A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease

Recruitment Status
ACTIVE, NOT RECRUITING
(See Contacts and Locations)Verified July 2025 by AbbVie
Sponsor
AbbVie
Information Provided by (Responsible Party)
AbbVie
Clinicaltrials.gov Identifier
NCT03105102
Other Study ID Numbers:
M16-000
First Submitted
April 3, 2017
First Posted
April 6, 2017
Last Update Posted
August 13, 2025
Last Verified
July 2025

ClinicalTrials.gov processed this data on August 2025. Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

Condition or DiseaseIntervention/Treatment
Crohn's Disease
Drug: Placebo for Risankizumab SCDrug: Risankizumab SCDrug: Risankizumab SCDrug: Placebo for Risankizumab IVDrug: Placebo for Risankizumab SCDrug: Risankizumab SCDrug: Risankizumab SCDrug: Risankizumab SC

Study Design

Study TypeInterventional
Actual Enrollment1336 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingQuadruple
Primary PurposeTreatment
Official TitleA Multicenter, Randomized, Double-Blind, Placebo Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects With Crohn's Disease
Study Start DateApril 8, 2018
Actual Primary Completion DateApril 30, 2026
Actual Study Completion DateApril 30, 2026

Groups and Cohorts

Group/CohortIntervention/Treatment
Double-blind Placebo for Risankizumab (Sub-Study 1)
Participants randomized to receive double-blind placebo for risankizumab for 52 weeks.
Drug: Placebo for Risankizumab SC
Placebo for Risankizumab SC Subcutaneous (SC) Injection
Double-blind Risankizumab Dose 1 (Sub-Study 1)
Participants randomized to receive double-blind risankizumab dose 1 for 52 weeks.
Drug: Risankizumab SC
Risankizumab SC Subcutaneous (SC) injection
Double-blind Risankizumab Dose 2 (Sub-Study 1)
Participants randomized to receive double-blind risankizumab dose 2 for 52 weeks.
Drug: Risankizumab SC
Risankizumab SC Subcutaneous (SC) injection
Maintenance Risankizumab Dose 1 (Sub-Study 2)
Participants will receive double-blind subcutaneous (SC)risankizumab dose 1 and intravenous placebo at Week 0 followed by open-label SC risankizumab dose 1 from Week 8 through Week 52.
Drug: Placebo for Risankizumab IV
Placebo for Risankizumab IV Intravenous (IV) infusion
Maintenance Risankizumab Dose 2 (Sub-Study 2)
Participants will receive double-blind subcutaneous placebo and intravenous risankizumab dose 3 at Week 0 followed by open-label SC risankizumab dose 1 from Week 8 through Week 52.
Drug: Placebo for Risankizumab SC
Placebo for Risankizumab SC Subcutaneous (SC) Injection
Open-label Risankizumab (Sub-Study 3)
Participants who completed Sub-study 1 or Sub-study 2 or other AbbVie risankizumab Crohn's disease study or M16-006 or M15-991 without endoscopy will receive open-label risankizumab dose 1 or dose 2 depending on their preceding study beginning at Week 56.
Drug: Risankizumab SC
Risankizumab SC Subcutaneous (SC) injection
Risankizumab On-Body Injector and Open Label (Sub-Study 4)
Participants in Sub-study 3 who meet eligible criteria for Sub-study 4 will receive risankizumab dose 1 or dose 2 via on-body injectors on Weeks 0,8 and 16. Beginning Week 24, participants will receive risankizumab dose 1 or dose 2 via pre-filled syringes Q8W.
Drug: Risankizumab SC
Risankizumab SC Subcutaneous (SC) injection
CTE: Open Label Continuous Treatment Extension
Participants who tolerate and derive benefit from receiving risankizumab and complete Sub-study 3 or Sub-study 4 will receive risankizumab dose 1 or dose 2 Q8W.
Drug: Risankizumab SC
Risankizumab SC Subcutaneous (SC) injection

Outcome Measures

Primary Outcome Measures
  1. Sub-Study 1: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
    The CDAI is used to evaluate disease activity in patients with Crohn's disease. The CDAI clinical remission is defined as a CDAI score of \< 150.
  2. Sub-Study 1: Percentage of Participants With Endoscopic Response
    Endoscopic response defined as decrease from Baseline of the induction study in Simple Endoscopic Score for Crohn's Disease (SES-CD).
  3. Sub-Study 3: Number of Participants With Adverse Events
    An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either probably related, possibly related, probably not related or not related. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the subject and may require medical or surgical intervention to prevent any of the outcomes listed above. Treatment-emergent AEs are defined as any event that began or worsened in severity after the first dose of study drug. For more details on adverse events please see the Adverse Event section.
  4. Sub-Study 4: Percentage of Participants With an Observer Rating of Successful Participant Self Administration
    Participant who successfully completed the sequence of critical steps in the instructions for use (IFU) without errors to administer study drug via the OBI at Week 0 and 16.
  5. Sub-Study 4: Percentage of Participants who had no Potential Hazards
    Measured by an observer on the possible use-related hazards checklist for self-administration with OBI at Week 0 and Week 16.
  6. Sub-Study 4: Percentage of Participants Rating of Acceptability Using Self-Injection Assessment Questionnaire (SIAQ) at Weeks 0, 8, 16
    SIAQ evaluations consist of the PRE module, which is self-completed immediately before the first OBI self-injection at baseline, and the POST module, which is self-completed 20 to 40 min following injections at Weeks 0, 8, 16. These modules are completed by participants while alone in a quiet environment. Participants rate each item of the SIAQ. The ratings are later transformed to scores ranging from 0 (worst experience) to 10 (best experience). The domain score is the mean of the item scores included in the domain. Domain scores are calculated only if at least half of the domain items are completed. Item and domain scores from the PRE module are compared with the corresponding item and domain scores from the POST modules.
  7. Sub-Study 4: Percentage of Participants in CDAI Clinical Remission at Week 0, 16
    Clinical remission per average daily stool frequency (SF) and average daily abdominal pain (AP) score.
Secondary Outcome Measures
  1. Sub-Study 1: Percentage of Participants With Clinical Remission
    Clinical remission per average daily stool frequency (SF) and average daily AP score.
  2. Sub-Study 1: Percentage of Participants With CDAI Clinical Remission Among Participants With CDAI Clinical Remission in Week 0
    The CDAI is used to evaluate disease activity in patients with Crohn's disease
  3. Sub-Study 1: Percentage of Participants With Ulcer-Free Endoscopy
    Endoscopic healing was assessed using SES-CD.
  4. Sub-Study 1: Percentage of Participants With Endoscopic Remission
    Endoscopic Remission is defined as SES-CD \<= 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable, as scored by a central reviewer
  5. Sub-Study 1: Change From Baseline of Induction in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue)
    The FACIT-Fatigue is a validated tool that measures an individual's level of fatigue during their usual daily activities over the past week.
  6. Sub-Study 1: Percentage of Participants Who Discontinued Corticosteroid Use for 90 Days and Achieved Clinical Remission in Participants Taking Steroids at Baseline
    Participants who discontinued corticosteroid use and achieved clinical remission per average daily SF and average daily AP score.
  7. Sub-Study 1: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
    The CDAI is used to evaluate disease activity in patients with Crohn's disease.
  8. Sub-Study 1: Percentage of Participants With Stool Frequency (SF) Remission
    SF Remission is defined by an average daily SF \<= 2.8 and not worse than baseline.
  9. Sub-Study 1: Percentage of Participants With Abdominal Pain (AP) Remission
    AP Remission is defined by an average daily AP \<= 1 and not worse than baseline.
  10. Sub-Study 1: Percentage of Participants With CDAI Clinical Remission and Endoscopic Response
    The CDAI is used to evaluate disease activity in patients with Crohn's disease. The CDAI clinical remission is defined as a CDAI score of \< 150. Endoscopic response defined as decrease from baseline of \> 50% of the induction study in Simple Endoscopic Score for Crohn's Disease (SES-CD).
  11. Sub-Study 1: Percentage of Participants With Deep Remission
    Deep remission defined as participants with both clinical remission (per average daily SF and average daily AP score) and endoscopic remission (assessed using SES-CD).
  12. Sub-Study 1: Percentage of Participants With Exposure Adjusted Occurrence of CD-related Hospitalizations From Week 0 Through Week 52
    Participants with an event that results in admission to the hospital.

Eligibility Criteria

Ages Eligible for Study(Child, Adult, Older Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersNo
Inclusion Criteria
Participants who have entered and completed Study M16-006 or Study M15-991 or other AbbVie risankizumab Crohn's disease study.
Participants have completed the study M16-006 or M15-991 and have achieved clinical response.
Sub-Study 4:
Participants receiving maintenance treatment in Sub-study 3 and willing to comply with the requirements of Sub-study 4, including self-administration of sub-cutaneous injections using the on-body injector (OBI).
Participant has received at least 16 weeks of stable dosing with risankizumab in Sub-study 3 (i.e., no rescue within 16 weeks and participant has surpassed the 72-week mark).
Exclusion Criteria
Participants should not be enrolled in Study M16-000 with high grade colonic dysplasia or colon cancer identified during Study M15-991, Study M16-006 or another AbbVie risankizumab Crohn's disease study if the final endoscopy was performed prior to enter Study M16-000 OR is considered by the Investigator, for any reason, to be an unsuitable candidate for the study.
Participant who has a known hypersensitivity to risankizumab or the excipients of any of the study drugs or the ingredients of Chinese hamster ovary (CHO), OR had an adverse event (AE) during Studies M16-006, M15-991 or another AbbVie risankizumab Crohn's disease study that in the Investigator's judgment makes the participant unsuitable for this study.
Participant is not in compliance with prior and concomitant medication requirements throughout Studies M16-006, M15-991 or another AbbVie risankizumab Crohn's disease study.
Confirmed positive urine pregnancy test at the Final Visit of Study M16-006, Study M15-991 or another AbbVie risankizumab Crohn's disease study.
Have a known history of lymphoproliferative disease, including lymphoma, or signs and symptoms suggestive of possible lymphoproliferative disease, such as lymphadenopathy and/or splenomegaly.
Any active or chronic recurring infections based on the Investigator's assessment makes the participant an unsuitable candidate for the study.

Contacts and Locations

Sponsors and CollaboratorsAbbVie
Locations
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211884 | Mesa Arizona, United States, 85206Phoenix VA Health Care System /ID# 162264 | Phoenix Arizona, United States, 85012Banner - University Medical Center Tucson /ID# 158502 | Tucson Arizona, United States, 85719Atria Clinical Research /ID# 164505 | Little Rock Arkansas, United States, 72209-7040Southern California Res. Ctr. /ID# 211991 | Coronado California, United States, 92118-1408Duplicate_Newport Huntington Medical Group /ID# 213035 | Huntington Beach California, United States, 92648UC San Diego Health Systems /ID# 155555 | La Jolla California, United States, 92093United Medical Doctors /ID# 207888 | Los Alamitos California, United States, 90720-3309TLC Clinical Research Inc /ID# 212719 | Los Angeles California, United States, 90048Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162657 | Los Angeles California, United States, 90067-2001United Medical Doctors - Murrieta /ID# 158300 | Murrieta California, United States, 92563University of California San Francisco - Mission Bay /ID# 157127 | San Francisco California, United States, 94158Duplicate_Cedars-Sinai Medical Center-West Hollywood /ID# 163839 | West Hollywood California, United States, 90048Peak Gastroenterology Associates, PC /ID# 165843 | Colorado Springs Colorado, United States, 80907Rocky Mountain Pediatric Gastroenterology /ID# 207170 | Lone Tree Colorado, United States, 80124-6798Duplicate_Western Connecticut Medical Group /ID# 165879 | Danbury Connecticut, United States, 06810Brandon Premier Health Care, PA/Gulf Coast Research Group, LLC /ID# 162262 | Brandon Florida, United States, 33510-3107South Lake Pain Institute, Inc /ID# 162808 | Clermont Florida, United States, 34711Omega Research Maitland, LLC /ID# 171082 | DeBary Florida, United States, 32713-2260Universal Axon Clinical Research /ID# 165428 | Doral Florida, United States, 33166Nature Coast Clinical Research - Inverness /ID# 159408 | Inverness Florida, United States, 34452-4717SIH Research Mumtaz, Inc /ID# 163083 | Kissimmee Florida, United States, 34741-4161Alliance Medical Research /ID# 163837 | Lighthouse PT Florida, United States, 33064Cfagi Llc /Id# 202479 | Maitland Florida, United States, 32751-6108Sylvester Comprehensive Cancer Center /ID# 155007 | Miami Florida, United States, 33136-1002Coral Research Clinic /ID# 158456 | Miami Florida, United States, 33186-4643South Florida Research Ph I-IV, Inc. /ID# 161832 | Miami Florida, United States, 33193Gastroenterology Group Naples /ID# 165204 | Naples Florida, United States, 34102Advanced Research Institute, Inc /ID# 161966 | New Port Richey Florida, United States, 34653Endoscopic Research, Inc. /ID# 205906 | Orlando Florida, United States, 32803IMIC Inc. Medical Research /ID# 154942 | Palmetto Bay Florida, United States, 33157Duplicate_Clinical Research of West Florida, Inc /ID# 208125 | Tampa Florida, United States, 33606-1246Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 205865 | Tampa Florida, United States, 33606Atlanta Gastro Assoc /ID# 154724 | Atlanta Georgia, United States, 30342Gastroenterology Associates of Central Georgia, LLC /ID# 154850 | Macon Georgia, United States, 31201Duplicate_Northwestern University /ID# 158261 | Chicago Illinois, United States, 60611-2927The University of Chicago Medical Center /ID# 157124 | Chicago Illinois, United States, 60637-1443NorthShore University-Endeavor Health Evanston Hospital /ID# 158265 | Evanston Illinois, United States, 60201Southwest Gastroenterology /ID# 164781 | Oak Lawn Illinois, United States, 60453Cotton O'Neil Clinical Research Center, Digestive Health /ID# 154722 | Topeka Kansas, United States, 66606Duplicate_University of Kentucky Chandler Medical Center /ID# 157120 | Lexington Kentucky, United States, 40536University of Louisville Hospital /ID# 210525 | Louisville Kentucky, United States, 40202GI Alliance /ID# 161963 | Baton Rouge Louisiana, United States, 70809Houma Digestive Health Special /ID# 158264 | Houma Louisiana, United States, 70360Delricht Research /ID# 206644 | New Orleans Louisiana, United States, 70115Nola Research Works, LLC /ID# 161317 | New Orleans Louisiana, United States, 70115Louisiana Research Center, LLC /ID# 162237 | Shreveport Louisiana, United States, 71105-6800Metropolitan Gastroenterology Group - Chevy Chase /ID# 154832 | Chevy Chase Maryland, United States, 20815Gastro Center of Maryland /ID# 165001 | Columbia Maryland, United States, 21045University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 157126 | Ann Arbor Michigan, United States, 48109Clin Res Inst of Michigan, LLC /ID# 169179 | Chesterfield Michigan, United States, 48047Center for Digestive Health /ID# 154683 | Troy Michigan, United States, 48098-6363Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161313 | Wyoming Michigan, United States, 49519Mayo Clinic - Rochester /ID# 163086 | Rochester Minnesota, United States, 55905-0001St. Louis University /ID# 161883 | St Louis Missouri, United States, 63104University of Nebraska Medical Center /ID# 210058 | Omaha Nebraska, United States, 68198-2000Vector Clinical Trials /ID# 160170 | Las Vegas Nevada, United States, 89128-0435Revival Research Institute, Inc /ID# 210985 | Las Vegas Nevada, United States, 89128-3157NY Scientific /ID# 158294 | Brooklyn New York, United States, 11235Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 213447 | Burnt Hills New York, United States, 12027Intercity Advanced Gastroentertology Center /ID# 215205 | Fresh Meadows New York, United States, 11366Duplicate_Northwell Health Division of Gastroenterology at Great Neck /ID# 168738 | Great Neck New York, United States, 11021-5206NYU Langone Long Island Clinical Research Associates /ID# 154829 | Lake Success New York, United States, 11042Digestive Disease Care /ID# 211777 | New Hyde Park New York, United States, 11040NYU Langone Medical Center /ID# 160169 | New York New York, United States, 10016-6402Weill Cornell Medicine /ID# 165878 | New York New York, United States, 10022Icahn School of Medicine at Mount Sinai /ID# 165612 | New York New York, United States, 10029Columbia Univ Medical Center /ID# 161899 | New York New York, United States, 10032-3725Lenox Hill Hospital /ID# 168467 | New York New York, United States, 10075Duplicate_DiGiovanna Institute for Medical Education & Research /ID# 171126 | North Massapequa New York, United States, 11758Univ NC Chapel Hill /ID# 154833 | Chapel Hill North Carolina, United States, 27514-4220Atrium Health Carolinas Medical Center /ID# 158428 | Charlotte North Carolina, United States, 28203Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154873 | Raleigh North Carolina, United States, 27612Plains Clinical Research Center, LLC /ID# 169718 | Fargo North Dakota, United States, 58104-5925Tri-State Endoscopy Center /ID# 154927 | Cincinnati Ohio, United States, 45219Cleveland Clinic Main Campus /ID# 209226 | Cleveland Ohio, United States, 44195The Ohio State University /ID# 164708 | Columbus Ohio, United States, 43210Optimed Research, Ltd. /ID# 167887 | Columbus Ohio, United States, 43235Hometown Urgent Care and Resea /ID# 170464 | Dayton Ohio, United States, 45424Great Lakes Gastroenterology Research, LLC /ID# 201770 | Mentor Ohio, United States, 44060-6211Hightower Clinical /ID# 211993 | Oklahoma City Oklahoma, United States, 73102Digestive Disease Specialists /ID# 170775 | Oklahoma City Oklahoma, United States, 73112Adult Gastroenterology Associates - Gen 1 Research /ID# 208864 | Tulsa Oklahoma, United States, 74136-7823Children's Hospital of Pittsburgh of UPMC /ID# 212544 | Pittsburgh Pennsylvania, United States, 15224-1334Digestive Disease Associates, LTD - Wyomissing /ID# 208297 | Wyomissing Pennsylvania, United States, 19610Medical University of South Carolina /ID# 212858 | Charleston South Carolina, United States, 29425Gastroenterology Associates, P.A. of Greenville /ID# 154904 | Greenville South Carolina, United States, 29607Rapid City Medical Center - GI Research /ID# 163838 | Rapid City South Dakota, United States, 57701Gastro One /ID# 154726 | Cordova Tennessee, United States, 38018East Tennessee Research Institute /ID# 168739 | Johnson City Tennessee, United States, 37604Clinical Neuroscience Solutions - Memphis /ID# 164180 | Memphis Tennessee, United States, 38119Vanderbilt University Medical Center /ID# 157121 | Nashville Tennessee, United States, 37232-0011TX Clinical Research Institute /ID# 159404 | Arlington Texas, United States, 76012Inquest Clinical Research /ID# 165694 | Baytown Texas, United States, 77521-2415Texas Digestive Disease Consultants /ID# 209946 | Cedar Park Texas, United States, 78613-5028GI Alliance /ID# 209797 | Cedar Park Texas, United States, 78613Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 159406 | Dallas Texas, United States, 75246Duplicate_DHAT Research Institute /ID# 158208 | Garland Texas, United States, 75044-2208Vilo Research Group Inc /ID# 207655 | Houston Texas, United States, 77017-2337Baylor College of Medicine /ID# 158203 | Houston Texas, United States, 77030Centex Studies, Inc. - Houston /ID# 201219 | Houston Texas, United States, 77058Clinical Associates in Research Therapeutics of America, LLC /ID# 161323 | San Antonio Texas, United States, 78212Southern Star Research Institute, LLC /ID# 168773 | San Antonio Texas, United States, 78229-5390Baylor Scott & White Center for Diagnostic Medicine /ID# 204131 | Temple Texas, United States, 76508Tyler Research Institute, LLC /ID# 166797 | Tyler Texas, United States, 75701Gastro Health & Nutrition - Victoria /ID# 164290 | Victoria Texas, United States, 77904Advanced Research Institute /ID# 154907 | Ogden Utah, United States, 84405Velocity Clinical Research - Salt Lake City /ID# 161778 | West Jordan Utah, United States, 84088Richmond VA Medical Center /ID# 159988 | Richmond Virginia, United States, 23249Duplicate_Virginia Mason Medical Center /ID# 155556 | Seattle Washington, United States, 98101West Virginia University Hospitals /ID# 167941 | Morgantown West Virginia, United States, 26506Cemic /Id# 168078 | Ciudad Autonoma Buenos Aires Buenos Aires, Argentina, 1431Hospital Britanico de Buenos Aires /ID# 168077 | Ciudad Autonoma de Buenos Aire Buenos Aires, Argentina, 1280Hospital Provincial del Centenario /ID# 170886 | Rosario Santa Fe Province, Argentina, 2000Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 168076 | Córdoba , Argentina, 5016Mater Misericordiae Limited /ID# 167220 | South Brisbane Queensland, Australia, 4101Griffith University /ID# 212635 | Southport Queensland, Australia, 4222Lyell McEwin Hospital /ID# 212215 | Elizabeth Vale South Australia, Australia, 5112Emeritus Research /ID# 213512 | Camberwell Victoria, Australia, 3124Universitaetsklinikum St. Poelten /ID# 166424 | Sankt Pölten Lower Austria, Austria, 3100Krankenhaus der Barmherzigen Brueder Wien /ID# 212060 | Vienna State of Vienna, Austria, 1020Medizinische Universitaet Wien /ID# 158141 | Vienna State of Vienna, Austria, 1090Medizinische Universitaet Graz /ID# 158140 | Graz Styria, Austria, 8010Grodno city clinical hospital #2 /ID# 205113 | Hrodna Grodnenskaya, Belarus, 230011Gomel Regional Clinical Hospital /ID# 205112 | Homyel , Belarus, 246029Vitebsk Regional Advanced Clin /ID# 206778 | Vitebsk , Belarus, 210001Imelda Ziekenhuis /ID# 157403 | Bonheiden Antwerpen, Belgium, 2820AZ Sint-Maarten /ID# 212876 | Mechelen Antwerpen, Belgium, 2800ZAS Palfijn /ID# 212877 | Merksem Antwerpen, Belgium, 2170Universite Libre de Bruxelles - Hopital Erasme /ID# 157408 | Anderlecht Brussels Capital, Belgium, 1070Cliniques Universitaires UCL Saint-Luc /ID# 157406 | Brussels Brussels Capital, Belgium, 1200Groupe Sante CHC - Clinique du MontLegia /ID# 157404 | Liège Liege, Belgium, 4000Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 157412 | Yvoir Namur, Belgium, 5530UZ Gent /ID# 157405 | Ghent Oost-Vlaanderen, Belgium, 9000Universitair Ziekenhuis Leuven /ID# 157407 | Leuven Vlaams-Brabant, Belgium, 3000AZ-Delta /ID# 157402 | Roeselare West-Vlaanderen, Belgium, 8800AZ Maria Middelares /ID# 213532 | Ghent , Belgium, 9000AZ Groeninge /ID# 211513 | Kortrijk , Belgium, 8500CHU de Liege /ID# 157409 | Liège , Belgium, 4000Klinicki centar Banja Luka /ID# 164513 | Banja Luka Republika Srpska, Bosnia and Herzegovina, 78000Clinical Center University of Sarajevo /ID# 165139 | Sarajevo , Bosnia and Herzegovina, 71000UMHAT Dr Georgi Stranski EAD /ID# 203976 | Pleven , Bulgaria, 5800Umbal Kaspela /ID# 165700 | Plovdiv , Bulgaria, 40012nd Mhat /ID# 165702 | Sofia , Bulgaria, 1202Tokuda Hospital Sofia /ID# 165701 | Sofia , Bulgaria, 1407UMHAT Sveti Ivan Rilski /ID# 204815 | Sofia , Bulgaria, 1431Duplicate_UMHAT Tsaritsa Joanna - ISUL /ID# 211242 | Sofia , Bulgaria, 1527MHAT Trakia /ID# 201668 | Stara Zagora , Bulgaria, 6004University of Calgary /ID# 157155 | Calgary Alberta, Canada, T2N 4Z6Allen Whey Khye Lim Professional Corporation /ID# 169763 | Edmonton Alberta, Canada, T5R 1W2University of Alberta Hospital /ID# 157099 | Edmonton Alberta, Canada, T6G 2B7Covenant Health /ID# 161632 | Edmonton Alberta, Canada, T6K 4B2Fraser Clinical Trials Inc /ID# 159055 | New Westminster British Columbia, Canada, V3L 3W4Giri Gi Research Institute - Vancouver /ID# 157096 | Vancouver British Columbia, Canada, V5Z 2K5Percuro Clinical Research, Ltd /ID# 161631 | Victoria British Columbia, Canada, V8V 3M9Queen Elizabeth II Health Sciences Centre - Victoria General /ID# 157088 | Halifax Nova Scotia, Canada, B3H 2Y9IWK Health Center /ID# 165905 | Halifax Nova Scotia, Canada, B3K 6R8Medicor Research Inc /ID# 157150 | Greater Sudbury Ontario, Canada, P3A 1W8Duplicate_Hamilton Health Sciences -McMaster University Medical Centre /ID# 157184 | Hamilton Ontario, Canada, L8S 4K1London Health Sciences Center- University Hospital /ID# 157161 | London Ontario, Canada, N6A 5W9Scott Shulman Medicine Professional Corporation /ID# 165906 | North Bay Ontario, Canada, P1B 2H3Mount Sinai Hospital /ID# 169764 | Toronto Ontario, Canada, M5G 1X5Toronto Digestive Disease Associates /ID# 157158 | Vaughan Ontario, Canada, L4L 4Y7Hotel Dieu de Levis /ID# 214377 | Lévis Quebec, Canada, G6V 3Z1CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159056 | Montreal Quebec, Canada, H1T 2M4Montreal General Hospital- McGill University Health Center /ID# 157085 | Montreal Quebec, Canada, H3G 1A4CISSS de la Monteregie Centre - Hopital Charles Le Moyne /ID# 161630 | Greenfield Park , Canada, J4V 2H1Hospital Guillermo Grant Benavente de Concepción /ID# 210760 | Concepción Biobio, Chile, 4070038Hospital Las Higueras /ID# 167092 | Talcahuano Biobio, Chile, 1740000Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171122 | Santiago Region Metropolitana Santiago, Chile, 8350488Complejo Asistencial Dr. Sotero del Rio /ID# 169384 | Santiago Santiago Metropolitan, Chile, 8207257Guangdong Provincial People's Hospital /ID# 212949 | Guangzhou Guangdong, China, 510080The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 210784 | Guangzhou Guangdong, China, 510655The Second Hospital of Hebei Medical University /ID# 212738 | Shijiazhuang Hebei, China, 050000Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 211039 | Wuhan Hubei, China, 430022Tongji Hospital Tongji Medical College of HUST /ID# 210858 | Wuhan Hubei, China, 430030Renmin Hospital of Wuhan University /ID# 214874 | Wuhan Hubei, China, 430060The Second Xiangya Hospital of Central South University /ID# 211700 | Changsha Hunan, China, 410011The First Affiliated Hospital of Nanchang University /ID# 211036 | Nanchang Jiangxi, China, 330006Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210840 | Shanghai Shanghai Municipality, China, 200065Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210705 | Shanghai Shanghai Municipality, China, 200127Shanghai East Hospital /ID# 212684 | Shanghai Shanghai Municipality, China, 200136West China Hospital, Sichuan University /ID# 210890 | Chengdu Sichuan, China, 610041Tianjin Medical University General Hospital /ID# 210926 | Tianjin Tianjin Municipality, China, 300052The second affiliated hospital of Zhejiang University school of medicine /ID# 210724 | Hangzhou Zhejiang, China, 310009Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210625 | Hangzhou Zhejiang, China, 310020Jinhua Municipal Central Hospital /ID# 215628 | Jinhua Zhejiang, China, 321000Instituto de Coloproctologia /ID# 158743 | Medellín Antioquia, Colombia, 050024Hospital Pablo Tobón Uribe /ID# 158730 | Medellín Antioquia, Colombia, 050034Hospital Universitario San Vic /ID# 171486 | Medellín Antioquia, Colombia, 50010Hospital Univ San Ignacio /ID# 158734 | Bogota Cundinamarca, Colombia, 110231Klinicka bolnica Dubrava Zagreb /ID# 157560 | Zagreb City of Zagreb, Croatia, 10000Klinicki bolnicki centar Sestre milosrdnice /ID# 157728 | Zagreb City of Zagreb, Croatia, 10000Klinicki bolnicki centar Zagreb /ID# 157561 | Zagreb City of Zagreb, Croatia, 10000Poliklinika Borzan d.o.o. /ID# 157559 | Osijek County of Osijek-Baranja, Croatia, 31000Klinicki Bolnicki Centar (KBC) Split /ID# 157562 | Split Split-Dalmatia County, Croatia, 21000Zadar General Hospital /ID# 157563 | Zadar , Croatia, 23000Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165465 | Prague Praha 4, Czechia, 140 00Iscare Klinické Centrum /ID# 225794 | Prague Praha 9, Czechia, 190 00Hepato-Gastroenterologie HK, s.r.o. /ID# 163225 | Hradec Králové , Czechia, 500 12Nemocnice Pardubickeho kraje, a.s. /ID# 163226 | Pardubice , Czechia, 530 03Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211306 | Prague , Czechia, 118 33Axon Clinical, s.r.o. /ID# 163223 | Prague , Czechia, 140 00Fakultni Thomayerova nemocnice /ID# 162941 | Prague , Czechia, 140 59ResTrial s.r.o. /ID# 211078 | Prague , Czechia, 143 00Nemocnice Horovice - NH Hospital a.s /ID# 211077 | Prague , Czechia, 155 00Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 155530 | Hvidovre Capital Region, Denmark, 2650Aarhus Universitetshospital - Skejby /ID# 155664 | Aarhus Central Jutland, Denmark, 8200Roskilde Sygehus /ID# 155532 | Roskilde Region Sjælland, Denmark, 4000Sygehusenheden Nyborg - OUH /ID# 161525 | Nyborg Region Syddanmark, Denmark, 5800Odense University Hospital /ID# 155531 | Odense Region Syddanmark, Denmark, 5000Alexandria University /ID# 157187 | Alexandria Alexandria Governorate, Egypt, 21131Alexandria University /ID# 164540 | Alexandria Alexandria Governorate, Egypt, 21131Zagazig University Hospitals /ID# 164539 | Al Sharqia , Egypt, 44519Clinical Research Center, Faculty of Medicine, Cairo university /ID# 157175 | Cairo , Egypt, 11559National Hepatology and Tropical Medicine Research Institute /ID# 157874 | Cairo , Egypt, 11559Duplicate_Internal Medicine Department, Faculty of Medicine, AinShams University /ID# 157506 | Cairo , Egypt, 11566North Estonia Medical Centre /ID# 164326 | Mustamäe Harju, Estonia, 13419West Tallinn Central Hospital /ID# 157075 | Tallinn Harju, Estonia, 10617East Tallinn Central Hospital /ID# 157074 | Tallinn , Estonia, 10138Chu de Nice-Hopital L'Archet Ii /Id# 162557 | Nice Alpes-Maritimes, France, 06202Centre Hospitalier Universitaire de Bordeaux /ID# 162558 | Pessac Gironde, France, 33604CHU Montpellier - Hopital Saint Eloi /ID# 215147 | Montpellier Herault, France, 34295Duplicate_CHU Grenoble - Hopital Michallon /ID# 212834 | La Tronche Isere, France, 38700CHRU Nancy - Hopitaux de Brabois /ID# 162561 | Vandœuvre-lès-Nancy Meurthe-et-Moselle, France, 54500CHRU Lille - Hopital Claude Huriez /ID# 162559 | Lille Nord, France, 59037Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 162562 | St-Priest-en-Jarez Pays de la Loire Region, France, 42270HCL - Hopital Lyon Sud /ID# 162560 | Pierre-Bénite Rhone, France, 69495CHU Amiens-Picardie Site Sud /ID# 165058 | Amiens Somme, France, 80054CHRU Pontchaillou /ID# 213209 | Rennes , France, 35033Hopital Beaujon /ID# 166284 | Clichy Île-de-France Region, France, 92110Centre Medico Chirurgical Ambroise Pare Hartmann /ID# 249858 | Neuilly-sur-Seine Île-de-France Region, France, 92200Universitaetsklinikum Freiburg /ID# 162030 | Freiburg im Breisgau Baden-Wurttemberg, Germany, 79106Praxis fuer Gastroenterologie /ID# 166150 | Heidelberg Baden-Wurttemberg, Germany, 69121Universitatsklinikum Mannheim /ID# 162031 | Mannheim Baden-Wurttemberg, Germany, 68167Universitaetsklinikum Ulm /ID# 164990 | Ulm Baden-Wurttemberg, Germany, 89081Medizinisches Versorgunszentrum Dachau /ID# 211555 | Dachau Bavaria, Germany, 85221Universitaetsklinikum Erlangen /ID# 159343 | Erlangen Bavaria, Germany, 91054Duplicate_Agaplesion Markus Krankenhaus /ID# 159345 | Frankfurt am Main Hesse, Germany, 60431Universitaetsklinikum Frankfurt /ID# 212979 | Frankfurt am Main Hesse, Germany, 60590Medizinische Hochschule Hannover /ID# 162032 | Hanover Lower Saxony, Germany, 30625Klinikum Lueneburg /ID# 163678 | Lüneburg Lower Saxony, Germany, 21339Universitaetsklinikum Koeln /ID# 164989 | Cologne North Rhine-Westphalia, Germany, 50937Evangelisches Krankenhaus Kalk /ID# 212726 | Cologne North Rhine-Westphalia, Germany, 51103Praxiszentrum fuer Gastroenterologie /ID# 211966 | Grevenbroich North Rhine-Westphalia, Germany, 41515Gastroenterologische Gemeinschaftspraxis Minden /ID# 162029 | Minden North Rhine-Westphalia, Germany, 32423Universitaetsklinikum Muenster /ID# 159344 | Münster North Rhine-Westphalia, Germany, 48149Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210528 | Saarbrücken Saarland, Germany, 66111Eugastro /ID# 212078 | Leipzig Saxony, Germany, 04103Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159349 | Kiel Schleswig-Holstein, Germany, 24105Universitaetsklinikum Jena /ID# 159351 | Jena Thuringia, Germany, 07747Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212220 | Berlin , Germany, 10117Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212894 | Berlin , Germany, 10117Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211974 | Berlin , Germany, 10787MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159350 | Berlin , Germany, 10825DRK Kliniken Berlin Westend /ID# 166151 | Berlin , Germany, 14050Krankenhaus Waldfriede /ID# 212727 | Berlin-Zehlendorf , Germany, 14163Stadtisches Klinikum Braunschweig /ID# 163680 | Braunschweig , Germany, 38126Universitaetsklinikum Magdeburg /ID# 211843 | Magdeburg , Germany, 39120Universitaetsklinikum Regensburg /ID# 163813 | Regensburg , Germany, 93042General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170914 | Athens Attica, Greece, 11527General Hospital of Nikaia-Piraeus "Agios Panteleimon" /ID# 157424 | Nikaia Attica, Greece, 18454Tzaneio general hospital of Piraeus /ID# 206443 | Piraeus Attica, Greece, 18536University General Hospital of Heraklion PA.G.N.I /ID# 157422 | Heraklion Crete, Greece, 71500General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157423 | Athens , Greece, 10676University General Hospital of Ioannina /ID# 157420 | Ioannina , Greece, 45500Theageneio Anticancer Hospital /ID# 163897 | Thessaloniki , Greece, 54639Queen Mary Hospital /ID# 163923 | Hong Kong , Hong Kong, 999077Tuen Mun Hospital /ID# 163905 | Hong Kong , Hong Kong, Duplicate_Beaumont Hospital /ID# 157543 | Beaumont Dublin, Ireland, D09 XR63St Vincent's University Hospital /ID# 157540 | Elm Park Dublin, Ireland, D04 T6F4University Hospital Galway /ID# 157541 | Galway , Ireland, H91 YR71Shaare Zedek Medical Center /ID# 163541 | Jerusalem Jerusalem, Israel, 91031Shaare Zedek Medical Center /ID# 171068 | Jerusalem Jerusalem, Israel, 91031Hadassah Medical Center-Hebrew University /ID# 165914 | Jerusalem Jerusalem, Israel, 91120The Edith Wolfson Medical Center /ID# 217331 | Ashkelon Southern District, Israel, 5822000Soroka University Medical Center /ID# 157794 | Beersheba Southern District, Israel, 8443901The Chaim Sheba Medical Center /ID# 157793 | Ramat Gan Tel Aviv, Israel, 5265601The Chaim Sheba Medical Center /ID# 171069 | Ramat Gan Tel Aviv, Israel, 5265601Tel Aviv Sourasky Medical Center /ID# 157792 | Tel Aviv Tel Aviv, Israel, 6423906Duplicate_Rambam Medical Center /ID# 171067 | Haifa , Israel, 3109601Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162436 | Torrette Ancona, Italy, 60123Duplicate_Ospedale Policlinico San Martino /ID# 162439 | Genoa Genova, Italy, 16132IRCCS Istituto Clinico Humanitas /ID# 155642 | Rozzano Lombardy, Italy, 20089ASST Fatebenefratelli Sacco /ID# 155639 | Milan Milano, Italy, 20157ASST Rhodense/Presidio Ospedaliero di Rho /ID# 212227 | Rho Milano, Italy, 20017Duplicate_Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 162438 | Rome Roma, Italy, 00128Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 158022 | Rome Roma, Italy, 00133Azienda Ospedaliera San Camillo Forlanini /ID# 155644 | Rome Roma, Italy, 00149Duplicate_Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166912 | Rome Roma, Italy, 00161Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155640 | Rome Roma, Italy, 00168Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 167992 | Florence Tuscany, Italy, 50139IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161299 | Negrar Verona, Italy, 37024IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 155643 | Bologna , Italy, 40138Ospedale Cannizzaro /ID# 161300 | Catania , Italy, 95126Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 212016 | Catanzaro , Italy, 88100Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 155641 | Milan , Italy, 20122Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212028 | Modena , Italy, 41124Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 155645 | Palermo , Italy, 90146Duplicate_Fondazione IRCCS Policlinico S. Matteo /ID# 212031 | Pavia , Italy, 27100Aichi Medical University Hospital /ID# 160097 | Nagakute Aichi-ken, Japan, 480-1195Daido Clinic - Nagoya /ID# 211476 | Nagoya Aichi-ken, Japan, 457-8511Nagoya University Hospital /ID# 160116 | Nagoya Aichi-ken, Japan, 466-8560Nagoya City University Hospital /ID# 160100 | Nagoya Aichi-ken, Japan, 467-8602Duplicate_Fujita Health University Hospital /ID# 163234 | Toyoake-shi Aichi-ken, Japan, 470-1192Tokatsu Tsujinaka Hospital /ID# 163352 | Abiko-shi Chiba, Japan, 270-1168Duplicate_Chiba University Hospital /ID# 217533 | Chiba Chiba, Japan, 260-8677Tsujinaka Hospital - Kashiwanoha /ID# 213848 | Kashiwa-shi Chiba, Japan, 277-0871The Jikei University Kashiwa Hospital /ID# 200030 | Kashiwa-shi Chiba, Japan, 277-8567Toho University Sakura Medical Center /ID# 160099 | Sakura-shi Chiba, Japan, 285-8741Fukuoka University Hospital /ID# 217793 | Fukuoka Fukuoka, Japan, 814-0180Kurume University Hospital /ID# 160106 | Kurume-shi Fukuoka, Japan, 830-0011National Hospital Organization Fukuyama Medical Center /ID# 163577 | Fukuyama-shi Hiroshima, Japan, 720-8520Hiroshima University Hospital /ID# 160109 | Hiroshima Hiroshima, Japan, 734-8551Duplicate_Asahikawa Medical University Hospital /ID# 162848 | Asahikawa-shi Hokkaido, Japan, 078-8510Sapporo Tokushukai Hospital /ID# 213492 | Sapporo Hokkaido, Japan, 004-0041Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160096 | Sapporo Hokkaido, Japan, 060-0033Sapporo Medical University Hospital /ID# 163056 | Sapporo Hokkaido, Japan, 060-8543Nishinomiya Municipal Central Hospital /ID# 210103 | Nishinomiya-shi Hyōgo, Japan, 663-8014Hyogo Medical University Hospital /ID# 160107 | Nishinomiya-shi Hyōgo, Japan, 663-8501NHO Mito Medical Center /ID# 160092 | Higashiibaraki-gun Ibaraki, Japan, 311-3193Kanazawa University Hospital /ID# 202258 | Kanazawa Ishikawa-ken, Japan, 920-8641Gokeikai Ofuna Chuo Hospital /ID# 171066 | Kamakura-shi Kanagawa, Japan, 247-0056Kitasato University Hospital /ID# 171065 | Sagamihara-shi Kanagawa, Japan, 252-0375Duplicate_Yokohama Municipal Citizen's Hospital /ID# 207161 | Yokohama Kanagawa, Japan, 221-0855Duplicate_Yokohama City University Medical Center /ID# 163907 | Yokohama Kanagawa, Japan, 232-0024Mie University Hospital /ID# 203640 | Tsu Mie-ken, Japan, 514-8507Yokkaichi Hazu Medical Center /ID# 163764 | Yokkaichi-shi Mie-ken, Japan, 510-0016Tohoku University Hospital /ID# 162847 | Sendai Miyagi, Japan, 9808574Tohoku Rosai Hospital /ID# 163229 | Sendai Miyagi, Japan, 981-8563Osaka Metropolitan University Hospital /ID# 160117 | Osaka Osaka, Japan, 545-8586Saitama Medical Center /ID# 160093 | Kawagoe Saitama, Japan, 350-8550Tokitokai Tokito clinic /ID# 160110 | Saitama-shi Saitama, Japan, 336-0963Shiga University of Medical Science Hospital /ID# 164025 | Ōtsu Shiga, Japan, 520-2192Hamamatsu University Hospital /ID# 205690 | Hamamatsu Shizuoka, Japan, 431-3192NHO Shizuoka Medical Center /ID# 163057 | Sunto-gun Shizuoka, Japan, 411-8611Institute of Science Tokyo Hospital /ID# 160095 | Bunkyo-ku Tokyo, Japan, 113-8519Tokai University Hachioji Hospital /ID# 160098 | Hachioji-shi Tokyo, Japan, 192-0032The Jikei University Hospital /ID# 163209 | Minato-ku Tokyo, Japan, 105-8471Kitasato University Kitasato Institute Hospital /ID# 160105 | Minato-ku Tokyo, Japan, 108-8642Kyorin University Hospital /ID# 160114 | Mitaka-shi Tokyo, Japan, 181-8611Tokyo Women's Medical University Hospital /ID# 205974 | Shinjuku-ku Tokyo, Japan, 162-8666Wakayama Medical University Hospital /ID# 202561 | Wakayama Wakayama, Japan, 641-8510Yamagata University Hospital /ID# 200159 | Yamagata Yamagata, Japan, 990-9585Yamanashi Prefectural Central Hospital /ID# 160094 | Kofu Yamanashi, Japan, 400-8506VCA Polyclinic Aura /ID# 159611 | Riga , Latvia, 1035Pauls Stradins Clinical University Hospital /ID# 159612 | Riga , Latvia, LV-1002Duplicate_Digestive Disease Center Gastro /ID# 163107 | Riga , Latvia, LV-1079Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 162583 | Kaunas , Lithuania, 50161Vilnius University Hospital Santaros Klinikos /ID# 162514 | Vilnius , Lithuania, 08661Universiti Sains Malaysia /ID# 160666 | Kelantan Kelantan, Malaysia, 16150Queen Elizabeth Hospital /ID# 160664 | Division Pantai Barat Utara Sabah, Malaysia, 88200Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 201363 | Kuala Lumpur Selangor, Malaysia, 56000Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 170734 | Zapopan Jalisco, Mexico, 45070JM Research SC /ID# 170729 | Cuernavaca Morelos, Mexico, 62290Unidad de Atencion Medica e Investigacion en Salud /ID# 170732 | Mérida Yucatán, Mexico, 97000Health Pharma Professional Research S.A de C.V /ID# 170730 | Del. Benito Juárez , Mexico, 03810Elisabeth Tweesteden Ziekenhuis /ID# 163632 | Tilburg North Brabant, Netherlands, 5022 GCAmsterdam UMC, locatie AMC /ID# 157956 | Amsterdam North Holland, Netherlands, 1105 AZAotearoa Clinical Trials /ID# 167226 | Papatoetoe Auckland, New Zealand, 2025Christchurch Hospital. /ID# 167224 | Christchurch Canterbury, New Zealand, 8011Dunedin Hospital /ID# 167227 | Otago Otago, New Zealand, 9016Duplicate_Wellington Hospital (Capital and Coast District Health Board) /ID# 167225 | Wellington , New Zealand, 6021Duplicate_Vestre viken - Baerum Sykehus /ID# 212996 | Gjettum Akershus, Norway, 1346Akershus Universitetssykehus /ID# 169379 | Nordbyhagen Akershus, Norway, 1474Helse More og Romsdal HF, Alesund sjukehus /ID# 212810 | Ålesund Møre og Romsdal, Norway, 6017Sykehuset Levanger Helse NT /ID# 201669 | Levanger Nord-Trondelag, Norway, 7601Solumed Centrum Medyczne /ID# 163569 | Poznan Greater Poland Voivodeship, Poland, 60-529Gastromed Sp. z o.o /ID# 212476 | Torun Kuyavian-Pomeranian Voivodeship, Poland, 87-100Duplicate_Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocl /ID# 212601 | Wroclaw Lower Silesian Voivodeship, Poland, 50-556Planetmed Sp. z o.o. /ID# 202799 | Wroclaw Lower Silesian Voivodeship, Poland, 52-2101 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 210940 | Lublin Lublin Voivodeship, Poland, 20-049Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie /ID# 210941 | Lublin Lublin Voivodeship, Poland, 20-954Centrum Zdrowia MDM /ID# 163570 | Warsaw Masovian Voivodeship, Poland, 00-189Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 163582 | Warsaw Masovian Voivodeship, Poland, 02-507Vivamed Sp. z o.o. /ID# 202800 | Warsaw Masovian Voivodeship, Poland, 03-580Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213580 | Warsaw Masovian Voivodeship, Poland, 04-730Centrum Medycznym Medyk /ID# 212891 | Rzeszów Podkarpackie Voivodeship, Poland, 35-055Centrum Medyczne Lukamed Sp. z o.o. /ID# 212478 | Chojnice Pomeranian Voivodeship, Poland, 89-600H-T Centrum Medyczne Endoterapia /ID# 212475 | Tychy Silesian Voivodeship, Poland, 43-100Wojewódzki Szpital Specjalistyczny W Olsztynie /ID# 212474 | Olsztyn Warmian-Masurian Voivodeship, Poland, 10-561Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212477 | Lodz Łódź Voivodeship, Poland, 90-153Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160737 | Guimarães Braga District, Portugal, 4835-044Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167752 | Portimão Faro District, Portugal, 8500-338Centro Hospitalar de Entre Douro e Vouga /ID# 160672 | Santa Maria DA Feira Porto District, Portugal, 4520-211Duplicate_Hospital Garcia de Orta, EPE /ID# 160745 | Almada Setúbal District, Portugal, 2805-267Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160713 | Faro , Portugal, 8000-386Centro Hospitalar de Lisboa Central /ID# 160673 | Lisbon , Portugal, 1169-050Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167751 | Lisbon , Portugal, 1349-019Unidade Local de Saude de Santa Maria, EPE /ID# 160692 | Lisbon , Portugal, 1649-035Hospital de Loures, E.P.E /ID# 207759 | Loures , Portugal, 2674-514Unidade Local de Saude Sao Joao, EPE /ID# 160693 | Porto , Portugal, 4200-319Centro Hosp de Tondela-Viseu /ID# 160699 | Viseu , Portugal, 3504-509Fundeni Clinical Institute /ID# 170899 | Bucharest , Romania, 022328Tvm Med Serv Srl /Id# 170902 | Cluj-Napoca , Romania, 400132Cabinet Particular Policlinic Algomed /ID# 170900 | Timișoara , Romania, 300002Duplicate_Centrul Medical Tuculanu SRL /ID# 170903 | Timișoara , Romania, 300168Kuzbass Regional Clinical Hospital /ID# 200962 | Kemerovo Kemerovo Oblast, Russia, 650099Novosibirski Gastrocenter /ID# 217552 | Novosibirsk Novosibirsk Oblast, Russia, 630007Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207439 | Perm Permskiy Kray, Russia, 614990Duplicate_St. Petersburg State Pediatric Medical University /ID# 211978 | Saint Petersburg Sankt-Peterburg, Russia, 194100Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 200970 | Stavropol Stavropol Kray, Russia, 355012Tver Regional Clinical Hospital /ID# 206858 | Tver' Tver Oblast, Russia, 170036Regional Clinical Hospital #1 /ID# 200973 | Tyumen Tyumen Oblast, Russia, 625023Alliance Biomedical Ural Group /ID# 200972 | Izhevsk Udmurtiya Republic, Russia, 426061National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 204808 | Moscow , Russia, 123423City Clinical Hospital No. 31 /ID# 208872 | Saint Petersburg , Russia, 197110Ulyanovsk Regional Clinical Hospital /ID# 200964 | Ulyanovsk , Russia, 432017Clinical Hosp Center Zvezdara /ID# 157052 | Belgrade Beograd, Serbia, 11000Military Medical Academy /ID# 157053 | Belgrade Beograd, Serbia, 11000University Children's Hospital 'Tirsova' /ID# 211482 | Belgrade Beograd, Serbia, 11000University Clinical Center Serbia /ID# 157047 | Belgrade Beograd, Serbia, 11000Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212799 | Belgrade Beograd, Serbia, 11040Clin Hosp Ctr Bezanijska Kosa /ID# 157050 | Belgrade Beograd, Serbia, 11080General Hospital Leskovac /ID# 209575 | Leskovac Jablanicki Okrug, Serbia, 16000Duplicate_University Clinical Center Kragujevac /ID# 157049 | Kragujevac Sumadijski Okrug, Serbia, 34000University Clinical Center Vojvodina /ID# 157046 | Novi Sad , Serbia, 21000Mount Elizabeth Hospital /ID# 205741 | Singapore Central Singapore, Singapore, 228510National University Hospital /ID# 160667 | Singapore , Singapore, 119074Singapore General Hospital /ID# 160668 | Singapore , Singapore, 169608Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156468 | Banská Bystrica Banská Bystrica Region, Slovakia, 975 17KM Management, spol. s.r.o. /ID# 206764 | Nitra Nitra Region, Slovakia, 949 01Gastro I., s.r.o. /ID# 156469 | Prešov Presov, Slovakia, 080 01Clinresco Centers /ID# 163865 | Johannesburg Gauteng, South Africa, 1619Wits Clinical Research /ID# 158114 | Johannesburg Gauteng, South Africa, 1864Private Practice Dr MN Rajabally /ID# 163112 | Cape Town Western Cape, South Africa, 7800Spoke Research Inc /ID# 158116 | CAPE TOWN Milnerton Western Cape, South Africa, 7441Inje University Haeundae Hospital /ID# 202518 | Busan Busan Gwang Yeogsi, South Korea, 48108Dong-A University Medical Center /ID# 158699 | Busan Busan Gwang Yeogsi, South Korea, 49201Pusan National University Hospital /ID# 158695 | Busan Busan Gwang Yeogsi, South Korea, 49241The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 213554 | Daejeon Daejeon Gwang Yeogsi, South Korea, 34943Hanyang University Guri Hospital /ID# 158690 | Guri-si Gyeonggido, South Korea, 11923Duplicate_CHA University Bundang Medical Center /ID# 158698 | Seongnam-si Gyeonggido, South Korea, 13496The Catholic University Of Korea St. Vincent's Hospital /ID# 158693 | Suwon Gyeonggido, South Korea, 16247Kangbuk Samsung Hospital /ID# 158694 | Seoul Seoul Teugbyeolsi, South Korea, 03181Asan Medical Center /ID# 158696 | Seoul Seoul Teugbyeolsi, South Korea, 05505Samsung Medical Center /ID# 158692 | Seoul Seoul Teugbyeolsi, South Korea, 06351Yeungnam University Medical Center /ID# 158691 | Daegu , South Korea, 42415Yonsei University Health System Severance Hospital /ID# 158689 | Seoul , South Korea, 03722Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157553 | Ferrol A Coruna, Spain, 15405Hospital Universitari de Bellvitge /ID# 208207 | L'Hospitalet de Llobregat Barcelona, Spain, 08907Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159237 | Sabadell Barcelona, Spain, 08208Hospital Universitario Puerta de Hierro - Majadahonda /ID# 157573 | Majadahonda Madrid, Spain, 28222Hospital Universitario Basurto /ID# 205190 | Bilbao Vizcaya, Spain, 48013Hospital Clinic de Barcelona /ID# 157552 | Barcelona , Spain, 08036Hospital General Universitario Gregorio Maranon /ID# 161145 | Madrid , Spain, 28007Hospital Universitario La Paz /ID# 159235 | Madrid , Spain, 28046Hospital Universitario de Salamanca /ID# 157558 | Salamanca , Spain, 37711Hospital Universitario Virgen Macarena /ID# 159967 | Seville , Spain, 41009Hospital Clinico Universitario de Valencia /ID# 209700 | Valencia , Spain, 46010Hospital Universitario y Politecnico La Fe /ID# 157556 | Valencia , Spain, 46026Hospital Clinico Universitario Lozano Blesa /ID# 212525 | Zaragoza , Spain, 50009Hospital Universitario Miguel Servet /ID# 157557 | Zaragoza , Spain, 50009Skane University hospital /ID# 211745 | Malmö Skåne County, Sweden, 214 28Karolinska University Hospital Solna /ID# 212025 | Solna Stockholm County, Sweden, 171 64GHP Stockholm Gastro Center /ID# 211748 | Stockholm Stockholm County, Sweden, 114 28Medicinkliniken, Gastroenheten /ID# 163744 | Stockholm Stockholm County, Sweden, 116 28Danderyd Hospital /ID# 202138 | Stockholm Stockholm County, Sweden, 182 88Duplicate_Sahlgrenska University Hospital /ID# 163792 | Gothenburg Västra Götaland County, Sweden, 413 45Duplicate_Sahlgrenska University Hospital /ID# 163797 | Gothenburg Västra Götaland County, Sweden, 413 46University Hospital Basel /ID# 164554 | Basel Town Canton of Basel-City, Switzerland, 4031University Hospital Zurich /ID# 163536 | Zurich Canton of Zurich, Switzerland, 8006Inselspital, Universitaetsspital Bern /ID# 163535 | Bern , Switzerland, 3010National Taiwan University Hospital /ID# 162190 | Taipei City Taipei, Taiwan, 100China Medical University Hospital /ID# 160141 | Taichung , Taiwan, 40447Taichung Veterans General Hospital /ID# 160140 | Taichung , Taiwan, 40705National Cheng Kung University Hospital /ID# 160142 | Tainan , Taiwan, 704Taipei Veterans General Hosp /ID# 212712 | Taipei , Taiwan, 11217Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165658 | Lviv Lviv Oblast, Ukraine, 79000MNE Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216474 | Vinnytsia Vinnytsia Oblast, Ukraine, 21018University Hospital of M.I. Pyrogov VNMU /ID# 212000 | Vinnytsia Vinnytsia Oblast, Ukraine, 21029ME Volyn Regional Clinical Hospital of Volyn Regional Council /ID# 206789 | Lutsk Volyn Oblast, Ukraine, 43005Transcarpathian Regional Clinical Hospital n.a. Andriy Novak /ID# 167960 | Uzhhorod Zakarpattia Oblast, Ukraine, 88018Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165657 | Kharkiv , Ukraine, 61037Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212399 | Kherson , Ukraine, 73000Kyiv City Clinical Hospital No.18 /ID# 162531 | Kyiv , Ukraine, 01030Medical Center OK Clinic LLC, International Institute of Clinical Research /ID# 211998 | Kyiv , Ukraine, 02091Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165659 | Kyiv , Ukraine, 02232Medical Center of LLC Medbud-Clinic /ID# 216998 | Kyiv , Ukraine, 03037Kyiv Railway Clinical Hosp No.2 /ID# 217366 | Kyiv , Ukraine, 03049Addenbrooke's Hospital /ID# 158034 | Cambridge Cambridgeshire, United Kingdom, CB2 2QQDuplicate_Royal Devon University Healthcare NHS Foundation Trust /ID# 157544 | Exeter Devon, United Kingdom, EX2 5DWHull University Teaching Hospitals NHS Trust /ID# 158761 | Hull East Riding Of Yorkshire, United Kingdom, HU3 2JZWestern General Hospital - NHS Lothian /ID# 207448 | Edinburgh Edinburgh, City of, United Kingdom, EH4 2XUGartnavel General Hospital /ID# 202568 | Glasgow Glasgow City, United Kingdom, G12 0YNDisc_Barts Health NHS Trust - The Royal London Hospital /ID# 163713 | London Greater London, United Kingdom, E1 2ESDup_Guys and St Thomas NHS Foundation Trust - Guy's Hospital /ID# 157546 | London Greater London, United Kingdom, SE1 9RTOxford University Hospitals NHS Foundation Trust /ID# 158036 | Oxford Oxfordshire, United Kingdom, OX3 9DUAshford and St Peter's Hospitals NHS Foundation Trust /ID# 207936 | Chertsey Surrey, United Kingdom, KT16 0PZLeeds Teaching Hospitals NHS Trust /ID# 157550 | Leeds West Yorkshire, United Kingdom, LS9 7TFBarnsley Hospital NHS Foundation Trust /ID# 202773 | Barnsley , United Kingdom, S75 2EPUniversity Hospitals Birmingham NHS Foundation Trust /ID# 157545 | Birmingham , United Kingdom, B15 2THCalderdale and Huddersfield NHS Foundation Trust /ID# 209570 | Huddersfield , United Kingdom, HX3 0PWKing's College Hospital NHS Foundation Trust /ID# 158760 | London , United Kingdom, SE5 9RSThe Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163708 | Newcastle upon Tyne , United Kingdom, NE3 3HDNorthern Care Alliance NHS Group /ID# 207766 | Salford , United Kingdom, M6 8HD
Investigators
Study Director: ABBVIE INC., AbbVie