A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56

Recruitment Status: ACTIVE, NOT RECRUITING
(See Contacts and Locations)Verified March 2026 by EyePoint Pharmaceuticals, Inc.
Sponsor: EyePoint Pharmaceuticals, Inc.
Information Provided by (Responsible Party): EyePoint Pharmaceuticals, Inc.

Clinicaltrials.gov Identifier: NCT06683742
Other Study ID Numbers:: EYP-1901-302

First Submitted: November 7, 2024
First Posted: November 11, 2024
Last Update Posted: April 1, 2026
Last Verified: March 2026

ClinicalTrials.gov processed this data on March 2026. Link to the current ClinicalTrials.gov record .

Study Details

Study Description

Condition or Disease	Intervention/Treatment
Wet Age Related Macular DegenerationwAMD	Drug: EYP-1901Drug: Aflibercept (2.0 mg)

Study Design

Study Type	Interventional
Actual Enrollment	400 participants
Design Allocation	Randomized
Interventional Model	Parallel Assignment
Masking	Quadruple
Primary Purpose	Treatment
Official Title	A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD
Study Start Date	November 26, 2024
Actual Primary Completion Date	5mos 1w from now
Actual Study Completion Date	1yr 5mos from now

Groups and Cohorts

Group/Cohort	Intervention/Treatment
EYP-1901 2686 µg EYP-1901	Drug: EYP-1901 Intravitreal Injection
Aflibercept	Drug: Aflibercept (2.0 mg) Intravitreal Injection

Outcome Measures

Primary Outcome Measures

Average change in best corrected visual acuity (BCVA)

Secondary Outcome Measures

Rate of injection burden
Average change in best corrected visual acuity (BCVA)

Eligibility Criteria

Ages Eligible for Study	(Adult, Older Adult)
Sexes Eligible for Study	All
Accepts Healthy Volunteers	No
Inclusion Criteria	Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit. Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1). For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.
Exclusion Criteria	Subfoveal fibrosis, atrophy, or scarring in the center subfield. BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.

Contacts and Locations

Sponsors and Collaborators	EyePoint Pharmaceuticals, Inc.
Locations	Associated Retina Consultans \| Gilbert Arizona, United States, 85297Associated Retina Consultants - Phoenix \| Phoenix Arizona, United States, 85020Phoenix Retina Clinical Trials, LLC \| Phoenix Arizona, United States, 85050Retina Macula Institute of Arizona \| Scottsdale Arizona, United States, 85255Win Retina \| Arcadia California, United States, 91006Doctor Retina, PC \| Beverly Hills California, United States, 90211The Retina Partners \| Encino California, United States, 91436RCOC Clinical Research Institute Inc. \| Fullerton California, United States, 92835Global Research Management, Inc. \| Glendale California, United States, 91204Atlantis Eyecare \| Huntington Beach California, United States, 92647South Coast Retina Center \| Long Beach California, United States, 90807Retinal Consultants Medical Group \| Modesto California, United States, 95356Northern California Retina Vitreous Associates Medical Group INC. \| Mountain View California, United States, 94040Kaiser Permanente \| Oakland California, United States, 94611California Retina Consultants Oxnard Office \| Oxnard California, United States, 93036Retina Consultants San Diego \| Poway California, United States, 92064California Eye Specialists Medical Group, Inc. \| Redlands California, United States, 92373Retina Consultants of Southern California \| Redlands California, United States, 92374VRMG Inc \| Sacramento California, United States, 95825West Coast Retina Medical Group \| San Francisco California, United States, 94109Macula Retina Vitreous Research Institute \| Torrance California, United States, 90503Bay Area Retina Associates \| Walnut Creek California, United States, 94598Retina Consultants of Southern Colorado \| Colorado Springs Colorado, United States, 80909RSC Research, PLLC \| Denver Colorado, United States, 80210Eye Center of Northern Colorado, PC \| Fort Collins Colorado, United States, 80528Colorado Retina Associates \| Lakewood Colorado, United States, 80228Connecticut Eye Consultants, P.C. \| Danbury Connecticut, United States, 06810SightSera Clinical Research LLC \| Greenwich Connecticut, United States, 06830Blue Ocean Clinical Research \| Clearwater Florida, United States, 33761Rand Eye Institute \| Deerfield Beach Florida, United States, 33064Retina Group of Florida \| Fort Lauderdale Florida, United States, 33308National Ophthalmic Research Institute \| Fort Myers Florida, United States, 33912The Eye Institute of West Florida \| Largo Florida, United States, 33770Retina Care Specialists \| Palm Beach Gardens Florida, United States, 45674Fort Lauderdale Eye Institute \| Plantation Florida, United States, 33324MedEye Associates \| South Miami Florida, United States, 33143Retina Vitreous Associates of Florida - Saint Petersburg \| St. Petersburg Florida, United States, 33711East Florida Eye Institute \| Stuart Florida, United States, 34994Retina Specialists of Tampa \| Tampa Florida, United States, 33618Gailey Eye Clinic \| Bloomington Illinois, United States, 60616Retina Associates \| Elmhurst Illinois, United States, 60126Illinois Retina Associates, S.C. \| Oak Park Illinois, United States, 60304Red River Research Partners \| Plainfield Illinois, United States, 60586AVRUC \| Carmel Indiana, United States, 46032Retina Associates of Kentucky \| Lexington Kentucky, United States, 40509The Eye Care Institute \| Louisville Kentucky, United States, 40206Retina Associates New Orleans \| Metairie Louisiana, United States, 70006Haik Humble Eye Center \| West Monroe Louisiana, United States, 71291Cumberland Valley Retina Consultants \| Hagerstown Maryland, United States, 21740Mid Atlantic Retina Specialists \| Hagerstown Maryland, United States, 21740Vitreo-Retinal Associates, PC \| Worcester Massachusetts, United States, 01605Retina Associates of Michigan \| Grand Blanc Michigan, United States, 48439Discover Vision Center \| Independence Missouri, United States, 64081Envision Ocular, LLC \| Bloomfield New Jersey, United States, 07003Mid Atlantic Retina \| Cherry Hill New Jersey, United States, 08034NJ Retina \| Edison New Jersey, United States, 08820NJ Retina \| Toms River New Jersey, United States, 08755Retina Vitreous Surgeons of CNY, PC \| Liverpool New York, United States, 13088NYC Retina \| New York New York, United States, 45604Retina Associates of Western NY, PC \| Rochester New York, United States, 14620VRCNY/Long Island Vitreoretinal Consultants \| Westbury New York, United States, 11590NC Retina Associates - Cary Research \| Cary North Carolina, United States, 27511Graystone Eye - Hickory Office \| Hickory North Carolina, United States, 28602North Carolina Retina Associates \| Wake Forest North Carolina, United States, 27587Retina Vitreous Center, PLLC \| Edmond Oklahoma, United States, 73013Cascade Medical Research lnstitute, LLC \| Springfield Oregon, United States, 97477Wills Eye Physician Mid Atlantic Retina \| Bethlehem Pennsylvania, United States, 18017Retina Vitreous Consultants (RVC) - Monroeville \| Monroeville Pennsylvania, United States, 45674Charleston Neuroscience Institute \| Ladson South Carolina, United States, 29456Black Hills Regional Eye Institute \| Rapid City South Dakota, United States, 45526Tennessee Retina \| Nashville Tennessee, United States, 37203Panhandle Eye Group, LLP. - Southwest Retina Specialists \| Amarillo Texas, United States, 79106Texas Retina Associates \| Arlington Texas, United States, 76012Austin Research Center for Retina \| Austin Texas, United States, 45674Austin Retina Associates \| Austin Texas, United States, 78705Austin Clinical Research LLC \| Austin Texas, United States, 78750TX RCTX Retina Consultants of Texas \| Beaumont Texas, United States, 77707Star Vision Research \| Burleson Texas, United States, 76028Retina of North Texas \| Dallas Texas, United States, 75243Berkeley Eye Center \| Houston Texas, United States, 77027Retina Consultants of Texas \| Katy Texas, United States, 77494Valley Retina Institute P.A. \| McAllen Texas, United States, 78503Red River Research Partners, LLC \| Plano Texas, United States, 75024Texas Retina Associates \| Plano Texas, United States, 75075TX RCTX Retina Consultants of Texas \| San Antonio Texas, United States, 78154San Antonio Eye Center \| San Antonio Texas, United States, 78215Retina Associates of South Texas \| San Antonio Texas, United States, 78240Tyler Retina Consultants \| Tyler Texas, United States, 75703Retina Associates of Utah \| Salt Lake City Utah, United States, 84107The Retina Group of Washington \| Fairfax Virginia, United States, 22031Emerson Clinical Research Institute \| Falls Church Virginia, United States, 22046Virginia Retina Center \| Warrenton Virginia, United States, 20186Pacific Northwest Retina \| Bellevue Washington, United States, 98004Retina Prime at Jardim Europa Medical Center \| Aracaju , Brazil, Centro Brasileiro de Pesquisa Clinica - Blumenau \| Blumenau , Brazil, Clínica Oftalmológica São Lucas - Retina Clinic \| São Paulo , Brazil, Hospital de Olhos Oeste Paulista \| São Paulo , Brazil, Hospital Oftalmológico de Sorocaba (Centro de Estudos) \| Sorocaba , Brazil, VISUS, spol s.r.o. \| Náchod , Czechia, Axon Clinical, s.r.o. \| Prague , Czechia, Fakultni nemocnice Kralovske Vinohrady \| Prague , Czechia, St Elisabeth Krankenhaus \| Cologne , Germany, Bajcsy-Zsilinszky Korhaz es Rendelointezet \| Budapest , Hungary, Budapest Retina Associates \| Budapest , Hungary, Debreceni Egyetem KK Szemklinika \| Debrecen , Hungary, Ganglion Medical Center \| Pécs , Hungary, Rising Retina Clinic \| Ahmedabad , India, Netralayam VIP \| Kolkata , India, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology \| Madurai , India, Shanti Saroj Netralay \| Miraj , India, K. B. Haji Bachooali Charitable Ophthalmic & E.N.T. Hospital \| Mumbai , India, Shroff Eye Hospital \| Mumbai , India, Netrodaya - The Eye City \| Varanasi , India, Shamir Medical Center Ophthalmology Out Patient Clinic \| Be’er Ya‘aqov , Israel, Bnai Zion Medical Center \| Haifa , Israel, Carmel Medical Center \| Haifa , Israel, Meir Medical Center Ophthalmology Department \| Kfar Saba , Israel, Rabin Medical Center \| Petah Tikva , Israel, Kaplan Medical Center \| Rehovot , Israel, The Tel-Aviv Sourasky Medical Centre \| Tel Aviv , Israel, OFTALMIKA Sp. z o.o \| Bydgoszcz , Poland, Szpital sw. Rozy- obsolete; New Name: Szpital Św. Róży sp. z o.o. \| Krakow , Poland, Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie \| Lublin , Poland, Centrum Diagnostyki i Mikrochirurgii Oka -LENS Sp. z o. o \| Olsztyn , Poland, Centrum Medyczne UNO-MED \| Tarnów , Poland, Piasta 47 Centrum Medyczne \| Warsaw , Poland, Warszawski Szpital Okulistyczny \| Warsaw , Poland, Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica \| Banská Bystrica , Slovakia, Imperial College Healthcare NHS Trust \| London , United Kingdom,

Sponsors and Collaborators

EyePoint Pharmaceuticals, Inc.

Locations

Associated Retina Consultans | Gilbert Arizona, United States, 85297Associated Retina Consultants - Phoenix | Phoenix Arizona, United States, 85020Phoenix Retina Clinical Trials, LLC | Phoenix Arizona, United States, 85050Retina Macula Institute of Arizona | Scottsdale Arizona, United States, 85255Win Retina | Arcadia California, United States, 91006Doctor Retina, PC | Beverly Hills California, United States, 90211The Retina Partners | Encino California, United States, 91436RCOC Clinical Research Institute Inc. | Fullerton California, United States, 92835Global Research Management, Inc. | Glendale California, United States, 91204Atlantis Eyecare | Huntington Beach California, United States, 92647South Coast Retina Center | Long Beach California, United States, 90807Retinal Consultants Medical Group | Modesto California, United States, 95356Northern California Retina Vitreous Associates Medical Group INC. | Mountain View California, United States, 94040Kaiser Permanente | Oakland California, United States, 94611California Retina Consultants Oxnard Office | Oxnard California, United States, 93036Retina Consultants San Diego | Poway California, United States, 92064California Eye Specialists Medical Group, Inc. | Redlands California, United States, 92373Retina Consultants of Southern California | Redlands California, United States, 92374VRMG Inc | Sacramento California, United States, 95825West Coast Retina Medical Group | San Francisco California, United States, 94109Macula Retina Vitreous Research Institute | Torrance California, United States, 90503Bay Area Retina Associates | Walnut Creek California, United States, 94598Retina Consultants of Southern Colorado | Colorado Springs Colorado, United States, 80909RSC Research, PLLC | Denver Colorado, United States, 80210Eye Center of Northern Colorado, PC | Fort Collins Colorado, United States, 80528Colorado Retina Associates | Lakewood Colorado, United States, 80228Connecticut Eye Consultants, P.C. | Danbury Connecticut, United States, 06810SightSera Clinical Research LLC | Greenwich Connecticut, United States, 06830Blue Ocean Clinical Research | Clearwater Florida, United States, 33761Rand Eye Institute | Deerfield Beach Florida, United States, 33064Retina Group of Florida | Fort Lauderdale Florida, United States, 33308National Ophthalmic Research Institute | Fort Myers Florida, United States, 33912The Eye Institute of West Florida | Largo Florida, United States, 33770Retina Care Specialists | Palm Beach Gardens Florida, United States, 45674Fort Lauderdale Eye Institute | Plantation Florida, United States, 33324MedEye Associates | South Miami Florida, United States, 33143Retina Vitreous Associates of Florida - Saint Petersburg | St. Petersburg Florida, United States, 33711East Florida Eye Institute | Stuart Florida, United States, 34994Retina Specialists of Tampa | Tampa Florida, United States, 33618Gailey Eye Clinic | Bloomington Illinois, United States, 60616Retina Associates | Elmhurst Illinois, United States, 60126Illinois Retina Associates, S.C. | Oak Park Illinois, United States, 60304Red River Research Partners | Plainfield Illinois, United States, 60586AVRUC | Carmel Indiana, United States, 46032Retina Associates of Kentucky | Lexington Kentucky, United States, 40509The Eye Care Institute | Louisville Kentucky, United States, 40206Retina Associates New Orleans | Metairie Louisiana, United States, 70006Haik Humble Eye Center | West Monroe Louisiana, United States, 71291Cumberland Valley Retina Consultants | Hagerstown Maryland, United States, 21740Mid Atlantic Retina Specialists | Hagerstown Maryland, United States, 21740Vitreo-Retinal Associates, PC | Worcester Massachusetts, United States, 01605Retina Associates of Michigan | Grand Blanc Michigan, United States, 48439Discover Vision Center | Independence Missouri, United States, 64081Envision Ocular, LLC | Bloomfield New Jersey, United States, 07003Mid Atlantic Retina | Cherry Hill New Jersey, United States, 08034NJ Retina | Edison New Jersey, United States, 08820NJ Retina | Toms River New Jersey, United States, 08755Retina Vitreous Surgeons of CNY, PC | Liverpool New York, United States, 13088NYC Retina | New York New York, United States, 45604Retina Associates of Western NY, PC | Rochester New York, United States, 14620VRCNY/Long Island Vitreoretinal Consultants | Westbury New York, United States, 11590NC Retina Associates - Cary Research | Cary North Carolina, United States, 27511Graystone Eye - Hickory Office | Hickory North Carolina, United States, 28602North Carolina Retina Associates | Wake Forest North Carolina, United States, 27587Retina Vitreous Center, PLLC | Edmond Oklahoma, United States, 73013Cascade Medical Research lnstitute, LLC | Springfield Oregon, United States, 97477Wills Eye Physician Mid Atlantic Retina | Bethlehem Pennsylvania, United States, 18017Retina Vitreous Consultants (RVC) - Monroeville | Monroeville Pennsylvania, United States, 45674Charleston Neuroscience Institute | Ladson South Carolina, United States, 29456Black Hills Regional Eye Institute | Rapid City South Dakota, United States, 45526Tennessee Retina | Nashville Tennessee, United States, 37203Panhandle Eye Group, LLP. - Southwest Retina Specialists | Amarillo Texas, United States, 79106Texas Retina Associates | Arlington Texas, United States, 76012Austin Research Center for Retina | Austin Texas, United States, 45674Austin Retina Associates | Austin Texas, United States, 78705Austin Clinical Research LLC | Austin Texas, United States, 78750TX RCTX Retina Consultants of Texas | Beaumont Texas, United States, 77707Star Vision Research | Burleson Texas, United States, 76028Retina of North Texas | Dallas Texas, United States, 75243Berkeley Eye Center | Houston Texas, United States, 77027Retina Consultants of Texas | Katy Texas, United States, 77494Valley Retina Institute P.A. | McAllen Texas, United States, 78503Red River Research Partners, LLC | Plano Texas, United States, 75024Texas Retina Associates | Plano Texas, United States, 75075TX RCTX Retina Consultants of Texas | San Antonio Texas, United States, 78154San Antonio Eye Center | San Antonio Texas, United States, 78215Retina Associates of South Texas | San Antonio Texas, United States, 78240Tyler Retina Consultants | Tyler Texas, United States, 75703Retina Associates of Utah | Salt Lake City Utah, United States, 84107The Retina Group of Washington | Fairfax Virginia, United States, 22031Emerson Clinical Research Institute | Falls Church Virginia, United States, 22046Virginia Retina Center | Warrenton Virginia, United States, 20186Pacific Northwest Retina | Bellevue Washington, United States, 98004Retina Prime at Jardim Europa Medical Center | Aracaju , Brazil, Centro Brasileiro de Pesquisa Clinica - Blumenau | Blumenau , Brazil, Clínica Oftalmológica São Lucas - Retina Clinic | São Paulo , Brazil, Hospital de Olhos Oeste Paulista | São Paulo , Brazil, Hospital Oftalmológico de Sorocaba (Centro de Estudos) | Sorocaba , Brazil, VISUS, spol s.r.o. | Náchod , Czechia, Axon Clinical, s.r.o. | Prague , Czechia, Fakultni nemocnice Kralovske Vinohrady | Prague , Czechia, St Elisabeth Krankenhaus | Cologne , Germany, Bajcsy-Zsilinszky Korhaz es Rendelointezet | Budapest , Hungary, Budapest Retina Associates | Budapest , Hungary, Debreceni Egyetem KK Szemklinika | Debrecen , Hungary, Ganglion Medical Center | Pécs , Hungary, Rising Retina Clinic | Ahmedabad , India, Netralayam VIP | Kolkata , India, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology | Madurai , India, Shanti Saroj Netralay | Miraj , India, K. B. Haji Bachooali Charitable Ophthalmic & E.N.T. Hospital | Mumbai , India, Shroff Eye Hospital | Mumbai , India, Netrodaya - The Eye City | Varanasi , India, Shamir Medical Center Ophthalmology Out Patient Clinic | Be’er Ya‘aqov , Israel, Bnai Zion Medical Center | Haifa , Israel, Carmel Medical Center | Haifa , Israel, Meir Medical Center Ophthalmology Department | Kfar Saba , Israel, Rabin Medical Center | Petah Tikva , Israel, Kaplan Medical Center | Rehovot , Israel, The Tel-Aviv Sourasky Medical Centre | Tel Aviv , Israel, OFTALMIKA Sp. z o.o | Bydgoszcz , Poland, Szpital sw. Rozy- obsolete; New Name: Szpital Św. Róży sp. z o.o. | Krakow , Poland, Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie | Lublin , Poland, Centrum Diagnostyki i Mikrochirurgii Oka -LENS Sp. z o. o | Olsztyn , Poland, Centrum Medyczne UNO-MED | Tarnów , Poland, Piasta 47 Centrum Medyczne | Warsaw , Poland, Warszawski Szpital Okulistyczny | Warsaw , Poland, Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica | Banská Bystrica , Slovakia, Imperial College Healthcare NHS Trust | London , United Kingdom,