EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction) Clinical Trial Results and Information

EMPACT-MI: A Streamlined, Multicentre, Randomised, Parallel Group, Double-blind Placebo-controlled Superiority Trial to Evaluate the Effect of EMPAgliflozin on Hospitalisation for Heart Failure and Mortality in Patients With aCuTe Myocardial Infarction

ClinicalTrials.gov processed this data on November 13, 2023. Link to the current ClinicalTrials.gov record.

Recruitment Status

COMPLETED (See Contacts and Locations)
Verified November 2023 by Boehringer Ingelheim, Eli Lilly and Company

Sponsor

Boehringer Ingelheim

Information Provided by (Responsible Party)

Boehringer Ingelheim

Clinicaltrials.gov Identifier

NCT04509674
Other Study ID Numbers: 1245-0202
First Submitted: August 10, 2020
First Posted: August 12, 2020
Last Update Posted: November 14, 2023
Last Verified: November 2023
History of Changes

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Study Description

Not Provided

Condition or Disease	Intervention/Treatment
Myocardial Infarction	Drug: Empagliflozin Drug: Placebo

Study Design

Study Type	Interventional
Actual Enrollment	6522 participants
Design Allocation	Randomized
Interventional Model	Parallel Assignment
Masking	Quadruple
Primary Purpose	Treatment
Official Title	EMPACT-MI: A Streamlined, Multicentre, Randomised, Parallel Group, Double-blind Placebo-controlled Superiority Trial to Evaluate the Effect of EMPAgliflozin on Hospitalisation for Heart Failure and Mortality in Patients With aCuTe Myocardial Infarction
Study Start Date	December 16, 2020
Actual Primary Completion Date	November 5, 2023
Actual Study Completion Date	November 5, 2023

Groups and Cohorts

Group/ Cohort	Intervention/ Treatment
Empagliflozin	Drug: Empagliflozin Empagliflozin
Placebo	Drug: Placebo

Outcome Measures

Primary Outcome Measures

Composite of time to first heart failure hospitalisation or all-cause mortality [up to 26 months]

Secondary Outcome Measures

Total number of HHF or all-cause mortality [up to 26 months]
Total number of non-elective Cardiovascular (CV) hospitalisations or all-cause mortality [up to 26 months]
Total number of non-elective all-cause hospitalisations or all-cause mortality [up to 26 months]
Total number of hospitalisations for MI or all-cause mortality [up to 26 months]
Time to CV mortality [up to 26 months]

Eligibility Criteria

Ages Eligible for Study	18 Years and Older (Adult, Older Adult)
Sexes Eligible for Study	All
Accepts Healthy Volunteers	No
Inclusion Criteria	Of full age of consent (according to local legislation, at least ≥ 18 years) at screening. Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial. Male or female patients. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information. Diagnosis of spontaneous Acute Myocardial Infarction (AMI): ST-Elevation Myocardial Infarction (STEMI) or Non-ST Elevation Myocardial Infarction (NSTEMI) with randomisation to occur no later than 14 calendar days after hospital admission. For patients with an in-hospital Myocardial Infarction (MI) as qualifying event, randomization must still occur within 14 days of hospital admission. High risk of HF, defined as EITHER Symptoms (e.g. dyspnea; decreased exercise tolerance; fatigue), or signs of congestion (e.g. pulmonary rales, crackles or crepitations; elevated jugular venous pressure; congestion on chest X-ray), that require treatment (e.g. augmentation or initiation of oral diuretic therapy; i.v. diuretic therapy; i.v. vasoactive agent; mechanical intervention etc.) at any time during the hospitalization. OR Newly developed Left Ventricular Ejection Fraction (LVEF) < 45% as measured by echocardiography, ventriculography, cardiac Computer Tomography (CT), Magnetic Resonance Imaging (MRI) or radionuclide imaging during index hospitalisation. In addition at least one of the following risk factors: Age > 65 years, Newly developed LVEF < 35%, Prior MI (before index MI) documented in medical records, Estimated Glomerular Filtration Rate (eGFR) < 60 ml/min/1.73m2 (using Chronic Kidney Disease Epidemiology Collaboration Equation (CKD-EPI) formula based on creatinine from local lab at any time during index hospitalisation), Atrial fibrillation (persistent or permanent ; if paroxysmal, only valid if associated with index MI), Type 2 diabetes mellitus (prior or new diagnosis), N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) >1,400 pg/mL for patients in sinus rhythm, >2,800 pg/mL if atrial fibrillation; Brain Natriuretic Peptide (BNP) >350 pg/mL for patients in sinus rhythm, >700 pg/mL if atrial fibrillation, measured at any time during hospitalisation, Uric acid >7.5 mg/dL (>446 μmol/L), measured at any time during hospitalisation, Pulmonary Artery Systolic Pressure [or right ventricular systolic pressure] >40 mmHg (non-invasive [usually obtained from clinically indicated post-MI echocardiography] or invasive, at any time during hospitalisation), Patient not revascularized (and no planned revascularization) for the index MI (Includes e.g. patients where no angiography is performed, unsuccessful revascularization attempts, diffuse atherosclerosis not amenable for intervention; but does NOT include if revascularization was not performed due to nonobstructive coronary arteries), 3-vessel coronary artery disease at time of index MI, Diagnosis of peripheral artery disease (extracoronary vascular disease, e.g. lower extremity artery disease or carotid artery disease).
Exclusion Criteria	Diagnosis of chronic Heart Failure (HF) prior to index MI. Systolic blood pressure < 90 mmHg at randomisation. Cardiogenic shock or use of i.v. inotropes in last 24 hours before randomisation. Coronary Artery Bypass Grafting planned at time of randomisation. Current diagnosis of Takotsubo cardiomyopathy. Any current severe (stenotic or regurgitant) valvular heart disease. eGFR < 20 ml/min/1.73m2 (using CKD-EPI formula based on most recent creatinine from local lab during index hospitalisation) or on dialysis. Type I diabetes mellitus. Further exclusion criteria apply.

Contacts and Locations

Sponsors and Collaborators	Boehringer Ingelheim, Eli Lilly and Company
	Eli Lilly and Company
Locations	Advanced Cardiovascular LLC \| Alexander City, Alabama, United States, 35010 Grandview Medical Center \| Birmingham, Alabama, United States, 35243 Heart Center Research, LLC \| Huntsville, Alabama, United States, 35801 Mercy Gilbert Medical Center \| Gilbert, Arizona, United States, 85297 Arkansas Cardiology, PA \| Little Rock, Arkansas, United States, 72205 Comprehensive Cardiovascular Medical Group \| Bakersfield, California, United States, 93309 Valley Clinical Trials, Inc. \| Covina, California, United States, 91723 Cardiovascular Innovation and Research Center \| Long Beach, California, United States, 90813 University of California Los Angeles \| Los Angeles, California, United States, 90095 InvivoCure \| Mission Hills, California, United States, 91346 Valley Clinical Trials, Inc. \| Northridge, California, United States, 91325 Valley Clinical Trials, Inc. \| Pasadena, California, United States, 91105 Kaiser Permanente \| San Diego, California, United States, 92123 San Diego Cardiac Center \| San Diego, California, United States, 92123 The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center \| Torrance, California, United States, 90502 Interventional Cardiology Medical Group \| West Hills, California, United States, 91307 George Washington University Medical Faculty Associates \| Washington, District of Columbia, United States, 20037 Clearwater Cardiovascular Consultants \| Clearwater, Florida, United States, 33756 Integrative Research Associates \| Fort Lauderdale, Florida, United States, 33312 University of Florida Health Jacksonville \| Jacksonville, Florida, United States, 32209 Cardiology Partners Clinical Research Institute \| Palm Beach Gardens, Florida, United States, 33410 Charlotte Heart Group Research Center \| Port Charlotte, Florida, United States, 33952 Grady Memorial Hospital \| Atlanta, Georgia, United States, 30303 Cardiovascular Consultants of South Georgia, LLC \| Thomasville, Georgia, United States, 31792 Atlanta Heart Specialists, LLC \| Tucker, Georgia, United States, 30084 Advanced Heart Care, LLC, Medicoricum, LLC \| Fairview Heights, Illinois, United States, 62208 Midwest Cardiovascular Research and Education Foundation \| Elkhart, Indiana, United States, 46514 Cardiovascular Research of Northwest Indiana, LLC \| Munster, Indiana, United States, 46321 Reid Physician Associates \| Richmond, Indiana, United States, 47374 Midwest Heart and Vascular Specialists \| Overland Park, Kansas, United States, 66211 University of Kentucky Medical Center \| Lexington, Kentucky, United States, 40536-0200 University of Louisville \| Louisville, Kentucky, United States, 40202 Eastern Maine Medical Center \| Bangor, Maine, United States, 04401 Cardiovascular Specialists of Central Maryland \| Columbia, Maryland, United States, 21044 Shady Grove Adventist Hospital \| Rockville, Maryland, United States, 20850 Healthy Heart Cardiology \| Grand Rapids, Michigan, United States, 49546 Western Michigan University \| Kalamazoo, Michigan, United States, 49009 Mid Michigan Medical Center \| Midland, Michigan, United States, 48670 Michigan Heart, PC \| Ypsilanti, Michigan, United States, 48197 Minneapolis Heart Institute Foundation \| Minneapolis, Minnesota, United States, 55407 Cardiology Associates Research, LLC \| Tupelo, Mississippi, United States, 38801 Missouri Cardiovascular Specialists, LLP \| Columbia, Missouri, United States, 65201 University of Missouri Health System \| Columbia, Missouri, United States, 65212 North Kansas City Hospital \| North Kansas City, Missouri, United States, 64116 Gateway Cardiology, PC \| Saint Louis, Missouri, United States, 63128 St. Louis Heart and Vascular, P.C. \| Saint Louis, Missouri, United States, 63136 Holy Name Medical Center \| Hackensack, New Jersey, United States, 07601 AtlantiCare \| Pomona, New Jersey, United States, 08240 The Heart House \| Vineland, New Jersey, United States, 08360 SJH Cardiology Associates \| Liverpool, New York, United States, 13088 Stony Brook University Hospital \| Stony Brook, New York, United States, 11794 Asheville Cardiology Associates \| Asheville, North Carolina, United States, 28803 The University of North Carolina at Chapel Hill \| Chapel Hill, North Carolina, United States, 27517 Duke University Medical Center \| Durham, North Carolina, United States, 27705 Moses H. Cone Memorial Hospital \| Greensboro, North Carolina, United States, 27401 Medication Management, LLC \| Greensboro, North Carolina, United States, 27405 North Carolina Heart and Vascular \| Raleigh, North Carolina, United States, 27607 Trinity Health Center Medical Arts \| Minot, North Dakota, United States, 58701 Aultman Hospital \| Canton, Ohio, United States, 44710 Cincinnati VA Medical Center \| Cincinnati, Ohio, United States, 45220 Kettering Medical Center \| Kettering, Ohio, United States, 45429 Oklahoma Heart Hospital Research Foundation, Incorporated \| Oklahoma City, Oklahoma, United States, 73120 South Oklahoma Heart Research Group \| Oklahoma City, Oklahoma, United States, 73135 Capital Area Research, LLC \| Camp Hill, Pennsylvania, United States, 17011 Penn Presbyterian Medical Center \| Philadelphia, Pennsylvania, United States, 19104 Guthrie Medical Group PC \| Sayre, Pennsylvania, United States, 18840 Upstate Cardiology, PA \| Greenville, South Carolina, United States, 29607 Carolina Heart Specialists, LLC \| Lancaster, South Carolina, United States, 29720 Monument Health \| Rapid City, South Dakota, United States, 57701 Centennial Heart Cardiovascular Consultants, LLC \| Nashville, Tennessee, United States, 37203 Parkway Cardiology Associates \| Oak Ridge, Tennessee, United States, 37830 Cardiovascular Research of Knoxville \| Powell, Tennessee, United States, 37849 Texas Health Presbyterian Hospital Allen \| Allen, Texas, United States, 75013 Amarillo Heart Clinical Research Institute, Incorporated \| Amarillo, Texas, United States, 79106 Pharmatex Research \| Amarillo, Texas, United States, 79109 Dallas VA Medical Center \| Dallas, Texas, United States, 75216 Baylor Scott and White Health \| Plano, Texas, United States, 75093 South Texas Cardiovascular Consultants \| San Antonio, Texas, United States, 78201 Revival Research Institute, LLC. \| Sherman, Texas, United States, 75092 Cardiovascular Associates of East Texas, PA \| Tyler, Texas, United States, 75701 Carient Heart and Vascular \| Manassas, Virginia, United States, 20109 Riverside Regional Medical Center \| Newport News, Virginia, United States, 23601 Tidewater Physicians Multispecialty Group \| Newport News, Virginia, United States, 23606 Sentara Hospitals \| Norfolk, Virginia, United States, 23507 Roanoke Heart Institute PLC \| Roanoke, Virginia, United States, 24014 Instituto Cardiovascular de Buenos Aires \| Belgrano, Argentina, C1428ART Fundacion Sanatorio Güemes \| Ciudad Autonoma Buenos Aires, Argentina, C1180 AAX Hospital Italiano de Córdoba \| Cordoba, Argentina, X5000 Sanatorio Allende \| Cordoba, Argentina, X5000 Centro Medico Luquez \| Cordoba, Argentina, X5006CBI Hospital Privado Centro Medico de Cordoba \| Cordoba, Argentina, X5016KEH Clinica Privada del Prado \| Cordoba, Argentina, X5020AAA Centro de Investigacion Clinica Coronel Suarez \| Coronel Suarez, Argentina, B7540GHD Instituto de Cardiología de Corrientes \| Corrientes, Argentina, 3400 Fundación Favaloro para la Docencia e Investigación Medica \| Monserrat, Argentina, C1093AAS Sanatorio Modelo de Quilmes \| Quilmes, Argentina, B1878GEG Instituto Cardiovascular de Rosario \| Rosario, Argentina, S2000 Sanatorio Delta \| Rosario, Argentina, S2000 Sanatorio Parque \| Rosario, Argentina, S2000 Corporacion Medica de Gral. San Martin S.A. \| San Martin, Argentina, B1650CSP Centro Privado de Cardiología \| San Miguel de Tucuman, Argentina, 4000 Clinica U.O.M. \| San Nicolas, Argentina, 2900 Sanatorio Diagnóstico \| Santa Fe, Argentina, 3081 Hospital "Dr. José Maria Cullen" \| Santa Fé, Argentina, S3000EOZ Clinica Privada Fusavim SRL \| Villa Maria, Argentina, 5900 Concord Repatriation General Hospital \| Concord, New South Wales, Australia, 2139 South Western Sydney Local Health District \| Liverpool, New South Wales, Australia, 2170 Royal North Shore Hospital \| St Leonards, New South Wales, Australia, 2065 Westmead Hospital \| Westmead, New South Wales, Australia, 2145 The Prince Charles Hospital \| Chermside, Queensland, Australia, 4032 Royal Brisbane and Women's Hospital \| Herston, Queensland, Australia, 4029 Gold Coast University Hospital \| Southport, Queensland, Australia, 4215 Alfred Hospital \| Melbourne, Victoria, Australia, 3004 JMF Clinica Do Coracao LTDA \| Aracaju - SE, Brazil, 49055-530 Hospital Santa Isabel \| Balneario Camboriu, Brazil, 88331-085 Hospital Madre Teresa \| Belo Horizonte, Brazil, 30441-070 Hospital do Coracao do Brasil \| Brasilia, Brazil, 70390 700 Hospital Angelina Caron \| Campina Grande do Sul, Brazil, 83430-000 Centro Especializado em Cardiol Loema Instituto de Pesq Clin \| Campinas, Brazil, 13010-001 IPECC - Instituto de Pesquisa Clínica de Campinas \| Campinas, Brazil, 13060-080 Hospital de Messejana Dr. Carlos Alberto Studart Gomes \| Fortaleza, Brazil, 60840-285 HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás \| Goiania, Brazil, 74605-020 Hospital Regional Hans Dieter Schmidt \| Joinville, Brazil, 89227-680 Santa Casa de Misericórdia de Marília \| Marília, Brazil, 17515-000 Hospital São Vicente de Paulo \| Passo Fundo, Brazil, 99010-080 Hospital Sao Lucas da PUCRS \| Porto Alegre, Brazil, 01046 010 Instituto de Cardiologia Rio Grande do Sul \| Porto Alegre, Brazil, 90620-001 Hospital Nossa Senhora da Conceição \| Porto Alegre, Brazil, 91350-200 Hospital Agamenon Magalhaes \| Recife, Brazil, 52051-380 Fundacao de apoio ao ensino e assitencia HCFMRP \| Ribeirao Preto, Brazil, 14051-140 Hospital Copa D'or \| Rio de Janeiro, Brazil, 22031-011 Instituto de Ensino E Pesquisa Do Hospital Da Bahia \| Salvador, Brazil, 41810-011 Hospital de Base - Fac Med de Sao Jose do Rio Preto \| Sao Jose do Rio Preto, Brazil, 15090-000 Hospital Samaritano \| Sao Paulo, Brazil, 01333-030 Hospital Sao Luiz Jabaquara \| Sao Paulo, Brazil, 04321-120 Hospital Sao Luiz Morumbi \| Sao Paulo, Brazil, 04544-000 Hospital das Clínicas de Sao Paulo - INCOR \| Sao Paulo, Brazil, 05403-000 CEMEC - Centro Multidisciplinar de Estudos Clínicos \| São Bernardo do Campo, Brazil, 09715-090 Santa Casa de Votuporanga \| Votuporanga, Brazil, 15500-003 Multiprofile Hospital For Active Treatment Pulse AD \| Blagoevgrad, Bulgaria, 2700 Multiprofile Hospital For Active Treatment "Dr. Tota Venkova" AD \| Gabrovo, Bulgaria, 5300 Multiprofile Hospital for Active Treatment AD Haskovo \| Haskovo, Bulgaria, 6304 Multiprofile Hospital For Active Treatment - Pazardzhik AD \| Pazardzhik, Bulgaria, 4400 Specialized Hospital for Active Treatment Sv. Georgi - Pernik \| Pernik, Bulgaria, 2300 Multiprofile Hospital for Active Treatment Heart and Brain EAD \| Pleven, Bulgaria, 5804 SHAT in Cardiology EAD, Pleven \| Pleven, Bulgaria, 5804 Medical Center Medconsult Pleven LTD \| Pleven, Bulgaria, 5808 Hospital MHAT Plovdiv, AD \| Plovdiv, Bulgaria, 4003 National Heart Hospital, Sofia \| Sofia, Bulgaria, 1309 City Clin.Univ.MPHAT EOOD,Clin.of Cardiology, Sofia \| Sofia, Bulgaria, 1407 University Multiprofile Hospital for Active Treatement "Alexandrovska" EAD \| Sofia, Bulgaria, 1431 UMHAT "Tsaritsa Yoannalsul" \| Sofia, Bulgaria, 1527 Medical Military Academy MHAT Sofia \| Sofia, Bulgaria, 1606 Multiprofile Hospital MHATEM 'Pirogov', Sofia \| Sofia, Bulgaria, 1606 MHAT Sv.Anna, Clinic of Internal Diseases, Sofia \| Sofia, Bulgaria, 1750 Hospital Trakia Park \| Stara Zagora, Bulgaria, 6004 Heritage Medical Research Clinic \| Calgary, Alberta, Canada, T2N 4Z6 Royal Alexandra Hospital \| Edmonton, Alberta, Canada, T5H 3V9 University of Alberta Hospital (University of Alberta) \| Edmonton, Alberta, Canada, T6G 2B7 Royal Inland Hospital \| Kamloops, British Columbia, Canada, V2C 2T1 Surrey Memorial Hospital \| Surrey, British Columbia, Canada, V3V 0C6 Vancouver General Hospital \| Vancouver, British Columbia, Canada, V5Z 1M9 Victoria Heart Institute Foundation \| Victoria, British Columbia, Canada, V8R 1B2 St. Boniface Hospital \| Winnipeg, Manitoba, Canada, R2H 2A6 GA Research Associates Ltd. \| Moncton, New Brunswick, Canada, E1G 1A7 QEII Health Sciences Centre \| Halifax, Nova Scotia, Canada, B3H 3A7 William Osler Health Centre \| Brampton, Ontario, Canada, L6R 3J7 Queen's University \| Kingston, Ontario, Canada, K7L 2V7 One Heart Care Ventures \| Mississauga, Ontario, Canada, L4Y 1M3 Southlake Regional Health Centre \| Newmarket, Ontario, Canada, L3Y 2P7 Peterborough Regional Health Centre \| Peterborough, Ontario, Canada, K9J 7C6 Heart Health Institute \| Scarborough, Ontario, Canada, M1B 4Z8 Women's College Hospital \| Toronto, Ontario, Canada, M5S 1B2 Montreal Heart Institute \| Montreal, Quebec, Canada, H1T 1C8 Centre Hospitalier de l'Universite de Montreal (CHUM) \| Montreal, Quebec, Canada, H2X 0A9 Montreal General Hospital - McGill University Health Centre \| Montreal, Quebec, Canada, H3G 1A4 McGill University Health Centre (MUHC) \| Montreal, Quebec, Canada, H4A 3J1 IUCPQ (Laval University) \| Sainte-Foy, Quebec, Canada, G1V 4G5 CIUSSS de l Estrie-CHUS \| Sherbrooke, Quebec, Canada, J1H 5N4 CSSS du Sud de Lanaudiere - Hopital Pierre-Le Gardeur \| Terrebonne (Lachenaie), Quebec, Canada, J6V 2H2 CIUSSS de la Mauricie-et-du-Centre-du-Quebec \| Trois-Rivieres, Quebec, Canada, G8Z 3R9 Prairie Vascular Research Inc. \| Regina, Saskatchewan, Canada, S4P 0W5 Oakville Trafalgar Memorial Hospital \| Oakville, Canada, L6M 0L8 Beijing Chao-Yang Hospital \| Beijing, China, 100020 Chinese PLA General Hospital \| Beijing, China, 100022 China-Japan Friendship Hospital \| Beijing, China, 100029 Peking University First Hospital \| Beijing, China, 100034 Beijing Luhe Hospital Capital Medical University \| Beijing, China, 101100 Changsha Central Hospital \| Changsha, China, 410007 Xiangya Hospital, Central South University \| Changsha, China, 410008 Guangdong Provincial People's Hospital \| Guangzhou, China, 510100 The First Affiliated Hospital of Harbin Medical University \| Haerbin, China, 150001 Hainan General Hospital \| Haikou, China, 570311 Shulan(Hanghzhou) Hospital \| Hangzhou, China, 310004 Zhejiang Hospital \| Hangzhou, China, 310013 Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine \| Hangzhou, China, 310016 The Second Affiliated Hospital of Lanzhou Medical University \| Lanzhou, China, 730030 Nanjing Drum Tower Hospital \| Nanjing, China, 210008 Zhongshan Hospital Fudan University \| Shanghai, China, 200032 People's Hospital of Liaoning Province \| Shenyang, China, 110016 Peking University Shenzhen Hospital \| Shenzhen, China, 518036 Renmin Hospital of Wuhan University \| Wuhan, China, 430060 Aalborg Universitetsshospital \| Aalborg, Denmark, 9000 Aarhus University Hospital \| Aarhus N, Denmark, 8200 Rigshospitalet \| Copenhagen, Denmark, 2100 Frederiksberg Hospital \| Frederiksberg, Denmark, 2000 Herlev and Gentofte Hospital \| Herlev, Denmark, 2730 Slagelse Sygehus \| Slagelse, Denmark, 4200 HOP Sud Francilien \| Corbeil Essonnes, France, 91106 HOP CHU de Grenoble \| Grenoble Cedex 9, France, 38043 CHRU Lille \| Lille, France, 59037 Hospital de Saint Joseph et Saint Luc \| Lyon, France, 69007 HOP Bichat \| Paris, France, 75018 CHU Rouen \| Rouen Cedex, France, 76031 HOP Trousseau \| Tours, France, 37044 HOP Brabois \| Vandoeuvre-lès-Nancy, France, 54511 SLK-Kliniken Heilbronn GmbH \| Bad Friedrichshall, Germany, 74177 Kerckhoff-Klinik, Bad Nauheim \| Bad Nauheim, Germany, 61231 Charité - Universitätsmedizin Berlin \| Berlin, Germany, 12203 Universitätsklinikum Bonn AöR \| Bonn, Germany, 53127 Bremer Institut für Herz- und Kreislaufforschung (BIHKF) am Klinikum Links der Weser \| Bremen, Germany, 28277 Klinikum Coburg gGmbH \| Coburg, Germany, 96450 St. Johannes Hospital Dortmund \| Dortmund, Germany, 44137 Städtisches Klinikum Dresden \| Dresden, Germany, 01067 Universitätsklinikum Frankfurt \| Frankfurt am Main, Germany, 60596 Klinikum Frankfurt Höchst GmbH \| Frankfurt/Main, Germany, 65929 Universitäts-Herzzentrum Freiburg, Bad Krozingen GmbH \| Freiburg I. Breisgau, Germany, 79106 Asklepios Kliniken GmbH & Co. KGaA \| Hamburg, Germany, 22307 Medizinische Hochschule Hannover \| Hannover, Germany, 30625 Ambulantes Herzzentrum Kassel \| Kassel, Germany, 34121 Universitätsklinikum Leipzig \| Leipzig, Germany, 04103 Katholisches Klinikum Mainz \| Mainz, Germany, 55131 Clemenshospital \| Münster, Germany, 48153 Kardiologische Praxis Papenburg \| Papenburg, Germany, 26871 Universitätsklinikum Regensburg \| Regensburg, Germany, 93053 Lausmed Kft. Outpatient Unit of Internal Medicine \| Baja, Hungary, 6500 Buda Hospital of the Hospitaller Order of Saint John of God \| Budapest, Hungary, 1023 Semmelweis University \| Budapest, Hungary, 1085 St. Imre Hospital, Budapest \| Budapest, Hungary, 1115 Semmelweis University \| Budapest, Hungary, 1122 Magyar Honvedseg Egeszsegugyi Kozpont \| Budapest, Hungary, 1134 Jahn Ferenc Del-Pest Hospital \| Budapest, Hungary, 1204 University Debrecen Hospital \| Debrecen, Hungary, 4032 Csongrad Megyei Eu. Ellato Kozp. Hodmezovasarhely-Mako \| Hodmezovasarhely, Hungary, 6800 Somogy County Kaposi Mor Teaching Hospital \| Kaposvar, Hungary, 7400 Bacs-Kiskun Megyei Onkormanyzat Hospital \| Kecskemet, Hungary, 6000 Pest Megyei Flor Ferenc Hospital \| Kistarcsa, Hungary, 2143 University of Szeged \| Szeged, Hungary, 6720 Fejer County Saint George University Teaching Hospital \| Szekesfehervar, Hungary, 8000 Jasz-Nagykun-Szolnok Megyei Hetenyi G. Korhaz-Rendelointezet \| Szolnok, Hungary, 5000 Zala County Hospital, Zalaegerszeg \| Zalaegerszeg, Hungary, 8900 Kamalnayan Bajaj Hospital \| Aurangabad, India, 431 010 Sri Jayadeva Institute of Cardiovascular Sciences & Research \| Bangalore, India, 560069 Narayana Institute of Cardiac Sciences \| Bangalore, India, 560099 KLES Dr.Prabhakar Kore Hospital and Medical Research Centre \| Belagavi, India, 590010 Madras Medical Mission, \| Chennai, India, 600037 Eternal Heart Care Centre & Research Institute Pvt. Ltd. \| Jaipur, India, 302017 KEM Hospital and Seth G S Medical College \| Mumbai, India, 400012 Sion Hospital (Lokmanya Tilak Municipal Hospital) \| Mumbai, India, 400022 Government Medical College & Hospital \| Nagpur, India, 440009 GB Pant Institute of Post Graduate Medical Education and Research \| New Delhi, India, 110002 Max Superspeciality Hospital \| New Delhi, India, 110017 Sir Gangaram Hospital \| New Delhi, India, 110060 Sahyadri Speciality Hospital \| Pune, India, 411004 Haemek Medical Center \| Afula, Israel, 18101 Assuta Medical Center \| Ashdod, Israel, 77000 Barzilai Medical Center \| Ashkelon, Israel, 78278 Soroka Univ. Medical Center \| Beer Sheba, Israel, 8410101 Assaf Harofe Medical Center \| Beer Yaacov, Israel, 70300 Hillel Yaffe Medical Center, Hadera \| Hadera, Israel, 38100 Rambam Medical Center \| Haifa, Israel, 31096 Bnei Zion Medical Center, Haifa \| Haifa, Israel, 33394 Lady Davis Carmel Medical Center \| Haifa, Israel, 34362 Hadassah Medical Center, Ein-Karem \| Jerusalem, Israel, 91000 Shaare Zedek Medical Center, Jerusalem 91031 \| Jerusalem, Israel, 9103102 Hadassah Medical Center, Ein-Karem \| Jerusalem, Israel, 91120 Meir Medical Center \| Kfar-Saba, Israel, 44281 West.Galilee Med.Cent.Naharia \| Nahariya, Israel, 22100 Rabin Medical Center Beilinson \| Petah Tikva, Israel, 49100 Rabin Medical Center Beilinson \| Petah Tikva, Israel, 4941492 The Chaim Sheba Medical Center Tel HaShomer \| Ramat Gan, Israel, 52621 Kaplan Medical Center \| Rehovot, Israel, 76100 Ziv Medical Center \| Safed, Israel, 13100 Sourasky Medical Center \| Tel Aviv, Israel, 64239 Baruch Padeh Medical Center \| Tiberias, Israel, 15208 Kasugai Municipal Hospital \| Aichi, Kasugai, Japan, 486-8510 Toyota Memorial Hospital \| Aichi, Toyota, Japan, 471-8513 Chibanishi General Hospital \| Chiba, Matsudo, Japan, 270-2251 Seikeikai New Tokyo Heart Clinic \| Chiba, Matsudo, Japan, 271-0077 Saiseikai Fukuoka General Hospital \| Fukuoka, Fukuoka, Japan, 810-0001 Gifu Prefectural General Medical Center \| Gifu, Gifu, Japan, 500-8717 Ogaki Municipal Hospital \| Gifu, Ogaki, Japan, 503-8502 Hiroshima General Hospital \| Hatsukaichi, Japan, 738-8503 Hiroshima Prefectural Hospital \| Hiroshima, Hiroshima, Japan, 734-8530 Hyogo Brain and Heart Center \| Hyogo, Himeji, Japan, 670-0981 Ibaraki Prefectural Central Hospital \| Ibaraki, Kasama, Japan, 309-1793 Tsuchiura Kyodo General Hospital \| Ibaraki, Tsuchiura, Japan, 300-0028 Ishikawa Prefectural Central Hospital \| Ishikawa, Kanazawa, Japan, 920-8530 Juntendo University Shizuoka Hospital \| Izunokuni, Japan, 410-2295 Tokai University Hospital \| Kanagawa, Isehara, Japan, 259-1193 Sagamihara Kyodo Hospital \| Kanagawa, Sagamihara, Japan, 252-5188 Yokohama City University Medical Center \| Kanagawa, Yokohama, Japan, 232-0024 Fukuoka Tokushukai Hospital \| Kasuga, Japan, 816-0864 Saiseikai Kumamoto Hospital \| Kumamoto, Kumamoto, Japan, 861-4193 Japanese Red Cross Kumamoto Hospital \| Kumamoto, Kumamoto, Japan, 861-8520 Kusatsu General Hospital \| Kusatsu, Japan, 525-8585 Miyazaki Medical Association Hospital \| Miyazaki, Japan, 880-2102 Nagano Chuo Hospital \| Nagano, Nagano, Japan, 380-0814 Osaka Police Hospital \| Osaka, Osaka, Japan, 543-0035 Kagawa Prefectural Central Hospital \| Takamatsu, Japan, 760-8557 Tokushima Prefectural Central Hospital \| Tokushima, Japan, 770-0042 St. Luke's International Hospital \| Tokyo, Chuo-ku, Japan, 104-8560 Tokyo Bay Urayasu Ichikawa Medical Center \| Urayasu, Japan, 279-0001 Showa University Fujigaoka Hospital \| Yokohama, Japan, 227-8501 Bucheon Sejong Hospital \| Bucheon, Korea, Republic of, 14754 Pusan National Univ. Hosp \| Busan, Korea, Republic of, 49241 Chungbuk National University Hospital \| Cheongiu, Korea, Republic of, 28644 Chungnam National University Hospital \| Daejoen, Korea, Republic of, 35015 Chonnam National University Hospital \| Gwangju, Korea, Republic of, 61469 Seoul National University Bundang Hospital \| Seongnam, Korea, Republic of, 13620 Yonsei University Wonju Severance Christian Hospital \| Wonju-si, Korea, Republic of, 26426 Noordwest Ziekenhuisgroep \| Alkmaar, Netherlands, 1815 JD Meander Medisch Centrum \| Amersfoort, Netherlands, 3813 TZ Amsterdam UMC Locatie VUMC \| Amsterdam, Netherlands, 1081HV Onze Lieve Vrouwe Gasthuis \| Amsterdam, Netherlands, 1091 HA Rijnstate Hospital \| Arnhem, Netherlands, 6815 AD Amphia Ziekenhuis \| Breda, Netherlands, 4819 EV IJsselland Ziekenhuis \| Capelle Aan Den Ijssel, Netherlands, 2906 ZC Catharina Ziekenhuis \| Eindhoven, Netherlands, 5623 EJ Medisch Spectrum Twente \| Enschede, Netherlands, 7513 ER Admiraal de Ruyter Ziekenhuis \| Goes, Netherlands, 4462 RA Universitair Medisch Centrum Groningen \| Groningen, Netherlands, 9713 GZ Spaarne Ziekenhuis \| Haarlem, Netherlands, 2035 RC Zuyderland Medisch Centrum \| Heerlen, Netherlands, 6419 PC Jeroen Bosch Ziekenhuis-Hertogenbosch \| Hertogenbosch, Netherlands, 5223 GZ Tergooi Ziekenhuis \| Hilversum, Netherlands, 1213 XZ Vasculair Onderzoek Centrum \| Hoorn, Netherlands, 1624 NP Medisch Centrum Leeuwarden \| Leeuwarden, Netherlands, 8934 AD Leids Universitair Medisch Centrum (LUMC) \| Leiden, Netherlands, 2300 RC Alrijne Ziekenhuis \| Leiden, Netherlands, 2334 CK Ziekenhuis Rivierenland \| Tiel, Netherlands, 4002 WP Tweesteden Ziekenhuis, locatie Tilburg \| Tilburg, Netherlands, 5042 AD Isala Zwolle \| Zwolle, Netherlands, 8025 AB American Heart of Poland \| Belchatow, Poland, 97-400 Univ. Clinic Hosp, Bialystok \| Bialystok, Poland, 15-276 American Heart of Poland Sp. z o.o. \| Bielsko-Biala, Poland, 43-316 American-Polish Heart Clinic, Lesser Poland Cardiovascular Centre \| Chorzow, Poland, 32-500 American Heart of Poland Sp. z o.o. \| Dabrowa Gornicza, Poland, 41-300 NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog. \| Gdynia, Poland, 81-423 Silesian Medical University in Katowice \| Katowice, Poland, 40-635 American Heart of Poland Sp. z o.o. \| Kedzierzyn-Kozle, Poland, 47-200 University Hospital in Krakow \| Krakow, Poland, 30-688 The John Paul II Hosp.,Dept.of Coronary Heart Disease,Krakow \| Krakow, Poland, 31-202 Podhalanski Special.Hosp,Intern.Med&Cardiology Dept,Nowy Tag \| Nowy Targ, Poland, 34-400 Mazowiecki Szpital Specjalistyczny im. dr Jozefa Psarskiego \| Ostroleka, Poland, 07-410 Medicome Limited Liability Company \| Oswiecim, Poland, 32-600 Independent Public Healthcare, Dept. of Cardiology, Pulawy \| Pulawy, Poland, 24-100 American Heart of Poland Sp. z o.o. \| Sztum, Poland, 82-400 American Heart of Poland Sp. z o.o. \| Tychy, Poland, 43-100 Dr Alfred Sokołowski Specialist Hospital \| Walbrzych, Poland, 58-309 Central Hospital of Medical Academy, Warsaw \| Warsaw, Poland, 02-097 Instytut Kardiologii, Warszawa \| Warsaw, Poland, 04-628 Jan Mikulicz-Radecki UnivClinic Hosp,Cardiology Dept,Wroclaw \| Wroclaw, Poland, 50-556 4. Military Clinical Hospital with Polyclinic SP ZOZ \| Wroclaw, Poland, 50-981 Emergency Clinical County Hospital, Baia Mare \| Baia Mare, Romania, 430031 Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu" \| Balotesti, Romania, 077016 Spitalul Judetean de Urgenta Braila \| Braila, Romania, 810325 Spitalul Clinic Judetean de Urgenta Brasov \| Brasov, Romania, 500326 Military Central Clinical Emergency Hospital \| Bucharest, Romania, 010825 Elias Emergency Hospital, Bucharest \| Bucharest, Romania, 011461 Prof.C.C.Iliescu Hospital, National Institute of Cardiology \| Bucharest, Romania, 022322 Emergency Clinical Hospital "Bagdasar-Arseni" \| Bucharest, Romania, 041915 Emergency University Hospital, Bucharest \| Bucharest, Romania, 050098 Heart Institute "Niculae Stancioiu", Cluj Napoca \| Cluj Napoca, Romania, 400001 Clincal Reabilitation Hospital, Cluj Napoca \| Cluj Napoca, Romania, 400347 Spitalul Clinic Judetean, Craiova \| Craiova, Romania, 200642 Cardiovascular Diseases Institute "Prof. Georgescu", Iasi \| Iasi, Romania, 700503 SC Cardiomed SRL, Iasi \| Iasi, Romania, 700732 SC Endodigest SRL \| Oradea, Romania, 410151 Sal Med Srl \| Pitesti, Romania, 110437 Emergency County Clinical Hospital, Sibiu \| Sibiu, Romania, 550245 Centrul Medical Cardiomed \| Targu-Mures, Romania, 540124 Country Clinical Emergency Hospital, Targu-Mures \| Targu-Mures, Romania, 540136 Cardiology and Cardiovascular Rehabilitation Clinic \| Timisoara, Romania, 300310 First City Clinical Hospital named after E. E. Volosevich \| Arkhangelsk, Russian Federation, 163001 Regional Clinical Hospital, Kirov \| Kirov, Russian Federation, 610014 Regional Clinical Hospital No.1 n.a. Ochapovskiy, Krasnodar \| Krasnodar, Russian Federation, 350086 State Healthcare Institution Clinical Hosp. No. 51, Moscow \| Moscow, Russian Federation, 121309 Reg.Clin.Hosp.n.a.Semashko \| Nizhniy Novgorod, Russian Federation, 603126 Penza Regional Clinical Hospital named after N.N.Burdenko \| Penza, Russian Federation, 440026 Republic Kareliya Republican Hosp. named after V.A. Baranov \| Petrozavodsk, Russian Federation, 185019 GUZ Ryazanskiy Regional Clin. Cardiology Dispensary, Ryazan \| Ryazan, Russian Federation, 390039 Samara Regional Clinical Cardiology Clinic, Day Hosp. Dept. \| Samara, Russian Federation, 443070 Saratov State Med.Univ.n.a.Razumovskogo \| Saratov, Russian Federation, 410012 Saratov Regional Cardiac Center \| Saratov, Russian Federation, 410039 Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine \| St. Petersburg, Russian Federation, 192242 Medical Academy named after I. Mechnikov, St. Petersburg \| St. Petersburg, Russian Federation, 195067 Komi Republican Cardiological Dispensary \| Syktyvkar, Russian Federation, 167981 Regional clinical hospital, Tver \| Tver, Russian Federation, 170036 Tyumen Cardiology Center, Dept.of Cardiac Arrhythmia \| Tyumen, Russian Federation, 625026 State Budg.Healthc.Instit Volgograd RegClin.Cardiology Centr \| Volgograd, Russian Federation, 400062 Institute for Cardiovascular diseases Dedinje \| Belgrade, Serbia, 11000 University Clinical Center of Serbia \| Belgrade, Serbia, 11000 Clinical Hospital Center Dr. Dragisa Misovic \| Belgrade, Serbia, 11040 Clinical Medical Center Zvezdara, Belgrade \| Belgrade, Serbia, 11050 University Clinical Center of Kragujevac \| Kragujevac, Serbia, 34000 General Hospital Leskovac \| Leskovac, Serbia, 16000 Institute for Treatment and Rehabilitation, Niska Banja \| Niska Banja, Serbia, 18205 University Clinical Center Nis \| Nis, Serbia, 18000 General Hospital Pancevo \| Pancevo, Serbia, 26101 Institute of Cardiovascular Diseases \| Sremska Kamenica, Serbia, 21204 General Hospital Sremska Mitrovica \| Sremska Mitrovica, Serbia, 22000 General Hospital Subotica, Internal Medicine \| Subotica, Serbia, 24107 Health Center Uzice \| Uzice, Serbia, 31000 Health Centre Zajecar \| Zajecar, Serbia, 19000 General Hospital - Djordje Joanovic \| Zrenjanin, Serbia, 23101 Hospital Germans Trias i Pujol \| Badalona, Spain, 08916 University Hospital of Bellvitge \| Barcelona, Spain, 08907 Hospital Universitario 12 de Octubre \| Madrid, Spain, 28041 Hospital Universitari Joan XXIII \| Tarragona, Spain, 43005 Complejo Hospitalario Universitario de Vigo \| Vigo, Spain, 36213 Cherkasy Regional Cardiological Center \| Cherkasy, Ukraine, 18009 City Joint Emergency Hospital, Dnepropetrovsk \| Dnepropetrovsk, Ukraine, 49006 Ivano-Frankivsk City Central Clinical Hospital \| Ivano-Frankivsk, Ukraine, 76005 Clinical Medical Diagnostic Center Simedgroup \| Ivano-Frankivsk, Ukraine, 76008 L.T. Malaya Institute of Therapy AMS of Ukraine \| Kharkiv, Ukraine, 61039 Reg.Clin.Hosp.Non-Commercial Enterprise \| Kharkiv, Ukraine, 61058 CI of Healthcare Kharkiv CCH #8, Kharkiv \| Kharkiv, Ukraine, 61176 Khmelnytskyi Regional Hospital \| Khmelnytskyi, Ukraine, 29007 Kiev City Clinical Hospital No. 5 \| Kiev, Ukraine, 03115 SI NSC M.D. Strazhesko Institute Cardiology of NAMSU, Kyiv \| Kiev, Ukraine, 03680 City Clinical Hospital No. 1, Kiev \| Kiev, Ukraine, 2091 Kiev Emergency Care Hospital \| Kiev, Ukraine, 2166 Lutsk City Clinical Hospital \| Lutsk, Ukraine, 43024 Communal Noncommercial Enterprise of Lviv Regional Council "Lviv Regional Clinical Psychiatric Hospital" \| Lviv, Ukraine, 79015 Odesa Regional Clinical Hospital \| Odesa, Ukraine, 65025 Regional Clinical Hospital, Ternopil \| Ternopil, Ukraine, 46001 Transcarpathian Regional Clinical Center \| Uzhgorod, Ukraine, 88000 Zhytomyr Regional Clinical Hospital, Dept. Endocrinology \| Zhytomyr, Ukraine, 10002

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Additional Relevant MeSH Terms

Heart Failure
Myocardial Infarction
Infarction
Heart Diseases
Cardiovascular Diseases
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Vascular Diseases