Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%

Recruitment Status
COMPLETED - HAS RESULTS
(See Contacts and Locations)Verified July 2025 by Bayer
Sponsor
Bayer
Information Provided by (Responsible Party)
Bayer
Clinicaltrials.gov Identifier
NCT04435626
Other Study ID Numbers:
20103
First Submitted
June 14, 2020
First Posted
June 16, 2020
Results First Posted
May 4, 2025
Last Update Posted
August 25, 2025
Last Verified
July 2025

ClinicalTrials.gov processed this data on August 2025Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

Condition or DiseaseIntervention/Treatment
Heart Failure
Drug: Finerenone (BAY94-8862)Other: Placebo

Study Design

Study TypeInterventional
Actual Enrollment6016 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingQuadruple
Primary PurposeTreatment
Official TitleA Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%)
Study Start DateSeptember 13, 2020
Actual Primary Completion DateMay 14, 2024
Actual Study Completion DateJune 13, 2024

Groups and Cohorts

Group/CohortIntervention/Treatment
Arm 1_BAY94-8862
Adult patients receive BAY94-8862
Drug: Finerenone (BAY94-8862)
For participants with an eGFR ≤60 mL/min/1.73 m\^2: Starting dose is 10 mg OD and maximum dose 20 mg OD. For participants with an eGFR \>60 mL/min/1.73 m\^2: Starting dose is 20 mg OD and maximum dose 40 mg OD. Finerenone is administered orally as immediate release tablets.
Arm 2_Placebo
Adult patients receive placebo
Other: Placebo
Placebo tablets matching BAY94-8862 are administered orally.

Outcome Measures

Primary Outcome Measures
  1. Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events
    Number of composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.
  2. Occurrence of the Composite Endpoint of Cardiovascular Death and Total (First and Recurrent) Heart Failure Events
    Number of participants with composite endpoint events of cardiovascular death and total (first and recurrent) heart failure (HF) events (hospitalization for heart failure or urgent HF visit) in HF patients.
Secondary Outcome Measures
  1. Occurrence of Total (First and Recurrent) Heart Failure Events
    Number of total (first and recurrent) heart failure events.
  2. Occurrence of Total (First and Recurrent) Heart Failure Events
    Number of participants with total (first and recurrent) heart failure events.
  3. Change From Baseline in Total Symptom Score (TSS) of the Kansas City Cardiomyopathy Questionnaire (KCCQ)
    The Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) is ranged from 0 to 100. A higher score (closer to 100) reflects fewer symptoms, indicating better heart failure symptom status. For the change from baseline the combined and averaged result across the entire time frame is reported.
  4. Proportion of Participants Who Showed Improvement in NHYA Class
    The New York Heart Association (NYHA) Functional Classification is a simple scale that classifies patients with heart failure based on the severity of their symptoms and how those symptoms affect their physical activity, which ranges from Class I to Class IV, a lower class number is indicative of a better condition. A patient was considered as having improved in NYHA class, if the NYHA class at Month 12 is at least one category improved compared to the baseline visit.
  5. First Occurrence of Renal Composite Events
    Number of participants with renal composite events encompassing the components sustained decrease in eGFR ≥50% relative to baseline over at least 4 weeks, sustained eGFR decline to \<15 mL/min/1.73 m2 over at least 4 weeks, initiation of chronic dialysis and renal transplantation.
  6. Occurence of All-cause Mortality (Full Analysis Set)
    Number of participants with death due to any cause were reported as descriptive result. Number of participants with outcome death reported here includes deaths occurred after randomization until the end of the study visit. Deaths after end of study visit are not included in this table.

Eligibility Criteria

Ages Eligible for Study(Adult, Older Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersNo
Inclusion Criteria
Participant (male or female) must be aged 40 years and older.
Diagnosis of heart failure with New York Heart Association(NYHA) class II-IV, ambulatory or hospitalized primarily for heart failure.
On diuretic treatment for at least 30 days prior to randomization.
Documented left ventricular ejection fraction (LVEF) of ≥40% measured by any modality within the last 12 months.
Structural heart abnormalities based on any local imaging measurement within the last 12 months, defined by at least one of the following findings: left atrial diameter (LAD) ≥3.8cm, left atrial area (LAA) ≥20cm2, left atrial volume index (LAVI) \>30 mL/m2, left ventricular mass index (LVMI) ≥115 g/m2 (♂)/ 95 g/m2 (♀), septal thickness or posterior wall thickness ≥1.1 cm
n-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥300 pg/mL (BNP ≥100 pg/mL) in sinus rhythm and patient does not have an ongoing diagnosis of paroxysmal atrial fibrillation or NT-proBNP ≥900 pg/mL (BNP ≥300 pg/mL) in atrial fibrillation (or if atrial fibrillation status is unknown or if patient has an ongoing diagnosis of paroxysmal atrial fibrillation) for participants obtained at the following time:
Within 90 days prior to randomization if patient had been hospitalized for heart failure (HF) requiring initiation or change in HF therapy or if patient had an urgent visit for HF requiring intravenous (IV) diuretic therapy, both within 90 days prior to randomization OR
Within 30 days prior to randomization if patient has not been hospitalized for HF nor had an urgent HF visit within the past 90 days.
Women of childbearing potential can only be included in the study if a pregnancy test is negative at screening and baseline and if they agree to use adequate contraception which is consistent with local regulations regarding the methods for contraception for those participating in clinical trials.
Exclusion Criteria
Estimated glomerular filtration rate (eGFR) \<25 mL/min/1.73 m² at either screening or randomization visit.
Serum/plasma potassium \>5.0 mmol/L at either screening or randomization visit.
Acute inflammatory heart disease, e.g. acute myocarditis, within 90 days prior to randomization
Myocardial infarction or any event which could have reduced the ejection fraction within 90 days prior to randomization
Coronary artery bypass graft surgery in the 90 days prior to randomization
Percutaneous coronary intervention in the 30 days prior to randomization
Stroke or transient ischemic cerebral attack within 90 days prior to randomization
Probable alternative cause of participants' HF symptoms that in the opinion of the investigator primarily accounts for patient's dyspnea such as significant pulmonary disease, anemia or obesity. Specifically, patients with the below are excluded: Severe pulmonary disease requiring home oxygen, or chronic oral steroid therapy, History of primary pulmonary arterial hypertension, Hemoglobin \<10 g/dl, Valvular heart disease considered by the investigator to be clinically significant, Body Mass Index (BMI) \>50 kg/m2 at screening
Systolic blood pressure(SBP) ≥160 mmHg if not on treatment with ≥3 blood pressure lowering medications or ≥180 mmHg irrespective of treatments, on 2 consecutive measurements at least 2-minute apart, at screening or at randomization.
Concomitant systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin) or moderate or potent CYP3A4 inducers, that cannot be discontinued 7 days prior to randomization and for the duration of the treatment period.

Contacts and Locations

Sponsors and CollaboratorsBayer
Locations
Cardiology, PC | Birmingham Alabama, United States, 35211Eastern Shore Research Institute, LLC | Fairhope, AL | Fairhope Alabama, United States, 36532Mobile Heart Specialists - Providence | Mobile Alabama, United States, 36608University of Arizona Clinical and Translational Sciences Research Center | Tucson Arizona, United States, 85724Heart Clinic Arkansas | Little Rock Arkansas, United States, 72205WestSide Medical | Beverly Hills California, United States, 90211CA Heart and Vein Specialists | Huntington Beach California, United States, 92648UCI Medical Center - Neurology | Orange California, United States, 92868Sutter Medical Center - Cardiology | Sacramento California, United States, 95816NorthBay Clinical Research, LLC | Santa Rosa, CA | Santa Rosa California, United States, 95405The Lundquist Institute - Gynecology | Torrance California, United States, 90502Blue Coast Research Center, LLC | Vista California, United States, 92081Interventional Cardio Medical- DCT Department | West Hills California, United States, 91307Interventional Cardiology Medical Group | West Hills, CA | West Hills California, United States, 91307VA Eastern Colorado Health Care System | Aurora Colorado, United States, 80045Colorado Springs Cardiology - Woodmen Medical Plaza | Colorado Springs Colorado, United States, 80923South Denver Cardiology Associates, PC | Littleton Colorado, United States, 80120Cardiovascular & Vein Center of Florida | Bradenton, FL | Bradenton Florida, United States, 34209Nova Clinical Research - Blake Medical Center | Bradenton Florida, United States, 34209Cardiology Associates Research Company | Daytona Beach Florida, United States, 32117North Florida Foundation for Research and Education - Clinical Trial Center | Gainesville Florida, United States, 32608LifeSpring Research Foundation, LLC | Miami Florida, United States, 33130Southwest Florida Research | Naples, FL | Naples Florida, United States, 34102-8143East Coast Institute for Research | St. Augustine, FL | Saint Augustine Florida, United States, 32086Cardiology Partners Clinical Research Institute | Wellington Office | Wellington Florida, United States, 33449Centricity Research at Talbotton | Columbus Georgia, United States, 31904Atlanta Heart Specialists - Tucker | Tucker Georgia, United States, 30084Advocate Illinois Masonic Medical Center - Cardiology | Chicago Illinois, United States, 60657Advocate Good Samaritan Hospital - Cardiology | Downers Grove Illinois, United States, 60515Advocate Condell Medical Center | Libertyville Illinois, United States, 60048Edward Hospital - Main Campus - Cardiology | Naperville Illinois, United States, 60540Captain James A. Lovell Federal Health Care Center | North Chicago Illinois, United States, 60064Carle Health Methodist Hospital - Cardiology | Peoria Illinois, United States, 61603Midwest Cardiovascular Research and Education Foundation | Elkhart, IN | Elkhart Indiana, United States, 46514Reid Physicians Associates - Cardiology Department | Richmond Indiana, United States, 47374Kansas Nephrology Research Institute | Wichita Kansas, United States, 67214Baptist Health Paducah - Cardiology | Paducah Kentucky, United States, 42003Cardiovascular Associates Research, LLC | Covington Louisiana, United States, 70433Heart Clinic of Hammond | Hammond Louisiana, United States, 70403Louisiana Heart Center - Slidell | Slidell Louisiana, United States, 70458Southern Clinical Research, LLC | Zachary Louisiana, United States, 70791MaineHealth Cardiology - Scarborough | Scarborough Maine, United States, 04039Johns Hopkins Hospital - Cardiology | Baltimore Maryland, United States, 21287Suburban Hospital - Cardiology | Bethesda Maryland, United States, 20814Cardiovascular Specialists of Central Maryland, PA | Columbia Maryland, United States, 21044Henry Ford Hospital - OB/GYN | Detroit Michigan, United States, 48202AA Medical Research Center | Flint, MI | Flint Michigan, United States, 48504M Health Fairview Heart Clinic - Maplewood | Maplewood Minnesota, United States, 55109M Health Fairview Heart Clinic - Fulton | Minneapolis Minnesota, United States, 55455St. Cloud Hospital | Saint Cloud Minnesota, United States, 56303Baptist Heart -Cardiology - DCT Dept | Jackson Mississippi, United States, 39202University Hospital - UMMC - Nephrology | Jackson Mississippi, United States, 39216Harry S Truman Memorial Veterans Hospital - Cardiology | Columbia Missouri, United States, 65201Clinical Research Consultants | Kansas City Missouri, United States, 64111Saint Luke's Mid America Heart Institute | Kansas City Missouri, United States, 64111Mercy Hospital Springfield - Cardiology | Springfield Missouri, United States, 65804Logan Health Research | Kalispell Montana, United States, 59901CHI Health Clinic Heart Institute - Grand Island | Grand Island Nebraska, United States, 68803CHI Health Nebraska Heart | Lincoln Nebraska, United States, 68526Advanced Heart Care, LLC | Bridgewater, NJ | Bridgewater New Jersey, United States, 08807NJ Heart | Linden, NJ | Linden New Jersey, United States, 07036Garden State Heart Care | Manalapan New Jersey, United States, 07726Nuvance Health - The Heart Center | Poughkeepsie New York, United States, 12601Division of Cardiovascular Research at Peconic Bay Medical Center | Riverhead New York, United States, 11901Laurelton Heart Specialists | Rosedale New York, United States, 11422Saratoga Clinical Research, LLC | Saratoga Springs New York, United States, 12866Cardiac Care & Vascular Medicine | The Bronx New York, United States, 10469Northwell Health Physician Partners Cardiology at Valley Stream | Valley Stream New York, United States, 11580Kernodle Clinic West | Burlington North Carolina, United States, 27215University of North Carolina | Chapel Hill North Carolina, United States, 27514Wake Forest Baptist Health | Winston-Salem North Carolina, United States, 27157Kettering Health Network | Research Institute | Kettering Ohio, United States, 45429Rama Research LLC | Marion, OH | Marion Ohio, United States, 43302-6774Mercy Health - St. Elizabeth Youngstown Hospital | Youngstown Ohio, United States, 44501South Oklahoma Heart Research, LLC | Oklahoma City Oklahoma, United States, 73135Capital Area Research | Camp Hill, PA | Camp Hill Pennsylvania, United States, 17011Doylestown Health Cardiology - DCA | Doylestown Pennsylvania, United States, 18901Kent Hospital | Warwick Rhode Island, United States, 02886Trident Cardiology Associates, PA | Ladson South Carolina, United States, 29456Carolina Heart Specialists | Lancaster, SC | Lancaster South Carolina, United States, 29720Monument Health Clinical Research | Rapid City South Dakota, United States, 57701Sanford USD Medical Center - Cardiology | Sioux Falls South Dakota, United States, 57105The Stern Cardiovascular Foundation - Germantown, TN | Germantown Tennessee, United States, 38138Apex Research Foundation, LLC. | Jackson, TN | Jackson Tennessee, United States, 38301Lt. Col. Luke Weathers, Jr. VA Medical Center - Cardiology | Memphis Tennessee, United States, 38105Cardiovascular Research of Knoxville | Powell Tennessee, United States, 37849Ascension Seton Heart Specialty Care and Transplant Center | Austin Texas, United States, 78705Texas Health & Vascular Specialists - Dallas | Dallas Texas, United States, 75231Southwest Family Medicine Associates | Dallas, TX | Dallas Texas, United States, 75235Texas Health Family Care - W Vickery Blvd | Fort Worth Texas, United States, 76107University of Texas Medical Branch at Galveston | Galveston Texas, United States, 77555Houston Heart & Vascular Associates | Humble Texas, United States, 77338South Texas Cardiovascular Consultants, PLLC / Kerrville, TX | Kerrville Texas, United States, 78028North Dallas Research Associates | McKinney Texas, United States, 75069ClinRx Research, LLC | Plano Texas, United States, 75024South Texas Cardiovascular Consultants - San Antonio | San Antonio Texas, United States, 78201Clinical Advancement Center, PLLC | San Antonio Texas, United States, 78212Northwest Houston Clinical Research - Tomball | Tomball Texas, United States, 77375University of Utah Clinical Neurosciences Center | Salt Lake City Utah, United States, 84312Inova Cardiology- Fairfax | Fairfax Virginia, United States, 22031Virginia Heart | Falls Church Virginia, United States, 22042Virginia Heart - Leesburg | Leesburg Virginia, United States, 20176Sentara Norfolk General Hospital | Norfolk Virginia, United States, 23507Salem VA Medical Center - Cardiology | Salem Virginia, United States, 24153Selma Medical Associates | Winchester Virginia, United States, 22601William S. Middleton Memorial Veterans Hospital | Madison Wisconsin, United States, 53705Aurora Saint Luke's Medical Center - Cardiology | Milwaukee Wisconsin, United States, 53215Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina | Ciudad Autónoma de Buenos Aire Buenos Aires, Argentina, C1056ABIClínica Coronel Suarez | Coronel Suárez Buenos Aires, Argentina, B7540GHDHospital Italiano de La Plata | Clinical Research Department | La Plata Buenos Aires, Argentina, B1900Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina | Lanus Buenos Aires, Argentina, B1824Sanatorio Modelo Quilmes | Quilmes Buenos Aires, Argentina, 1878Corporación Médica de General San Martín | San Martín Buenos Aires, Argentina, 1650Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina | Zárate Buenos Aires, Argentina, B2800DGHInstituto Cardiovascular de Buenos Aires | Buenos Aires, Argentina | Buenos Aires Buenos Aires F.D., Argentina, C1428ARTHospital Militar Central "CIR. MY. C. Argerich" | Buenos Aires Ciudad Auton. de Buenos Aires, Argentina, 1426Centro de Especialidades Medicas (CEMEDIC) | Buenos Aires Ciudad Auton. de Buenos Aires, Argentina, C1440CFDCEDIC Centro de Investigación Clínica | Buenos Aires, Argentina | CABA Ciudad Auton. de Buenos Aires, Argentina, C1018DESGrupo Orono | Instituto Cardiovascular de Rosario - Insuficiencia Cardiaca y Trasplante Department | Rosario Santa Fe Province, Argentina, 2000Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos | Rosario Santa Fe Province, Argentina, S2000DEJInstituto de Cardiologia | Tucuman, AR | San Miguel de Tucumán Tucumán Province, Argentina, 4000Investigaciones Medicas IMOBA S.R.L. | Buenos Aires , Argentina, C1056ABHInstituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina | Corrientes , Argentina, 3400Clínica Privada del Prado | Córdoba , Argentina, 5000Instituto Médico DAMIC- Fundación Rusculleda | Córdoba , Argentina, 5003Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina | Santa Fe , Argentina, S3000FWORoyal Prince Alfred Hospital | Camperdown New South Wales, Australia, 2050Gosford Hospital | Gosford New South Wales, Australia, 2250John Hunter Hospital | New Lambton Heights New South Wales, Australia, 2305The Wesley Hospital | Auchenflower Queensland, Australia, 4066The Prince Charles Hospital | Chermside Queensland, Australia, 4032Royal Brisbane and Women's Hospital | Herston Queensland, Australia, 4029Gold Coast University Hospital | Southport Queensland, Australia, 4215Flinders Medical Centre | Bedford Park South Australia, Australia, 5042Advara HeartCare Leabrook | Leabrook South Australia, Australia, 5068Advara HeartCare Ringwood | Bundoora Victoria, Australia, 3083Klinikum Klagenfurt am Wörthersee | Klagenfurt Carinthia, Austria, 9020Universitätsklinikum St. Pölten | Sankt Pölten Lower Austria, Austria, 3100Medizinische Universität Graz | Graz Styria, Austria, 8036Krankenhaus St. Josef Braunau | Innere Medizin I | Braunau am Inn Upper Austria, Austria, 5280Landeskrankenhaus Feldkirch | Feldkirch Vorarlberg, Austria, 6807Uniklinikum Salzburg - Landeskrankenhaus | Salzburg , Austria, 5020Universitätsklinikum AKH Wien | Vienna , Austria, 1090Imed19-privat | Vienna , Austria, 1190Klinik Floridsdorf - Krankenhaus Nord | Vienna , Austria, 1210Santa Casa de Misericórdia da Bahia | Salvador Estado de Bahia, Brazil, 50040-410Hospital do Coração do Brasil | Brasília Federal District, Brazil, 70390-700Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia | Goiânia Goiás, Brazil, 74605-020Quanta Diagnostico Por Imagem | Research and Innovation Department | Curitiba Paraná, Brazil, 80045-170Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa | Paraná Paraná, Brazil, 83430-000Fundação Universidade de Caxias do Sul | Caxias do Sul Rio Grande do Sul, Brazil, 95070-560Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center | Porto Alegre Rio Grande do Sul, Brazil, 90035-903Hospital Mae de Deus | Porto Alegre Rio Grande do Sul, Brazil, 90850-170FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil | Porto Alegre Rio Grande do Sul, Brazil, 91350-280MK Consultoria Médico Científica Ltda/Angiocor Blumenau | Blumenau Santa Catarina, Brazil, 89020-430Centro de Pesquisa Clinica do Coração | Aracaju, Brasil | Aracaju Sergipe, Brazil, 49055-530Hospital Felício Rocho | Belo Horizonte São Paulo, Brazil, 30110-130Campinas Clinical Research Institute (IPECC) | Campinas, Brazil | Campinas São Paulo, Brazil, 13060-080Instituto do Coração de Marilia | Marilia, Brasil | Marília São Paulo, Brazil, 17515-000Centro Avançado de Pesquisa para Diagnóstico - CAPED | Ribeirão Preto São Paulo, Brazil, 14026-020Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas | São Paulo São Paulo, Brazil, 13034-685IMC - Instituto de Moléstias Cardiovasculares Tatui | Tatuí São Paulo, Brazil, 18270-170Santa Casa de Misericórdia de Votuporanga | Votuporanga São Paulo, Brazil, 15500-003Eurolatino Pesquisas Medicas | Uberlandia, MG | Minas Gerais , Brazil, 38400-368Ambulatory facility for specialized outpatient medical care | Burgas , Bulgaria, 8000MHAT Haskovo | Haskovo , Bulgaria, 6304MHAT Zdrave | Pazardzhik , Bulgaria, 4400Multiprofile Hospital for Active Treatment Sveti Georgi OOD, Pernik - Department of Cardiology | Pernik , Bulgaria, 2300Medical Center Medconsult Pleven | Pleven , Bulgaria, 5800Medical centre Hipokrat - N EOOD | Plovdiv , Bulgaria, 4000Multiprofile Hospital for Active Treatment Medline | Cardiology Department | Plovdiv , Bulgaria, 4000Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department | Plovdiv , Bulgaria, 4004Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine | Shumen , Bulgaria, 9700MHAT Hadzhi Dimitar | Sliven , Bulgaria, 8800Second Medical Center Sofia EOOD | Sofia , Bulgaria, 1202Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department | Sofia , Bulgaria, 1233NMTH Tzar Boris III | Sofia , Bulgaria, 1233Multiprofile Hospital for Active Treatment 'National Cardiology Hospital' EAD, Sofia | Sofia , Bulgaria, 1309Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department | Sofia , Bulgaria, 1404Medical Center Hera | Sofia , Bulgaria, 1510UMHAT Tsaritsa Joanna-ISUL EAD Sofia | Sofia , Bulgaria, 1527MHAT Trakia | Stara Zagora , Bulgaria, 6000Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department | Veliko Tarnovo , Bulgaria, 5000Multiprofile Hospital for Active Treatment Sveti Panteleymon Yambol | Cardiology Department | Yambol , Bulgaria, 8600Fraser Clinical Trials, Inc. | New Westminster British Columbia, Canada, V3L 3W4St. Boniface Hospital | Winnipeg Manitoba, Canada, R2H 2A6G.A. Research Associates, Ltd. | Moncton New Brunswick, Canada, E1G 1A7Dalhousie University - Queen Elizabeth II (QEII) Health Sciences Centre - Halifax Infirmary (HI) | Halifax Nova Scotia, Canada, B3H 3A7Brampton Clinical Trials | Brampton Ontario, Canada, L6Z 4N5Cambridge Cardiac Care Centre | Cambridge Ontario, Canada, N1R 6V6Vizel Cardiac Research | Cambridge Ontario, Canada, N1R 7R1London Health Sciences Centre (LHSC) - University Hospital | London Ontario, Canada, N6A 5A5KMH Cardiology Clinics Inc. | Mississauga Ontario, Canada, L5K 2L3North York Diagnostic and Cardiac Centre | North York Ontario, Canada, M6B 3H7Oakville Cardiovascular Research | Oakville Ontario, Canada, L6K 3W7Office of Dr. James Cha, MD | Oshawa Ontario, Canada, L1J 2K1Kawartha Cardiology Clinical Trials | Peterborough Ontario, Canada, K9J 0B2Corcare | Scarborough Village Ontario, Canada, M1B 5N1Medicus MFC Inc. | Toronto Ontario, Canada, M4P 1E4Mount Sinai Hospital | Toronto Ontario, Canada, M5G 1X5Women's College Hospital | Toronto Ontario, Canada, M5S 1B2Centre intégré de santé et de services sociaux de Laval, Hôp | Laval Quebec, Canada, H7M 3L9Clinique Sante Cardio MC | Montreal Quebec, Canada, H1T 3Y7Centre Hospitalier de l'Université de Montréal-CHUM | Montreal Quebec, Canada, H2X 0C1Montreal General Hospital | Montreal Quebec, Canada, H4A 3J1Fujian Provincial Hospital | Fuzhou Fujian, China, 350001Lanzhou University Second Hospital | Lanzhou Gansu, China, 730030Guangdong Provincial People's Hospital | Guangzhou Guangdong, China, 510000The First Affiliated Hospital of Sun Yat-Sen University | Guangzhou Guangdong, China, 510080Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ. | Guangzhou Guangdong, China, 510120The First Affiliated Hospital of Guangzhou University of TCM | Guangzhou Guangdong, China, 510405Nanfang Hospital, Southern Medical University | Guangzhou Guangdong, China, 510515The First Affiliated Hospital of Jinan University | Guangzhou Guangdong, China, 510630Guizhou Provincial People's Hospital | Guiyang Guizhou, China, 550002Hainan Provincial People's Hospital | Haikou Hainan, China, 570311Hainan Third People's Hospital (Province Nongken Sanya Hopt) | Sanya Hainan, China, 572000The First Hospital of Hebei Medical Univesity | Shijiazhuang Hebei, China, 050000Daqing Oilfield General Hospital | Daqing Heilongjiang, China, 163311Xinxiang Central Hospital | Xinxiang Henan, China, 453000The Third Xiangya Hospital of Central South University | Changsha Hunan, China, 410000Changsha Central Hospital | Changsha Hunan, China, 410004Hunan Provincial People's Hospital | Changsha Hunan, China, 410005Huai'an First People's Hospital, Nanjing Medical University | Huai'an Jiangsu, China, 223300The First People's Hospital of Lianyungang | Lianyungang Jiangsu, China, 222002The Second Affiliated Hospital of Nanjing Medical university | Nanjing Jiangsu, China, 210000NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School | Nanjing Jiangsu, China, 210008Zhongda Hospital Southeast University | Nanjing Jiangsu, China, 210009Jiangsu Province Hospital | Nanjing Jiangsu, China, 210029Nanjing Jiangning Hospital | Nanjing Jiangsu, China, 2111031st Affiliated hospital of Soochow University | Suzhou Jiangsu, China, 215000Jilin Province People's Hospital | Changchun Jilin, China, 130021The First Hospital of Jilin University | Changchun Jilin, China, 130061Panjin Liaohe Oilfield Gem Flower Hospital | Panjin Liaoning, China, 124010Yinchuan No.1 People's Hospital | Yinchuan Ningxia, China, 750001General Hospital of Ningxia Medical University | Yinchuan Ningxia, China, 750004Shaanxi Provincial People's Hospital | Xi'an Shaanxi, China, 710068The First Affiliated Hospital of Xi'an Jiaotong University | Xi'an Shaanxi Sheng, China, 710061Jinan Central Hospital | Jinan Shandong, China, 250013Shanxi Provincial People's Hospital | Taiyuan Shanxi, China, 030012West China Hospital Sichuan University | Chengdu Sichuan, China, 610041SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos | Chengdu Sichuan, China, 610072People's Hospital of Xinjiang Uygur Autonomous Region | Ürümqi Xinjiang, China, 830001The First Affiliated Hospital of Xinjiang Medical University | Ürümqi Xinjiang, China, 8300111st Affiliated Hospital of College Medicine, Zhejiang Univ. | Hangzhou Zhejiang, China, 310003Beijing Anzhen Hospital, Capital Medical University | Beijing , China, 100029Beijing Friendship Hospital, Capital Medical University | Beijing , China, 100050Beijing Tsinghua Changgung Hospital | Beijing , China, 102218Shanghai Tongji Hospital of Tongji University | Shanghai , China, 200065Shanghai East Hospital Affiated to Tongji University | Shanghai , China, 200100Tianjin People's Hospital | Tianjin , China, 300000Hospital Alma Mater de Antioquia | Medellín Antioquia, Colombia, 050010Hospital General de Medellin | Medellín Antioquia, Colombia, 050015Rodrigo Botero S.A.S | Medellín Antioquia, Colombia, 050021Sociedad Médica Rionegro SOMER S.A. | Rionegro Antioquia, Colombia, 054040Clínica de la Costa SAS | Baranquilla Atlántico, Colombia, 080020Corazón IPS S.A.S. | Barranquilla Atlántico, Colombia, 080020IPS Centro Cientifico Asistencial S.A.S | Barranquilla Atlántico, Colombia, 080020Caja de Compensación Familiar CAFAM | Bogotá Bogota D.C., Colombia, 111061Hospital Universitario Mayor-MÉDERI | Bogotá Bogota D.C., Colombia, 111411Cardiomet Cequin Sas | Armenia Quindío Department, Colombia, 630004Instituto del Corazón de Bucaramanga | Bucaramanga Santander Department, Colombia, 680002Mediservis del Tolima IPS S.A.S | Ibague Tolima Department, Colombia, 730008Clínica Imbanaco S.A.S | Cali Valle del Cauca Department, Colombia, 760042Fundacio del Caribe para la Investigacio Bio-Medica (BIOS) | Barranquilla , Colombia, 080001Fundación Cardioinfantil | Bogotá , Colombia, 110131Hospital Universitario de San Ignacio | Bogotá , Colombia, 110231Hospital Universitario Clínica San Rafael | Bogotá , Colombia, 110621Hospital San Vicente Fundación | Medellín , Colombia, 050010Clinica Cardio VID | Medellín , Colombia, 050034Fakultní nemocnice Brno - Interní kardiologická klinika | Brno South Moravian, Czechia, 625 00Kardiologie MUDr. Libor Nechvatal s.r.o. | Brno , Czechia, 602 00Kardiologicka ambulance Brno s.r.o. | Brno , Czechia, 612 00Kardio Chlumec s.r.o.- Kardiologicka ambulance | Chlumec nad Cidlinou , Czechia, 503 51Kardiologicka ambulance | Český Krumlov , Czechia, 381 01Poliklinika Dolní Brežany | Dolní Břežany , Czechia, 252 41Fakultní Nemocnice Hradec Kralové | Hradec Králové , Czechia, 500 05Kromerizska nemocnice a.s. | Kroměříž , Czechia, 767 01LUNACOR, Centrum pro choroby srdce a cev | Kroměříž , Czechia, 767 01Krajska Nemocnice Liberec | Liberec , Czechia, 460 63KardioBusak s.r.o. | Louny , Czechia, 440 01Fakultni nemocnice Plzen | Pilsen , Czechia, 301 00Kardiologicka a interni ambulance | Písek , Czechia, 39701Polabska zdravotni, s.r.o. | Poděbrady , Czechia, 290 01Všeobecná fakultní nemocnice v Praze - II. interní klinika - klinika kardiologie a angiologie | Prague , Czechia, 12808Institut Klinicke a Experimentalni Mediciny | Prague , Czechia, 140 21Fakultní nemocnice v Motole | Prague , Czechia, 150 06Ustredni vojenska nemocnice Praha | Prague , Czechia, 169 02Affidea Praha s.r.o - Kardiologie | Praha 11 - Chodov , Czechia, 148 00Kardio s.r.o. | Třebíč , Czechia, 67401Nemocnice Podlesi | Třinec , Czechia, 73961Angiocor s.r.o. | Zlín , Czechia, 760 01Nemocnice Znojmo | Znojmo , Czechia, 669 02Aarhus Universitetshospital - Børn og Unge | Århus N , Denmark, 8200Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed | Esbjerg , Denmark, 6700Capital Region | Gentofte Hospital - Cardiology Research | Hellerup , Denmark, 2900Capital Region | Herlev Hospital - Heart Disease Department | Herlev , Denmark, 2730Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research | Herning , Denmark, 7400Region Sjælland | Holbaek Sygehus - Cardiology department | Holbæk , Denmark, 4300Hvidovre Hospital - Hjertesygdomme | Hvidovre , Denmark, 2650Regionshospitalet Randers - Medicinsk afdeling | Randers , Denmark, 8930Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit | Svendborg , Denmark, 5700HUS Jorvin sairaala | Espoo , Finland, 2740Tampereen yliopistollinen sairaala | Tampere , Finland, 33520Turun yliopistollinen keskussairaala | Turku , Finland, 20520Herzklinik Ulm GbR | Ulm Baden-Wurttemberg, Germany, 89077Klinikum der Universität Würzburg | Würzburg Bavaria, Germany, 97080Medizinische Hochschule Hannover (MHH) | Hanover Lower Saxony, Germany, 30625Städt. Kliniken Bielefeld gGmbH | Bielefeld North Rhine-Westphalia, Germany, 33604Sana-Klinikum Remscheid GmbH | Remscheid North Rhine-Westphalia, Germany, 42859Forschungszentrum Ruhr | KliFoCenter GmbH | Witten North Rhine-Westphalia, Germany, 58455Universitätsklinikum Hamburg Eppendorf (UKE) | Hamburg , Germany, 20246KAT General Hospital of Athens | Kifissia Attica, Greece, 14561University General Hospital of Alexandroupoli | Alexandroupoli , Greece, 68100General Hosp of Athens "Korgialenio-Benakeio" RCH | Ampelokipi - Athens , Greece, 11526HIPPOKRATION General Hospital of Athens | Athens , Greece, 115 27G. GENNIMATAS General State Hospital of Athens | Athens , Greece, 11527ALEXANDRA General Hospital of Athens | Athens , Greece, 11528University General Hospital of Athens "ATTIKON" | Chaïdári , Greece, 12462University General Hospital of Heraklion - Department of Paediatrics | Heraklion , Greece, 711 10University General Hospital of Larissa | Larissa , Greece, 41110Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA | Nea Ionia , Greece, 14233University General Hospital of Patras | Pátrai , Greece, 26504Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit' | Thessaloniki , Greece, 54642Prince of Wales Hospital | Hong Kong N.T, Hong Kong, MISSINGPrincess Margaret Hospital | Hong Kong , Hong Kong, MISSINGQueen Mary Hospital | Hong Kong , Hong Kong, MISSINGQueen Elizabeth Hospital Hong Kong | Hong Kong , Hong Kong, Cardiomobile Egeszsegugyi Szolgaltato Kft. | Balatonfüred , Hungary, 8230Budai Irgalmasrendi Korhaz | Budapest , Hungary, 1023Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet | Budapest , Hungary, 1024University of Semmelweis/ Semmelweis Egyetem | Budapest , Hungary, 1083Eszak-Pesti Centrumkorhaz-Honvedkorhaz | Budapest , Hungary, 1134Budapesti Uzsoki Utcai Kórház | Budapest , Hungary, 1145Bugat Pal Korhaz | Gyöngyös , Hungary, 3200Pharma4Trial Kft. | Gyöngyös , Hungary, 3200Csongrad-Csanad Varmegyei Egeszsegugyi Ellato Kozpont Hodmezovasarhelyi Tagintezmeny | Hódmezővásárhely , Hungary, 6800Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz | Miskolc , Hungary, 3526Nagykanizsai Kanizsai Dorottya Korhaz | Nagykanizsa , Hungary, 8800Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft. | Nyíregyháza , Hungary, 4400Coromed Smo Kft | Pécs , Hungary, 7623Da Vinci Maganklinika | Pécs , Hungary, 7635SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont | Szeged , Hungary, 6720Tolna Varmegyei Balassa Janos Korhaz | Szekszárd , Hungary, 7100Csongrad-Csanad Megyei Dr. Bugyi Istvan Korhaz | Szentes , Hungary, 6600Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz - II. Belgyogyaszat | Székesfehérvár , Hungary, 8000KEM hospital | Berlin Maharashtra, India, 10365Deenanath Mangeshkar Hospital | Pune Maharashtra, India, 411004Max Super Speciality Hospital, Saket | New Delhi National Capital Territory of Delhi, India, 110017Safdarjung Hospital | New Delhi National Capital Territory of Delhi, India, 110029The Madras Medical Mission (MMM) | Chennai Tamil Nadu, India, 600037Assuta Ashdod Public Hospital (R.A) | Ashdod , Israel, 7747629Barzilai Ashkelon University Medical Center | Cardiology Department | Ashkelon , Israel, 7830604Rambam Health Corporation | Haifa , Israel, 3109601Bnai Zion Medical Center | Cardiology Department | Haifa , Israel, 3339419Lady Davis Carmel Medical Center | Haifa , Israel, 3436212Hadassah Hebrew University Hospital Ein Kerem | Jerusalem , Israel, 9112001Meir Medical Center | Kfar Saba , Israel, 4428164Health Corporation of Galilee Medical Center | Nahariya , Israel, 2210001Chaim Sheba Medical Center | Ramat Gan , Israel, 5262000Kaplan Medical Center | Rehovot , Israel, 7610001Health Corporation of the Ziv Medical Center (R.A.) | Safed , Israel, 1311001Tel-Aviv Sourasky Medical Center | Tel Aviv , Israel, 6423906Poria Medical Center | Cardiovascular Department | Tiberias , Israel, 1528001Shamir Medical Center (Assaf Harofeh) | Ẕerifin , Israel, 7030000Azienda Ospedaliero Universitaria Renato Dulbecco | Catanzaro Calabria, Italy, 88100Azienda Ospedaliera Universitaria Federico II Di Napoli - DAI Emergenze Cardiovascolari, Medicina Clinica e Dell'Invecchiamento | Naples Campania, Italy, 80131Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - Medicina A | Bologna Emilia-Romagna, Italy, 40133Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Medicina Interna Cardiovascolare | Bologna Emilia-Romagna, Italy, 40138University Hospital Of Ferrara | Ferrara Emilia-Romagna, Italy, 44124Azienda Unita Sanitaria Locale Di Piacenza | Piacenza Emilia-Romagna, Italy, 29121Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Cardiologia 1 | Bergamo Lombardy, Italy, 24127Azienda Socio-Sanitaria Territoriale Del Garda | Brescia Lombardy, Italy, 25085Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - Cardiologia | Brescia Lombardy, Italy, 25123Azienda Socio Sanitaria Territoriale Di Cremona | Cremona Lombardy, Italy, 26100Centro Cardiologico Monzino S.p.A. | Milan Lombardy, Italy, 20138ASST di Monza | Monza Brianza Lombardy, Italy, 20832IRCCS Fondazione Policlinico San Matteo | Pavia Lombardy, Italy, 27100Istituti Clinici Scientifici Maugeri S.p.A | Pavia Lombardy, Italy, 27100Humanitas Mirasole S.p.A. - Cardiologia Clinica e Interventistica | Rozzano Lombardy, Italy, 20089ASST Sette Laghi_Ospedale Galmarini - Medicina Generale | Tradate Lombardy, Italy, 21049Azienda Socio Sanitaria Territoriale Della Brianza _Ospedale di Vimercate - Medicina Interna | Vimercate Lombardy, Italy, 20871A.O.U. Maggiore della Carità | Novara Piedmont, Italy, 28100Azienda Unita' Sanitaria Locale Toscana Sud Est | Cortona Tuscany, Italy, 52040Azienda Ospedaliera Universitaria Senese | Siena Tuscany, Italy, 53100A.O. di Perugia_Hospital Santa Maria della Misericordia - S.C. Cardiologia | Perugia Umbria, Italy, 06129Azienda Ospedaliera Universitaria Integrata Verona_Borgo Trento - Cardiologia | Verona Veneto, Italy, 37126Kasugai Municipal Hospital | Kasugai Aichi-ken, Japan, 486-8510TOYOTA Memorial Hospital | Toyota Aichi-ken, Japan, 471-8513Funabashi Municipal Medical Center | Funabashi Chiba, Japan, 273-8588Steel Memorial Yawata Hospital | Kitakyushu Fukuoka, Japan, 805-8508Onga Nakama Medical Association Onga Hospital | Onga-gun Fukuoka, Japan, 811-4342Ogaki Municipal Hospital | Ōgaki Gifu, Japan, 503-8502Shobara Red Cross Hospital | Shōbara Hiroshima, Japan, 727-0013Hyogo Prefectural HarimaHimeji General Medical Center | Himeji Hyōgo, Japan, 670-8560National Hospital Organization Kobe Medical Center | Kobe Hyōgo, Japan, 654-0155Higashi Takarazuka Satoh Hospital | Takarazuka Hyōgo, Japan, 665-0873JA Toride Medical Center | Toride Ibaraki, Japan, 302-0022Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office | Hakusan Ishikawa-ken, Japan, 924-8588National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office | Kanazawa Ishikawa-ken, Japan, 920-8650Iwate Prefectural Central Hospital | Morioka Iwate, Japan, 020-0066Kagawa Prefectural Central Hospital | Takamatsu Kagawa-ken, Japan, 760-8557Mitoyo General Hospital | Kagawa, Japan | Toyohama-Cho,Kanonji-City Kagawa-ken, Japan, 769-1695Kitasato University Hospital | Sagamihara Kanagawa, Japan, 252-0375Sagamihara Kyodo Hospital | Sagamihara Kanagawa, Japan, 252-5188Japan Red Cross Society Azumino Hospital | Azumino Nagano, Japan, 399-8292National Hospital Organization Shinshu Ueda Medical Center | Ueda Nagano, Japan, 386-8610R.I.A.C Naha City Hospital | Naha Okinawa, Japan, 902-8511Kishiwada Tokushukai Hospital | Kishiwada Osaka, Japan, 596-0042Takatsuki Red Cross Hospital | Takatsuki Osaka, Japan, 569-1045Ageo Central General Hospital | Ageo Saitama, Japan, 362-8588Kawaguchi Cardiovascular and Respiratory Hospital | Kawaguchi Saitama, Japan, 333-0842Saitama Sekishinkai Hospital | Sayama Saitama, Japan, 350-1305National Hospital Organization Hamada Medical Center | Hamada Shimane, Japan, 697-8511Nishiarai Heart Central Clinic | Adachi-ku Tokyo, Japan, 123-0845Minamino Cardiovascular Hospital | Hachiōji Tokyo, Japan, 192-0918National Hospital Organization Tokyo Medical Center | Meguro-ku Tokyo, Japan, 152-8902Toho University Omori Medical Center | Ōta-ku Tokyo, Japan, 143-8541Japan Organization of Occupational Health and Safety Sanin Rosai Hospital | Yonago Tottori, Japan, 683-8605National Hospital Organization Iwakuni Clinical Center | Iwakuni Yamaguchi, Japan, 740-8510JCHO Shimonoseki Medical Center | Shimonoseki Yamaguchi, Japan, 750-0061Fukuoka University Nishijin Hospital | Fukuoka , Japan, 814-8522Gifu Prefectural General Medical Center | Gifu , Japan, 500-8717National Hospital Organization Kumamoto Medical Center | Kumamoto , Japan, 860-0008Kumamoto University Hospital | Kumamoto , Japan, 860-8556Miyazaki Medical Association Hospital | Miyazaki , Japan, 880-2102Shinrakuen Hospital | Niigata , Japan, 950-2087The Sakakibara Heart Institute of Okayama | Okayama , Japan, 700-0804Osaka Police Hospital | Clinical Research and Trial Center | Osaka , Japan, 543-0035Osaka General Medical Center | Osaka , Japan, 558-8558Social Corporation Keigakukai Minamiosaka Hospital | Osaka , Japan, 559-0012Oita Prefectural Hospital | Ōita , Japan, 870-8511Toyama University Hospital | Toyama , Japan, 930-0194Seiyu Memorial Hospital | Wakayama , Japan, 649-6335Daugavpils Regional Hospital | Daugavpils , Latvia, LV-5417Jelgava Outpatient Clinic | Jelgava , Latvia, LV-3001Liepaja Regional Hospital | Liepāja , Latvia, LV-34141st Riga Clinical Hospital | Riga , Latvia, LV-1001P. Stradins Clinical University Hospital | Riga , Latvia, LV-1002GK Neiroklinika | Riga , Latvia, LV-1024Gita Rancane - cardiology private practice | Ventspils , Latvia, LV-3601UAB "Klinikiniai sprendimai" Alytus | Alytus , Lithuania, LT-63200LUHS Kauno Hospital (Laisves ave.) | Kaunas , Lithuania, LT-44320LUHS Kauno Hospital (Josvainiu str.) | Kaunas , Lithuania, LT-47144Saules family medicine center | Kaunas , Lithuania, LT-49449Klaipedos Jurininku Ligonine | Klaipėda , Lithuania, LT-92288Siauliai Republican hospital | Šiauliai , Lithuania, 76231Vilnius University Hospital Santaros Klinikos | Vilnius , Lithuania, LT-08661Gleneagles Penang Medical Center | George Town , Malaysia, 10050Institute Jantung Negara | Kuala Lumpur , Malaysia, 50400University Malaya Medical Centre | Kuala Lumpur , Malaysia, 59100Hospital Sultan Idris Shah Serdang (Hospital Serdang) | Kuala Selangor , Malaysia, 43000Hospital Raja Permaisuri Bainun | Perak , Malaysia, 30450Hospital Pulau Pinang | Pulau Pinang , Malaysia, 10450Sarawak Heart Centre | Sarawak , Malaysia, 94300Centro de Investigación Médica Dr. Alberto Bazzoni SA de CV | Torreón Coahuila, Mexico, 27000Hospital General de Acapulco | Acapulco de Juárez Guerrero, Mexico, 39910Consultorio de Medicina Especializada del Sector Privado | Guadalajara Jalisco, Mexico, 44657Fundación de Atencion e Investigacion Medica Lindavista SC | Alcaldia Gustavo A. Madero Mexico City, Mexico, 7300Hospital de Jesús | Alcaldía Cuauhtemoc Mexico City, Mexico, 6090Centro de Estudios Clinicos de Queretaro S. C. (CECLIQ) | Querétaro City Querétaro, Mexico, 76000Hospital Ángeles de Xalapa | Xalapa Veracruz, Mexico, 91193Hospital Cardiologica Aguascalientes | Aguascalientes , Mexico, 20230Centro de Investigacion y Atencion Integral Durango S.C. | Durango , Mexico, 34080Catharina Ziekenhuis | Eindhoven North Brabant, Netherlands, 5623 EJZiekenhuis Groep Twente | Almelo , Netherlands, 7609 PPDeventer Ziekenhuis | Deventer , Netherlands, 7416 SESlingeland Ziekenhuis | Doetinchem , Netherlands, 7009 BLZiekenhuis Gelderse Vallei | Ede , Netherlands, 6716 RPUniversitair Medisch Centrum Groningen | Groningen , Netherlands, 9713 GZZiekenhuis St. Jansdal | Harderwijk , Netherlands, 3844 DGTergooiziekenhuizen-Blaricum | Hilversum , Netherlands, 1212 VGMaastricht UMC | Maastricht , Netherlands, 6229 HXIsala Meppel | Meppel , Netherlands, 7943 KAAntonius Ziekenhuis Sneek | Sneek , Netherlands, 8601 ZRETZ TweeSteden Ziekenhuis (vh Maria Ziekenhuis) | Tilburg , Netherlands, 5042 ADMaxima Medisch Centrum, locatie Veldhoven | Veldhoven , Netherlands, 5504 DBUniversity of Auckland | Auckland , New Zealand, 1023Christchurch Heart Institute | Christchurch , New Zealand, 8140Dunedin Hospital | Dunedin , New Zealand, 9016P3 Research Ltd Tauranga | Hawkes Bay , New Zealand, 4130Hutt Hospital | Lower Hutt , New Zealand, 5010Nelson Hospital | Nelson , New Zealand, 7042P3 Research | Tauranga , New Zealand, 3110KLIMED Marek Klimkiewicz | Bialystok , Poland, 15-704MICS Centrum Medyczne Bydgoszcz | Bydgoszcz , Poland, 85-065Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej | Gdynia , Poland, 81-519Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. sw. Jana Pawla II | Grodzisk Mazowiecki , Poland, 05 825CLINICAL MEDICAL RESEARCH Sp. z o. o. | Katowice , Poland, 40-156Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn | Krakow , Poland, 31-271IMEDICA Centrum Medyczne | Lublin , Poland, 20-068NZOZ "Twoja Przychodnia" Sp. z o.o. | Lublin , Poland, 20-857Zechowicz Medeusz-Plus Lekarska Spolka Partnerska | Olsztyn , Poland, 10-010Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o. | Oświęcim , Poland, 32-600Uniwersytecki Szpital Kliniczny w Poznaniu | Poznan , Poland, 61-848Szpital Specjalistyczny SPZOZ | Puławy , Poland, 24-100NZOZ Pro-Cordis Sopockie Centrum Badan Kardiologicznych | Sopot , Poland, 81-717Twoja Przychodnia - Szczecinskie Centrum Medyczne | Szczecin , Poland, 71-500Gessek Jacek Prywatny Gabinet Lekarski | Torun , Poland, 87-100Hospital da Senhora da Oliveira | Clinical Research Department | Guimaraes, Braga Braga District, Portugal, 4835-044Centro Hospitalar Universitario Cova de Beira | Clinical Research Department | Covilha Castelo Branco District, Portugal, 6200-251Hospital Pedro Hispano | Clinical Research Center | Matosinhos Municipality Porto District, Portugal, 4464-513Luz Saude | Hospital da Luz Setubal - Clinical Research Department | Setúbal Setúbal District, Portugal, 2900-722Hospital Prof. Dr. Fernando Fonseca | Amadora , Portugal, 2720-276BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos | Aveiro , Portugal, 3810-501Unidade Local de Saúde de Coimbra, E.P.E. - Cardiology Department - Research Unit | Coimbra , Portugal, 3004-561ULSG - Unidade Local de Saude da Guarda | Guarda , Portugal, 6300-659Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center | Leiria , Portugal, 2410-197Unidade Local De Saúde De Lisboa Ocidental E.P.E. | Lisbon , Portugal, 1449-005Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica | Lisbon , Portugal, 1500-650Centro Hospitalar Universitario do Porto | Porto , Portugal, 4099-001CMI. Dr. Podoleanu Cristian | Târgu Mureş Mureș County, Romania, TBCSpitalul Clinic Municipal de Urgenta "Timisoara" | Timișoara Timiș County, Romania, 300040Municipal Clinical Emergency Hospital of Timisoara | Timișoara Timiș County, Romania, 300254Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare | Baia Mare , Romania, 430031S.C Thera Card S.R.L | Brasov , Romania, 500102Emergency County Hospital, Braila | Brăila , Romania, 810318Emergency Institute for Cardiovascular Diseases | Bucharest , Romania, 22322Spitalul Universitar de Urgenta Bucuresti | Bucharest , Romania, 50098Spitalul Clinic de Urgenta "Sf. Pantelimon" | Bucharest , Romania, TBCSpitalul Clinic Judetean De Urgenta Craiova | Craiova Dolj , Romania, 200642Sf. Ap. Andrei Emergency Clinical County Hospital Galati | Galati , Romania, 800578S.C. CARDIOMED S.R.L. Iasi | Iași , Romania, 700732S.C. Sal Med SRL | Piteşti , Romania, TBCS.C. Cardio Med S.R.L. | Târgu Mureş , Romania, 540124Institutul De Boli Cardiovasculare Timisoara | Timișoara , Romania, 300310SBHI of Sverdlovsk Region Aramil City Hospital | Aramil , Russia, 624003First City Clinical Hospital n.a. E.E. Volosevich | Arkhangelsk , Russia, 163001Altai Regional Cardiological Dispensary | Barnaul , Russia, 656055SBEI "Chita State Medical Academy" | Chita , Russia, 672000Izhevsk City Clinical Hospital #9 | Izhevsk , Russia, 426063Kazan Federal University | Kazan' , Russia, 420043Clinical Diagnostic Center | Kazan' , Russia, 420101Sci-Res. Institute of Complex Cardiovascular Disorders | Kemerovo , Russia, 650002Center of cardiology and neurology | Kirov , Russia, 610014Research center of therapy and prophylactic medicine | Moscow , Russia, 101990City Clinical Hospital #29 n.a. N.E. Bauman - Clinical-Diagnostic dept | Moscow , Russia, 111020City clinical hospital n.a. V.V. Vinogradov | Moscow , Russia, 117292Moscow State University n.a. M.V. Lomonosov | Moscow , Russia, 119192Russian Clinical and Research Center of Gerontology | Moscow , Russia, 129226State Novosibirsk Regional Clinical Hospital | Novosibirsk , Russia, 630087Omsk Region "Clinical Health Unit No. 9" | Omsk , Russia, 644018Penza Regional Clinical Hospital n.a. N.N. Burdenko | Penza , Russia, 440026Perm Regional Hospital for War Veterans | Perm , Russia, 614097Rostov-on-Don Emergency Clinical Hospital | Rostov-on-Don , Russia, 344068SBI of the Ryazan region "Regional clinical hospital" | Ryazan , Russia, 390039Scien. Res. Inst. of Emergency Care n.a. I.I. Dzhanelidze | Saint Petersburg , Russia, 192242St. Petersburg Clinical Hospital of RAS | Saint Petersburg , Russia, 194017LLC Astarta | Saint Petersburg , Russia, 199226Samara Regional Clinical Cardiology Dispensary n.a. Polyakov | Samara , Russia, 443070Clinical Hospital #3 n.a. S.R. Mirotvortsev | Saratov , Russia, 410054Scientific Research Institute of Cardiology | Tomsk , Russia, 634012Tomsk Regional Clinical Hospital | Tomsk , Russia, 634063Sverdlovsk Regional Clinical Hospital #1 | Yekaterinburg , Russia, 620102Stredoslovensky ustav srdcovych a cievnych chorob, a.s. | Banská Bystrica , Slovakia, 974 01ALIAN s.r.o. | Bardejov , Slovakia, 085 01Nemocnica svateho Michala, a.s. | Bratislava , Slovakia, 81108Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto | Bratislava , Slovakia, 813 69Narodny ustav srdcovych a cievnych chorob, a.s | Bratislava , Slovakia, 833 48Centrum interv. neuroradiologie a endovaskularnej liecby | Bratislava , Slovakia, 84103Kardiosanus | Bratislava, Slovakia | Bratislava , Slovakia, 84107Nemocnica s poliklinikou Brezno, n.o. | Brezno , Slovakia, 977 01Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho | Dolný Kubín , Slovakia, 026 14JG-COR s.r.o. | Košice , Slovakia, 040 01Medical Group Kosice s.r.o. | Kosice, Slovakia | Košice , Slovakia, 04001KARDIO-ANGIO s.r.o. | Levice , Slovakia, 93401KardioMed s.r.o. | Lučenec , Slovakia, 984 01MEDI M&M, s.r.o. | Moldava nad Bodvou , Slovakia, 045 01Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department | Nitra , Slovakia, 949 01KARDIOMED NZ s.r.o. | Nové Zámky , Slovakia, 940 01MEDISPOL s.r.o. | Prešov , Slovakia, 08001COR, s.r.o | Šahy , Slovakia, 936 01Medivasa s.r.o. | Žilina , Slovakia, 1001Yonsei University Wonju Christian Hospital | Wŏnju Gang''weondo, South Korea, 26426Hallym University Sacred Heart Hospital | Anyang-si Gyeonggido, South Korea, 14068Bundang Cha Hospital | Seongnam-si Gyeonggido, South Korea, 13496Chungbuk National University Hospital | Cheongju-si North Chungcheong, South Korea, 28644Severance Hospital, Yonsei University Health System | Seoul Seoul Teugbyeolsi, South Korea, 03722Seoul National University Hospital | Seoul Seoul Teugbyeolsi, South Korea, 3080Dong-A University Hospital | Busan , South Korea, 49201Pusan National University Hospital | Busan , South Korea, 49241Chung Nam National University Hospital | Daejeon , South Korea, 35015Chonnam National University Hospital | Gwangju , South Korea, 501-757Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial | Ferrol A Coruña, Spain, 15405Hospital Vega Baja De Orihuela - Medicina Interna | San Bartolomé Alicante, Spain, 03314Hospital Santa María del Puerto - Medicina Interna | El Puerto de Santa María Cádiz, Spain, 11500Hospital Virgen del Camino - Medicina Interna | Sanlúcar de Barrameda Cádiz, Spain, 11540Hospital Virgen De Las Montanas - Medicina Interna | Villamartín Cádiz, Spain, 11650Hospital Universitario de Gran Canaria Dr. Negrin - Cardiologia | Las Palmas de Gran Canaria Las Palmas, Spain, 35010Hospital Universitario Virgen De La Victoria - Cardiologia | Málaga Málaga, Spain, 29010Hospital Central de Asturias | Oviedo Principality of Asturias, Spain, 33011Hospital Alta Resolucion de Utrera - Cardiologia | Utrera Sevilla, Spain, 41710Instituto Medico Quirurgico San Rafael S.A. - Cardiologia | A Coruña , Spain, 15006Hospital del Mar | Barcelona , Spain, 08003Ciutat Sanitaria i Universitaria de la Vall d'Hebron | Barcelona , Spain, 08035Hospital Universitari de Bellvitge (HUB) | Barcelona , Spain, 8908Hospital Universitario Virgen De Las Nieves - Cardiologia | Granada , Spain, 18014Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida - Medicina Interna | Lleida , Spain, 25198Hospital Universitario La Zarzuela - Cardiologia | Madrid , Spain, 28023Hospital Ramón y Cajal | Medicina Interna | Madrid , Spain, 28034Hospital Universitario 12 de Octubre | Madrid , Spain, 28041Hospital Universitario Virgen de Valme - Medicina Interna | Seville , Spain, 41014Hospital Clinico Universitario de Valencia (CHUV) | Valencia , Spain, 46010Hospital General Universitario de Valencia | Valencia , Spain, 46014Hospital Universitario Y Politecnico La Fe - Cardiologia | Valencia , Spain, 46026Hospital de Manises - Medicina Interna | Valencia , Spain, 46940Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung City Kaohsiung, Taiwan, 807377Changhua Christian Hospital | Changhua , Taiwan, 50006Mackay Memorial Hospital - Hsinchu Branch | Hsinchu , Taiwan, 300Taichung Veterans General Hospital | Taichung , Taiwan, 40705National Taiwan University Hospital | Taipei , Taiwan, 100Taipei Medical University Hospital | Taipei , Taiwan, 100Taipei Veterans General Hospital | Taipei , Taiwan, 11217Chang Gung Memorial Hospital at Linkou | Taoyuan , Taiwan, 33305Afyonkarahisar Saglik Bilimleri Universitesi | Afyonkarahisar , Turkey (Türkiye), 3218Saglik Bilimleri Universitesi Antalya EA Hastanesi | Antalya , Turkey (Türkiye), 7100Trakya Univ. Tip Fak. | Edirne , Turkey (Türkiye), 22030Eskisehir Osmangazi Universitesi Tip Fakultesi | Eskişehir , Turkey (Türkiye), 26480Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi | Istanbul , Turkey (Türkiye), 34098Istanbul Universitesi Kardiyoloji Enstitusu | Istanbul , Turkey (Türkiye), 34304Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H. | Istanbul , Turkey (Türkiye), TBCDokuz Eylul Universitesi Tip Fakultesi | Izmir , Turkey (Türkiye), 35340Erciyes Universitesi Tip Fakultesi | Kayseri , Turkey (Türkiye), 38039Kocaeli Universitesi Tip Fakultesi | Kocaeli , Turkey (Türkiye), 41380Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi | Konya , Turkey (Türkiye), 42080Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti | Kütahya , Turkey (Türkiye), 43040Mersin Universitesi Tip Fakultesi | Mersin , Turkey (Türkiye), 33079MNPE "Cherkasy Regional Cardiology Center" - Department of Coronary Heart Disease and Non-Coronary Myocardial Diseases | Cherkasy , Ukraine, 18009Clinical Emergency Hospital" of Dnipro City Council - Department of Cardiology | Dnipro , Ukraine, 49006National Institute of Therapy L.T.Maloyi, Department of Chronic Non-Communicable Diseases | Kharkiv , Ukraine, 61039Regional Dispensary of Radiation Protection of Population - Cardiology Department | Kharkiv , Ukraine, 61166MNPE "City Clinical Hospital No. 8" of the Kharkiv City Council, Cardiology Department No. 2 | Kharkiv , Ukraine, 61176Municipal Non-Profit Enterprise "Kyiv City Clinical Hospital No. 1" - Department of Cardiology | Kiev , Ukraine, 02 091Medical Center "Medbud" - Treatment and prophylactic department | Kyiv , Ukraine, 03037National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Cardiac Arrhythmias | Kyiv , Ukraine, 03151National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Heart Failure | Kyiv , Ukraine, 03151National Scientific Center Institute of Cardiology named M.D. Strazhesko of the NAMSU - Department of Hypertension | Kyiv , Ukraine, 03151LLC "Medical Center "Consilium Medical", Clinical and Consultative Departmen 1 | Kyiv , Ukraine, 04050Railway Clinical Hospital #2 | Kyiv , Ukraine, 3049Lviv Regional Clinical Treatment and Diagnostic Cardiology Center, consulting polyclinic | Lviv , Ukraine, 79015Poltava Regional Clinical Hospital. M.V. Sklifosovsky, Cardiology Department | Poltava , Ukraine, 36011Zakarpatsky Oblasnyi Kardiologichnyi Dyspanser, Infarction department | Uzhhorod , Ukraine, 880000Vinnytsia Regional Clinical Hospital, Clinical Cardiology Department | Vinnytsia , Ukraine, 21018Vinnytsia City Clinical Hospital #1, Therapeutic Department | Vinnytsia , Ukraine, 21029Regional Medical Center for Cardiovascular Diseases-Heart failure department | Zaporizhzhia , Ukraine, 69005Zaporizhia Municipal Clinical Hospital No.10, Cardiology Department | Zaporizhzhya , Ukraine, 69001Zaporizhzhya City Emergency Care Hospital, Cardiology Department | Zaporizhzhya , Ukraine, 69005Hospital No. 1 of the Zhytomyr City - consulting and treatment department Scientific and research center | Zhytomyr , Ukraine, 10002Royal Bournemouth General Hospital | Bournemouth Dorset, United Kingdom, BH7 7DWPoole Hospital NHS Trust | Poole Dorset, United Kingdom, BH15 2JBQueen Elizabeth University Hospital | Glasgow Glasgow City, United Kingdom, G51 4TFNorth Hampshire Hospital | Basingstoke Hampshire, United Kingdom, RG24 9NALister Hospital | Stevenage Hertfordshire, United Kingdom, SG1 4ABBlackpool Victoria Hospital | Blackpool Lancashire, United Kingdom, FY3 8NRUniversity Hospitals Leicester | Leicester Leicestershire, United Kingdom, LE3 9QPWansbeck General Hospital | Ashington Northumberland, United Kingdom, NE63 9JJDudley Group NHS Foundation Trust ¦Russells Hall Hopsital - Oncology | Dudley West Midlands, United Kingdom, DY1 2HQUniversity Hospitals Sussex NHS Foundation Trust | St Richard's Hospital - Cardiology services | Chichester West Sussex, United Kingdom, PO19 6SEHull University Teaching Hospitals NHS Trust | Castle Hill Hospital - Cardiology | Cottingham , United Kingdom, HU16 5JQNHS Greater Glasgow and Clyde | Glasgow Royal Infirmary |Glasgow Research Facility - Cardiology | Glasgow , United Kingdom, G31 2ERManchester Royal Infirmary | Manchester , United Kingdom, M13 9WLGreat Western Hospital | Swindon , United Kingdom, SN3 6BB
Study Documents (Full Text)
Documents provided by BayerStudy Protocol  May 15, 2022Documents provided by BayerStatistical Analysis Plan  June 19, 2024