 3; NOTE: patients with PS 3 are eligible only if it is documented by the treating physician that the patient's multiple myeloma is the central cause of his/her disability; patients who have a PS of 3 due to other concurrent medical conditions are not eligible for this trial Platelet count \>= 80 x 10\^3/mcL; must be obtained within 28 days prior to registration; exception: patients with biopsy-proven heavy-marrow involvement, as defined by having at least 30% marrow cellularity, with \> 50% of the cells being malignant plasma cells (documented marrow results required); in this case, although there are no required lower limits of normal for the blood counts, the treating physician must use his/her medical judgment as to the appropriateness of this study therapy for these patients Absolute neutrophil count (ANC) \>= 1 x 10\^3/mcL; must be obtained within 28 days prior to registration; exception: patients with biopsy-proven heavy-marrow involvement, as defined by having at least 30% marrow cellularity, with \> 50% of the cells being malignant plasma cells (documented marrow results required); in this case, although there are no required lower limits of normal for the blood counts, the treating physician must use his/her medical judgment as to the appropriateness of this study therapy for these patients Hemoglobin (including patients who have been either transfused or treated with erythropoietin \[EPO\]) \>= 9 g/dL; must be obtained within 28 days prior to registration; exception: patients with biopsy-proven heavy-marrow involvement, as defined by having at least 30% marrow cellularity, with \> 50% of the cells being malignant plasma cells (documented marrow results required); in this case, although there are no required lower limits of normal for the blood counts, the treating physician must use his/her medical judgment as to the appropriateness of this study therapy for these patients Patients must be offered participation in the Myeloma Specimen Repository for banking and future research; with the patient's consent, bone marrow aspirates and serum specimens will be submitted to the Myeloma Specimen Repository for additional testing and banking (including SNP testing); patient consent must be obtained before specimens may be submitted Patients must have baseline skeletal survey to include lateral skull, anterior-posterior (AP) pelvis and posterior-anterior (PA) chest within 28 days prior to registration Institutions must submit a local cytogenetics report and fluorescence in situ hybridization (FISH) analysis report obtained prior to enrollment to S0777; for FISH analysis two probes will be utilized: LSI 13 (RBI) 13q14 SpectrumOrange Probe for detection of chromosome 13 deletion and LSI p53 (17p13.1) SpectrumOrange probe for detection of tumor protein (p)53 locus on chromosome 17; if these exact probes are not available locally, it is acceptable to submit results using local protocol; this must be noted on the prestudy form; NOTE: it is not required that the results of the FISH analysis be known prior to registration, only that pre-registration specimens be drawn and sent for analysis prior to registration, and the FISH analysis report be submitted Patients with pathologic fractures, pneumonia at diagnosis or symptomatic hyperviscosity must have these conditions attended to prior to registration (i.e., intramedullary rod, I.V. antibiotics, plasmapheresis) Patients must have a calculated or measured creatinine clearance \> 30 cc/min; measured creatinine clearance or serum creatinine used in calculation must be obtained within 28 days prior to registration Patients must not have uncontrolled, active infection requiring intravenous antibiotics, New York Heart Association (NYHA) class III or class IV heart failure, myocardial infarction within the last 6 months, history of treatment for clinically significant ventricular cardiac arrhythmias, poorly controlled hypertension, or poorly controlled diabetes mellitus; patients must have undergone an electrocardiogram (EKG) within 28 days prior to registration Patients must not have any psychiatric illness that could potentially interfere with the completion of treatment according to this protocol Patients must not be hepatitis B, hepatitis C or human immunodeficiency virus (HIV) positive; patients must have a negative hepatitis B and HIV test performed within 28 days prior to registration; exception: treatment-sensitive HIV infection patients will be eligible provided that immunological and virologic indices are indicative of favorable long-term survival prospects on the basis of HIV infection, but whose life expectancy is limited predominantly by multiple myeloma rather than HIV infection in the judgment of the treating physician Patients must not have a history of cerebral vascular accident with persistent neurologic deficits Patients must be able to take aspirin 325 mg daily (or enoxaparin 40 mg subcutaneously \[SQ\] daily if patient is unable to take aspirin) as prophylactic anticoagulation; exception: patients receiving anticoagulation therapy such as Coumadin or heparin will NOT receive aspirin, and therefore need not be able to take it Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days and again within 24 hours prior to starting cycle 1 of lenalidomide; further, they must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy; a FCBP is a sexually mature woman who: has not undergone a hysterectomy or bilateral oophorectomy; or has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); all patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure No prior malignancy is allowed except for adequately treated basal cell (or squamous cell) skin cancer, in situ cervical cancer or other cancer for which the patient has been disease-free for five years Patients must be offered participation in gene expression profiling (GEP) molecular studies for the evaluation of genetic polymorphisms All patients must be informed of the investigational nature of this study and must sign and give written consent in accordance with institutional federal guidelines At the time of patient registration, the treating institution's name and identification (ID) number must be provided to the statistical center in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered into the data base

Contacts and Locations

Sponsors and Collaborators	National Cancer Institute (NCI)
Locations	Providence Alaska Medical Center \| Anchorage Alaska, United States, 99508Mayo Clinic in Arizona \| Scottsdale Arizona, United States, 85259University of Arizona Cancer Center-Orange Grove Campus \| Tucson Arizona, United States, 85704Banner University Medical Center - Tucson \| Tucson Arizona, United States, 85719University of Arizona Cancer Center-North Campus \| Tucson Arizona, United States, 85719University of Arkansas for Medical Sciences \| Little Rock Arkansas, United States, 72205Kaiser Permanente-Deer Valley Medical Center \| Antioch California, United States, 94531PCR Oncology \| Arroyo Grande California, United States, 93420Alta Bates Summit Medical Center-Herrick Campus \| Berkeley California, United States, 94704Providence Saint Joseph Medical Center/Disney Family Cancer Center \| Burbank California, United States, 91505Mills-Peninsula Medical Center \| Burlingame California, United States, 94010Kaiser Permanente-Fremont \| Fremont California, United States, 94538Kaiser Permanente-Fresno \| Fresno California, United States, 93720Saint Jude Medical Center \| Fullerton California, United States, 92835Marin General Hospital \| Greenbrae California, United States, 94904Fremont - Rideout Cancer Center \| Marysville California, United States, 95901Providence Holy Cross Medical Center \| Mission Hills California, United States, 91346-9600Palo Alto Medical Foundation-Camino Division \| Mountain View California, United States, 94040Sutter Cancer Research Consortium \| Novato California, United States, 94945Kaiser Permanente-Oakland \| Oakland California, United States, 94611Saint Joseph Hospital - Orange \| Orange California, United States, 92868Desert Regional Medical Center \| Palm Springs California, United States, 92262Palo Alto Medical Foundation Health Care \| Palo Alto California, United States, 94301Valley Medical Oncology Consultants \| Pleasanton California, United States, 94588Eisenhower Medical Center \| Rancho Mirage California, United States, 92270Kaiser Permanente-Redwood City \| Redwood City California, United States, 94063Kaiser Permanente-Richmond \| Richmond California, United States, 94801Kaiser Permanente-Roseville \| Roseville California, United States, 95661University of California Davis Comprehensive Cancer Center \| Sacramento California, United States, 95817Kaiser Permanente-South Sacramento \| Sacramento California, United States, 95823Kaiser Permanente Sacramento Medical Center \| Sacramento California, United States, 95825California Pacific Medical Center-Pacific Campus \| San Francisco California, United States, 94115Kaiser Permanente-San Francisco \| San Francisco California, United States, 94115Kaiser Permanente-Santa Teresa-San Jose \| San Jose California, United States, 95119Kaiser Permanente San Leandro \| San Leandro California, United States, 94577Kaiser Permanente-San Rafael \| San Rafael California, United States, 94903Kaiser Permanente Medical Center - Santa Clara \| Santa Clara California, United States, 95051Kaiser Permanente-Santa Rosa \| Santa Rosa California, United States, 95403Kaiser Permanente-South San Francisco \| South San Francisco California, United States, 94080Kaiser Permanente-Stockton \| Stockton California, United States, 95210Gene Upshaw Memorial Tahoe Forest Cancer Center \| Truckee California, United States, 96161Kaiser Permanente Medical Center-Vacaville \| Vacaville California, United States, 95688Kaiser Permanente-Vallejo \| Vallejo California, United States, 94589Sutter Solano Medical Center/Cancer Center \| Vallejo California, United States, 94589Kaiser Permanente-Walnut Creek \| Walnut Creek California, United States, 94596The Medical Center of Aurora \| Aurora Colorado, United States, 80012UCHealth University of Colorado Hospital \| Aurora Colorado, United States, 80045Boulder Community Foothills Hospital \| Boulder Colorado, United States, 80303Penrose-Saint Francis Healthcare \| Colorado Springs Colorado, United States, 80907Denver Health Medical Center \| Denver Colorado, United States, 80204Kaiser Permanente-Franklin \| Denver Colorado, United States, 80205AdventHealth Porter \| Denver Colorado, United States, 80210Presbyterian - Saint Lukes Medical Center - Health One \| Denver Colorado, United States, 80218Saint Joseph Hospital - Cancer Centers of Colorado \| Denver Colorado, United States, 80218Rose Medical Center \| Denver Colorado, United States, 80220Western States Cancer Research NCORP \| Denver Colorado, United States, 80222Swedish Medical Center \| Englewood Colorado, United States, 80113Poudre Valley Hospital \| Fort Collins Colorado, United States, 80524Saint Mary's Hospital and Regional Medical Center \| Grand Junction Colorado, United States, 81501Banner North Colorado Medical Center \| Greeley Colorado, United States, 80631Kaiser Permanente-Rock Creek \| Lafayette Colorado, United States, 80026CommonSpirit Saint Anthony Hospital Cancer Center \| Lakewood Colorado, United States, 80228Sky Ridge Medical Center \| Lone Tree Colorado, United States, 80124Longmont United Hospital \| Longmont Colorado, United States, 80501Banner North Colorado Medical Center - Loveland Campus \| Loveland Colorado, United States, 80539AdventHealth Parker \| Parker Colorado, United States, 80138Saint Mary Corwin Medical Center \| Pueblo Colorado, United States, 81004North Suburban Medical Center \| Thornton Colorado, United States, 80229Intermountain Health Lutheran Hospital \| Wheat Ridge Colorado, United States, 80401Danbury Hospital \| Danbury Connecticut, United States, 06810Smilow Cancer Hospital Care Center at Saint Francis \| Hartford Connecticut, United States, 06105The Hospital of Central Connecticut \| New Britain Connecticut, United States, 06050Norwalk Hospital \| Norwalk Connecticut, United States, 06856Beebe Medical Center \| Lewes Delaware, United States, 19958Christiana Care Health System-Christiana Hospital \| Newark Delaware, United States, 19718Mayo Clinic in Florida \| Jacksonville Florida, United States, 32224-9980AdventHealth Orlando \| Orlando Florida, United States, 32803Orlando Health Cancer Institute \| Orlando Florida, United States, 32806Martin Medical Center \| Stuart Florida, United States, 34994Robert and Carol Weissman Cancer Center at Martin Health \| Stuart Florida, United States, 34994Martin Hospital South \| Stuart Florida, United States, 34997Piedmont Hospital \| Atlanta Georgia, United States, 30309Atlanta Regional CCOP \| Atlanta Georgia, United States, 30342Emory Saint Joseph's Hospital \| Atlanta Georgia, United States, 30342Northside Hospital \| Atlanta Georgia, United States, 30342WellStar Cobb Hospital \| Austell Georgia, United States, 30106John B Amos Cancer Center \| Columbus Georgia, United States, 31904Emory Decatur Hospital \| Decatur Georgia, United States, 30033Piedmont Fayette Hospital \| Fayetteville Georgia, United States, 30214Northside Hospital - Gwinnett \| Lawrenceville Georgia, United States, 30046Wellstar Kennestone Hospital \| Marietta Georgia, United States, 30060Southern Regional Medical Center \| Riverdale Georgia, United States, 30274Harbin Clinic Medical Oncology and Clinical Research \| Rome Georgia, United States, 30165Hawaii Cancer Care Inc - Waterfront Plaza \| Honolulu Hawaii, United States, 96813Queen's Medical Center \| Honolulu Hawaii, United States, 96813Straub Clinic and Hospital \| Honolulu Hawaii, United States, 96813University of Hawaii Cancer Center \| Honolulu Hawaii, United States, 96813Queen's Cancer Center - Kuakini \| Honolulu Hawaii, United States, 96817The Cancer Center of Hawaii-Liliha \| Honolulu Hawaii, United States, 96817Kaiser Permanente Moanalua Medical Center \| Honolulu Hawaii, United States, 96819Kapiolani Medical Center for Women and Children \| Honolulu Hawaii, United States, 96826Castle Medical Center \| Kailua Hawaii, United States, 96734Wilcox Memorial Hospital and Kauai Medical Clinic \| Lihue Hawaii, United States, 96766Maui Memorial Medical Center \| Wailuku Hawaii, United States, 96793Pacific Cancer Institute of Maui \| Wailuku Hawaii, United States, 96793Pali Momi Medical Center \| ‘Aiea Hawaii, United States, 96701OSF Saint Anthony's Health Center \| Alton Illinois, United States, 62002Rush-Copley Medical Center \| Aurora Illinois, United States, 60504MacNeal Hospital and Cancer Center \| Berwyn Illinois, United States, 60402OSF Saint Joseph Medical Center \| Bloomington Illinois, United States, 61701Illinois CancerCare-Bloomington \| Bloomington Illinois, United States, 61704Graham Hospital Association \| Canton Illinois, United States, 61520Illinois CancerCare-Canton \| Canton Illinois, United States, 61520Illinois CancerCare-Carthage \| Carthage Illinois, United States, 62321Memorial Hospital \| Carthage Illinois, United States, 62321Hematology and Oncology Associates \| Chicago Illinois, United States, 60611Northwestern University \| Chicago Illinois, United States, 60611University of Illinois \| Chicago Illinois, United States, 60612Decatur Memorial Hospital \| Decatur Illinois, United States, 62526Heartland Cancer Research NCORP \| Decatur Illinois, United States, 62526Advocate Good Samaritan Hospital \| Downers Grove Illinois, United States, 60515Eureka Hospital \| Eureka Illinois, United States, 61530Illinois CancerCare-Eureka \| Eureka Illinois, United States, 61530NorthShore University HealthSystem-Evanston Hospital \| Evanston Illinois, United States, 60201Galesburg Cottage Hospital \| Galesburg Illinois, United States, 61401Illinois CancerCare-Galesburg \| Galesburg Illinois, United States, 61401Illinois CancerCare-Havana \| Havana Illinois, United States, 62644Mason District Hospital \| Havana Illinois, United States, 62644Hematology Oncology Associates of Illinois-Highland Park \| Highland Park Illinois, United States, 60035Hopedale Medical Complex - Hospital \| Hopedale Illinois, United States, 61747Midwest Center for Hematology Oncology \| Joliet Illinois, United States, 60432Duly Health and Care Joliet \| Joliet Illinois, United States, 60435Presence Saint Mary's Hospital \| Kankakee Illinois, United States, 60901Illinois CancerCare-Kewanee Clinic \| Kewanee Illinois, United States, 61443AMG Libertyville - Oncology \| Libertyville Illinois, United States, 60048Illinois CancerCare-Macomb \| Macomb Illinois, United States, 61455Mcdonough District Hospital \| Macomb Illinois, United States, 61455Loyola University Medical Center \| Maywood Illinois, United States, 60153Holy Family Medical Center \| Monmouth Illinois, United States, 61462Illinois CancerCare-Monmouth \| Monmouth Illinois, United States, 61462SSM Health Good Samaritan \| Mount Vernon Illinois, United States, 62864DuPage Medical Group-Ogden \| Naperville Illinois, United States, 60563Illinois Cancer Specialists-Niles \| Niles Illinois, United States, 60714Carle BroMenn Medical Center \| Normal Illinois, United States, 61761Carle Cancer Institute Normal \| Normal Illinois, United States, 61761Illinois CancerCare-Community Cancer Center \| Normal Illinois, United States, 61761Illinois CancerCare-Ottawa Clinic \| Ottawa Illinois, United States, 61350Ottawa Regional Hospital and Healthcare Center \| Ottawa Illinois, United States, 61350Illinois CancerCare-Pekin \| Pekin Illinois, United States, 61554OSF Saint Francis Radiation Oncology at Pekin \| Pekin Illinois, United States, 61554Pekin Hospital \| Pekin Illinois, United States, 61554Proctor Hospital \| Peoria Illinois, United States, 61614Illinois CancerCare-Peoria \| Peoria Illinois, United States, 61615Methodist Medical Center of Illinois \| Peoria Illinois, United States, 61636OSF Saint Francis Medical Center \| Peoria Illinois, United States, 61637Illinois CancerCare-Peru \| Peru Illinois, United States, 61354Illinois Valley Hospital \| Peru Illinois, United States, 61354Illinois CancerCare-Princeton \| Princeton Illinois, United States, 61356Perry Memorial Hospital \| Princeton Illinois, United States, 61356Hematology Oncology Associates of Illinois - Skokie \| Skokie Illinois, United States, 60076Illinois CancerCare-Spring Valley \| Spring Valley Illinois, United States, 61362Saint Margaret's Hospital \| Spring Valley Illinois, United States, 61362Springfield Memorial Hospital \| Springfield Illinois, United States, 62781Carle Cancer Center \| Urbana Illinois, United States, 61801Northwestern Medicine Cancer Center Warrenville \| Warrenville Illinois, United States, 60555Northwestern Medicine Central DuPage Hospital \| Winfield Illinois, United States, 60190Franciscan Saint Francis Health-Beech Grove \| Beech Grove Indiana, United States, 46107Elkhart Clinic \| Elkhart Indiana, United States, 46514-2098Michiana Hematology Oncology PC-Elkhart \| Elkhart Indiana, United States, 46514Elkhart General Hospital \| Elkhart Indiana, United States, 46515Fort Wayne Medical Oncology and Hematology Inc-Parkview \| Fort Wayne Indiana, United States, 46845Goshen Center for Cancer Care \| Goshen Indiana, United States, 46526Community Howard Regional Health \| Kokomo Indiana, United States, 46904IU Health La Porte Hospital \| La Porte Indiana, United States, 46350Franciscan Saint Anthony Health-Michigan City \| Michigan City Indiana, United States, 46360Michiana Hematology Oncology PC-Mishawaka \| Mishawaka Indiana, United States, 46545Saint Joseph Regional Medical Center-Mishawaka \| Mishawaka Indiana, United States, 46545The Community Hospital \| Munster Indiana, United States, 46321Michiana Hematology Oncology PC-Plymouth \| Plymouth Indiana, United States, 46563Reid Health \| Richmond Indiana, United States, 47374Memorial Hospital of South Bend \| South Bend Indiana, United States, 46601Northern Indiana Cancer Research Consortium \| South Bend Indiana, United States, 46628Michiana Hematology Oncology PC-Westville \| Westville Indiana, United States, 46391Mercy Hospital \| Cedar Rapids Iowa, United States, 52403Oncology Associates at Mercy Medical Center \| Cedar Rapids Iowa, United States, 52403Iowa-Wide Oncology Research Coalition NCORP \| Des Moines Iowa, United States, 50309Mercy Medical Center - North Iowa \| Mason City Iowa, United States, 50401Ottumwa Regional Health Center \| Ottumwa Iowa, United States, 52501Siouxland Regional Cancer Center \| Sioux City Iowa, United States, 51101Mercy Medical Center-Sioux City \| Sioux City Iowa, United States, 51102Saint Luke's Regional Medical Center \| Sioux City Iowa, United States, 51104Lawrence Memorial Hospital \| Lawrence Kansas, United States, 66044Menorah Medical Center \| Overland Park Kansas, United States, 66209Saint Luke's South Hospital \| Overland Park Kansas, United States, 66213Kansas City NCI Community Oncology Research Program \| Prairie Village Kansas, United States, 66208Salina Regional Health Center \| Salina Kansas, United States, 67401AdventHealth Shawnee Mission \| Shawnee Mission Kansas, United States, 66204Cotton O'Neil Cancer Center / Stormont Vail Health \| Topeka Kansas, United States, 66606Wesley Medical Center \| Wichita Kansas, United States, 67214Wichita NCI Community Oncology Research Program \| Wichita Kansas, United States, 67214Mary Bird Perkins Cancer Center \| Baton Rouge Louisiana, United States, 70809Louisiana State University Health Science Center \| New Orleans Louisiana, United States, 70112University Medical Center New Orleans \| New Orleans Louisiana, United States, 70112Harold Alfond Center for Cancer Care \| Augusta Maine, United States, 04330Eastern Maine Medical Center \| Bangor Maine, United States, 04401York Hospital \| York Village Maine, United States, 03909Greater Baltimore Medical Center \| Baltimore Maryland, United States, 21204Sinai Hospital of Baltimore \| Baltimore Maryland, United States, 21215Christiana Care - Union Hospital \| Elkton Maryland, United States, 21921Boston Medical Center \| Boston Massachusetts, United States, 02118Beth Israel Deaconess Medical Center \| Boston Massachusetts, United States, 02215Commonwealth Hematology Oncology PC-Concord \| Concord Massachusetts, United States, 01742Dana Farber Community Cancer Care-Haverhill \| Haverhill Massachusetts, United States, 01830Dana Farber-Merrimack Valley \| Methuen Massachusetts, United States, 01844Dana Farber Community Cancer Care-Quincy \| Quincy Massachusetts, United States, 02169Baystate Medical Center \| Springfield Massachusetts, United States, 01199Dana Farber Community Cancer Care-Stoneham \| Stoneham Massachusetts, United States, 02180Dana Farber Community Cancer Care-Weymouth \| Weymouth Massachusetts, United States, 02189Commonwealth Hematology Oncology PC-Worcester \| Worcester Massachusetts, United States, 01605Bixby Medical Center \| Adrian Michigan, United States, 49221Hickman Cancer Center \| Adrian Michigan, United States, 49221Michigan Cancer Research Consortium NCORP \| Ann Arbor Michigan, United States, 48106Trinity Health Saint Joseph Mercy Hospital Ann Arbor \| Ann Arbor Michigan, United States, 48106University of Michigan Rogel Cancer Center \| Ann Arbor Michigan, United States, 48109Bronson Battle Creek \| Battle Creek Michigan, United States, 49017Spectrum Health Big Rapids Hospital \| Big Rapids Michigan, United States, 49307Corewell Health Dearborn Hospital \| Dearborn Michigan, United States, 48124Wayne State University/Karmanos Cancer Institute \| Detroit Michigan, United States, 48201Henry Ford Health Saint John Hospital \| Detroit Michigan, United States, 48236OSF Saint Francis Hospital and Medical Group \| Escanaba Michigan, United States, 49829Hurley Medical Center \| Flint Michigan, United States, 48503Genesys Regional Medical Center-West Flint Campus \| Flint Michigan, United States, 48532Cancer Research Consortium of West Michigan NCORP \| Grand Rapids Michigan, United States, 49503Corewell Health Grand Rapids Hospitals - Butterworth Hospital \| Grand Rapids Michigan, United States, 49503Trinity Health Grand Rapids Hospital \| Grand Rapids Michigan, United States, 49503Holland Community Hospital \| Holland Michigan, United States, 49423Allegiance Health \| Jackson Michigan, United States, 49201Bronson Methodist Hospital \| Kalamazoo Michigan, United States, 49007West Michigan Cancer Center \| Kalamazoo Michigan, United States, 49007Beacon Kalamazoo \| Kalamazoo Michigan, United States, 49048University of Michigan Health - Sparrow Lansing \| Lansing Michigan, United States, 48912Trinity Health Saint Mary Mercy Livonia Hospital \| Livonia Michigan, United States, 48154UP Health System Marquette \| Marquette Michigan, United States, 49855Mercy Memorial Hospital \| Monroe Michigan, United States, 48162Toledo Clinic Cancer Centers-Monroe \| Monroe Michigan, United States, 48162McLaren Cancer Institute-Macomb \| Mount Clemens Michigan, United States, 48043Mercy Health Partners-Hackley Campus \| Muskegon Michigan, United States, 49442Trinity Health Muskegon Hospital \| Muskegon Michigan, United States, 49444Corewell Health Lakeland Hospitals - Niles Hospital \| Niles Michigan, United States, 49120Trinity Health Saint Joseph Mercy Oakland Hospital \| Pontiac Michigan, United States, 48341Lake Huron Medical Center \| Port Huron Michigan, United States, 48060Corewell Health William Beaumont University Hospital \| Royal Oak Michigan, United States, 48073MyMichigan Medical Center Saginaw \| Saginaw Michigan, United States, 48601Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center \| Saint Joseph Michigan, United States, 49085Corewell Health Lakeland Hospitals - Saint Joseph Hospital \| Saint Joseph Michigan, United States, 49085Henry Ford Health Providence Southfield Hospital \| Southfield Michigan, United States, 48075Munson Medical Center \| Traverse City Michigan, United States, 49684Henry Ford Health Warren Hospital \| Warren Michigan, United States, 48093University of Michigan Health - West \| Wyoming Michigan, United States, 49519Medini, Eitan MD (UIA Investigator) \| Alexandria Minnesota, United States, 56308Essentia Health Saint Joseph's Medical Center \| Brainerd Minnesota, United States, 56401Fairview Ridges Hospital \| Burnsville Minnesota, United States, 55337Mercy Hospital \| Coon Rapids Minnesota, United States, 55433Essentia Health Cancer Center \| Duluth Minnesota, United States, 55805Essentia Health Saint Mary's Medical Center \| Duluth Minnesota, United States, 55805Miller-Dwan Hospital \| Duluth Minnesota, United States, 55805Fairview Southdale Hospital \| Edina Minnesota, United States, 55435Etzell, Paul S MD (UIA Investigator) \| Fergus Falls Minnesota, United States, 56537Swenson, Wade II, MD (UIA Investigator) \| Fergus Falls Minnesota, United States, 56537Unity Hospital \| Fridley Minnesota, United States, 55432Hutchinson Area Health Care \| Hutchinson Minnesota, United States, 55350Meeker County Memorial Hospital \| Litchfield Minnesota, United States, 55355Minnesota Oncology Hematology PA-Maplewood \| Maplewood Minnesota, United States, 55109Saint John's Hospital - Healtheast \| Maplewood Minnesota, United States, 55109Abbott-Northwestern Hospital \| Minneapolis Minnesota, United States, 55407Virginia Piper Cancer Institute \| Minneapolis Minnesota, United States, 55407Hennepin County Medical Center \| Minneapolis Minnesota, United States, 55415North Memorial Medical Health Center \| Robbinsdale Minnesota, United States, 55422Mayo Clinic in Rochester \| Rochester Minnesota, United States, 55905Coborn Cancer Center at Saint Cloud Hospital \| Saint Cloud Minnesota, United States, 56303Saint Cloud Hospital \| Saint Cloud Minnesota, United States, 56303Metro Minnesota Community Oncology Research Consortium \| Saint Louis Park Minnesota, United States, 55416Park Nicollet Clinic - Saint Louis Park \| Saint Louis Park Minnesota, United States, 55416Regions Hospital \| Saint Paul Minnesota, United States, 55101Saint Joseph's Hospital - Healtheast \| Saint Paul Minnesota, United States, 55102United Hospital \| Saint Paul Minnesota, United States, 55102Saint Francis Regional Medical Center \| Shakopee Minnesota, United States, 55379Lakeview Hospital \| Stillwater Minnesota, United States, 55082Ridgeview Medical Center \| Waconia Minnesota, United States, 55387Rice Memorial Hospital \| Willmar Minnesota, United States, 56201Fairview Cancer Center - Woodbury \| Woodbury Minnesota, United States, 55125Minnesota Oncology Hematology PA-Woodbury \| Woodbury Minnesota, United States, 55125University of Mississippi Medical Center \| Jackson Mississippi, United States, 39216Keesler Medical Center \| Keesler Air Force Base Mississippi, United States, 39534Singing River Hospital \| Pascagoula Mississippi, United States, 39581Southeast Missouri Hospital \| Cape Girardeau Missouri, United States, 63701Saint Francis Medical Center \| Cape Girardeau Missouri, United States, 63703Freeman Health System \| Joplin Missouri, United States, 64804University Health Truman Medical Center \| Kansas City Missouri, United States, 64108Saint Luke's Hospital of Kansas City \| Kansas City Missouri, United States, 64111Saint Joseph Health Center \| Kansas City Missouri, United States, 64114North Kansas City Hospital \| Kansas City Missouri, United States, 64116Heartland Hematology and Oncology Associates Incorporated \| Kansas City Missouri, United States, 64118Research Medical Center \| Kansas City Missouri, United States, 64132Saint Luke's East - Lee's Summit \| Lee's Summit Missouri, United States, 64086Liberty Hospital \| Liberty Missouri, United States, 64068Heartland Regional Medical Center \| Saint Joseph Missouri, United States, 64506Mercy Infusion Center - Chippewa \| St Louis Missouri, United States, 63109Mercy Hospital Saint Louis \| St Louis Missouri, United States, 63141Saint Louis-Cape Girardeau CCOP \| St Louis Missouri, United States, 63141Billings Clinic Cancer Center \| Billings Montana, United States, 59101Northern Rockies Radiation Oncology Center \| Billings Montana, United States, 59101Saint Vincent Healthcare \| Billings Montana, United States, 59101Montana Cancer Consortium NCORP \| Billings Montana, United States, 59102Saint Vincent Frontier Cancer Center \| Billings Montana, United States, 59102Bozeman Health Deaconess Hospital \| Bozeman Montana, United States, 59715Saint James Community Hospital and Cancer Treatment Center \| Butte Montana, United States, 59701Benefis Sletten Cancer Institute \| Great Falls Montana, United States, 59405Berdeaux, Donald MD (UIA Investigator) \| Great Falls Montana, United States, 59405Great Falls Clinic \| Great Falls Montana, United States, 59405Northern Montana Hospital \| Havre Montana, United States, 59501Saint Peter's Community Hospital \| Helena Montana, United States, 59601Glacier Oncology PLLC \| Kalispell Montana, United States, 59901Kalispell Medical Oncology \| Kalispell Montana, United States, 59901Logan Health Medical Center \| Kalispell Montana, United States, 59901Montana Cancer Specialists \| Missoula Montana, United States, 59802Saint Patrick Hospital - Community Hospital \| Missoula Montana, United States, 59802Community Medical Center \| Missoula Montana, United States, 59804Guardian Oncology and Center for Wellness \| Missoula Montana, United States, 59804University Medical Center of Southern Nevada \| Las Vegas Nevada, United States, 89102Nevada Cancer Research Foundation NCORP \| Las Vegas Nevada, United States, 89120Cooper Hospital University Medical Center \| Camden New Jersey, United States, 08103CentraState Medical Center \| Freehold New Jersey, United States, 07728Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital \| New Brunswick New Jersey, United States, 08903Rutgers Cancer Institute of New Jersey \| New Brunswick New Jersey, United States, 08903Rutgers New Jersey Medical School \| Newark New Jersey, United States, 07101Lovelace Medical Center-Saint Joseph Square \| Albuquerque New Mexico, United States, 87102University of New Mexico Cancer Center \| Albuquerque New Mexico, United States, 87106Memorial Medical Center-Las Cruces \| Las Cruces New Mexico, United States, 88011San Juan Regional Medical Center \| San Juan New Mexico, United States, 87401Adirondack Cancer Center \| Glens Falls New York, United States, 12801Garnet Health Medical Center \| Middletown New York, United States, 10940NYU Langone Hospital - Long Island \| Mineola New York, United States, 11501Mount Sinai Union Square \| New York New York, United States, 10003Mount Sinai West \| New York New York, United States, 10019Highland Hospital \| Rochester New York, United States, 14620University of Rochester \| Rochester New York, United States, 14642Montefiore Medical Center-Wakefield Campus \| The Bronx New York, United States, 10466Mission Hospital \| Asheville North Carolina, United States, 28801Novant Health Presbyterian Medical Center \| Charlotte North Carolina, United States, 28204Wayne Memorial Hospital \| Goldsboro North Carolina, United States, 27534Margaret R Pardee Memorial Hospital \| Hendersonville North Carolina, United States, 28791ECU Health Oncology Kinston \| Kinston North Carolina, United States, 28501Rutherford Hospital \| Rutherfordton North Carolina, United States, 28139Southeast Clinical Oncology Research Consortium NCORP \| Winston-Salem North Carolina, United States, 27104Mid Dakota Clinic \| Bismarck North Dakota, United States, 58501Saint Alexius Medical Center \| Bismarck North Dakota, United States, 58501Sanford Bismarck Medical Center \| Bismarck North Dakota, United States, 58501Cleveland Clinic Cancer Center Beachwood \| Beachwood Ohio, United States, 44122Toledo Clinic Cancer Centers-Bowling Green \| Bowling Green Ohio, United States, 43402Case Western Reserve University \| Cleveland Ohio, United States, 44106MetroHealth Medical Center \| Cleveland Ohio, United States, 44109Cleveland Clinic Cancer Center/Fairview Hospital \| Cleveland Ohio, United States, 44111Cleveland Clinic Foundation \| Cleveland Ohio, United States, 44195North Coast Cancer Care-Clyde \| Clyde Ohio, United States, 43410Grandview Hospital \| Dayton Ohio, United States, 45405Good Samaritan Hospital - Dayton \| Dayton Ohio, United States, 45406Miami Valley Hospital \| Dayton Ohio, United States, 45409Miami Valley Hospital North \| Dayton Ohio, United States, 45415Dayton Veterans Affairs Medical Center \| Dayton Ohio, United States, 45428Dayton NCI Community Oncology Research Program \| Dayton Ohio, United States, 45459Hematology Oncology Center Incorporated \| Elyria Ohio, United States, 44035Mercy Cancer Center-Elyria \| Elyria Ohio, United States, 44035Blanchard Valley Hospital \| Findlay Ohio, United States, 45840Atrium Medical Center-Middletown Regional Hospital \| Franklin Ohio, United States, 45005-1066Wayne Hospital \| Greenville Ohio, United States, 45331Cleveland Clinic Cancer Center Independence \| Independence Ohio, United States, 44131Kettering Medical Center \| Kettering Ohio, United States, 45429Saint Rita's Medical Center \| Lima Ohio, United States, 45801Lima Memorial Hospital \| Lima Ohio, United States, 45804Saint Luke's Hospital \| Maumee Ohio, United States, 43537Toledo Clinic Cancer Centers-Maumee \| Maumee Ohio, United States, 43537Toledo Radiation Oncology at Northwest Ohio Onocolgy Center \| Maumee Ohio, United States, 43537Hillcrest Hospital Cancer Center \| Mayfield Heights Ohio, United States, 44124Fisher-Titus Medical Center \| Norwalk Ohio, United States, 44857Saint Charles Hospital \| Oregon Ohio, United States, 43616Toledo Clinic Cancer Centers-Oregon \| Oregon Ohio, United States, 43616University Hospitals Parma Medical Center \| Parma Ohio, United States, 44129North Coast Cancer Care \| Sandusky Ohio, United States, 44870ProMedica Flower Hospital \| Sylvania Ohio, United States, 43560Mercy Hospital of Tiffin \| Tiffin Ohio, United States, 44883ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital \| Toledo Ohio, United States, 43606Mercy Health - Saint Vincent Hospital \| Toledo Ohio, United States, 43608University of Toledo \| Toledo Ohio, United States, 43614Toledo Community Hospital Oncology Program CCOP \| Toledo Ohio, United States, 43617Mercy Health - Saint Anne Hospital \| Toledo Ohio, United States, 43623Toledo Clinic Cancer Centers-Toledo \| Toledo Ohio, United States, 43623Upper Valley Medical Center \| Troy Ohio, United States, 45373Fulton County Health Center \| Wauseon Ohio, United States, 43567Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center \| Wilmington Ohio, United States, 45177Cleveland Clinic Wooster Family Health and Surgery Center \| Wooster Ohio, United States, 44691Greene Memorial Hospital \| Xenia Ohio, United States, 45385Clackamas Radiation Oncology Center \| Clackamas Oregon, United States, 97015Legacy Mount Hood Medical Center \| Gresham Oregon, United States, 97030Providence Milwaukie Hospital \| Milwaukie Oregon, United States, 97222Providence Newberg Medical Center \| Newberg Oregon, United States, 97132Providence Willamette Falls Medical Center \| Oregon City Oregon, United States, 97045Legacy Good Samaritan Hospital and Medical Center \| Portland Oregon, United States, 97210Providence Portland Medical Center \| Portland Oregon, United States, 97213Adventist Medical Center \| Portland Oregon, United States, 97216Providence Saint Vincent Medical Center \| Portland Oregon, United States, 97225Compass Oncology Rose Quarter \| Portland Oregon, United States, 97227Legacy Emanuel Hospital and Health Center \| Portland Oregon, United States, 97227Legacy Meridian Park Hospital \| Tualatin Oregon, United States, 97062Lehigh Valley Hospital-Cedar Crest \| Allentown Pennsylvania, United States, 18103Butler Memorial Hospital \| Butler Pennsylvania, United States, 16001Geisinger Medical Center \| Danville Pennsylvania, United States, 17822Oncology Hematology Associates of Northern Pennsylvania \| DuBois Pennsylvania, United States, 15801Geisinger Medical Center-Cancer Center Hazleton \| Hazleton Pennsylvania, United States, 18201Penn State Milton S Hershey Medical Center \| Hershey Pennsylvania, United States, 17033-0850Lancaster General Hospital \| Lancaster Pennsylvania, United States, 17602Pennsylvania Hospital \| Philadelphia Pennsylvania, United States, 19107Geisinger Medical Group \| State College Pennsylvania, United States, 16801Mount Nittany Medical Center \| State College Pennsylvania, United States, 16803Associates In Hematology Oncology PC-Upland \| Upland Pennsylvania, United States, 19013Jennersville Regional Hospital \| West Grove Pennsylvania, United States, 19390Reading Hospital \| West Reading Pennsylvania, United States, 19611Geisinger Wyoming Valley/Henry Cancer Center \| Wilkes-Barre Pennsylvania, United States, 18711Geisinger South Wilkes-Barre \| Wilkes-Barre Pennsylvania, United States, 18765Hematology and Oncology Associates of Rhode Island Inc \| Cranston Rhode Island, United States, 02920Memorial Hospital of Rhode Island \| Pawtucket Rhode Island, United States, 02860Kent Hospital \| Warwick Rhode Island, United States, 02886AnMed Health Hospital \| Anderson South Carolina, United States, 29621Spartanburg Medical Center \| Spartanburg South Carolina, United States, 29303Rapid City Regional Hospital \| Rapid City South Dakota, United States, 57701Sanford Cancer Center Oncology Clinic \| Sioux Falls South Dakota, United States, 57104Avera Cancer Institute \| Sioux Falls South Dakota, United States, 57105Medical X-Ray Center \| Sioux Falls South Dakota, United States, 57105Avera McKennan Hospital and University Health Center \| Sioux Falls South Dakota, United States, 57117-5045Sanford USD Medical Center - Sioux Falls \| Sioux Falls South Dakota, United States, 57117-5134Erlanger Medical Center \| Chattanooga Tennessee, United States, 37403Jackson-Madison County General Hospital \| Jackson Tennessee, United States, 38301The Jackson Clinic PA \| Jackson Tennessee, United States, 38301Wellmont Holston Valley Hospital and Medical Center \| Kingsport Tennessee, United States, 37660University of Tennessee Health Science Center \| Memphis Tennessee, United States, 38163The Don and Sybil Harrington Cancer Center \| Amarillo Texas, United States, 79106Brooke Army Medical Center \| Fort Sam Houston Texas, United States, 78234Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center \| Houston Texas, United States, 77030Baylor Saint Luke's Medical Center \| Houston Texas, United States, 77030Ben Taub General Hospital \| Houston Texas, United States, 77030Houston Methodist Hospital \| Houston Texas, United States, 77030M D Anderson Cancer Center \| Houston Texas, United States, 77030Michael E DeBakey VA Medical Center \| Houston Texas, United States, 77030Wilford Hall Medical Center \| Lackland Air Force Base Texas, United States, 78236Danville Regional Medical Center \| Danville Virginia, United States, 24541Fredericksburg Oncology Inc \| Fredericksburg Virginia, United States, 22401Sovah Health Martinsville \| Martinsville Virginia, United States, 24112Ballad Health Cancer Care - Norton \| Norton Virginia, United States, 24273Virginia Mason Medical Center \| Seattle Washington, United States, 98101PeaceHealth Southwest Medical Center \| Vancouver Washington, United States, 98664Compass Oncology Vancouver \| Vancouver Washington, United States, 98684Legacy Salmon Creek Hospital \| Vancouver Washington, United States, 98686Wheeling Hospital/Schiffler Cancer Center \| Wheeling West Virginia, United States, 26003Aurora Cancer Care-Southern Lakes VLCC \| Burlington Wisconsin, United States, 53105Marshfield Clinic-Chippewa Center \| Chippewa Falls Wisconsin, United States, 54729HSHS Sacred Heart Hospital \| Eau Claire Wisconsin, United States, 54701Marshfield Clinic Cancer Center at Sacred Heart \| Eau Claire Wisconsin, United States, 54701Green Bay Oncology at Saint Vincent Hospital \| Green Bay Wisconsin, United States, 54301-3526Saint Vincent Hospital Cancer Center Green Bay \| Green Bay Wisconsin, United States, 54301Saint Vincent Hospital Cancer Center at Saint Mary's \| Green Bay Wisconsin, United States, 54303Aurora BayCare Medical Center \| Green Bay Wisconsin, United States, 54311University of Wisconsin Carbone Cancer Center - Johnson Creek \| Johnson Creek Wisconsin, United States, 53038Gundersen Lutheran Medical Center \| La Crosse Wisconsin, United States, 54601Mayo Clinic Health System-Franciscan Healthcare \| La Crosse Wisconsin, United States, 54601Marshfield Medical Center - Ladysmith \| Ladysmith Wisconsin, United States, 54848University of Wisconsin Carbone Cancer Center - University Hospital \| Madison Wisconsin, United States, 53792Holy Family Memorial Hospital \| Manitowoc Wisconsin, United States, 54221Aurora Bay Area Medical Group-Marinette \| Marinette Wisconsin, United States, 54143Bay Area Medical Center \| Marinette Wisconsin, United States, 54143Marshfield Medical Center-Marshfield \| Marshfield Wisconsin, United States, 54449Marshfield Medical Center \| Marshfield Wisconsin, United States, 54449Ascension Southeast Wisconsin Hospital - Saint Joseph Campus \| Milwaukee Wisconsin, United States, 53210Marshfield Medical Center - Minocqua \| Minocqua Wisconsin, United States, 54548Saint Vincent Hospital Cancer Center at Oconto Falls \| Oconto Falls Wisconsin, United States, 54154Aspirus Cancer Care - James Beck Cancer Center \| Rhinelander Wisconsin, United States, 54501Marshfield Medical Center-Rice Lake \| Rice Lake Wisconsin, United States, 54868HSHS Saint Nicholas Hospital \| Sheboygan Wisconsin, United States, 53081Vince Lombardi Cancer Clinic-Sheboygan \| Sheboygan Wisconsin, United States, 53081Aspirus Cancer Care - Stevens Point \| Stevens Point Wisconsin, United States, 54481Saint Vincent Hospital Cancer Center at Sturgeon Bay \| Sturgeon Bay Wisconsin, United States, 54235-1495Aurora Medical Center in Summit \| Summit Wisconsin, United States, 53066Vince Lombardi Cancer Clinic-Two Rivers \| Two Rivers Wisconsin, United States, 54241Marshfield Medical Center - Weston \| Weston Wisconsin, United States, 54476Marshfield Clinic - Wisconsin Rapids Center \| Wisconsin Rapids Wisconsin, United States, 54494Rocky Mountain Oncology \| Casper Wyoming, United States, 82609Welch Cancer Center \| Sheridan Wyoming, United States, 82801San Juan City Hospital \| San Juan , Puerto Rico, 00936King Faisal Specialist Hospital and Research Centre \| Riyadh , Saudi Arabia, 11211
Investigators	Principal Investigator: Brian M Durie, SWOG Cancer Research Network

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Publications

Banerjee R, Sexton R, Cowan AJ, Rosenberg AS, Ailawadhi S, Rajkumar SV, Kumar S, Dispenzieri A, Lonial S, Durie BGM, Richardson PG, Usmani SZ, Hoering A, Orlowski RZ. Dexamethasone dose intensity does not impact outcomes in newly diagnosed multiple myeloma: a secondary SWOG analysis. Blood. 2025 Jan 2;145(1):75-84. doi: 10.1182/blood.2024025939. Unger JM, LeBlanc M, Blanke CD. The Effect of Positive SWOG Treatment Trials on Survival of Patients With Cancer in the US Population. JAMA Oncol. 2017 Oct 1;3(10):1345-1351. doi: 10.1001/jamaoncol.2017.0762. Durie BGM, Hoering A, Abidi MH, Rajkumar SV, Epstein J, Kahanic SP, Thakuri M, Reu F, Reynolds CM, Sexton R, Orlowski RZ, Barlogie B, Dispenzieri A. Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet. 2017 Feb 4;389(10068):519-527. doi: 10.1016/S0140-6736(16)31594-X. Epub 2016 Dec 23. Usmani SZ, Heuck C, Mitchell A, Szymonifka J, Nair B, Hoering A, Alsayed Y, Waheed S, Haider S, Restrepo A, Van Rhee F, Crowley J, Barlogie B. Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents. Haematologica. 2012 Nov;97(11):1761-7. doi: 10.3324/haematol.2012.065698. Epub 2012 Jun 11.