A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

Recruitment Status: COMPLETED - HAS RESULTS
(See Contacts and Locations)Verified May 2026 by Eli Lilly and Company
Sponsor: Eli Lilly and Company
Information Provided by (Responsible Party): Eli Lilly and Company

Clinicaltrials.gov Identifier: NCT04255433
Other Study ID Numbers:: 17073

First Submitted: February 2, 2020
First Posted: February 4, 2020
Results First Posted: June 10, 2026
Last Update Posted: July 7, 2026
Last Verified: May 2026

ClinicalTrials.gov processed this data on June 2026. Link to the current ClinicalTrials.gov record .

Study Details

Study Description

Condition or Disease	Intervention/Treatment
Type 2 Diabetes Mellitus	Drug: TirzepatideDrug: Dulaglutide

Study Design

Study Type	Interventional
Actual Enrollment	13299 participants
Design Allocation	Randomized
Interventional Model	Parallel Assignment
Masking	Double
Primary Purpose	Treatment
Official Title	The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)
Study Start Date	May 28, 2020
Actual Primary Completion Date	June 11, 2025
Actual Study Completion Date	June 11, 2025

Groups and Cohorts

Group/Cohort	Intervention/Treatment
Tirzepatide - Maximum Tolerated Dose (MTD) Participants received a starting dose of 2.5 milligrams (mg) tirzepatide administered as subcutaneous (SC) injection once weekly (QW) and escalated by 2.5 mg every 4 weeks to a maximum of 15 mg QW or MTD tolerated by the participant (5 mg QW or 10 mg QW) for up to 5 years.	Drug: Tirzepatide Administered SC
1.5 mg Dulaglutide Participants received 1.5 mg dulaglutide administered as SC injection QW for up to 5 years.	Drug: Dulaglutide Administered SC

Outcome Measures

Primary Outcome Measures

Number of Participants From Randomization to First Occurrence of Death From MACE-3 [Composite Endpoint of Major Adverse Cardiovascular Events Death From Cardiovascular Causes, Myocardial Infarction (MI) or Stroke]
Number of participants with first occurrence of Clinical Endpoint Committee (CEC), a composite endpoint i.e., from time of randomization to first occurrence of cardiovascular (CV) death, myocardial infarction and stroke combined data was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of any of these events during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.

Secondary Outcome Measures

Number of Participants From Randomization to Time to Occurrence of All-Cause Death
The number of participants from randomization to time to occurrence of Clinical Endpoint Committee (CEC) confirmed all-cause death was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of all-cause death during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Number of Participants From Randomization to Time of Occurrence of CV Death
Number of participants from time of randomization to time to occurrence of CEC confirmed CV death was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of CV death during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Number of Participants From Randomization to Time to First Occurrence of Myocardial Infarction (MI)
The number of participants from randomization to first occurrence of CEC confirmed MI was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of nonfatal MI during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Number of Participants From Randomization toTime to First Occurrence of Stroke
The number of participants from randomization to first occurrence of CEC confirmed stroke was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of nonfatal stroke during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Number of Participants From Randomization to Time to First Occurrence of the Expanded Composite of CV Death, MI, Stroke or Coronary Revascularization (MACE-4)
The number of participants from randomization to first occurrence of MACE-4 was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of any of these events during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Number of Participants From Randomization to Time to First Occurrence of CV Deaths or Heart Failure Events Requiring Hospitalization and/or Urgent Heart Failure Visits
The number of participants from randomization to first occurrence of Clinical Endpoint Committee (CEC) confirmed heart failure requiring hospitalisation or urgent heart failure was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of any of these events during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Number of Participants From Randomization to Time to First Occurrence of Revascularization
The number of participants from randomization to first occurrence of coronary revascularization was reported. Time to event was defined as the number of days from the date of randomization to the first occurrence of revascularization during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Number of Participants From Randomization to Time to First Occurrence of New or Worsening Nephropathy
New or worsening nephropathy (Composite Endpoint 1) was defined as the first occurrence of any of the following events: persistent macroalbuminuria (urine albumin-to-creatinine ratio \>300 mg/g), persistent doubling of serum creatinine with eGFR \<45 mL/min/1.73 m², onset of end-stage renal disease (including initiation of chronic dialysis or kidney transplantation), or death due to renal disease. Time to event was defined as the number of days from the date of randomization to the first occurrence any of these events. during the study follow-up period. Participants without an event were censored at their last known contact or end of follow-up.
Change From Baseline to 36 Months in Estimated Glomerular Filtration Rate (eGFR) in Patients With High or Very-high Risk Chronic Kidney Disease (CKD)
Change from baseline in eGFR calculated as difference between value at 36 months and baseline value. Participants included in this analysis were classified as having high or very high risk of chronic kidney disease at baseline based on their kidney function (eGFR) and urine albumin-to-creatinine ratio (UACR). High risk included participants with eGFR 45 to less than 60 milliliters/minutes/1.73 square metres (mL/min/1.73 m²) and UACR greater than 30 mg/g, or eGFR 60 mL/min/1.73 m² or higher with UACR greater than 300 mg/g. Very high risk included participants with eGFR less than 45 mL/min/1.73 m² or severely increased UACR (greater than 300 mg/g). These criteria are associated with an increased risk of worsening kidney function. Least squares (LS) mean was calculated using analysis of covariance (ANCOVA) model for endpoint measures: Variable = Baseline + Treatment + Analysis Country + Baseline sodium-glucose cotransporter-2 (SGLT-2) Use Flag.
Change From Baseline to 36 Months in Hemoglobin A1c (HbA1c)
HbA1c is the glycosylated fraction of hemoglobin A. HbA1c is measured primarily to identify average plasma glucose concentration over prolonged periods of time. Change in HbA1c from baseline up to 36 months during in-trial period were reported. In-trial observation period was defined as the period from date of randomization to the first of (both inclusive): date of follow-up visit, date when participant withdrew consent, date of last contact with participant (for participant lost to follow-up), and date of death. LS mean was calculated using ANCOVA model for endpoint measures: Variable = Baseline + Treatment + Analysis Country + Baseline SGLT-2i Use Flag (Type III sum of squares).
Percent Change From Baseline to 36 Months in Body Weight
LS mean was calculated using ANCOVA model for endpoint measures: Variable = Baseline + Treatment + Analysis Country + Baseline SGLT-2i Use Flag (Type III sum of squares)
Percent Change From Baseline to 36 Months in Urinary Albumin to Creatinine Ratio (UACR)
Urine samples were collected for the analysis of UACR. UACR (gram per kilograms \[g/kg\]) was calculated as urine albumin (gram per liter \[g/L\])/urine creatinine (kg/L). Percent change from baseline at 36 months was calculated as: \[(UACR at 36 months - baseline UACR) / baseline UACR\] × 100. LS mean was calculated using ANCOVA model for endpoint measures: log(Actual Measurement/Baseline) = log(Baseline) + Treatment + Analysis Country + Baseline SGLT-2i Use Flag (Type III sum of squares).
Percent Change From Baseline to 24 Months in Blood Lipids (Total Cholesterol (TC), Low-Density Lipoprotein Cholesterol (LDL-C), High-Density Lipoprotein Cholesterol (HDL-C), and Triglycerides (TG))
Blood samples of participants who had fasted for 12 to 14 hours were collected for lipid profile (TC, LDL-C, HDL-C, TG) assessment. The lipid profile asesses the risk of heart disease. Percent change from baseline = 100\*(post-baseline assessment - baseline assessment)/baseline assessment. LS mean was calculated using ANCOVA model for endpoint measures: log(Actual Measurement/Baseline) = log(Baseline) + Treatment + Analysis Country + Baseline SGLT-2i Use Flag.

Eligibility Criteria

Ages Eligible for Study	(Adult, Older Adult)
Sexes Eligible for Study	All
Accepts Healthy Volunteers	No
Inclusion Criteria	Men or women at least 40 years old with a diagnosis of type 2 diabetes Established cardiovascular disease, including at least 1 of the following: Coronary artery disease (CAD) with any of the following: Documented history of spontaneous myocardial infarction (MI) ≥50% stenosis in 1 or more major coronary arteries, determined by invasive angiography ≥50% stenosis in 2 or more major coronary arteries, determined by computed tomography coronary angiography (CTCA) History of surgical or percutaneous coronary revascularization procedure Cerebrovascular disease - any of the following: Documented history of ischemic stroke Carotid arterial disease with ≥50% stenosis, documented by carotid ultrasound, magnetic resonance imaging (MRI), or angiography Carotid stenting or surgical revascularization Peripheral arterial disease with either of the following: Intermittent claudication and ankle-brachial index \<0.9 Prior nontraumatic amputation or peripheral vascular procedure (eg, stenting or surgical revascularization), due to peripheral arterial ischemia Note: Supporting medical documentation is required in all instances HbA1c ≥7% (≥53 mmol/mol) and ≤10.5% (≤91.3 mmol/mol) based on central laboratory assessment at screening Body mass index (BMI) ≥25 kg/m2 At the time of signing the informed consent: Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical trials. Male patients: Men, regardless of their fertility status, with nonpregnant women of childbearing potential (WOCBP) partners must agree to either remain abstinent (if this is their preferred and usual lifestyle) or use condoms, as well as 1 additional highly effective (less than 1% failure rate) method of contraception (such as combination oral contraceptives, implanted contraceptives, or intrauterine devices) or effective method of contraception (such as diaphragms with spermicide or cervical sponges) for the duration of the study and until their plasma concentrations are below the level that could result in a relevant potential exposure to a possible fetus, predicted to be 90 days following the last dose of study drug. Men and their partners may choose to use a double-barrier method of contraception. (Barrier protection methods without concomitant use of a spermicide are not an effective or acceptable method of contraception. Thus, each barrier method must include use of a spermicide. It should be noted, however, that the use of male and female condoms as a double barrier method is not considered acceptable due to the high failure rate when these barrier methods are combined). Periodic abstinence (eg, calendar, ovulation, symptothermal, or postovulation methods), declaration of abstinence just for the duration of a trial, and withdrawal are not acceptable methods of contraception. Men with pregnant partners should use condoms during intercourse for the duration of the study and until the end of the estimated relevant potential exposure in WOCBP (90 days). Men should refrain from sperm donation for the duration of the study and until their plasma concentrations are below the level that could result in a relevant potential exposure to a possible fetus, predicted to be 90 days following the last dose of study drug. Men who are in exclusively same-sex relationships (as their preferred and usual lifestyle) are not required to use contraception. Female patients: Women of childbearing potential who are abstinent (if this is complete abstinence, as their preferred and usual lifestyle) or in a same-sex relationship (as part of their preferred and usual lifestyle) must agree to either remain abstinent or stay in a same-sex relationship without sexual relationships with males. Periodic abstinence (eg, calendar, ovulation, symptothermal, or postovulation methods), declaration of abstinence just for the duration of a trial, and withdrawal are not acceptable methods of contraception. Otherwise, WOCBP participating must agree to use 2 forms of effective contraception, where at least 1 form is highly effective (less than 1% failure rate), for the entirety of the study. Contraception must continue following completion of study drug administration for the entirety of the study and for 30 days thereafter. WOCBP participating must test negative for pregnancy prior to initiation of treatment as indicated by a negative serum pregnancy test at the screening visit followed by a negative urine pregnancy test within 24 hours prior to exposure. Two forms of effective contraception, where at least 1 form is highly effective, (such as combination oral contraceptives, implanted contraceptives, or intrauterine devices) will be used. Effective contraception (such as male or female condoms with spermicide, diaphragms with spermicide, or cervical sponges) may be used as the second therapy. Barrier protection methods without concomitant use of a spermicide are not a reliable or acceptable method. Thus, each barrier method must include use of a spermicide (ie, condom with spermicide, diaphragm with spermicide, or female condom with spermicide). It should be noted that the use of male and female condoms as a double barrier method is not considered acceptable due to the high failure rate when these methods are combined. Women not of childbearing potential may participate and include those who are: infertile due to surgical sterilization (hysterectomy, bilateral oophorectomy, or tubal ligation), congenital anomaly such as mullerian agenesis, or postmenopausal - defined as either: A woman at least 40 years of age with an intact uterus, not on hormone therapy, who has cessation of menses for at least 1 year without an alternative medical cause, AND a follicle-stimulating hormone \>40 mIU/mL; or ii. A woman 55 or older not on hormone therapy, who has had at least 12 months of spontaneous amenorrhea; or A woman at least 55 years of age with a diagnosis of menopause prior to starting hormone replacement therapy. In the investigator's opinion, are well motivated, capable, and willing to: learn how to self-inject treatment (tirzepatide or dulaglutide), as required for this protocol (visually impaired persons who are not able to perform the injections must have the assistance of a sighted individual trained to inject the study drug; persons with physical limitations who are not able to perform the injections must have the assistance of an individual trained to inject the study drug), inject study drug weekly, have a sufficient understanding of 1 of the provided languages of the country such that they will be able to complete the patient questionnaires, and make themselves available for the duration of the study, and who will comply with the required study visits. Capable of giving signed informed consent
Exclusion Criteria	Have type 1 diabetes mellitus Have uncontrolled diabetes requiring immediate therapy (such as diabetic ketoacidosis) at screening or randomization, in the judgment of the physician Have had 1 or more events of severe hypoglycemia and/or 1 or more events of hypoglycemia unawareness within 6 months prior to screening Are currently planning treatment for diabetic retinopathy and/or macular edema. Have been hospitalized for congestive heart failure (CHF) within 2 months prior to screening Have chronic New York Heart Association Functional Classification IV CHF Are currently planning a coronary, carotid, or peripheral artery revascularization Had chronic or acute pancreatitis any time prior to screening, irrespective of etiology Have a known clinically significant gastric emptying abnormality such as severe gastroparesis or gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery Have acute or chronic hepatitis, signs or symptoms of any other liver disease, an alanine aminotransferase (ALT) level ≥3 times the upper limit of normal (ULN) for the reference range, as determined by the central laboratory (Note: Patients with nonalcoholic fatty liver disease are eligible to participate if their ALT level is \<3 times the ULN for the reference range) Have known chronic severe renal failure (defined as a known estimated glomerular filtration rate (eGFR) \<15 mL/minute/1.73 m2) or are on chronic dialysis Have evidence of a significant, uncontrolled endocrine abnormality (eg, thyrotoxicosis or adrenal crises) Have a family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (MTC) or personal history of nonfamilial MTC Have a serum calcitonin level at screening of: (based on central laboratory results) ≥20 ng/L at Visit 1, if eGFR ≥60 mL/min/1.73 m2, or ≥35 ng/L at Visit 1, if eGFR \<60 mL/min/1.73 m2 Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years. An exception for this criterion is basal or squamous cell skin cancer, in situ carcinomas of the cervix, or in situ prostate cancer Have a history of any other condition (such as known drug or alcohol abuse or psychiatric disorder) that, in the opinion of the investigator, may preclude the patient from following and completing the protocol Have had a transplanted organ (corneal transplants \[keratoplasty\] allowed) or awaiting an organ transplant Have any other condition (eg, hypersensitivity) that is a contraindication to any incretin or glucagon-like peptide-1 (GLP-1) receptor agonist (RA) Have had an MI, percutaneous coronary revascularization procedure, ischemic stroke, carotid stenting or surgical revascularization, nontraumatic amputation, or peripheral vascular procedure (eg, stenting or surgical revascularization) less than 60 days prior to screening Have had coronary artery bypass graft surgery less than 5 years prior to screening Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement Treatment with GLP-1 RA or pramlintide, in a period of 3 months prior to Visit 1 Discontinuation of GLP-1 RA or pramlintide, due to intolerability any time prior to Visit 1 Are currently enrolled in any other clinical study involving an investigational product or any other type of medical research judged not to be scientifically or medically compatible with this study Have participated within the last 30 days in a clinical trial involving an investigational product. If the previous investigational product has a long half-life, 3 months or 5 half-lives (whichever is longer) should have passed Have previously completed or withdrawn from this study or randomized into any other study investigating tirzepatide

Contacts and Locations

Sponsors and Collaborators	Eli Lilly and Company
Locations	University of Alabama at Birmingham Medical Center \| Birmingham Alabama, United States, 35294-0012John Muir Medical Center - Concord Campus \| Concord California, United States, 94520Valley Clinical Trials, Inc. \| Covina California, United States, 91723AMCR Institute \| Escondido California, United States, 92025Valley Research \| Fresno California, United States, 93720NorCal Medical Research, Inc \| Greenbrae California, United States, 94904UCSD - Altman Clinical and Translational Research Institute (ACTRI) \| La Jolla California, United States, 92037First Valley Medical Group \| Lancaster California, United States, 93534Monterey Endocrine & Diabetes Institute, Inc. \| Monterey California, United States, 93940Riverside University Health System - Medical Center \| Moreno Valley California, United States, 92555Diabetes Associates Medical Group \| Orange California, United States, 92868Pasadena Clinical Research \| Pasadena California, United States, 91105LCGK Research \| San Carlos California, United States, 94070Norcal Endocrinology & Internal Medicine \| San Ramon California, United States, 94583Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center \| Torrance California, United States, 90502University of Colorado Anschutz Medical Campus \| Aurora Colorado, United States, 80045CMR of Greater New Haven, LLC \| Hamden Connecticut, United States, 06517Chase Medical Research, LLC \| Waterbury Connecticut, United States, 06708Orlando Heart & Vascular Institute, LLC \| Altamonte Springs Florida, United States, 32714Excel Medical Clinical Trials \| Boca Raton Florida, United States, 33434Encore Medical Research \| Hollywood Florida, United States, 33024East Coast Institute for Research, LLC \| Jacksonville Florida, United States, 32204Jacksonville Center for Clinical Research \| Jacksonville Florida, United States, 32216Accel Research Sites - St. Pete-Largo Clinical Research Unit \| Largo Florida, United States, 33777Ocala Caridovascular Research \| Ocala Florida, United States, 34474Cardiology Partners Clinical Research Institute - Palm Beach Gardens \| Palm Beach Gardens Florida, United States, 33410Peace River Cardiovascular Center \| Port Charlotte Florida, United States, 33952Professional Health Care of Pinellas \| St. Petersburg Florida, United States, 33713Cardiology Partners Clinical Research Institute - Wellington \| Wellington Florida, United States, 33449Clinical Research of Central Florida \| Winter Haven Florida, United States, 33880Atlanta Diabetes Associates \| Atlanta Georgia, United States, 30318Kaiser Permanente - Dutluth, GA \| Duluth Georgia, United States, 30096NSC Research \| Johns Creek Georgia, United States, 30024Physicians Research Associates \| Lawrenceville Georgia, United States, 30045East Coast Institute for Research at The Jones Center \| Macon Georgia, United States, 31210Atlanta Heart Specialists \| Tucker Georgia, United States, 30084East-West Medical Research Institute \| Honolulu Hawaii, United States, 96814VA Pacific Islands Health Care System \| Honolulu Hawaii, United States, 96819Elite Clinical Trials \| Blackfoot Idaho, United States, 83221Rocky Mountain Clinical Research \| Idaho Falls Idaho, United States, 83404Northwest Heart Clinical Research \| Arlington Heights Illinois, United States, 60005Cedar-Crosse Research Center \| Chicago Illinois, United States, 60607Clinical Investigation Specialists \| Gurnee Illinois, United States, 60031Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative \| Springfield Illinois, United States, 62711University of Iowa \| Iowa City Iowa, United States, 52242Iowa Diabetes and Endocrinology Research Center \| West Des Moines Iowa, United States, 50266The University of Kansas - Clinical Research Center \| Fairway Kansas, United States, 66205Cotton O'Neil Diabetes & Endocrinology \| Topeka Kansas, United States, 66606Cotton O'Neil Mulvane \| Topeka Kansas, United States, 66606Qualmedica Research \| Bowling Green Kentucky, United States, 42101L-MARC Research Center \| Louisville Kentucky, United States, 40213Qualmedica Research, LLC \| Owensboro Kentucky, United States, 42301Ascension Saint Agnes Heart Care \| Baltimore Maryland, United States, 21229MedStar Health Research Institute (MedStar Physician Based Research Network) \| Hyattsville Maryland, United States, 20782MD Medical Research \| Oxon Hill Maryland, United States, 20745Endocrine and Metabolic Consultants \| Rockville Maryland, United States, 20852Brigham and Women's Hospital Diabetes Program \| Boston Massachusetts, United States, 02115Joslin Diabetes Center \| Boston Massachusetts, United States, 02215ActivMed Practices and Research \| Methuen Massachusetts, United States, 01844Infinity Medical Research \| North Dartmouth Massachusetts, United States, 02747Arcturus Healthcare , PLC, Troy Internal Medicine Research Division \| Troy Michigan, United States, 48098St. John's Hospital \| Edina Minnesota, United States, 55435M Health Fairview St. John's Hospital \| Maplewood Minnesota, United States, 55109CentraCare Heart & Vascular Center \| Saint Cloud Minnesota, United States, 56303StudyMetrix Research \| City of Saint Peters Missouri, United States, 63303Clinvest Research LLC \| Springfield Missouri, United States, 65807Mercy Research - Smith Glynn Callaway \| Springfield Missouri, United States, 65807Billings Clinic \| Billings Montana, United States, 59101Mercury Street Medical Group, PLLC \| Butte Montana, United States, 59701VA Nebraska-Western Iowa Health Care System \| Omaha Nebraska, United States, 68105University Of Nebraska Medical Center \| Omaha Nebraska, United States, 68198-4130Palm Research Center Tenaya \| Las Vegas Nevada, United States, 89128Palm Research Center Sunset \| Las Vegas Nevada, United States, 89148Southern Nh Diabetes and Endocrinology \| Nashua New Hampshire, United States, 03060Albany Medical College, Division of Community Endocrinology \| Albany New York, United States, 12203Great Lakes Medical Research, LLC \| Westfield New York, United States, 14787Atrium Health - Department of Family Medicine Research \| Charlotte North Carolina, United States, 28207Duke University \| Durham North Carolina, United States, 27710PMG Research Inc., d/b/a PMG of Piedmont Healthcare \| Mooresville North Carolina, United States, 28117Accellacare - Wilmington \| Wilmington North Carolina, United States, 24801Lillestol Research \| Fargo North Dakota, United States, 58104Cleveland Clinic Foundation \| Cleveland Ohio, United States, 44195Alliance for Multispecialty Research, LLC \| Norman Oklahoma, United States, 73069Heritage Valley Medical Group, Inc. \| Beaver Pennsylvania, United States, 15009Capital Area Research, LLC \| Camp Hill Pennsylvania, United States, 17011Decpa, Llc \| Feasterville Pennsylvania, United States, 19053Thomas Jefferson University - Clinical Research Institute \| Philadelphia Pennsylvania, United States, 19107Northeast Endocrine Metabolic Associates \| Philadelphia Pennsylvania, United States, 19114Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18) \| Pittsburgh Pennsylvania, United States, 15236Cardiology Consultants of Philadelphia Yardley \| Yardley Pennsylvania, United States, 19067Ralph H. Johnson VA Medical Center \| Charleston South Carolina, United States, 29401Tribe Clinical Research, LLC \| Greenville South Carolina, United States, 29607Accellacare - Mt Pleasant \| Mt. Pleasant South Carolina, United States, 29464Monument Health Rapid City Hospital \| Rapid City South Dakota, United States, 57701Holston Medical Group \| Bristol Tennessee, United States, 37620PMG Research, Inc. d/b/a PMG Research of Knoxville \| Knoxville Tennessee, United States, 37938Endocrine Clinic \| Memphis Tennessee, United States, 38119Private Practice - Dr. Osvaldo A. Brusco \| Corpus Christi Texas, United States, 78414Dallas Diabetes Research Center \| Dallas Texas, United States, 75230North Texas Endocrine Center \| Dallas Texas, United States, 75231Research Institute of Dallas \| Dallas Texas, United States, 75231Texas Health Physicians Group \| Dallas Texas, United States, 75231Galenos Research \| Dallas Texas, United States, 75251Academy of Diabetes, Thyroid and Endocrine \| El Paso Texas, United States, 79935Diabetes and Thyroid Center of Ft. Worth \| Fort Worth Texas, United States, 76132Northwest Houston Cardiology - Cypress \| Houston Texas, United States, 77070Southern Endocrinology Associates \| Mesquite Texas, United States, 75149North Hills Family Medicine/North Hills Medical Research \| North Richland Hills Texas, United States, 76180Audie L Murphy VA Hospital \| San Antonio Texas, United States, 75231Consano Clinical Research, LLC \| Shavano Park Texas, United States, 78231Northwest Houston Heart Center \| Tomball Texas, United States, 77375Physicians' Research Options \| Draper Utah, United States, 84020Advanced Research Institute \| Ogden Utah, United States, 84405Alpine Medical Group \| Salt Lake City Utah, United States, 84102Kalo Clinical Research \| West Valley City Utah, United States, 84120Virginia Heart \| Falls Church Virginia, United States, 22042MultiCare Good Samaritan Hospital \| Puyallup Washington, United States, 98372VA Puget Sound Health Care System \| Seattle Washington, United States, 98108Multicare Institute for Research and Innovation \| Spokane Washington, United States, 99202Central Washington Health Services Association d/b/a Confluence Health \| Wenatchee Washington, United States, 98801Clinical Investigation Specialists \| Kenosha Wisconsin, United States, 53144Instituto de Investigaciones Clínicas Bahia Blanca \| Bahía Blanca Buenos Aires, Argentina, 8000Organizacion Medica de Investigacion \| CABA Buenos Aires, Argentina, C1015CEDIC \| CABA Buenos Aires, Argentina, C1060ABNStat Research S.A. \| Capital Federal Buenos Aires, Argentina, 1023Centro de Investigaciones Metabólicas (CINME) \| Ciudad Autónoma de Buenos Aires Buenos Aires, Argentina, C1056ABIInstituto de Investigaciones Clínicas Mar del Plata \| Mar del Plata Buenos Aires, Argentina, 7600DIM Clínica Privada \| Ramos Mejía Buenos Aires, Argentina, 1704Go Centro Medico San Nicolás \| San Nicolás de los Arroyos Buenos Aires, Argentina, 2900Instituto de Investigaciones Clinicas Zarate \| Zárate Buenos Aires, Argentina, B2800DGHCentro Médico Viamonte \| Buenos Aires Buenos Aires F.D., Argentina, C1120AACMautalen Salud e Investigación \| Buenos Aires Buenos Aires F.D., Argentina, C1128AAFCentro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada \| Buenos Aires Buenos Aires F.D., Argentina, C1425AGCCEMEDIAB \| C.a.b.a. Buenos Aires F.D., Argentina, C1205AAOCentro Medico Privado CEMAIC \| Capital Córdoba Province, Argentina, X5008HHWCentro Medico Privado San Vicente Diabetes \| Córdoba Córdoba Province, Argentina, 5006Instituto Médico Catamarca IMEC \| Rosario Santa Fe Province, Argentina, 2000Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica \| Rosario Santa Fe Province, Argentina, 2000Instituto de Investigaciones Clinicas Rosario \| Rosario Santa Fe Province, Argentina, S2000CVDCentro de Investigaciones Médicas Tucuman \| SAN M. de Tucuman Tucumán Province, Argentina, T4000AXLClínica Mayo de Urgencias Médicas Cruz Blanca S.R.L \| San Miguel de Tucumán Tucumán Province, Argentina, 4000Investigaciones Clínicas Tucumán \| San Miguel de Tucumán Tucumán Province, Argentina, 4000CEMEDIC \| Buenos Aires , Argentina, 1407Glenny Corp \| Buenos Aires , Argentina, 1430CIPREC \| Buenos Aires , Argentina, C1061Asociación de Beneficencia Hospital Sirio Libanés \| Buenos Aires , Argentina, C1419AHNCentro Universitario de Investigación en Farmacologia Clínic \| Corrientes , Argentina, 3400Instituto de Cardiología "Juana F. Cabral" \| Corrientes , Argentina, 3400CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani \| Córdoba , Argentina, X5000AVECentro Diabetológico Dr. Waitman \| Córdoba , Argentina, X5000JJSInstituto Médico Alas \| Salta , Argentina, 4400Sanatorio Norte \| Santiago del Estero , Argentina, 4200The AIM Centre / Hunter Diabetes Centre \| Merewether New South Wales, Australia, 2291Nepean Hospital \| Penrith New South Wales, Australia, 2747University of Sydney - Charles Perkins Centre \| Sydney New South Wales, Australia, 2006Illawarra Shoalhaven Local Health District \| Wollongong New South Wales, Australia, 2500Royal Brisbane and Women's Hospital \| Brisbane Queensland, Australia, 4029Core Research Group \| Brisbane Queensland, Australia, 4064Mater Misericordiae Limited \| Brisbane Queensland, Australia, 4101Gold Coast University Hospital \| Southport Queensland, Australia, 4215The Townsville Hospital \| Townsville Queensland, Australia, 4814Nightingale Research \| Adelaide South Australia, Australia, 5000Royal Adelaide Hospital \| Adelaide South Australia, Australia, 5000Southern Adelaide Diabetes & Endocrine Services \| Oaklands Park South Australia, Australia, 5046Launceston General Hospital \| Launceston Tasmania, Australia, 7250Box Hill Hospital \| Box Hill Victoria, Australia, 3128Victorian Heart Hospital \| Clayton Victoria, Australia, 3168Barwon Health \| Geelong Victoria, Australia, 3220Austin Health - Repatriation Hospital \| Heidelberg West Victoria, Australia, 3084School of Medicine, Fremantle Hospital \| Fremantle Western Australia, Australia, 6160Advara HeartCare Joondalup \| Joondalup Western Australia, Australia, 6027GenesisCare - Murdoch - Murdoch Drive \| Murdoch Western Australia, Australia, 6150Medizinische Universität Graz \| Graz Styria, Austria, 8036Uniklinikum Salzburg \| Salzburg , Austria, 5020Klinik Landstraße \| Vienna , Austria, 1030Zentrum für klinische Studien Dr Hanusch Gmbh \| Vienna , Austria, 1060Universitaetsklinikum Allgemeines Krankenhaus Wien \| Vienna , Austria, 1090Klinik Hietzing \| Vienna , Austria, 1130Imelda General Hospital \| Bonheiden Antwerpen, Belgium, 2820Algemeen Ziekenhuis klina \| Brasschaat Antwerpen, Belgium, 2930Antwerp University Hospital \| Edegem Antwerpen, Belgium, 2650Université Libre de Bruxelles - Hôpital Erasme \| Brussels Bruxelles-Capitale, Région de, Belgium, 1070UZ Brussel \| Brussels Bruxelles-Capitale, Région de, Belgium, 1090ZAS Jan Palfijn \| Merksem Flanders, Belgium, 2170AZORG Campus Aalst-Moorselbaan \| Aalst Oost-Vlaanderen, Belgium, 9300AZ Nikolaas \| Sint-Niklaas Oost-Vlaanderen, Belgium, B-9100UZ Leuven \| Leuven Vlaams-Brabant, Belgium, 3000AZ Sint-Jan Brugge-Oostende AV \| Bruges West-Vlaanderen, Belgium, 8000AZ Groeninge Campus Kennedylaan \| Kortrijk West-Vlaanderen, Belgium, 8500Az Damiaan vzw \| Ostend West-Vlaanderen, Belgium, 8400AZ Delta vzw \| Roeselare West-Vlaanderen, Belgium, 8800Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman \| Liège , Belgium, 4000Private Practice - Dr.Miguel N. Hissa \| Fortaleza Ceará, Brazil, 60430-350CEDOES \| Vitória Espírito Santo, Brazil, 29055450Quanta Diagnóstico e Terapia \| Curitiba Paraná, Brazil, 80045170Núcleo de Pesquisa Clínica do Rio Grande do Sul \| Porto Alegre Rio Grande do Sul, Brazil, 90430-001Instituto de Pesquisa clinica de Campinas \| Campinas São Paulo, Brazil, 13060-080Loema Instituto de Pesquisa Clinica \| Campinas São Paulo, Brazil, 13092-133CECIP - Centro de Estudos do Interior Paulista \| Jaú São Paulo, Brazil, 17201130Faculdade de Medicina do ABC \| Santo André São Paulo, Brazil, 09060-870ISPEM - Instituto São José dos Campos em Pesquisas Médicas \| São José dos Campos São Paulo, Brazil, 12243-280Instituto de Pesquisa Clinica \| São Paulo São Paulo, Brazil, 01223-001CPCLIN \| São Paulo São Paulo, Brazil, 01228-200IBPClin - Instituto Brasil de Pesquisa Clínica \| Rio de Janeiro , Brazil, 22241-180CPQuali Pesquisa Clínica \| São Paulo , Brazil, 01228-000Hospital das Clinicas FMUSP \| São Paulo , Brazil, 04266-010Hospital das Clinicas FMUSP \| São Paulo , Brazil, 05403-000LMC Diabetes & Endocrinology \| Calgary Alberta, Canada, T2H 2G4BC Diabetes Office \| Vancouver British Columbia, Canada, V5Y 3W2Dr. M.B. Jones Inc. \| Victoria British Columbia, Canada, V8V 4A1Winnipeg Clinic \| Winnipeg Manitoba, Canada, MB R3C 0N2NSHA-QEII Health Sciences Centre-Dickson Bldg \| Halifax Nova Scotia, Canada, B3H 1V7LMC Clinical Research Inc. (Barrie) \| Barrie Ontario, Canada, L4N 7L3LMC Diabetes & Endocrinology \| Brampton Ontario, Canada, L6S 0C9Aggarwal and Associates Limited \| Brampton Ontario, Canada, L6T 0G1Cambridge Cardiac Care Centre \| Cambridge Ontario, Canada, N1R 6V6LMC Clinical Research Inc. (Thornhill) \| Concord Ontario, Canada, L4K 4M2Janik Research Corporation \| Greater Sudbury Ontario, Canada, P3C 1S8Milestone Research Inc. \| London Ontario, Canada, N5W 6A2St. Joseph's Health Care \| London Ontario, Canada, N6A 4V2North York Diagnostic and Cardiac Centre \| North York Ontario, Canada, M6B 3H7LMC Clinical Research Inc. (Oakville) \| Oakville Ontario, Canada, L6M 1M1Private Practice - Dr. James Cha \| Oshawa Ontario, Canada, L1G 2K1LMC Manna Research \| Ottawa Ontario, Canada, K2J 0V2Kawartha Cardiology Clinical Trials \| Peterborough Ontario, Canada, K9J 0B2Bluewater Clinical Research Group Inc. \| Sarnia Ontario, Canada, N7T 4X3Diabetes Clinic \| Smiths Falls Ontario, Canada, K7A 4W8Canadian Phase Onward \| Toronto Ontario, Canada, M3J 0K2LMC Clinical Research Inc. (Bayview) \| Toronto Ontario, Canada, M4G 3E8Diabetes Heart Research Centre \| Toronto Ontario, Canada, M6G 1M2Dr. Anil K. Gupta Medicine Professional Corporation \| Toronto Ontario, Canada, M9V 4B4Viacar Recherche Clinique \| Greenfield Park Quebec, Canada, J4V 2G8Centre de Recherche Clinique de Laval \| Laval Quebec, Canada, H7T 2P5Manna Research \| Lévis Quebec, Canada, G6W 0M5Clinique Sante Cardio MC \| Montreal Quebec, Canada, H1T 3Y7Diex Recherche Quebec \| Québec , Canada, G1V 4T3Beijing Anzhen Hospital, Capital Medical University \| Beijing Beijing Municipality, China, 100029Peking University First Hospital \| Beijing Beijing Municipality, China, 100034Peking University People's Hospital \| Beijing Beijing Municipality, China, 100034Beijing Friendship Hospital \| Beijing Beijing Municipality, China, 100050The First Hospital of Lanzhou University \| Lanzhou Gansu, China, 730000Lanzhou university second hospital \| Lanzhou Gansu, China, 730030The First Affiliated Hospital, Sun Yat-sen University \| Guangzhou Guangdong, China, The Fourth Affiliated Hospital of Harbin Medical University \| Harbin Heilongjiang, China, 150001Hunan Provincial People's Hospital \| Changsha Hunan, China, 410005First Huai'an Hospital Affiliated to Nanjing Medical University \| Huai'an Jiangsu, China, 223300Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School \| Nanjing Jiangsu, China, 210000Zhongda Hospital Southeast University \| Nanjing Jiangsu, China, 210009The Second Affiliated Hospital of Nanjing Medical University \| Nanjing Jiangsu, China, 210011Nanjing First Hospital \| Nanjing Jiangsu, China, 210012Affiliated Hospital of Jiangsu University \| Zhenjiang Jiangsu, China, 212000The First Affiliated Hospital of Nanchang University \| Nanchang Jiangxi, China, 330006Jiangxi Pingxiang People's Hospital \| Pingxiang Jiangxi, China, 337055China-Japan Union Hospital \| Changchun Jilin, China, 130033The People's Hospital of Liaoning Province \| Shenyang Liaoning, China, 110016General Hospital of Ningxia Medical University \| Yinchuan Ningxia, China, 750004The First Affiliated Hospital of Xi'an Jiaotong University \| Xi'an Shaanxi, China, 710061Jinan Central Hospital \| Jinan Shandong, China, 250013Tianjin Medical University General Hospital \| Tianjin Tianjin Municipality, China, 300052MUDr. Tomas Edelsberger \| Krnov Moravian-Silesian Region, Czechia, 79401Interni a diabetologicka ordinace, s.r.o. \| Náchod Náchod, Czechia, 547 01Diabet2 s.r.o., diabetologicka a interni ambulance \| Prague Praha 1, Czechia, 11000ResTrial s.r.o. \| Prague Praha 8, Czechia, 18100MUDr. Barbora Diepoltova \| Praha 9 - Klanovice Praha 9, Czechia, 190 14Diacentrum Brandys n.L. s.r.o. \| Brandýs nad Labem Praha-východ, Czechia, 25001MUDr. Alena Vachova \| České Budějovice South Bohemian Region, Czechia, 37011Vseobecna fakultni nemocnice v Praze \| Prague , Czechia, 12808MUDr. Michala Pelikanova s.r.o. \| Prague , Czechia, 140 00Milan Kvapil s.r.o., Diabetologicka ambulance \| Prague , Czechia, 14900CHU Bordeaux Haut-Leveque \| Pessac Aquitaine, France, 33600Groupe Hospitalier Mutualiste Les Portes du Sud \| Vénissieux Auvergne-Rhône-Alpes, France, 69200Hôtel-Dieu du Creusot - site Harfleur \| Le Creusot Bourgogne-Franche-Comté, France, 71200Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand \| Dijon Côte-d'Or, France, 21000CHU Rangueil \| Toulouse Haute-Garonne, France, 31059Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes \| Saint-Herblain Loire-Atlantique, France, 44800Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois \| Vandœuvre-lès-Nancy Lorraine, France, 54511Assistance Publique Hôpitaux de Paris - Groupe Hospitalier 10e - Hôpital Lariboisière \| Paris , France, 75010Hôpital Bichat - Claude-Bernard \| Paris , France, 75018Centre Hospitalier Sud Francilien \| Corbeil-Essonnes Île-de-France Region, France, 91106Groupe hospitalier Paris saint Joseph \| Paris Île-de-France Region, France, 75014Gemeinschaftspraxis Dres. Jung \| Deggingen Baden-Wurttemberg, Germany, 73326Marienhospital Stuttgart \| Stuttgart Baden-Wurttemberg, Germany, 70199Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob \| Villingen-Schwenningen Baden-Wurttemberg, Germany, 78048Praxis Sauter & Sauter & Vorbach \| Wangen Baden-Wurttemberg, Germany, 88239CIMS Studienzentrum Bamberg \| Bamberg Bavaria, Germany, 96049Private Practice - Dr. Ilka Simon-Wagner \| Lichtenfels Bavaria, Germany, 96215CDG Studienambulanz Hartard \| München Bavaria, Germany, 80809ZKS Suedbrandenburg \| Elsterwerda Brandenburg, Germany, 04910ZKS Dr. Lüdemann \| Falkensee Brandenburg, Germany, 14612ClinPhenomics GmbH & Co KG \| Frankfurt am Main Hesse, Germany, 60596MVZ im Altstadt-Carree Fulda GmbH \| Fulda Hesse, Germany, 36037Diabetes Zentrum Dr. Tews \| Gelnhausen Hesse, Germany, 63571Diabetologische Schwerpunktpraxis Marck Linn Pickel \| Pohlheim Hesse, Germany, 35415Praxis Oedeme \| Lüneburg Lower Saxony, Germany, 21339Praxis Dr. Veronika Wenzl-Bauer \| Rehlingen Lower Saxony, Germany, 66780Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen \| Bad Oeynhausen North Rhine-Westphalia, Germany, 32545Diabetes- und Stoffwechselpraxis Bochum \| Bochum North Rhine-Westphalia, Germany, 44869Private Practice - Dr. Claus Busch, Dr. Christian Busch & Dr. Christopher Cramer \| Dortmund North Rhine-Westphalia, Germany, 44137InnoDiab Forschung Gmbh \| Essen North Rhine-Westphalia, Germany, 45136Medizentrum Essen Borbeck \| Essen North Rhine-Westphalia, Germany, 45355Private Practice - Dr. Bernd Becker \| Essen North Rhine-Westphalia, Germany, 45355Institut für Diabetesforschung GmbH Münster \| Münster North Rhine-Westphalia, Germany, 48145Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz \| Ludwigshafen am Rhein Rhineland-Palatinate, Germany, 67059Diabetologische Schwerpunktpraxis Diabetologikum Speyer \| Speyer Rhineland-Palatinate, Germany, 67346Practice Dr.med. Denger and Dr.med. Pfitzner \| Friedrichsthal Saarland, Germany, 66299Zentrum für klinische Studien \| Saint Ingbert Saarland, Germany, 66386Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien \| Dresden Saxony, Germany, 1277Universitaetsklinikum Carl Gustav Carus Dresden \| Dresden Saxony, Germany, 1307Velocity Clinical Research Leipzig GmbH \| Leipzig Saxony, Germany, 04177Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut \| Leipzig Saxony, Germany, 04249AmBeNet GmbH \| Leipzig Saxony, Germany, 4107Private Practice - Dr. Christine Kosch \| Pirna Saxony, Germany, 1796MVZ Riesa am Klinikum Döbeln GmbH \| Riesa Saxony, Germany, 1589Praxis für Inner Medizin - Diabetologische Schwerpunktpraxis \| Zwenkau Saxony, Germany, 04442Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels \| Hohenmölsen Saxony-Anhalt, Germany, 06679SMO.MD GmbH \| Magdeburg Saxony-Anhalt, Germany, 39120Universität zu Lübeck - Institut für Endokrinologie und Diabetes \| Lübeck Schleswig-Holstein, Germany, 23562RED-Institut GmbH \| Oldenburg in Holstein Schleswig-Holstein, Germany, 23758Private Practice - Dr. Joachim Weimer \| Reinfeld Schleswig-Holstein, Germany, 23858Medizinisches Versorgungszentrum am Bahnhof Spandau \| Spandau State of Berlin, Germany, 13597Gemeinschaftspraxis für Diabetologie \| Eisenach Thuringia, Germany, 99817Institut für klinische Forschung und Entwicklung \| Berlin , Germany, 10437Diabetespraxis Prenzlauer Alle \| Berlin , Germany, 13187Diabetologische Schwerpunktpraxis Harburg \| Hamburg , Germany, 21073Diabetes Zentrum Wilhelmsburg \| Hamburg , Germany, 21109Diabeteszentrum Hamburg West \| Hamburg , Germany, 22607St. Josefskrankenhaus Heidelberg \| Heidelberg , Germany, 69115Athens Euroclinic \| Athens Attikí (Region), Greece, 115 21Iatriko Paleou Falirou Medical Center \| Palaió Fáliro Attikí (Region), Greece, 17562General Hospital of Athens "G. Gennimatas" \| Athens Attikí, Greece, 11527Attikon General University Hospital \| Chaïdári Attikí, Greece, 12462Ippokrateio General Hospital of Thessaloniki \| Thessaloniki Kentrikí Makedonía, Greece, 54642Thermi Clinic \| Thermi, Thessaloniki Thessaloníki, Greece, 570 01AHEPA University General Hospital of Thessaloniki \| Thessaloniki Thessaloníki, Greece, 546 36Euromedica General Clinic of Thessaloniki \| Thessaloniki Thessaloníki, Greece, 546 45Papageorgiou General Hospital of Thessaloniki \| Thessaloniki Thessaloníki, Greece, 564 03University General Hospital of Larissa \| Larissa Thessalía, Greece, 41110Studium Egeszseghaz Kft \| Kalocsa Bács-Kiskun county, Hungary, 6300Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ \| Szeged Csongrád megye, Hungary, 6725Fejér Megyei Szent György Egyetemi Oktató Kórház \| Székesfehérvár Fejér, Hungary, 8000Debreceni Egyetem Kenézy Gyula Egyetemi Kórház \| Debrecen Hajdú-Bihar, Hungary, 4031Markhot Ferenc Oktatókórház \| Eger Heves County, Hungary, 3300Pharma 4 Trial \| Gyöngyös Heves County, Hungary, 3200Selye János Kórház \| Komárom Komárom-Esztergom, Hungary, 2900CLINFAN Szolgáltató Kft \| Szekszárd Tolna County, Hungary, 7100DRC Gyógyszervizsgáló Központ \| Balatonfüred Veszprém megye, Hungary, 8230Kanizsai Dorottya Korhaz \| Nagykanizsa Zala County, Hungary, 8800Zala Megyei Szent Rafael Kórház \| Zalaegerszeg Zala County, Hungary, 8900Szent Margit Rendelőintézet Nonprofit Kft \| Budapest , Hungary, 1032ClinDiab Kft. \| Budapest , Hungary, 1089Szent János Kórház \| Budapest , Hungary, 1125Magyar Honvedseg Egeszsegugyi Kozpont \| Budapest , Hungary, 1134Strazsahegy Medicina Bt. \| Budapest , Hungary, H1171Debreceni Egyetem Klinikai Kozpont \| Debrecen , Hungary, 4032Gujarat Endocrin Pvt Ltd \| Ahmedabad Gujarat, India, 380052Marengo CIMS Hospital \| Ahmedabad Gujarat, India, 380060Bangalore Diabetes Centre \| Bangalore Karnataka, India, 560043CARE CHL-Hospitals \| Indore Madhya Pradesh, India, 452008Topiwala National Medical College & B. Y. L. Nair Charitable Hospital \| Mumbai Maharashtra, India, 400008King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College \| Mumbai Maharashtra, India, 400012Kingsway Hospitals (Best Multispeciality Hospital in Nagpur) \| Nagpur Maharashtra, India, 440001G.B. Pant Institute of Postgraduate Medical Education & Research \| New Delhi National Capital Territory of Delhi, India, 110002All India Institute of Medical Sciences \| New Delhi National Capital Territory of Delhi, India, 110029Sir Ganga Ram Hospital \| New Delhi National Capital Territory of Delhi, India, 110060Batra Hospital and Medical Research Centre \| New Delhi National Capital Territory of Delhi, India, 110062Madras Diabetes Research Foundation \| Chennai Tamil Nadu, India, 600086Care Hospitals Hyderabad- Banjara Hills \| Hyderabad Telangana, India, 500034Apollo Multispeciality Hospitals limited \| Kolkata West Bengal, India, 700054Edith Wolfson Medical Center \| Holon Central District, Israel, 5810001Meir Medical Center \| Kfar Saba Central District, Israel, 4428164Rabin Medical Center - Hasharon Campus \| Petah Tikva Central District, Israel, 49202Rabin Medical Center \| Petah Tikva Central District, Israel, Sheba Medical Center \| Ramat Gan Central District, Israel, 5262100Kaplan Medical Center \| Rehovot Central District, Israel, 7610001Shaare Zedek Medical Center \| Jerusalem Jerusalem, Israel, 9013102Hadassah Medical Center \| Jerusalem Jerusalem, Israel, 9112001Hadassah Mount Scopus Medical Centre \| Jerusalem Jerusalem, Israel, 9124001Clalit Health Services Diabetes and Endocrinology Clinic Jerusalem \| Jerusalem Jerusalem, Israel, 93106Emek Medical Center \| Afula Northern District, Israel, 1834111Hillel Yaffe Medical Center \| Hadera Northern District, Israel, 3810101Rambam Health Care Campus \| Haifa Northern District, Israel, 3109601Galilee Medical Center \| Nahariya Northern District, Israel, 2210001Holy Family Hospital \| Nazareth Northern District, Israel, 16100ZIV Medical Center \| Safed Northern District, Israel, 1311001Clalit Health Services - Sakhnin Community Clinic \| Sakhnin Northern District, Israel, 3081000Barzilai Medical Center \| Ashkelon Southern District, Israel, 7830604Soroka Medical Center \| Beersheba Southern District, Israel, 8410101Sourasky Medical Center \| Tel Aviv Tell Abīb, Israel, 6423906Clalit Health Services - Atlit \| Atlit Ḥeifā, Israel, 30300Bnai Zion Medical Center \| Haifa Ḥeifā, Israel, 3339419Linn Medical Center \| Haifa Ḥeifā, Israel, 3515209A.O.U.C. Policlinico di Bari \| Bari Apulia, Italy, 70124Universita degli Studi della Campania Luigi Vanvitelli \| Naples Campania, Italy, 80138Fondazione Policlinico Tor Vergata \| Rome Lazio, Italy, 133Fondazione Policlinico Universitario Agostino Gemelli \| Rome Lazio, Italy, 168Ospedale San Giovanni Calibita Fatebenefratelli \| Rome Lazio, Italy, 186Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII \| Bergamo Lombardy, Italy, 24127Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico \| Milan Lombardy, Italy, 20122Ospedale san Giovanni di Dio-Diabetologia \| Olbia Sardinia, Italy, 7026A.O.U. Policlinico Paolo Giaccone \| Palermo Sicily, Italy, 90129Ospedale Maggiore Pronto Soccorso \| Chieri Torino, Italy, 10023Azienda Ospedaliera Universitaria Careggi \| Florence Tuscany, Italy, 50134Azienda Ospedaliera Universitaria Pisana \| Pisa Tuscany, Italy, 56124Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento \| Verona Veneto, Italy, 37126IRCCS - AOU di Bologna \| Bologna , Italy, 40138Azienda Ospedaliera Garibaldi \| Catania , Italy, 95124Azienda Ospedaliera Mater Domini \| Catanzaro , Italy, 88100Università degli Studi Gabriele D' Annunzio \| Chieti , Italy, 66100Centro Cardiologico Monzino \| Milan , Italy, 20138Azienda Ospedaliero Universitaria di Parma \| Parma , Italy, 43126Fondazione Salvatore Maugeri Clinica del lavoro \| Pavia , Italy, 27100Uji-Tokushukai Medical Center \| Uji Kyoto, Japan, 611-0041Takatsuki Red Cross Hospital \| Takatsuki Osaka, Japan, 569-1045The Institute of Medical Science, Asahi Life Foundation \| Chuo-ku Tokyo, Japan, 103-0002Tokyo-Eki Center-building Clinic \| Chuo-ku Tokyo, Japan, 103-0027Fukuwa Clinic \| Chuo-ku Tokyo, Japan, 104-0031Medical Corporation Sato Medical clinic \| Ootaku Tokyo, Japan, 143-0015Jinnouchi Hospital \| Kumamoto , Japan, 862-0976AMC Nishiumeda Clinic \| Osaka , Japan, 530-0001Sakurabashi Watanabe Advanced Healthcare Hospital \| Osaka , Japan, 530-0005Centro de Investigacion Cardiovascular y Metabólica \| Tijuana Estado de Baja California, Mexico, 22500Diseno y Planeacion en Investigacion Medica \| Guadalajara Jalisco, Mexico, 44130Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente \| Guadalajara Jalisco, Mexico, 44150Centro de Investigacion Medica Integral \| Guadalajara Jalisco, Mexico, 44160Centro de Investigacion Medica de Occidente, S.C. \| Guadalajara Jalisco, Mexico, 44260Universidad de Guadalajara \| Guadalajara Jalisco, Mexico, 44340Instituto Jalisciense de Investigacion en Diabetes y Obesidad \| Guadalajara Jalisco, Mexico, 4460Private Practice - Dr. Arechavaleta Granell Maria del Rosario \| Guadalajara Jalisco, Mexico, 44670Salud Cardiovascular \| Guadalajara Jalisco, Mexico, 44860Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares \| Mexico City Mexico City, Mexico, 11650Instituto de Diabetes, Obesidad y Nutricion \| Cuernavaca Morelos, Mexico, 62250Cardiolink Clin Trials \| Monterrey Nuevo León, Mexico, 64060Hospital Universitario "Dr. Jose Eleuterio Gonzalez" \| Monterrey Nuevo León, Mexico, 66460Unidad Médica para la Salud Integral \| San Nicolás de los Garza Nuevo León, Mexico, 66465Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C. \| Culiacán Sinaloa, Mexico, 80230Centro de Estudios de Investigacion Metabolicos y Cardiovasculares \| Ciudad Madero Tamaulipas, Mexico, 89440Hospital Angeles Xalapa \| Xalapa Veracruz, Mexico, 91193Medical Care and Research SA de CV \| Mérida Yucatán, Mexico, 97070Centro de Investigacion Medica Aguascalientes \| Aguascalientes , Mexico, 20116Fundación Cardiovascular de Aguascalientes A.C. \| Aguascalientes , Mexico, 20230Hospital Cardiologica Aguescalientes \| Aguascalientes , Mexico, 20230Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos \| Chihuahua City , Mexico, 31110Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia \| Durango , Mexico, 34000Centro de Estudios Clínicos de Querétaro (CECLIQ) \| Querétaro , Mexico, 76000Ziekenhuis Bethesda \| Hoogeveen Drenthe, Netherlands, 7909 AAEB Utrecht \| Almere Stad Flevoland, Netherlands, 1311RLZiekenhuis Rijnstate \| Arnhem Gelderland, Netherlands, 6815 ADSlingeland Ziekenhuis \| Doetinchem Gelderland, Netherlands, 7009 BLZiekenhuis Gelderse Vallei \| Ede Gelderland, Netherlands, 6716 RPRadboudumc \| Nijmegen Gelderland, Netherlands, 6525 GACanisius-Wilhelmina Ziekenhuis \| Nijmegen Gelderland, Netherlands, 6532 SZJeroen Bosch ziekenhuis \| 's-Hertogenbosch North Brabant, Netherlands, 5223 GZZiekenhuis Amstelland \| Amstelveen North Holland, Netherlands, 1186 AMAmsterdam UMC, locatie VUmc \| Amsterdam North Holland, Netherlands, 1081 HVAmsterdam UMC, locatie AMC \| Amsterdam North Holland, Netherlands, 1105 AZSpaarne Gasthuis, Haarlem Zuid \| Haarlem North Holland, Netherlands, 2035 RCSaxenburgh Medisch Centrum \| Hardenberg Overijssel, Netherlands, 7772 SEReinier de Graaf Ziekenhuis, locatie Delft \| Delft South Holland, Netherlands, 2625 ADHet Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland \| Dirksland South Holland, Netherlands, 3247 BWFranciscus Gasthuis & Vlietland, Locatie Gasthuis \| Rotterdam South Holland, Netherlands, 3045 PMDiakonessenhuis, locatie Utrecht \| Utrecht , Netherlands, 3582 KEUniversitair Medisch Centrum Utrecht \| Utrecht , Netherlands, 3584 CXOMEDICA Medical Center \| Poznan Greater Poland Voivodeship, Poland, 60-111Gaja Poradnie Lekarskie Maciej Wiza \| Poznan Greater Poland Voivodeship, Poland, 61-251Private Practice - Dr. Ewa Krzyzagorska \| Poznan Greater Poland Voivodeship, Poland, 61-655Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET \| Krakow Lesser Poland Voivodeship, Poland, 31-261Private Practice - Dr. Robert Witek \| Tarnów Lesser Poland Voivodeship, Poland, 33-100NZOZ Regionalna Poradnia Diabetologiczna \| Wroclaw Lower Silesian Voivodeship, Poland, 50-127Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej \| Wroclaw Lower Silesian Voivodeship, Poland, 50-403CenterMed Lublin NZOZ \| Lublin Lublin Voivodeship, Poland, 20-044Gabinety TERPA \| Lublin Lublin Voivodeship, Poland, 20-333NZOZ Medica \| Lublin Lublin Voivodeship, Poland, 20-538Centrum Medyczne AMED \| Warsaw Masovian Voivodeship, Poland, 00-215Instytut Diabetologii \| Warsaw Masovian Voivodeship, Poland, 02-117ETG NETWORK Sp. z o.o. \| Warsaw Masovian Voivodeship, Poland, 02-677Legeartis - Poradnie Specjalistyczne \| Bialystok Podlaskie Voivodeship, Poland, 15-404Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna \| Bialystok Podlaskie Voivodeship, Poland, 15445Centrum Badan Klinicznych PI-House sp. z o.o. \| Gdansk Pomeranian Voivodeship, Poland, 80-546NZOZ Salvia CM \| Katowice Silesian Voivodeship, Poland, 40-772NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki \| Ruda Śląska Silesian Voivodeship, Poland, 41-709Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna \| Lodz Łódź Voivodeship, Poland, 90338Advanced Clinical Research, LLC \| Bayamón , Puerto Rico, 00959Manati Center for Clinical Research \| Manati , Puerto Rico, 00674Research and Cardiovascular Corp. \| Ponce , Puerto Rico, 00717GCM Medical Group, PSC - Hato Rey Site \| San Juan , Puerto Rico, 00917San Juan City Hospital \| San Juan , Puerto Rico, 00935Private Practice - Dr. Diana Barbonta \| Alba Iulia Alba, Romania, 510134Diabdana \| Oradea Bihor County, Romania, 410147Centrul Medical Grandmed \| Oradea Bihor County, Romania, 410159C.M.D.T.A. Neomed \| Brasov Brașov County, Romania, 500283Nicodiab \| Bucharest Bucharest, Romania, 10507Geea Medical Easy Diet \| Bucharest Bucharest, Romania, 10627Centrul Medical NutriLife \| Bucharest Bucharest, Romania, 13764The National Institute of Diabetes, Nutrition and Metabolic Diseases "Prof. Dr. N. Paulescu" \| Bucharest Bucharest, Romania, 20475Gama Diamed \| Mangalia Constanța County, Romania, 905500Top Diabet SRL \| Craiova Dolj, Romania, 200678CMI DNBM Dr. Pop Lavinia \| Baia Mare Maramureş, Romania, 430222SC Dentosim Queen SRL - Centrul Medical Diamed \| Târgu Mureş Mureș County, Romania, 540098Diabmed Dr. Popescu Alexandrina \| Ploieşti Prahova, Romania, 100163Dianutrilife Medica \| Ploieşti Prahova, Romania, 100561Centru Medical Dr. Negrisanu \| Timișoara Timiș County, Romania, 300456CMI Dr.Pletea Noemi SRL \| Bacau , Romania, 600154SC Minimed SRL \| Bacau , Romania, 600238Diamed Obesity \| Galați , Romania, 800291Olimpia Med \| Iași , Romania, 400002Centrul Medical Consultmed \| Iași , Romania, 700514Arkhangelsk Regional Clinical Hospital \| Arkhangelsk Arkhangelskaya oblast, Russia, 163045First City Clinical Hospital E.E. Volosevich \| Arkhangelsk Arkhangelskaya oblast, Russia, 163045Advisory Diagnostic Centre \| Syktyvkar Komi, Russia, 167000City Mariinskaya Hospital \| Saint Petersburg Leningradskaya Oblast', Russia, 191104National Medical Research Center for therapy and preventive medicine \| Moscow Moscow, Russia, 101990Endocrinology Research Center of Rosmedtechnologies \| Moscow Moscow, Russia, 117036Pirogov Russian National Research Medical University \| Moscow Moscow, Russia, 117997First Moscow State Medical University I.M. Sechenov \| Moscow Moscow, Russia, 119991Russian Cardiology Research and Production Complex \| Moscow Moscow, Russia, 121552Moscow City Clinical Hospital Number 52 \| Moscow Moscow, Russia, 123182M. F. Vladimirskiy Moscow Regional Research Clinical Institute \| Moscow Moscow, Russia, 129110Moscow City Clinical Hospital Number 52 \| Moscow Moscow, Russia, Novosibirsk State Medical University \| Novosibirsk Novosibirsk Oblast, Russia, 630087Rostov State Medical University \| Rostov-on-Don Rostov Oblast, Russia, 344022Ryazan Regional Clinical Cardiological Dispensary \| Ryazan Ryazan Oblast, Russia, 390026S.M. Kirov Military Medical Academy \| Saint Petersburg Sankt-Peterburg, Russia, 194044Saint-Petersburg City Hospital of Saint Elizabeth \| Saint Petersburg Sankt-Peterburg, Russia, 195257Astarta Clinic \| Saint Petersburg Sankt-Peterburg, Russia, 199226Regional Clinical Hospital of the Saratov Region \| Saratov Saratov Oblast, Russia, 410053Tomsk Regional Clinical Hospital \| Tomsk Tomsk Oblast, Russia, 634063Siberian State Medical University \| Tomsk Tomsk Oblast, Russia, Research & Practice \| Yaroslavl Yaroslavl Oblast, Russia, 150003Yaroslavl State Med Acad Clinical Hospital \| Yaroslavl Yaroslavl Oblast, Russia, 150010IN-DIA \| Lučenec Banská Bystrica Region, Slovakia, 984 01Diacrin s.r.o. \| Bratislava Bratislava Region, Slovakia, 831 01Sin Azucar \| Malacky Bratislava Region, Slovakia, 901 01DIAB sro \| Rožňava Košice Region, Slovakia, 048 01Funkystuff \| Nové Zámky Nitra Region, Slovakia, 940 01Diabetol \| Prešov Presov, Slovakia, 080 01MED-DIA s.r.o \| Sabinov Presov, Slovakia, 8301DIA-MED CENTRUM s.r.o. \| Púchov Trenčín Region, Slovakia, 020 01Diabetes Centrum \| Trenčín Trenčín Region, Slovakia, 911 01Yonsei University-Wonju Severance Christian Hospital \| Wŏnju Kang-won-do, South Korea, 26426Korea University Anam Hospital \| Seoul Seoul-teukbyeolsi [Seoul], South Korea, 2841Seoul National University Hospital \| Seoul Seoul-teukbyeolsi [Seoul], South Korea, 3080Severance Hospital, Yonsei University Health System \| Seoul Seoul-teukbyeolsi [Seoul], South Korea, 3722Kyung Hee University Hospital at Gangdong \| Seoul Seoul-teukbyeolsi [Seoul], South Korea, 5278Asan Medical Center \| Seoul Seoul-teukbyeolsi [Seoul], South Korea, 5505The Catholic Univ. of Korea Seoul St. Mary's Hospital \| Seoul Seoul-teukbyeolsi [Seoul], South Korea, 6591Hallym University Kangnam Sacred Heart Hospital \| Seoul Seoul-teukbyeolsi [Seoul], South Korea, 7441Keimyung University Dongsan Hospital \| Daegu Taegu-Kwangyǒkshi, South Korea, 42601Ulsan University Hospital \| Ulsan Ulsan-Kwangyǒkshi, South Korea, 44033CHUAC-Complejo Hospitalario Universitario A Coruña \| A Coruña A Coruña [La Coruña], Spain, 15006Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval \| Ferrol A Coruña [La Coruña], Spain, 15405CHUS - Hospital Clinico Universitario \| Santiago de Compostela A Coruña [La Coruña], Spain, 15706Centro Periférico de Especialidades Bola Azul \| Almería Almería, Spain, 4009Hospital Universitario Virgen de la Victoria \| Málaga Andalusia, Spain, 29010Hospital Quiron Infanta Luisa \| Seville Andalusia, Spain, 41010Hospital Universitario Central de Asturias \| Oviedo Asturias, Principado de, Spain, 33011Hospital Clínico Universitario de Valladolid \| Valladolid Castille and León, Spain, 47003Hospital Virgen del Camino \| Sanlúcar de Barrameda Cádiz, Spain, 11540Hospital Virgen de las Montañas \| Villamartín Cádiz, Spain, 11650Hospital Universitario Quironsalud Madrid \| Pozuelo de Alarcón Madrid, Spain, 28223Hospital Universitario Príncipe de Asturias \| Alcalá de Henares Madrid, Comunidad de, Spain, 28805Hospital Universitario Ramón y Cajal \| Madrid Madrid, Comunidad de, Spain, 28034Hospital General Universitario de Valencia \| Valencia Valenciana, Comunitat, Spain, 46014Hospital Universitario de La Ribera \| Alzira València, Spain, 46600Hospital Unviersitario Virgen Nieves \| Granada , Spain, 18012Hospital Universitario La Paz \| Madrid , Spain, 28046Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE) \| Seville , Spain, 41003Hospital Universitario Virgen Macarena \| Seville , Spain, 41009Hospital Universitari i Politecnic La Fe \| Valencia , Spain, 46026Dalecarlia Clinical Research Center \| Rättvik Dalarnas Län [se-20], Sweden, 795 30Östersunds Sjukhus \| Östersund Jämtlands Län [se-23], Sweden, 831 31ProbarE \| Lund Skåne Län [se-12], Sweden, 222 22Citydiabetes \| Stockholm Stockholms Län [se-01], Sweden, 112 21Sahlgrenska Universitetssjukhuset Mölndal \| Mölndal Västra Götalands Län [se-14], Sweden, 431 80Universitetssjukhuset Örebro \| Örebro Örebro Län [se-18], Sweden, 701 85Changhua Christian Hospital \| Changhua County Changhua, Taiwan, 50006Mackay Memorial Hospital-Hsinchu \| Hsinchu Hsinchu, Taiwan, 300Hualien Tzu Chi Medical Center \| Hualien City Hualien, Taiwan, 970Chang Gung Memorial Hospital at Kaohsiung \| Kaohsiung Niao Sung Dist Kaohsiung, Taiwan, 83301Chi Mei Medical Center \| Tainan Tainan, Taiwan, 71004Taichung Veterans General Hospital \| Taichung , Taiwan, 407National Cheng-Kung Uni. Hosp. \| Tainan , Taiwan, 704Taipei Veterans General Hospital \| Taipei , Taiwan, 11217Chang Gung Medical Foundation-Linkou Branch \| Taoyuan , Taiwan, 333Baskent University Dr. Turgut Noyan Research and Training Center \| Yüreğir Adana, Turkey (Türkiye), 01250Dicle Üniversitesi \| Sur Diyarbakır, Turkey (Türkiye), 21200Eskisehir Osmangazi University \| Eskişehir Eskişehir, Turkey (Türkiye), 26040Dokuz Eylül Üniversitesi \| Balçova İzmir, Turkey (Türkiye), 35340Ege Universitesi Hastanesi \| Bornova İzmir, Turkey (Türkiye), 35100Mersin University Medical Faculty \| Yenişehir Mersin, Turkey (Türkiye), 33110Akdeniz Universitesi Hastanesi \| Antalya , Turkey (Türkiye), 7070Adnan Menderes University Medical Faculty \| Aydin , Turkey (Türkiye), 9100Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre \| Denizli , Turkey (Türkiye), Atatürk Üniversitesi \| Erzurum , Turkey (Türkiye), 25070Gaziantep Üniversitesi Gaziantep Onkoloji Hastanesi \| Gaziantep , Turkey (Türkiye), 27000Koç Üniversitesi Hastanesi \| Istanbul , Turkey (Türkiye), 34010Dr. Sadi Konuk Egitim ve Arastirma Hastanesi \| Istanbul , Turkey (Türkiye), 34147Acibadem Universitesi Atakent Hastanesi \| Istanbul , Turkey (Türkiye), 34303Göztepe Eitim Ve Aratrma Hastanesi \| Istanbul , Turkey (Türkiye), 34722Fatih Sultan Mehmet Training and Research Hospital \| Istanbul , Turkey (Türkiye), 34752Erciyes University Medical Faculty \| Kayseri , Turkey (Türkiye), 38030Kocaeli Üniversitesi \| Kocaeli , Turkey (Türkiye), 41380İnönü Üniversitesi Turgut Özal Tıp Merkezi \| Malatya , Turkey (Türkiye), 44280Regional Communal Non-commercial enterprise "Chernivtsi regional clinical hospital" \| Chernivtsi Chernivetska Oblast, Ukraine, 58000Dnipropetrovsk City Clinical Hospital No. 9 \| Dnipro Dnipropetrovsk Oblast, Ukraine, 49023Ukrainian State Research Institute Of Medical And Social Problems Of Disability \| Dnipro Dnipropetrovsk Oblast, Ukraine, 49027City Clinical Hospital No. 2 \| Kharkiv Kharkiv Oblast, Ukraine, 61037L.T. Mala National Institute of Therapy of NAMS of Ukraine \| Kharkiv Kharkiv Oblast, Ukraine, 61039Municipal Non-Profit Enterprise "City clinical hospital №8" of Kharkiv city council \| Kharkiv Kharkiv Oblast, Ukraine, 61176Institute of Endocrinology and Metabolism named after Komissarenko \| Kiev Kyiv Oblast, Ukraine, 04114Medical Center of Limited Liability Company "Medical Center "Consilium Medical" \| Kiev Kyiv Oblast, Ukraine, 4050Institute of Endocrinology and Metabolism named after Komissarenko \| Kiev Kyiv Oblast, Ukraine, 4114ARTEM \| Kiev Kyivska Oblast, Ukraine, 04050Medbud Clinic \| Kyiv Kyivska Oblast, Ukraine, 3037Branch "Center of Endocrinological Health" of "Lviv Regional Clinical Diagnostic Center" \| Lviv Lviv Oblast, Ukraine, 79000Lviv City Clinical Hospital #4 \| Lviv Lviv Oblast, Ukraine, 79011Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council \| Odesa Odesa Oblast, Ukraine, 65025Municipal non-profit enterprise "Consultative-diagnostic center №20" of Odesa city council \| Odesa Odesa Oblast, Ukraine, 65114Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho \| Poltava Poltava Oblast, Ukraine, 36011Municipal enterprise "1st City clinical hospital of Poltava City Council", Poltava State Medical University \| Poltava Poltava Oblast, Ukraine, 36038Municipal Non-Profit Enterprise Of Sumy Regional Council ''Sumy Regional Clinical Hospital'' \| Sumy Sumska Oblast, Ukraine, 40031Vinnytsia Regional Clinical Endocrinology Dispensary \| Vinnytsia Vinnytsia Oblast, Ukraine, 21010Municipal non-profit enterprise "City Hospital #7" of Zaporizhzhia City Council \| Zaporizhzhya Zaporizhzhia Oblast, Ukraine, 69118Medical Center Ok!Clinic+ \| Kyiv , Ukraine, 02091Aberdeen Royal Infirmary \| Aberdeen Aberdeen City, United Kingdom, AB25 2ZNNinewells Hospital and Medical School \| Dundee Angus, United Kingdom, DD1 9SYSouthmead Hospital \| Bristol Bristol, City of, United Kingdom, BS10 5NBStaploe Medical Centre \| Ely Cambridgeshire, United Kingdom, CB7 5JDKnowle House Surgery \| Plymouth Devon, United Kingdom, PL5 3JBThe Royal Cornwall Hospital \| Truro England, United Kingdom, TR1 3LJGlasgow Royal Infirmary \| Glasgow Glasgow City, United Kingdom, G4 0SFHull Royal Infirmary \| Hull Kingston Upon Hull, United Kingdom, HU3 2JZLeicester General Hospital \| Leicester Leicestershire, United Kingdom, LE5 4PWIpswich Hospital \| Ipswich Suffolk, United Kingdom, IP4 5PDMorriston Hospital \| Swansea Swansea [Abertawe Gb-ata], United Kingdom, SA6 6SGUniversity Hospital Aintree \| Liverpool , United Kingdom, L9 7AL
Investigators	Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Study Documents (Full Text)

Documents provided by Eli Lilly and Company: Study Protocol April 15, 2024Documents provided by Eli Lilly and Company: Statistical Analysis Plan July 23, 2025

More Information

Publications

Nissen SE, Wolski K, D'Alessio D, Weerakkody G, Kiljanski J, Wiese RJ, Pavo I, Cariou B, Nicholls SJ. Cardiorenal Outcomes With Tirzepatide Compared With Dulaglutide in Patients With Diabetes and Cardiovascular Disease: A Post Hoc Analysis of the SURPASS-CVOT Randomized Clinical Trial. JAMA Cardiol. 2026 Jun 1;11(6):544-552. doi: 10.1001/jamacardio.2026.0767. Nicholls SJ, Pavo I, Bhatt DL, Buse JB, Del Prato S, Kahn SE, Lincoff AM, McGuire DK, Miller D, Nauck MA, Nishiyama H, Nissen SE, Sattar N, Weerakkody G, Wiese RJ, Zinman B, Zoungas S, Basile J, Davies MJ, Giorgino F, Kellerer M, Ji L, Varkonyi T, Menon V, Broder JC, Herschtal A, D'Alessio D; SURPASS-CVOT Investigators. Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes. N Engl J Med. 2025 Dec 18;393(24):2409-2420. doi: 10.1056/NEJMoa2505928. Khawaji A, A Jaly A, A Bakri H, Ravi R, Hattan A, Khawaji A, Najmi W. Weight Loss Efficacy of Tirzepatide Compared to Placebo or GLP-1 Receptor Agonists in Adults With Obesity or Overweight: A Meta-Analysis of Randomized Controlled Trials With >/= 20 Weeks Treatment Duration. J Obes. 2025 Jul 24;2025:3442754. doi: 10.1155/jobe/3442754. eCollection 2025. Kaneko S. Tirzepatide: A Novel, Once-weekly Dual GIP and GLP-1 Receptor Agonist for the Treatment of Type 2 Diabetes. touchREV Endocrinol. 2022 Jun;18(1):10-19. doi: 10.17925/EE.2022.18.1.10. Epub 2022 Jun 16.

Additional Relevant MeSH Terms

Diabetes Mellitus, Type 2Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesEndocrine System DiseasesNutritional and Metabolic Diseases