A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

Recruitment Status
ACTIVE, NOT RECRUITING
(See Contacts and Locations)Verified March 2026 by Bristol-Myers Squibb
Sponsor
Bristol-Myers Squibb
Information Provided by (Responsible Party)
Bristol-Myers Squibb
Clinicaltrials.gov Identifier
NCT06025578
Other Study ID Numbers:
IM027-1015
First Submitted
August 29, 2023
First Posted
September 5, 2023
Last Update Posted
April 22, 2026
Last Verified
March 2026

ClinicalTrials.gov processed this data on April 2026. Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

Condition or DiseaseIntervention/Treatment
Progressive Pulmonary Fibrosis
Drug: BMS-986278Drug: BMS-986278Drug: BMS-986278 Placebo

Study Design

Study TypeInterventional
Actual Enrollment1057 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingQuadruple
Primary PurposeTreatment
Official TitleA Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
Study Start DateOctober 24, 2023
Actual Primary Completion Date1yr 7mos from now
Actual Study Completion Date1yr 7mos from now

Groups and Cohorts

Group/CohortIntervention/Treatment
BMS-986278 Dose 1
Drug: BMS-986278
Specified dose on specified days
BMS-986278 Dose 2
Drug: BMS-986278
Specified dose on specified days
BMS-986278 Placebo
Drug: BMS-986278 Placebo
Specified dose on specified days

Outcome Measures

Primary Outcome Measures
  1. Number of participants that experience spontaneous syncopal events
    Cohort 1
  2. Absolute change from baseline in forced vital capacity (FVC) measured in mL
    Cohort 2
Secondary Outcome Measures
  1. Number of participants who discontinued treatment due to any low BP-related Adverse Events
    Cohort 1
  2. Disease progression
    Cohort 2 Disease progression will be measured by the time to first disease progression event in at least 1 of the following parameters: * Absolute percent predicted forced vital capacity (ppFVC) decline of ≥ 10% from baseline * Acute exacerbation of pulmonary fibrosis * Respiratory-related hospitalization * All-cause mortality
  3. Change from baseline in Living with Pulmonary Fibrosis Questionnaire (L-PF) cough domain score
    Cohort 2
  4. Change from baseline in L-PF dyspnea domain score
    Cohort 2
  5. Change from baseline in walking distance measured in 6-minute walk test (6MWT)
    Cohort 2
  6. Time to the first occurrence of any of the components of the composite endpoint: time to first acute exacerbation of pulmonary fibrosis, first respiratory-related hospitalization, or all-cause mortality
    Cohort 2
  7. Time to absolute percent ppFVC decline of ≥ 10% from baseline
    Cohort 2
  8. Time to first acute exacerbation of pulmonary fibrosis
    Cohort 2
  9. Time to first respiratory-related hospitalization
    Cohort 2
  10. Time to first pulmonary fibrosis-related hospitalization.
    Cohort 2
  11. Time to all-cause mortality
    Cohort 2
  12. Change from baseline in L-PF fatigue domain score
    Cohort 2
  13. Change from baseline in L-PF impacts module score
    Cohort 2
  14. Change from baseline in cough numeric rating scale (NRS)
    Cohort 2
  15. Change from baseline in EuroQol 5 Dimension 5 Level (EQ-5D-5L) health utility index score
    Cohort 2
  16. Change from baseline in EQ-5D-5L visual analog scale score
    Cohort 2
  17. Rate of decline from baseline in FVC (mL)
    Cohort 2
  18. Rate of decline in ppFVC from baseline
    Cohort 2
  19. Change in ppFVC from baseline
    Cohort 2
  20. Proportion of participants with absolute decline in ppFVC ≥10%
    Cohort 2
  21. Proportion of participants with relative decline in ppFVC ≥10%
    Cohort 2
  22. Change from baseline in single-breath diffusing capacity of the lung for carbon monoxide (DLCO SB) (corrected for hemoglobin) (mL/min/mm Hg)
    Cohort 2
  23. Change in percent predicted single breath diffusing capacity of the lung for carbon monoxide (ppDLCO SB) (corrected for hemoglobin) from baseline
    Cohort 2
  24. Change from baseline in quantitative lung fibrosis (QLF) score via high-resolution computed tomography (HRCT)
    Cohort 2
  25. Number of participants with Adverse Events (AEs)
    Cohort 2
  26. Number of participants with Serious AEs (SAEs)
    Cohort 2
  27. Number of participants with AEs leading to early discontinuation of investigational medicinal product (IMP)
    Cohort 2
  28. Number of participants with AEs related to IMP
    Cohort 2
  29. Number of treatment-emergent deaths
    Cohort 2
  30. Number of participants with clinical laboratory abnormalities
    Cohort 2
  31. Number of participants with electrocardiogram (ECG) abnormalities
    Cohort 2
  32. Number of participants with vital sign abnormalities
    Cohort 2

Eligibility Criteria

Ages Eligible for Study(Adult, Older Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersNo
Inclusion Criteria
Inclusion Criteria
Diagnosis of interstitial lung disease (ILD) with features consistent with progressive ILD within 24 months prior to screening, and ≥ 10% extent of fibrosis on screening high-resolution computed tomography (HRCT).
If on pirfenidone or nintedanib, participants must have been on a stable dose for at least 90 days prior to screening.
If not currently on pirfenidone or nintedanib, participants must not have received either of these medications within 28 days prior to screening.
Mycophenolate mofetil (MMF), mycophenolic acid (MA), azathioprine (AZA), and Tacrolimus are permitted provided that the participant is on a stable dose for at least 90 days prior to screening. If not currently on MMF, MA, AZA, or tacrolimus, participants must not have taken these medications within 28 days prior to screening.
Traditional disease-modifying antirheumatic drug (DMARDs) (eg. Methotrexate, leflunomide, sulfasalazine, or hydroxychloroquine) are permitted provided that the participant is on a stable dose for at least 90 days prior to screening. If not currently on traditional DMARD, participants must not have taken these medications within 28 days prior to screening.
Biologic DMARDs (eg. TNF blockers and IL-1 inhibitors) and Janus kinase inhibitors (JAK inhibitors eg. tofacitinib, upadacitinib) are permitted provided that the participant is on a stable dose for at least 90 days prior to screening. If not currently on Biologic DMARD or JAK inhibitor, participants must not have taken these medications within 28 days prior to screening.
Women who are of childbearing potential must have a highly effective form of contraception and must provide a negative urine/serum pregnancy test.
Men who are sexually active with women of childbearing potential agree to use male barrier contraception.
Exclusion Criteria
Inclusion Criteria
Diagnosis of interstitial lung disease (ILD) with features consistent with progressive ILD within 24 months prior to screening, and ≥ 10% extent of fibrosis on screening high-resolution computed tomography (HRCT).
If on pirfenidone or nintedanib, participants must have been on a stable dose for at least 90 days prior to screening.
If not currently on pirfenidone or nintedanib, participants must not have received either of these medications within 28 days prior to screening.
Mycophenolate mofetil (MMF), mycophenolic acid (MA), azathioprine (AZA), and Tacrolimus are permitted provided that the participant is on a stable dose for at least 90 days prior to screening. If not currently on MMF, MA, AZA, or tacrolimus, participants must not have taken these medications within 28 days prior to screening.
Traditional disease-modifying antirheumatic drug (DMARDs) (eg. Methotrexate, leflunomide, sulfasalazine, or hydroxychloroquine) are permitted provided that the participant is on a stable dose for at least 90 days prior to screening. If not currently on traditional DMARD, participants must not have taken these medications within 28 days prior to screening.
Biologic DMARDs (eg. TNF blockers and IL-1 inhibitors) and Janus kinase inhibitors (JAK inhibitors eg. tofacitinib, upadacitinib) are permitted provided that the participant is on a stable dose for at least 90 days prior to screening. If not currently on Biologic DMARD or JAK inhibitor, participants must not have taken these medications within 28 days prior to screening.
Women who are of childbearing potential must have a highly effective form of contraception and must provide a negative urine/serum pregnancy test.
Men who are sexually active with women of childbearing potential agree to use male barrier contraception. Exclusion Criteria
Idiopathic pulmonary fibrosis with usual interstitial pneumonia (UIP) verification at screening.
History of stroke or transient ischemic attack within 3 months prior to screening.
Participants who exhibit symptoms of heart failure at rest.
Participants who have a current malignancy; a previous malignancy with less than 2 years free of recurrence; and a biopsy that is suspicious for malignancy and the possibility of malignancy cannot be reasonably excluded following additional clinical, laboratory, or other diagnostic evaluations.
Use of systemic corticosteroids equivalent to prednisone \> 15 mg/day is not allowed within 4 weeks prior to screening and during the study.
Other protocol-defined Inclusion/Exclusion criteria apply.

Contacts and Locations

Sponsors and CollaboratorsBristol-Myers Squibb
Locations
Local Institution - 0046 | Birmingham Alabama, United States, 35294Local Institution - 0314 | Phoenix Arizona, United States, 85013-4220Local Institution - 0336 | La Jolla California, United States, 92037-1027Local Institution - 0212 | Los Angeles California, United States, 90033-5313Local Institution - 0019 | Los Angeles California, United States, 90095-3075Local Institution - 0535 | Newport Beach California, United States, 92663-3661Local Institution - 0366 | Orange California, United States, 92868-3201Local Institution - 0341 | Sacramento California, United States, 95817Local Institution - 0015 | San Francisco California, United States, 94143-2202Local Institution - 0352 | Stanford California, United States, 94305Local Institution - 0321 | Aurora Colorado, United States, 80045Local Institution - 0376 | Denver Colorado, United States, 80206Local Institution - 0211 | New Haven Connecticut, United States, 06510Local Institution - 0418 | Stamford Connecticut, United States, 06904Local Institution - 0067 | Newark Delaware, United States, 19713-1337Local Institution - 0354 | Washington D.C. District of Columbia, United States, 20007-2113Local Institution - 0195 | Brandon Florida, United States, 33511-5706Local Institution - 0380 | Celebration Florida, United States, 34747-1818Local Institution - 0013 | Clearwater Florida, United States, 33765Local Institution - 0396 | DeBary Florida, United States, 32713-1817Local Institution - 0036 | Gainesville Florida, United States, 32608Local Institution - 0193 | Gainesville Florida, United States, 32610Local Institution - 0073 | Loxahatchee Groves Florida, United States, 33411Local Institution - 0220 | Ocala Florida, United States, 34470Local Institution - 0452 | Pensacola Florida, United States, 32503Local Institution - 0389 | St. Petersburg Florida, United States, 33704Local Institution - 0316 | Tampa Florida, United States, 33601-1289Local Institution - 0070 | Atlanta Georgia, United States, 30322-1013Local Institution - 0368 | Dublin Georgia, United States, 31021-2561Local Institution - 0435 | Chicago Illinois, United States, 60611Local Institution - 0023 | Chicago Illinois, United States, 60637-1447Local Institution - 0040 | Evanston Illinois, United States, 60201-1779Local Institution - 0082 | Maywood Illinois, United States, 60153-3328Local Institution - 0080 | Iowa City Iowa, United States, 522242-1009Local Institution - 0049 | Kansas City Kansas, United States, 66103-2937Local Institution - 0045 | Louisville Kentucky, United States, 40207-4652Local Institution - 0361 | Louisville Kentucky, United States, 40218-2497Local Institution - 0305 | Baltimore Maryland, United States, 21201-1544Local Institution - 0033 | Towson Maryland, United States, 21204-7700Local Institution - 0404 | Boston Massachusetts, United States, 02114-2621Local Institution - 0079 | Springfield Massachusetts, United States, 01199-1002Local Institution - 0207 | Ann Arbor Michigan, United States, 48109-5000Local Institution - 0031 | Detroit Michigan, United States, 48202Local Institution - 0050 | Grand Rapids Michigan, United States, 49546-8293Local Institution - 0509 | Royal Oak Michigan, United States, 48073-6712Local Institution - 0384 | Minneapolis Minnesota, United States, 55455-4800Local Institution - 0004 | Chesterfield Missouri, United States, 63017Local Institution - 0223 | St Louis Missouri, United States, 63110-1010Local Institution - 0525 | Reno Nevada, United States, 89502-1576Local Institution - 0068 | Mount Kisco New York, United States, 10549-3417Local Institution - 0357 | New York New York, United States, 10029-6574Local Institution - 0428 | Durham North Carolina, United States, 27710Local Institution - 0392 | Wilmington North Carolina, United States, 28401-7307Local Institution - 0325 | Winston-Salem North Carolina, United States, 27103Local Institution - 0419 | Cincinnati Ohio, United States, 45267Local Institution - 0186 | Cleveland Ohio, United States, 44106Local Institution - 0209 | Columbus Ohio, United States, 43201Local Institution - 0343 | Toledo Ohio, United States, 43608-2603Local Institution - 0198 | Oklahoma City Oklahoma, United States, 73104-5417Local Institution - 0008 | Tulsa Oklahoma, United States, 74133Local Institution - 0037 | Portland Oregon, United States, 97239-3011Local Institution - 0205 | Hershey Pennsylvania, United States, 17033-2360Local Institution - 0334 | Philadelphia Pennsylvania, United States, 19104-5161Local Institution - 0348 | Philadelphia Pennsylvania, United States, 19107-5109Local Institution - 0196 | Philadelphia Pennsylvania, United States, 19140-5103Local Institution - 0364 | Wynnewood Pennsylvania, United States, 19096Local Institution - 0531 | Anderson South Carolina, United States, 29621Local Institution - 0071 | Charleston South Carolina, United States, 29425Local Institution - 0373 | Greenville South Carolina, United States, 29615Local Institution - 0363 | Nashville Tennessee, United States, 37204Local Institution - 0024 | Dallas Texas, United States, 75235-5351Local Institution - 0317 | Dallas Texas, United States, 75246Local Institution - 0028 | Houston Texas, United States, 77030-4202Local Institution - 0041 | Houston Texas, United States, 77030Local Institution - 0221 | McKinney Texas, United States, 75069Local Institution - 0217 | San Antonio Texas, United States, 78229-4404Local Institution - 0014 | Salt Lake City Utah, United States, 84108Local Institution - 0504 | Burlington Vermont, United States, 05401Local Institution - 0414 | Richmond Virginia, United States, 23298-5002Local Institution - 0190 | Everett Washington, United States, 98208-6526Local Institution - 0043 | Seattle Washington, United States, 98195Local Institution - 0020 | Mar del Plata Buenos Aires, Argentina, 7600Local Institution - 0446 | San Juan Bautista Buenos Aires, Argentina, 1888Local Institution - 0025 | Buenos Aires B, Argentina, C1426ABOLocal Institution - 0039 | Caba B, Argentina, C1425FVHLocal Institution - 0003 | Florida B, Argentina, 1602Local Institution - 0182 | Mar del Plata B, Argentina, 7600Local Institution - 0501 | Quilmes, Provincia de Buenos Aires B, Argentina, 1878Local Institution - 0162 | Ciudad Autónoma Buenos Aires C, Argentina, 1181Local Institution - 0032 | Córdoba Córdoba Province, Argentina, K5003DCELocal Institution - 0288 | Godoy Cruz M, Argentina, 5501Local Institution - 0401 | Mendoza M, Argentina, M5500Local Institution - 0400 | Rosario S, Argentina, 2000Local Institution - 0005 | San Miguel de Tucuman, Tucumán T, Argentina, T4000Local Institution - 0165 | Buenos Aires , Argentina, C1056ABJLocal Institution - 0450 | Santa Fe , Argentina, 3000Local Institution - 0065 | Camperdown New South Wales, Australia, 2050Local Institution - 0089 | Westmead New South Wales, Australia, 2145Local Institution - 0090 | Brisbane Queensland, Australia, 4032Local Institution - 0091 | Greenslopes Queensland, Australia, 4120Local Institution - 0342 | South Brisbane Queensland, Australia, 4101Local Institution - 0275 | Adelaide South Australia, Australia, 5000Local Institution - 0359 | Box Hill Victoria, Australia, 3128Local Institution - 0299 | Heidelberg,VIC Victoria, Australia, 3084Local Institution - 0059 | Melbourne Victoria, Australia, 3004Local Institution - 0303 | Murdoch Western Australia, Australia, 6150Local Institution - 0459 | Nedlands Western Australia, Australia, 6009Local Institution - 0474 | Salzburg Salzburger Land, Austria, 5020Local Institution - 0349 | Linz Upper Austria, Austria, 4020Local Institution - 0387 | Vienna , Austria, 1130Local Institution - 0475 | Vienna , Austria, 1210Local Institution - 0240 | Yvoir Namur, Belgium, 5530Local Institution - 0239 | Leuven VBR, Belgium, 3000Local Institution - 0242 | Brussels , Belgium, 1200Local Institution - 0257 | Kortrijk , Belgium, 8500Local Institution - 0237 | Liège , Belgium, 4000Local Institution - 0038 | Belo Horizonte Minas Gerais, Brazil, 30130-100Local Institution - 0017 | Belo Horizonte Minas Gerais, Brazil, 30380 090Local Institution - 0507 | Barra Mansa Rio de Janeiro, Brazil, 27323-240Local Institution - 0388 | Rio de Janeiro Rio de Janeiro, Brazil, 20950-003Local Institution - 0243 | Porto Alegre Rio Grande do Sul, Brazil, 90035-074Local Institution - 0016 | Porto Alegre Rio Grande do Sul, Brazil, 90160-092Local Institution - 0522 | Porto Alegre Rio Grande do Sul, Brazil, 91010-004Local Institution - 0048 | Blumenau Santa Catarina, Brazil, 89030-100Local Institution - 0047 | Botucatu São Paulo, Brazil, 18618-687Local Institution - 0403 | Santo André São Paulo, Brazil, 09060-870Local Institution - 0026 | São Bernardo do Campo São Paulo, Brazil, 09715-090Local Institution - 0042 | Porto Alegre , Brazil, 90610-000Local Institution - 0502 | São Paulo , Brazil, 01327-001Local Institution - 0006 | São Paulo , Brazil, 04032-052Local Institution - 0108 | Sherwood Park Alberta, Canada, T8H 0N2Local Institution - 0097 | Kelowna British Columbia, Canada, V1W 1V3Local Institution - 0107 | Vancouver British Columbia, Canada, V5Z 1M9Local Institution - 0462 | Vancouver British Columbia, Canada, V6Z 1Y6Local Institution - 0053 | Burlington Ontario, Canada, L7N 3V2Local Institution - 0111 | Hamilton Ontario, Canada, L8N 4A6Local Institution - 0075 | Owen Sound Ontario, Canada, N4K 6M9Local Institution - 0106 | Toronto Ontario, Canada, M5T 3A9Local Institution - 0440 | Montreal Quebec, Canada, H2X 0C1Local Institution - 0102 | Québec Quebec, Canada, G1V 4G5Local Institution - 0514 | Saint-Charles-Borromée Quebec, Canada, J6E 2B4Local Institution - 0099 | Sherbrooke Quebec, Canada, J1H 5N4Local Institution - 0074 | Trois-Rivières Quebec, Canada, G8T 7A1Local Institution - 0492 | Trois-Rivières Quebec, Canada, G9S4P3Local Institution - 0532 | Concepción Biobio, Chile, 4070280Local Institution - 0101 | Curicó Maule Region, Chile, 3440000Local Institution - 0104 | Talca Maule Region, Chile, 3466706Local Institution - 0109 | Santiago RM, Chile, 7620157Local Institution - 0112 | Santiago RM, Chile, 8320000Local Institution - 0094 | Quillota Valparaiso, Chile, 2260000Local Institution - 0530 | Viña del Mar Valparaiso, Chile, 2531172Local Institution - 0447 | Santiago , Chile, 750691Local Institution - 0489 | Viña del Mar , Chile, 1702Local Institution - 0087 | Hefei AH, China, 230022Local Institution - 0113 | Beijing Beijing Municipality, China, 100020Local Institution - 0086 | Beijing BJ, China, 100050Local Institution - 0100 | Beijing BJ, China, 100730Local Institution - 0322 | Lanzhou Gansu, China, 730000Local Institution - 0431 | Guangzhou GD, China, 510515Local Institution - 0308 | Guangzhou Guangdong, China, 510062Local Institution - 0494 | Guangzhou Guangdong, China, 510120Local Institution - 0085 | Shenzhen Guangdong, China, 518036Local Institution - 0510 | Shenzhen Shi Guangdong, China, 518020Local Institution - 0425 | Zhengzhou HA, China, 450003Local Institution - 0309 | Shijiazhuang Hebi, China, 50005Local Institution - 0495 | Yichang Shi HE, China, 443099Local Institution - 0455 | Zhengzhou HN, China, 450000Local Institution - 0312 | Wuhan Hubei, China, 430002Local Institution - 0432 | Wuhan HUB, China, 430060Local Institution - 0458 | Suzhou Jiangsu, China, 215006Local Institution - 0172 | Wuxi Jiangsu, China, 214023Local Institution - 0327 | Nanjing JS, China, 210008Local Institution - 0496 | Xuzhou JS, China, 221002Local Institution - 0443 | Nanchang JX, China, 330019Local Institution - 0323 | Shenyang Liaoning, China, 110001Local Institution - 0497 | Shenyang Liaoning, China, 110044Local Institution - 0311 | Xi'an Shan3xi, China, 710117Local Institution - 0329 | Shanghai Shanghai Municipality, China, 200002Local Institution - 0386 | Shanghai Shanghai Municipality, China, 200233Local Institution - 0096 | Shanghai Shanghai Municipality, China, 200433Local Institution - 0098 | Shanghai Shi Shanghai Municipality, China, 200032Local Institution - 0083 | Shanghai Shi Shanghai Sheng, China, 200092Local Institution - 0088 | Shanghai SH, China, 200030Local Institution - 0324 | Shanghai SH, China, 201112Local Institution - 0318 | Chengdu Sichuan, China, 610041Local Institution - 0372 | Tianjin Tianjin Municipality, China, 300052Local Institution - 0326 | Tianjin TJ, China, 300222Local Institution - 0454 | Ningxia Yinchuan, China, 750000Local Institution - 0508 | Hangzhou Zhejiang, China, 310009Local Institution - 0319 | Hangzhou Zhejiang, China, 310016Local Institution - 0298 | Ningbo Zhejiang, China, 315010Local Institution - 0429 | Hangzhou ZJ, China, 310006Local Institution - 0426 | Changsha , China, 410011Local Institution - 0313 | Chengdu , China, 610072Local Institution - 0084 | Hefei , China, 230001Local Institution - 0105 | Hohhot , China, 010010Local Institution - 0433 | Jinan , China, 250033Local Institution - 0434 | Shijiazhuang , China, 050051Local Institution - 0413 | Medellín ANT, Colombia, 050021Local Institution - 0515 | Medellín ANT, Colombia, 050034Local Institution - 0168 | Manizales CL, Colombia, 170004Local Institution - 0402 | Bogota Cundinamarca, Colombia, 110231Local Institution - 0076 | Zipaquirá Cundinamarca, Colombia, 250252Local Institution - 0408 | Bogotá DC, Colombia, 110111Local Institution - 0451 | Bogotá DC, Colombia, 110131Local Institution - 0175 | Floridablanca Santander Department, Colombia, 681004Local Institution - 0286 | Santiago de Cali VAC, Colombia, 760046Local Institution - 0095 | Bogotá , Colombia, 11031Local Institution - 0238 | Prague , Czechia, 140 52Local Institution - 0110 | Aarhus Central Jutland, Denmark, 8200Local Institution - 0103 | Odense C Region Syddanmark, Denmark, 5000Local Institution - 0333 | Copenhagen , Denmark, 2100Local Institution - 0092 | Hellerup , Denmark, 2900Local Institution - 0301 | Helsinki Etelae-Suomen Laeaeni, Finland, 00029Local Institution - 0265 | Turku Laensi-Suomen Laeaeni, Finland, 20521Local Institution - 0156 | Bron Auvergne-Rhône-Alpes, France, 69677Local Institution - 0254 | Grenoble Auvergne-Rhône-Alpes, France, 38043Local Institution - 0534 | Angers Pays de la Loire Region, France, 49933Local Institution - 0126 | Nantes Pays de la Loire Region, France, 44093Local Institution - 0279 | Marseille Provence-Alpes-Côte d'Azur Region, France, 13015Local Institution - 0130 | Bobigny , France, 93009Local Institution - 0278 | Brest , France, 29609Local Institution - 0136 | Dijon , France, 21000Local Institution - 0252 | Lille , France, 59037Local Institution - 0374 | Nice , France, 06000Local Institution - 0260 | Pessac , France, 33604Local Institution - 0146 | Toulouse , France, 31059Local Institution - 0263 | Tours , France, 37044Local Institution - 0236 | Paris Île-de-France Region, France, 75018Local Institution - 0135 | Freiburg I. Breisgau Baden-Wurttemberg, Germany, 79106Local Institution - 0125 | Wangen I. Allgaeu Baden-Wurttemberg, Germany, 88239Local Institution - 0152 | Munich Bavaria, Germany, 81377Local Institution - 0159 | Münnerstadt Bavaria, Germany, 97702Local Institution - 0141 | Immenhausen Hesse, Germany, 34376Local Institution - 0160 | Stralsund Mecklenburg-Vorpommern, Germany, 18435Local Institution - 0151 | Essen North Rhine-Westphalia, Germany, 45239Local Institution - 0393 | Cologne Northwest, Germany, 50678Local Institution - 0142 | Münster Northwest, Germany, 48149Local Institution - 0154 | Berlin State of Berlin, Germany, 14165Local Institution - 0132 | Ahrensburg , Germany, 22926Local Institution - 0287 | Berlin , Germany, 12351Local Institution - 0140 | Coswig , Germany, 01640Local Institution - 0248 | Hamburg , Germany, 20251Local Institution - 0340 | Heidelberg , Germany, 69126Local Institution - 0134 | Leipzig , Germany, 04103Local Institution - 0258 | Mainz , Germany, 55131Local Institution - 0244 | Marousi Attica, Greece, 15125Local Institution - 0115 | Ioannina Epirus, Greece, 45500Local Institution - 0410 | Heraklion Iraklio Kritis, Greece, 715 00Local Institution - 0118 | Athens , Greece, 12462Local Institution - 0064 | Corfu , Greece, 491 00Local Institution - 0114 | Larissa , Greece, 413 34Local Institution - 0122 | Rio , Greece, 26504Local Institution - 0268 | Thessaloniki , Greece, 57010Local Institution - 0035 | Budapest , Hungary, 1083Local Institution - 0280 | Győr , Hungary, 9024Local Institution - 0415 | Ahmedabad Gujarat, India, 380060Local Institution - 0167 | Surat Gujarat, India, 395010Local Institution - 0246 | Belagavi Karnataka, India, 590010Local Institution - 0382 | Bhopal Madhya Pradesh, India, 462001Local Institution - 0335 | Nagpur Maharashtra, India, 044009Local Institution - 0379 | Nagpur Maharashtra, India, 440012Local Institution - 0297 | Pune Maharashtra, India, 411001Local Institution - 0524 | Pune Maharashtra, India, 411001Local Institution - 0176 | Pune Maharashtra, India, 411004Local Institution - 0276 | Pune Maharashtra, India, 411043Local Institution - 0330 | New Delhi National Capital Territory of Delhi, India, 110017Local Institution - 0421 | New Delhi National Capital Territory of Delhi, India, 110029Local Institution - 0249 | Mohali Punjab, India, 160062Local Institution - 0247 | Jaipur Rajasthan, India, 302018Local Institution - 0266 | Jaipur Rajasthan, India, 302023Local Institution - 0490 | Lucknow Uttar Pradesh, India, 226003Local Institution - 0262 | Dehradun Uttarakhand, India, 248001Local Institution - 0264 | Kolkata West Bengal, India, 700014Local Institution - 0272 | Kolkata West Bengal, India, 700027Local Institution - 0291 | Bangalore , India, 560034Local Institution - 0250 | Lucknow , India, 226006Local Institution - 0150 | Drogheda LH, Ireland, A92 VW28Local Institution - 0513 | Dublin , Ireland, D04 T6F4Local Institution - 0213 | Dublin , Ireland, D15 X40DLocal Institution - 0345 | Dublin , Ireland, D24 NR0ALocal Institution - 0121 | Rehovot Central District, Israel, 76100Local Institution - 0339 | Beersheba D, Israel, 8410101Local Institution - 0116 | Haifa HA, Israel, 3436212Local Institution - 0027 | Be’er Ya‘aqov M, Israel, 7030000Local Institution - 0117 | Tel Aviv TA, Israel, 6423906Local Institution - 0273 | Haifa , Israel, 3109601Local Institution - 0120 | Jerusalem , Israel, 9112001Local Institution - 0119 | Petah Tikva , Israel, 4941492Local Institution - 0139 | Ancona AN, Italy, 60126Local Institution - 0282 | Modena Emilia-Romagna, Italy, 41125Local Institution - 0155 | Florence FI, Italy, 50134Local Institution - 0180 | Milan MI, Italy, 20122Local Institution - 0251 | Milan MI, Italy, 20132Local Institution - 0174 | Pisa PI, Italy, 56126Local Institution - 0137 | Roma RM, Italy, 00168Local Institution - 0166 | Trieste TS, Italy, 34149Local Institution - 0123 | Bergamo , Italy, 24127Local Institution - 0011 | Foggia , Italy, 71122Local Institution - 0124 | Forlì , Italy, 47121Local Institution - 0009 | Milan , Italy, 20142Local Institution - 0143 | Monza , Italy, 20900Local Institution - 0267 | Naples , Italy, 80131Local Institution - 0295 | Palermo , Italy, 90127Local Institution - 0290 | Pavia , Italy, 27100Local Institution - 0148 | Sassari , Italy, 7100Local Institution - 0442 | Siena , Italy, 53100Local Institution - 0235 | Showa-Ku Aichi-ken, Japan, 466-8560Local Institution - 0051 | Toyoake-shi Aichi-ken, Japan, 470-1192Local Institution - 0061 | Chiba Chiba, Japan, 2608677Local Institution - 0029 | Kamogawa-shi Chiba, Japan, 296-8602Local Institution - 0289 | Yoshida-gun Fukui, Japan, 910-1193Local Institution - 0302 | Chikushino-shi Fukuoka, Japan, 8188502Local Institution - 0233 | Fukuoka Fukuoka, Japan, 8108563Local Institution - 0461 | Fukuoka Fukuoka, Japan, 812-8582Local Institution - 0128 | Koriyama-shi Fukushima, Japan, 9630197Local Institution - 0001 | Naka-gun Gunma, Japan, 3191113Local Institution - 0300 | Hiroshima Hirohima-ken, Japan, 734-8530Local Institution - 0144 | Sapporo Hokkaido, Japan, 0608543Local Institution - 0063 | Sapporo Hokkaido, Japan, 0608648Local Institution - 0018 | Himeji-Shi Hyōgo, Japan, 670-8520Local Institution - 0145 | Kobe Hyōgo, Japan, 6500047Local Institution - 0261 | Sagamihara Kanagawa, Japan, 2520375Local Institution - 0307 | Matsusaka-shi Mie-ken, Japan, 515-8544Local Institution - 0157 | Nagasaki NGS, Japan, 852-8501Local Institution - 0227 | Osakasayama-shi Osaka, Japan, 589-8511Local Institution - 0149 | Sakai OSK, Japan, 591-8555Local Institution - 0138 | Hamamatsu Shizuoka, Japan, 431-3192Local Institution - 0226 | Bunkyō City TKY, Japan, 1138431Local Institution - 0034 | Shimotsuge-shi Tochigi, Japan, 329-0498Local Institution - 0230 | Tokushina-Shi Tokushima, Japan, 770-8503Local Institution - 0133 | Bunkyo-Ku Tokyo, Japan, 113-8519Local Institution - 0229 | Bunkyo-ku Tokyo, Japan, 113-8603Local Institution - 0253 | Meguro-ku Tokyo, Japan, 153-8515Local Institution - 0010 | Minato-ku Tokyo, Japan, 105-8470Local Institution - 0234 | Minato-ku Tokyo, Japan, 105-8471Local Institution - 0310 | Mitaka-shi Tokyo, Japan, 181-8611Local Institution - 0054 | Shinjuku-Ku Tokyo, Japan, 160-0023Local Institution - 0320 | Shinjuku-ku Tokyo, Japan, 160-8582Local Institution - 0055 | Shinjuku-Ku Tokyo, Japan, 162-0054Local Institution - 0523 | Ube-shi Yamaguchi, Japan, 755-0241Local Institution - 0228 | Bunkyō City , Japan, 113-8655Local Institution - 0231 | Fukuoka , Japan, 830-0011Local Institution - 0052 | Iizuka-shi , Japan, 820-8505Local Institution - 0127 | Izumo-Shi , Japan, 693-8501Local Institution - 0021 | Kumamoto , Japan, 861-4193Local Institution - 0129 | Seto , Japan, 489-8642Local Institution - 0147 | Shinjyu-Ku , Japan, 162-8655Local Institution - 0328 | Takatsuki-Shi , Japan, 569-8686Local Institution - 0002 | Tenri-Shi , Japan, 632-8552Local Institution - 0158 | Tokyo , Japan, 143-8541Local Institution - 0232 | Yokohama , Japan, 236-0051Local Institution - 0482 | Cheras Kuala Lumpur, Malaysia, 56000Local Institution - 0480 | Kuala Lumpur Kuala Lumpur, Malaysia, 53000Local Institution - 0484 | Kuching , Malaysia, 93586Local Institution - 0218 | Aguascalientes Aguascalientes, Mexico, 20116Local Institution - 0521 | México DIF, Mexico, 14050Local Institution - 0194 | Guadalajara Jalisco, Mexico, 44160Local Institution - 0511 | Guadalajara Jalisco, Mexico, 44340Local Institution - 0355 | Morelia Michoacán, Mexico, 58260Local Institution - 0375 | Oaxaca City Oaxaca, Mexico, 68000Local Institution - 0189 | Oaxaca City Oaxaca, Mexico, 68020Local Institution - 0030 | Córdoba Veracruz, Mexico, 94550Local Institution - 0406 | Mérida Yucatán, Mexico, 97070Local Institution - 0405 | Mérida Yucatán, Mexico, 97300Local Institution - 0493 | Chihuahua City , Mexico, 31200Local Institution - 0362 | Guadalajara , Mexico, 44130Local Institution - 0007 | Mexico City , Mexico, 14080Local Institution - 0315 | Leiden South Holland, Netherlands, 2333 ZALocal Institution - 0399 | Rotterdam South Holland, Netherlands, 3061BCLocal Institution - 0472 | Nieuwegein Utrecht, Netherlands, 3430Local Institution - 0350 | Amsterdam , Netherlands, 1081 BTLocal Institution - 0338 | Amsterdam , Netherlands, North HollandLocal Institution - 0439 | Heerlen , Netherlands, 6419 PCLocal Institution - 0369 | San Borja Lima region, Peru, 15036Local Institution - 0022 | Lima LIM, Peru, 15036Local Institution - 0409 | Lima LIM, Peru, 33Local Institution - 0225 | San Miguel LIM, Peru, 15088Local Institution - 0077 | Piura PIU, Peru, 20001Local Institution - 0012 | Lima , Peru, 15073Local Institution - 0044 | Lima , Peru, 31Local Institution - 0192 | Bydgoszcz Kuyavian-Pomeranian Voivodeship, Poland, 85-065Local Institution - 0206 | Bydgoszcz Kuyavian-Pomeranian Voivodeship, Poland, 85-079Local Institution - 0259 | Krakow Lesser Poland Voivodeship, Poland, 30-688Local Institution - 0201 | Bialystok Podlaskie Voivodeship, Poland, 15-044Local Institution - 0283 | Gdansk Pomeranian Voivodeship, Poland, 80-952Local Institution - 0271 | Olsztyn Warmian-Masurian Voivodeship, Poland, 10-357Local Institution - 0153 | Będzin , Poland, 42-500Local Institution - 0131 | Katowice , Poland, 40-635Local Institution - 0187 | Lodz , Poland, 90-153Local Institution - 0164 | Braga , Portugal, 4710-243Local Institution - 0202 | Lisbon , Portugal, 1169-024Local Institution - 0460 | Lisbon , Portugal, 1350-352Local Institution - 0173 | Lisbon , Portugal, 1769-001Local Institution - 0185 | Loures , Portugal, 2674-514Local Institution - 0199 | Porto , Portugal, 4099-001Local Institution - 0179 | Porto , Portugal, 4200-319Local Institution - 0161 | Vila Nova de Gaia , Portugal, 4434-502Local Institution - 0214 | Guaynabo PR, Puerto Rico, 968Local Institution - 0081 | Goyang-si Gyeonggi-do, South Korea, 10380Local Institution - 0430 | Goyang-si Gyeonggi-do, South Korea, 10475Local Institution - 0306 | Jongno-gu Seoul, South Korea, 03080Local Institution - 0060 | Songpa-gu Seoul, South Korea, 138-736Local Institution - 0284 | Yongsan-gu Seoul, South Korea, 4401Local Institution - 0453 | Dong-gu Ulsan, South Korea, 44033Local Institution - 0344 | Bucheon-si , South Korea, 14584Local Institution - 0062 | Bucheonsi Weonmigu , South Korea, 14647Local Institution - 0448 | Busan , South Korea, 47392Local Institution - 0058 | Gyeonggi-do , South Korea, 13620Local Institution - 0216 | Haeundae-Gu , South Korea, 48108Local Institution - 0057 | Iksansi , South Korea, 54538Local Institution - 0056 | Incheon , South Korea, 21565Local Institution - 0210 | Seoul , South Korea, 03722Local Institution - 0332 | Seoul , South Korea, 06355Local Institution - 0072 | Suwon , South Korea, 443-380Local Institution - 0169 | Badalona B, Spain, 08916Local Institution - 0390 | Barcelona B, Spain, 08035Local Institution - 0178 | Santander CB, Spain, 39008Local Institution - 0203 | Santiago de Compostela Galicia, Spain, 15706Local Institution - 0519 | Málaga MA, Spain, 29010Local Institution - 0177 | Madrid M, Spain, 28006Local Institution - 0163 | Madrid M, Spain, 28040Local Institution - 0184 | Madrid M, Spain, 28046Local Institution - 0188 | Majadahonda M, Spain, 28222Local Institution - 0208 | Oviedo Principality of Asturias, Spain, 33011Local Institution - 0197 | Valencia V, Spain, 46015Local Institution - 0204 | Barcelona , Spain, 08017Local Institution - 0449 | Barcelona , Spain, 08036Local Institution - 0293 | Barcelona , Spain, 08907Local Institution - 0518 | Madrid , Spain, 28027Local Institution - 0274 | Madrid , Spain, 28040Local Institution - 0438 | Madrid , Spain, 28822Local Institution - 0270 | Pamplona , Spain, 31008Local Institution - 0170 | Basel Canton of Basel-City, Switzerland, 4031Local Institution - 0477 | Bern Canton of Bern, Switzerland, 3010Local Institution - 0486 | Geneva Canton of Geneva, Switzerland, 1205Local Institution - 0506 | Changhua CHA, Taiwan, 500Local Institution - 0500 | Kaohsiung City Kao-Hsiung, Taiwan, 83301Local Institution - 0255 | Kaohsiung City KHH, Taiwan, 807Local Institution - 0498 | Taichung TXG, Taiwan, 40447Local Institution - 0296 | Douliu Shi YUN, Taiwan, 640Local Institution - 0417 | Taichung , Taiwan, 40705Local Institution - 0269 | Taipei , Taiwan, 100Local Institution - 0277 | Taipei , Taiwan, 112Local Institution - 0191 | Bursa , Turkey (Türkiye), 16059Local Institution - 0215 | Izmir , Turkey (Türkiye), 35100Local Institution - 0222 | Izmir , Turkey (Türkiye), 35110Local Institution - 0281 | Topkapı , Turkey (Türkiye), 34093Local Institution - 0377 | Birmingham BIR, United Kingdom, B9 5SSLocal Institution - 0337 | Cambridge Cambridgeshire, United Kingdom, CB2 0AYLocal Institution - 0183 | Dundee DND, United Kingdom, DD1 9SYLocal Institution - 0171 | Edinburgh EDH, United Kingdom, EH16 4SALocal Institution - 0292 | London Greater London, United Kingdom, SW3 6NPLocal Institution - 0370 | Oxford Oxfordshire, United Kingdom, OX3 7LELocal Institution - 0285 | Peterborough PTE, United Kingdom, PE3 9GZLocal Institution - 0219 | Exeter South West, United Kingdom, EX2 5DWLocal Institution - 0444 | Leeds West Yorkshire, United Kingdom, LS9 7TFLocal Institution - 0358 | Cottingham Yorkshire and the Humber, United Kingdom, HU16 5JQLocal Institution - 0394 | Birmingham , United Kingdom, B15 2WB
Investigators
Study Director: Bristol-Myers Squibb, Bristol-Myers Squibb