Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis

Recruitment Status: ACTIVE, NOT RECRUITING
(See Contacts and Locations)Verified March 2026 by Alumis Inc
Sponsor: Alumis Inc
Information Provided by (Responsible Party): Alumis Inc

Clinicaltrials.gov Identifier: NCT06846541
Other Study ID Numbers:: ESK-001-018

First Submitted: January 26, 2025
First Posted: February 25, 2025
Last Update Posted: April 12, 2026
Last Verified: March 2026

ClinicalTrials.gov processed this data on April 2026. Link to the current ClinicalTrials.gov record .

Study Details

Study Description

Condition or Disease	Intervention/Treatment
Plaque PsoriasisPsoriasis (PsO)PsoriasisModerate PsoriasisSevere Psoriasis	Drug: Open-Label EnvudeucitinibDrug: Blinded EnvudeucitinibDrug: Placebo

Study Design

Study Type	Interventional
Actual Enrollment	1680 participants
Design Allocation	Randomized
Interventional Model	Parallel Assignment
Masking	Quadruple
Primary Purpose	Treatment
Official Title	An Extension Study in Patients With Moderate to Severe Plaque Psoriasis to Evaluate the Long-term Safety, Efficacy, and Durability of Response to ESK-001
Study Start Date	January 7, 2025
Actual Primary Completion Date	2yrs 5mos from now
Actual Study Completion Date	2yrs 5mos from now

Groups and Cohorts

Group/Cohort	Intervention/Treatment
Open-Label ESK-001 Open-Label ESK-001 administered as an oral tablet	Drug: Open-Label Envudeucitinib Open-Label ESK-001
Blinded ESK-001 Blinded ESK-001 administered as an oral tablet	Drug: Blinded Envudeucitinib Blinded ESK-001 during Randomized Treatment Withdrawal Period
Placebo Matching placebo administered as an oral tablet	Drug: Placebo Placebo during Randomized Treatment Withdrawal Period

Outcome Measures

Primary Outcome Measures

To assess the long-term safety and tolerability of ESK-001 throughout the duration of the study
Incidence and severity of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs)

Secondary Outcome Measures

To assess the long-term efficacy of ESK-001 using the Psoriasis Area and Severity Index (PASI-75)
Proportion of patients achieving ≥75% reduction in PASI
To assess the long-term efficacy of ESK-001 using the Psoriasis Area and Severity Index (PASI-90)
Proportion of patients achieving ≥90% reduction in PASI
To assess the long-term efficacy of ESK-001 using the Psoriasis Area and Severity Index (PASI-100)
Proportion of patients achieving 100% reduction in PASI
To assess the long-term efficacy of ESK-001 using the Static Physician's Global Assessment (sPGA 0/1)
Proportion of patients achieving a score of 0 or 1 on sPGA
To assess the long-term efficacy of ESK-001 based on change in Psoriasis Area and Severity Index (PASI)
Change in Psoriasis Area and Severity Index (PASI) from baseline assessments
To assess the long-term efficacy of ESK-001 based on change in Affected Body Surface Area (%BSA)
Change in affected body surface area (%BSA) from baseline assessments
To characterize the loss of PASI-75 response following withdrawal of ESK-001 treatment (only for patients randomized to the treatment withdrawal phase)
Median time to loss of PASI-75 response
To characterize the loss of PASI-90 response following withdrawal of ESK-001 treatment (only for patients randomized to the treatment withdrawal phase)
Median time to loss of PASI-90 response
To characterize the loss of sPGA-0/1 response following withdrawal of ESK-001 treatment (only for patients randomized to the treatment withdrawal phase)
Median time to loss of sPGA-0/1 response
To assess the change in quality of life (QoL) using Dermatology Life Quality Index after long-term ESK-001 administration
Proportion of patients achieving a DLQI-0/1 score of 0 (no effect) or 1 (minimal effect)

Eligibility Criteria

Ages Eligible for Study	(Adult, Older Adult)
Sexes Eligible for Study	All
Accepts Healthy Volunteers	No
Inclusion Criteria	1. Males or females, age ≥18 years 2. Completed either of the two previous (parent) studies of ESK-001 (ESK-001-016 or ESK-001-017) 3. ESK-001 safety and tolerability were acceptable in the parent study 4. Women of childbearing potential (WOCBP) and males who are sexually active with WOCBP must agree to adhere to highly effective methods of contraception for the entirety of the study
Exclusion Criteria	1. Pregnant, lactating, or planning to get pregnant during the study period 2. Any acute or chronic illness/condition or evidence of an unstable clinical condition that in the Investigator's judgment will substantially increase the risk to the patient if they continue to receive ESK-001 treatment in this extension study 3. Deemed by the Investigator to be inappropriate for the study or unable to comply with the protocol

Contacts and Locations

Sponsors and Collaborators	Alumis Inc
Locations	Total Dermatology \| Birmingham Alabama, United States, 35203Chandler Clinical Trials \| Chandler Arizona, United States, 85224Alliance Dermatology \| Pheonix Arizona, United States, 85032Scottsdale Clinical Trials \| Scottsdale Arizona, United States, 85260Noble Clinical Research \| Tucson Arizona, United States, 85704Northwest AR Clinical Trials Center PLLC \| Rogers Arkansas, United States, 72758Zenith Research Inc. \| Beverly Hills California, United States, 90212Exalt Clinical Research Inc \| Chula Vista California, United States, 91910California Dermatology and Clinical Research Institute \| Encinitas California, United States, 92024Raoof MD \| Encino California, United States, 91436First OC Dermatology Research Inc \| Fountain Valley California, United States, 92708Marvel Clinical Research LLC \| Huntington Beach California, United States, 92647Long Beach Research Institute \| Long Beach California, United States, 90805Olive View UCLA Education and Research Institute \| Los Angeles California, United States, 90024Dermatology Research Associates \| Los Angeles California, United States, 90045Wallace Medical Group Inc \| Los Angeles California, United States, 90056Northridge Clinical Trials \| Northridge California, United States, 91325Pasadena Clinical Trials \| Pasadena California, United States, 91101Empire Clinical Research Pomona \| Pomona California, United States, 91767Integrative Skin Science and Research \| Sacramento California, United States, 95815Therapeutics Clinical Research \| San Diego California, United States, 92123Southern California Clinical Research \| Santa Ana California, United States, 92701Clinical Science Institute Dermatology Institute \| Santa Monica California, United States, 90404Unison Clinical Trials \| Sherman Oaks California, United States, 91403California Dermatology Institute Thousand Oaks \| Thousand Oaks California, United States, 91320Sunwise Clinical Research LLC \| Walnut Creek California, United States, 94596Clearlyderm Dermatology West Boca Raton \| Boca Raton Florida, United States, 33428Driven Clinical Research \| Coral Gables Florida, United States, 33134FXM Clinical Research Ft. Lauderdale LLC \| Fort Lauderdale Florida, United States, 33308Direct Helpers Research Center \| Hialeah Florida, United States, 33012Jacksonville Center for Clinical Research \| Jacksonville Florida, United States, 32216Glick Skin Institute \| Margate Florida, United States, 33063AppleMed Research Group \| Miami Florida, United States, 33126FAX Pharma Clinical Research Inc \| Miami Florida, United States, 33146FXM Clinical Research Miami LLC \| Miami Florida, United States, 33175Las Mercedes Medical Research \| Miami Florida, United States, 33196Procare Research Center \| Miami Gardens Florida, United States, 33014San Marcus Research Clinic Inc - Miami \| Miami Lakes Florida, United States, 33014Savin Medical Group LLC \| Miami Lakes Florida, United States, 33014FXM Clinical Research Miramar LLC \| Miramar Florida, United States, 33027Oceanic Research Group \| North Miami Beach Florida, United States, 33169Renstar Medical Research \| Ocala Florida, United States, 34470Lenus Research and Medical Group LLC \| Sweetwater Florida, United States, 33172Advanced Clinical Research Institute \| Tampa Florida, United States, 33607ForCare Medical Center \| Tampa Florida, United States, 33613Arlington Dermatology \| Rolling Meadows Illinois, United States, 60008NorthShore Medical Group Dermatology Skokie \| Skokie Illinois, United States, 60077Dundee Dermatology \| West Dundee Illinois, United States, 60118DS Research of Southern Indiana \| Clarksville Indiana, United States, 47129Dawes Fretzin Clinical Research Group \| Columbus Indiana, United States, 47201The Indiana Clinical Trials Center \| Plainfield Indiana, United States, 46168The South Bend Clinic \| South Bend Indiana, United States, 46617Equity Medical \| Bowling Green Kentucky, United States, 42104DS Research of Kentucky \| Louisville Kentucky, United States, 40241Velocity Clinical Research \| Baton Rouge Louisiana, United States, 70808Tulane University School of Medicine \| New Orleans Louisiana, United States, 70112MetroBoston Clinical Partners \| Brighton Massachusetts, United States, 02135Michigan Center for Research Company \| Clarkston Michigan, United States, 48346Henry Ford Medical Center Farmington \| Detroit Michigan, United States, 48202Revival Research Institute \| Troy Michigan, United States, 48084Grekin Skin Institute \| Warren Michigan, United States, 48088Associated Skin Care Specialists Minnesota Clinical Study Center \| New Brighton Minnesota, United States, 55112Cleaver Dermatology \| Kirksville Missouri, United States, 63501Schlessinger MD \| Omaha Nebraska, United States, 68144Las Vegas Clinical Trials \| Las Vegas Nevada, United States, 89030NYC Health and Hospitals Elmhurst \| Elmhurst New York, United States, 11373Pioneer Clinical Research NY \| New York New York, United States, 10016Cameron Dermatology \| New York New York, United States, 10023OptiSkin \| New York New York, United States, 10128DermResearchCenter of New York \| Stony Brook New York, United States, 11790Asheville Clinical Trials \| Asheville North Carolina, United States, 28803WDC Cosmetic and Research \| Wilmington North Carolina, United States, 28405Optima Research Boardman \| Boardman Ohio, United States, 44512The Ohio State University Wexner Medical Center OSUWMC OSU Dermatology East Columbus \| Gahanna Ohio, United States, 43230Dermatologists of Southwestern Ohio LLC \| Mason Ohio, United States, 45040Unity Clinical Research UCR \| Oklahoma City Oklahoma, United States, 73118Velocity Clinical Research \| Medford Oregon, United States, 97504Oregon Medical Research Center \| Portland Oregon, United States, 97201Paddington Testing Company Inc \| Philadelphia Pennsylvania, United States, 19103UPMC Department of Dermatology \| Pittsburgh Pennsylvania, United States, 15213Clinical Partners LLC \| Johnston Rhode Island, United States, 02919Studies in Dermatology LLC \| Cypress Texas, United States, 77433Modern Research Associates PLLC \| Dallas Texas, United States, 75231Reveal Research Institute \| Frisco Texas, United States, 75033Center for Clinical Studies Texas Medical Center \| Houston Texas, United States, 77004Austin Institute for Clinical Research \| Houston Texas, United States, 77056SMS Clinical Research \| Mesquite Texas, United States, 75149Progressive Clinical Research San Antonio \| San Antonio Texas, United States, 78213Center for Clinical Studies (CCS) - Webster/Clear Lake Location \| Webster Texas, United States, 77598University of Utah Health Care Midvalley Health Center \| Murray Utah, United States, 84107Jordan Valley Dermatology \| South Jordan Utah, United States, 84095Frontier Dermatology \| Mill Creek Washington, United States, 98012Premier Specialist \| Kogarah New South Wales, Australia, 2217North Eastern Health Specialists \| Campbelltown South Australia, Australia, 5074Skin Health Institute \| Carlton Victoria, Australia, 3053Sinclair Dermatology \| East Melbourne Victoria, Australia, 3002Multiprofile Hospital for Active Treatment Dr Tota Venkova \| Gabrovo , Bulgaria, 5300Medikal Center Kordis \| Pleven , Bulgaria, 5800Skin and Venereal Diseases Center EOOD \| Sofia , Bulgaria, 1404DCC Aleksandrovka \| Sofia , Bulgaria, 1431University Multiprofile Hospital for Active Treatment Alexandrovska \| Sofia , Bulgaria, 1431Rejuvenation Medical Group Edmonton Downtown \| Edmonton Alberta, Canada, T5J 3S9Alberta DermaSurgery \| Edmonton Alberta, Canada, T6G 1C3VIDA Dermatology/VIDA Clinical Research \| Edmonton Alberta, Canada, T6H 4J8CaRe Clinic Red Deer \| Red Deer Alberta, Canada, T4P 1K4Enverus Medical \| Surrey British Columbia, Canada, V3V 0C6CCA Medical Research Corp \| Ajax Ontario, Canada, L1S 7K8SimcoDerm Medical and Surgical Dermatology Center \| Barrie Ontario, Canada, L4M 7G1SKiN Health \| Coburg Ontario, Canada, K9A 0Z4Guelph Dermatology Research \| Guelph Ontario, Canada, N1L 0B3Dermatrials Research Inc \| Hamilton Ontario, Canada, L8N 1Y2Centricity Research London \| London Ontario, Canada, N6A 2C2Derm Effects \| London Ontario, Canada, N6H 5L5Lynderm Research \| Markham Ontario, Canada, L3P1X2DermEdge Research Inc \| Mississauga Ontario, Canada, L4Y 4C5Clear Skin Dermatology \| Newmarket Ontario, Canada, L3Y 5G8North Bay Dermatolgy Centre \| North Bay Ontario, Canada, P1B 3Z7Canadian Dermatology Centre \| North York Ontario, Canada, M3B 0A7Rejuvenation Dermatology - Oakville \| Oakville Ontario, Canada, L6H6P8Institute of Cosmetic and Laser Surgery \| Oakville Ontario, Canada, L6J 7W5The Centre for Dermatology \| Richmond Hill Ontario, Canada, L4B 1A5North York Research Inc \| Toronto Ontario, Canada, M2N 3A6Toronto Research Centre \| Toronto Ontario, Canada, M3H 5Y8Dermatology on Bloor \| Toronto Ontario, Canada, M4W 2N4Alliance Clinical Trials Inc \| Waterloo Ontario, Canada, N2J 1C4XLR8 Medical Research \| Windsor Ontario, Canada, N8T 1E6Innovaderm \| Montreal Quebec, Canada, H2X 2V1Centre of Research in Dermatology Quebec CRDQ \| Québec Quebec, Canada, G1V 4X7Dermatologie Sima Inc \| Verdun Quebec, Canada, H4G 3E7Skinsense Medical Research \| Saskatoon Saskatchewan, Canada, S7K 2C1Dermamedica \| Náchod Hradec Králové Region, Czechia, 547 01Vesalion s.r.o \| Ostrava Moravian Silesian, Czechia, 70200Sanatorium Profesora Arenbergera \| Prague Prague, Czechia, 1 110 00Clintrial sro \| Prague Prague, Czechia, 100 00Pratia Brno \| Brno , Czechia, 602 00Lékárna Pod Kaňkem \| Kutná Hora , Czechia, 284 01Nemocnice Novy Jicin \| Nový Jičín , Czechia, 74101Dermskin sro \| Olomouc , Czechia, 77900CCR Ostrava \| Ostrava , Czechia, 70200Pratia Pardubice as \| Pardubice , Czechia, 530 02Fakultni nemocnice Plzen Dermatovenerologicka klinika \| Pilsen , Czechia, 301 00Fakultni Nemocnice Kralovske Vinohrady FNKV Dermatovenerologicka Klinika \| Prague , Czechia, 10034Pratia Prague \| Prague , Czechia, 101 00Praglandia \| Prague , Czechia, 15000Dermatologicka ambulance Svitavy \| Svitavy , Czechia, 568 02Innomedica \| Tallinn Harju, Estonia, 10117Tartu University Hospital \| Tartu Tartu, Estonia, 50417Center for Clinical and Basic Research AS \| Tallinn , Estonia, 10128Kliiniliste Uuringute Keskus OU \| Tartu , Estonia, 50106Centre Azur Nice \| Nice Alpes Maritimes, France, 6000CHU de Rouen \| Rouen Essais Cliniques, France, 76031Hautarztpraxis Dr Mihaescu \| Augsburg Augsburg, Germany, 86150Eberhard Karls Universitaet Tuebingen Universitaets Hautklinik Tuebingen \| Tübingen Baden-Wurttemberg, Germany, 72076Universitatsklinikum Erlangen \| Erlangen Bavaria, Germany, 91054Hautarztpraxis Mahlow \| Mahlow Brandenburg, Germany, 15831Rosenpark Research \| Darmstadt Hesse, Germany, 64283Universitatsklinikum Frankfurt \| Frankfurt am Main Hesse, Germany, 60590Fachklinik Bad Bentheim \| Bad Bentheim Lower Saxony, Germany, 48455Hautarztpraxis an der Hase \| Bramsche Lower Saxony, Germany, 49565Klinikum Oldenburg \| Oldenburg Lower Saxony, Germany, 26133Klinische Forschung Schwerin GmbH \| Schwerin Mecklenburg-Vorpommern, Germany, 19055Klinikum Bielefeld \| Bielefeld North Rhine-Westphalia, Germany, 33647Hautarztpraxis Dr Niesmann and Dr Othlinghaus \| Bochum North Rhine-Westphalia, Germany, 44793Intramedis CSS \| Remscheid North Rhine-Westphalia, Germany, 42897Dermatologische Praxis Dres Quist \| Mainz Rhinelkand-Palatinate, Germany, 55128Klinische Forschung Dresden GmbH \| Dresden Saxony, Germany, 1069Praxis fur Dermatologie und Venerologie \| Dresden Saxony, Germany, 1097Haut Ambulatorium Magdeburg \| Magdeburg Saxony-Anhalt, Germany, 39104Universitatsklinikum Schleswig Holstein \| Kiel Schleswig-Holstein, Germany, 24105MVZ DermaKiel GmbH \| Kiel Schleswig-Holstein, Germany, 24148Universitatsklinikum Schleswig Holstein \| Lübeck Schleswig-Holstein, Germany, 23538ISA - Interdisciplinary Study Association GmbH \| Berlin , Germany, 10789Universitaetsklinikum Muenster \| Münster , Germany, NRW 48149KliFOs Klinische Forschung Osnabruck \| Osnabrück , Germany, 49074Bacs Kiskun County Teaching Hospital \| Kecskemét Bács-Kiskun county, Hungary, 6000Bőrgyógyászati Klinika, Debreceni Egyetem Orvos - és Egészségtudományi Centrum \| Debrecen Hajdú-Bihar, Hungary, 4032Allergo-Derm Bakos Kft \| Szolnok JN, Hungary, 5000DermaMed Research Kf \| Békés Oroshaza, Hungary, 5900UNO Medical Trials Kft. \| Budapest , Hungary, 1152Orvostudomanyi Kutato es Fejleszto Kft \| Debrecen , Hungary, 4027DERMA B Kft \| Debrecen , Hungary, 4031Medmare Bt \| Veszprém , Hungary, 8200Nagoya City University Hospital \| Nagoya Aichi-ken, Japan, 467-8602Fukuoka University Hospital \| Fukuoka Fukuoka, Japan, 814-0180Asahikawa Medical University Hospital \| Asahikawa Hokkaido, Japan, 078-8510Tokyo Medical University Ibaraki Medical Center \| Ibaraki Inashiki-gun, Japan, 300-0395Saruwatari Dermatology Clinic \| Kagoshima Kagoshima-Shi, Japan, 890-0046National Hospital Organization Sagamihara National Hospital \| Sagamihara Kanagawa, Japan, 252-0392Yokohama City University Hospital \| Yokohama Kanagawa-shi, Japan, 236-0004Kanto Rosai Hospital \| Kanagawa Kawasaki-shi, Japan, 211-8510Mie University Hospital \| Tsu Mie-ken, Japan, 514-8507Okayama University Hospital \| Okayama Okayama-shi, Japan, 700-8558Dermatology and Ophthalmology Kume Clinic \| Sakai Osaka, Japan, 593-8324Osaka University Hospital \| Suita Osaka, Japan, 565-0871Osaka Metropolitan University Hospital \| Osaka Osaka-shi, Japan, 545-8586Nippon Life Hospital \| Osaka Osaka-Shi, Japan, 550-0006Hokkaido University Hospital \| Hokkaido Sapporo-shi, Japan, 060-8648Kindai University Hospital \| Osaka Sayama-Shi, Japan, 589-8511Tokyo Medical University Hospital \| Tokyo Shinjuku-Ku, Japan, 160-0023Nihon University Itabashi Hospital \| tabashi City Tokyo, Japan, 173-8610Medical Corporation Jitai kai Tachikawa Dermatology Clinic \| Tachikawa Tokyo, Japan, 190-0023Yamaguchi University Hospital \| Ube Yamaguchi, Japan, 755-8505Semigallia Ltd \| Kuldīga Kuldigas, Latvia, LV3301Riga 1st Hospital \| Riga Riga, Latvia, LV1001SIA Veseliba un estetika \| Riga Riga, Latvia, LV1009Smite Aija medical practice in dermatology venereology \| Talsi Talsi, Latvia, LV3201Med Art clinic \| Riga , Latvia, LV1003Veselibas Centrs 4 \| Riga , Latvia, LV1003Veselibas Centrs 4 Filiale Dermatologijas Klinika \| Riga , Latvia, LV1013Specderm \| Podlaski Bialystok, Poland, 15 - 375Centrum Medyczne Pratia Bydgoszcz \| Bydgoszcz Kuyavian-Pomeranian Voivodeship, Poland, 85-796Synexus Centrum Medyczne Osteomed Wroclaw \| Wroclaw Lower Silesian Voivodeship, Poland, 50-381WroMedica \| Wroclaw Lower Silesian Voivodeship, Poland, 51-685Centrum Medyczne dr Rajzer spolka zoo \| Krakow Malopolska, Poland, 30-438Diamond Clinic \| Krakow Malopolska, Poland, 31-559RCMed Oddział Sochaczew \| Sochaczew Masovian Voivodeship, Poland, 96-500FutureMeds Warszawa Centrum \| Warsaw Masovian Voivodeship, Poland, 00-215Clinical Best Solutions \| Warsaw Masovian Voivodeship, Poland, 00-710MICS Medical Center Warsaw \| Warsaw Masovian Voivodeship, Poland, 00-874High Med Przychodnia Specjalistyczna \| Warsaw Masovian Voivodeship, Poland, 01-817Centrum Medyczne Evimed \| Warsaw Masovian Voivodeship, Poland, 02-625Centrum Medyczne Reuma Park \| Warsaw Masovian Voivodeship, Poland, 02-665RoyalDerm \| Warsaw Mazowiecke, Poland, 02-962ClinicMed Daniluk Nowak SpK \| Bialystok Podlaskie Voivodeship, Poland, 15-879AES Gdansk \| Gdansk Pomeranian Voivodeship, Poland, 80-382Pratia Gdynia \| Gdynia Pomeranian Voivodeship, Poland, 81-338Derm Art Institute \| Gdynia Pomeranian Voivodeship, Poland, 81-415Synexus Sp zo o Oddzial w Gdyni \| Gdynia Pomeranian Voivodeship, Poland, 81-537Centrum Badan Klinicznych PI House \| Gdansk Poneranian, Poland, 80-546Pratia Katowice \| Katowice Silesian Voivodeship, Poland, 40-018Centrum Medyczne Angelius Provita \| Katowice Silesian Voivodeship, Poland, 40-611Research Solutions \| Katowice Silesian Voivodeship, Poland, 40-748Laser Clinic \| Szczecin West Pomeranian Voivodeship, Poland, 70-332Care Clinic Katowice \| Katowice , Poland, 40-568Centrum Medyczne All Med Badania Kliniczne \| Krakow , Poland, 30-033Pratia MCM Krakow \| Krakow , Poland, 30-727Krakowskie Centrum Medyczne \| Krakow , Poland, 31-501Luxderm \| Lublin , Poland, 20-573Zanamed Medical Clinic Sp z o o \| Lublin , Poland, 20-601Klinika Dermatologii Uniwersytecki Szpital Kliniczny im F Chopina \| Rzeszów , Poland, 35-329Rheuma Medicus \| Warsaw , Poland, 02-118MTZ Clinical Research Sp z o o \| Warsaw , Poland, 02-172Centrum Medyczne Synexus Warszawa \| Warsaw , Poland, 02-672Klinika Ambroziak Dermatologia Kliniczna \| Warsaw , Poland, 02-953dermMedica \| Wroclaw , Poland, 51-503Dermoklinika \| Lodz Łódź Voivodeship, Poland, 90-436FutureMeds Lodz \| Lodz Łódź Voivodeship, Poland, 91-363Velocity Clinical Research Skierniewice \| Skierniewice Łódź Voivodeship, Poland, 96-100Hospital da Senhora da Oliveira \| Guimarães Braga District, Portugal, 4835-044Hospital CUF Descobertas \| Lisbon Lisbon District, Portugal, 1998-018Unidade Local de Saude Santo Antonio Hospital de Santo Antonio \| Porto , Portugal, 4099-001Centro Reumatologico de Cagus \| Caguas Puerto Rico, Puerto Rico, 00725Ponce Medical School Foundation Inc \| Ponce Puerto Rico, Puerto Rico, 00716Clinical Research Puerto Rico \| San Juan Puerto Rico, Puerto Rico, 00909GCM Medical Group PSC Hato Rey Site \| San Juan , Puerto Rico, 00917Pusan National University Hospital \| Seogu Busan, South Korea, 49241Chosun Universtiy Hospital \| Gwangju Dong-gu, South Korea, 61453Hallym University Sacred Heart Hospital \| Anyang-si Gyeonggi-do, South Korea, 14068Seoul National University Bundang Hospital \| Seongnam-si Gyeonggi-do, South Korea, 13620Seoul National University Hospital \| Seoul , South Korea, 3080Konkuk University Medical Center \| Seoul , South Korea, 5030University General Hospital Dr Balmis \| Alicante Alicante, Spain, 3010Hospital del Mar \| Barcelona Barcelona, Spain, 8003Hospital Universitario La Paz \| Madrid Madrid, Spain, 28046Hospital Clínico Universitario de Santiago de Compostela \| A Coruña Santiago de Compostela, Spain, 15706Hospital de la Santa Creu i Sant Pau \| Barcelona , Spain, 8041Hospital Germans Trias i Pujol \| Barcelona , Spain, 8916Hospital de Manises \| Manises , Spain, 46940

Sponsors and Collaborators

Alumis Inc

Locations

Total Dermatology | Birmingham Alabama, United States, 35203Chandler Clinical Trials | Chandler Arizona, United States, 85224Alliance Dermatology | Pheonix Arizona, United States, 85032Scottsdale Clinical Trials | Scottsdale Arizona, United States, 85260Noble Clinical Research | Tucson Arizona, United States, 85704Northwest AR Clinical Trials Center PLLC | Rogers Arkansas, United States, 72758Zenith Research Inc. | Beverly Hills California, United States, 90212Exalt Clinical Research Inc | Chula Vista California, United States, 91910California Dermatology and Clinical Research Institute | Encinitas California, United States, 92024Raoof MD | Encino California, United States, 91436First OC Dermatology Research Inc | Fountain Valley California, United States, 92708Marvel Clinical Research LLC | Huntington Beach California, United States, 92647Long Beach Research Institute | Long Beach California, United States, 90805Olive View UCLA Education and Research Institute | Los Angeles California, United States, 90024Dermatology Research Associates | Los Angeles California, United States, 90045Wallace Medical Group Inc | Los Angeles California, United States, 90056Northridge Clinical Trials | Northridge California, United States, 91325Pasadena Clinical Trials | Pasadena California, United States, 91101Empire Clinical Research Pomona | Pomona California, United States, 91767Integrative Skin Science and Research | Sacramento California, United States, 95815Therapeutics Clinical Research | San Diego California, United States, 92123Southern California Clinical Research | Santa Ana California, United States, 92701Clinical Science Institute Dermatology Institute | Santa Monica California, United States, 90404Unison Clinical Trials | Sherman Oaks California, United States, 91403California Dermatology Institute Thousand Oaks | Thousand Oaks California, United States, 91320Sunwise Clinical Research LLC | Walnut Creek California, United States, 94596Clearlyderm Dermatology West Boca Raton | Boca Raton Florida, United States, 33428Driven Clinical Research | Coral Gables Florida, United States, 33134FXM Clinical Research Ft. Lauderdale LLC | Fort Lauderdale Florida, United States, 33308Direct Helpers Research Center | Hialeah Florida, United States, 33012Jacksonville Center for Clinical Research | Jacksonville Florida, United States, 32216Glick Skin Institute | Margate Florida, United States, 33063AppleMed Research Group | Miami Florida, United States, 33126FAX Pharma Clinical Research Inc | Miami Florida, United States, 33146FXM Clinical Research Miami LLC | Miami Florida, United States, 33175Las Mercedes Medical Research | Miami Florida, United States, 33196Procare Research Center | Miami Gardens Florida, United States, 33014San Marcus Research Clinic Inc - Miami | Miami Lakes Florida, United States, 33014Savin Medical Group LLC | Miami Lakes Florida, United States, 33014FXM Clinical Research Miramar LLC | Miramar Florida, United States, 33027Oceanic Research Group | North Miami Beach Florida, United States, 33169Renstar Medical Research | Ocala Florida, United States, 34470Lenus Research and Medical Group LLC | Sweetwater Florida, United States, 33172Advanced Clinical Research Institute | Tampa Florida, United States, 33607ForCare Medical Center | Tampa Florida, United States, 33613Arlington Dermatology | Rolling Meadows Illinois, United States, 60008NorthShore Medical Group Dermatology Skokie | Skokie Illinois, United States, 60077Dundee Dermatology | West Dundee Illinois, United States, 60118DS Research of Southern Indiana | Clarksville Indiana, United States, 47129Dawes Fretzin Clinical Research Group | Columbus Indiana, United States, 47201The Indiana Clinical Trials Center | Plainfield Indiana, United States, 46168The South Bend Clinic | South Bend Indiana, United States, 46617Equity Medical | Bowling Green Kentucky, United States, 42104DS Research of Kentucky | Louisville Kentucky, United States, 40241Velocity Clinical Research | Baton Rouge Louisiana, United States, 70808Tulane University School of Medicine | New Orleans Louisiana, United States, 70112MetroBoston Clinical Partners | Brighton Massachusetts, United States, 02135Michigan Center for Research Company | Clarkston Michigan, United States, 48346Henry Ford Medical Center Farmington | Detroit Michigan, United States, 48202Revival Research Institute | Troy Michigan, United States, 48084Grekin Skin Institute | Warren Michigan, United States, 48088Associated Skin Care Specialists Minnesota Clinical Study Center | New Brighton Minnesota, United States, 55112Cleaver Dermatology | Kirksville Missouri, United States, 63501Schlessinger MD | Omaha Nebraska, United States, 68144Las Vegas Clinical Trials | Las Vegas Nevada, United States, 89030NYC Health and Hospitals Elmhurst | Elmhurst New York, United States, 11373Pioneer Clinical Research NY | New York New York, United States, 10016Cameron Dermatology | New York New York, United States, 10023OptiSkin | New York New York, United States, 10128DermResearchCenter of New York | Stony Brook New York, United States, 11790Asheville Clinical Trials | Asheville North Carolina, United States, 28803WDC Cosmetic and Research | Wilmington North Carolina, United States, 28405Optima Research Boardman | Boardman Ohio, United States, 44512The Ohio State University Wexner Medical Center OSUWMC OSU Dermatology East Columbus | Gahanna Ohio, United States, 43230Dermatologists of Southwestern Ohio LLC | Mason Ohio, United States, 45040Unity Clinical Research UCR | Oklahoma City Oklahoma, United States, 73118Velocity Clinical Research | Medford Oregon, United States, 97504Oregon Medical Research Center | Portland Oregon, United States, 97201Paddington Testing Company Inc | Philadelphia Pennsylvania, United States, 19103UPMC Department of Dermatology | Pittsburgh Pennsylvania, United States, 15213Clinical Partners LLC | Johnston Rhode Island, United States, 02919Studies in Dermatology LLC | Cypress Texas, United States, 77433Modern Research Associates PLLC | Dallas Texas, United States, 75231Reveal Research Institute | Frisco Texas, United States, 75033Center for Clinical Studies Texas Medical Center | Houston Texas, United States, 77004Austin Institute for Clinical Research | Houston Texas, United States, 77056SMS Clinical Research | Mesquite Texas, United States, 75149Progressive Clinical Research San Antonio | San Antonio Texas, United States, 78213Center for Clinical Studies (CCS) - Webster/Clear Lake Location | Webster Texas, United States, 77598University of Utah Health Care Midvalley Health Center | Murray Utah, United States, 84107Jordan Valley Dermatology | South Jordan Utah, United States, 84095Frontier Dermatology | Mill Creek Washington, United States, 98012Premier Specialist | Kogarah New South Wales, Australia, 2217North Eastern Health Specialists | Campbelltown South Australia, Australia, 5074Skin Health Institute | Carlton Victoria, Australia, 3053Sinclair Dermatology | East Melbourne Victoria, Australia, 3002Multiprofile Hospital for Active Treatment Dr Tota Venkova | Gabrovo , Bulgaria, 5300Medikal Center Kordis | Pleven , Bulgaria, 5800Skin and Venereal Diseases Center EOOD | Sofia , Bulgaria, 1404DCC Aleksandrovka | Sofia , Bulgaria, 1431University Multiprofile Hospital for Active Treatment Alexandrovska | Sofia , Bulgaria, 1431Rejuvenation Medical Group Edmonton Downtown | Edmonton Alberta, Canada, T5J 3S9Alberta DermaSurgery | Edmonton Alberta, Canada, T6G 1C3VIDA Dermatology/VIDA Clinical Research | Edmonton Alberta, Canada, T6H 4J8CaRe Clinic Red Deer | Red Deer Alberta, Canada, T4P 1K4Enverus Medical | Surrey British Columbia, Canada, V3V 0C6CCA Medical Research Corp | Ajax Ontario, Canada, L1S 7K8SimcoDerm Medical and Surgical Dermatology Center | Barrie Ontario, Canada, L4M 7G1SKiN Health | Coburg Ontario, Canada, K9A 0Z4Guelph Dermatology Research | Guelph Ontario, Canada, N1L 0B3Dermatrials Research Inc | Hamilton Ontario, Canada, L8N 1Y2Centricity Research London | London Ontario, Canada, N6A 2C2Derm Effects | London Ontario, Canada, N6H 5L5Lynderm Research | Markham Ontario, Canada, L3P1X2DermEdge Research Inc | Mississauga Ontario, Canada, L4Y 4C5Clear Skin Dermatology | Newmarket Ontario, Canada, L3Y 5G8North Bay Dermatolgy Centre | North Bay Ontario, Canada, P1B 3Z7Canadian Dermatology Centre | North York Ontario, Canada, M3B 0A7Rejuvenation Dermatology - Oakville | Oakville Ontario, Canada, L6H6P8Institute of Cosmetic and Laser Surgery | Oakville Ontario, Canada, L6J 7W5The Centre for Dermatology | Richmond Hill Ontario, Canada, L4B 1A5North York Research Inc | Toronto Ontario, Canada, M2N 3A6Toronto Research Centre | Toronto Ontario, Canada, M3H 5Y8Dermatology on Bloor | Toronto Ontario, Canada, M4W 2N4Alliance Clinical Trials Inc | Waterloo Ontario, Canada, N2J 1C4XLR8 Medical Research | Windsor Ontario, Canada, N8T 1E6Innovaderm | Montreal Quebec, Canada, H2X 2V1Centre of Research in Dermatology Quebec CRDQ | Québec Quebec, Canada, G1V 4X7Dermatologie Sima Inc | Verdun Quebec, Canada, H4G 3E7Skinsense Medical Research | Saskatoon Saskatchewan, Canada, S7K 2C1Dermamedica | Náchod Hradec Králové Region, Czechia, 547 01Vesalion s.r.o | Ostrava Moravian Silesian, Czechia, 70200Sanatorium Profesora Arenbergera | Prague Prague, Czechia, 1 110 00Clintrial sro | Prague Prague, Czechia, 100 00Pratia Brno | Brno , Czechia, 602 00Lékárna Pod Kaňkem | Kutná Hora , Czechia, 284 01Nemocnice Novy Jicin | Nový Jičín , Czechia, 74101Dermskin sro | Olomouc , Czechia, 77900CCR Ostrava | Ostrava , Czechia, 70200Pratia Pardubice as | Pardubice , Czechia, 530 02Fakultni nemocnice Plzen Dermatovenerologicka klinika | Pilsen , Czechia, 301 00Fakultni Nemocnice Kralovske Vinohrady FNKV Dermatovenerologicka Klinika | Prague , Czechia, 10034Pratia Prague | Prague , Czechia, 101 00Praglandia | Prague , Czechia, 15000Dermatologicka ambulance Svitavy | Svitavy , Czechia, 568 02Innomedica | Tallinn Harju, Estonia, 10117Tartu University Hospital | Tartu Tartu, Estonia, 50417Center for Clinical and Basic Research AS | Tallinn , Estonia, 10128Kliiniliste Uuringute Keskus OU | Tartu , Estonia, 50106Centre Azur Nice | Nice Alpes Maritimes, France, 6000CHU de Rouen | Rouen Essais Cliniques, France, 76031Hautarztpraxis Dr Mihaescu | Augsburg Augsburg, Germany, 86150Eberhard Karls Universitaet Tuebingen Universitaets Hautklinik Tuebingen | Tübingen Baden-Wurttemberg, Germany, 72076Universitatsklinikum Erlangen | Erlangen Bavaria, Germany, 91054Hautarztpraxis Mahlow | Mahlow Brandenburg, Germany, 15831Rosenpark Research | Darmstadt Hesse, Germany, 64283Universitatsklinikum Frankfurt | Frankfurt am Main Hesse, Germany, 60590Fachklinik Bad Bentheim | Bad Bentheim Lower Saxony, Germany, 48455Hautarztpraxis an der Hase | Bramsche Lower Saxony, Germany, 49565Klinikum Oldenburg | Oldenburg Lower Saxony, Germany, 26133Klinische Forschung Schwerin GmbH | Schwerin Mecklenburg-Vorpommern, Germany, 19055Klinikum Bielefeld | Bielefeld North Rhine-Westphalia, Germany, 33647Hautarztpraxis Dr Niesmann and Dr Othlinghaus | Bochum North Rhine-Westphalia, Germany, 44793Intramedis CSS | Remscheid North Rhine-Westphalia, Germany, 42897Dermatologische Praxis Dres Quist | Mainz Rhinelkand-Palatinate, Germany, 55128Klinische Forschung Dresden GmbH | Dresden Saxony, Germany, 1069Praxis fur Dermatologie und Venerologie | Dresden Saxony, Germany, 1097Haut Ambulatorium Magdeburg | Magdeburg Saxony-Anhalt, Germany, 39104Universitatsklinikum Schleswig Holstein | Kiel Schleswig-Holstein, Germany, 24105MVZ DermaKiel GmbH | Kiel Schleswig-Holstein, Germany, 24148Universitatsklinikum Schleswig Holstein | Lübeck Schleswig-Holstein, Germany, 23538ISA - Interdisciplinary Study Association GmbH | Berlin , Germany, 10789Universitaetsklinikum Muenster | Münster , Germany, NRW 48149KliFOs Klinische Forschung Osnabruck | Osnabrück , Germany, 49074Bacs Kiskun County Teaching Hospital | Kecskemét Bács-Kiskun county, Hungary, 6000Bőrgyógyászati Klinika, Debreceni Egyetem Orvos - és Egészségtudományi Centrum | Debrecen Hajdú-Bihar, Hungary, 4032Allergo-Derm Bakos Kft | Szolnok JN, Hungary, 5000DermaMed Research Kf | Békés Oroshaza, Hungary, 5900UNO Medical Trials Kft. | Budapest , Hungary, 1152Orvostudomanyi Kutato es Fejleszto Kft | Debrecen , Hungary, 4027DERMA B Kft | Debrecen , Hungary, 4031Medmare Bt | Veszprém , Hungary, 8200Nagoya City University Hospital | Nagoya Aichi-ken, Japan, 467-8602Fukuoka University Hospital | Fukuoka Fukuoka, Japan, 814-0180Asahikawa Medical University Hospital | Asahikawa Hokkaido, Japan, 078-8510Tokyo Medical University Ibaraki Medical Center | Ibaraki Inashiki-gun, Japan, 300-0395Saruwatari Dermatology Clinic | Kagoshima Kagoshima-Shi, Japan, 890-0046National Hospital Organization Sagamihara National Hospital | Sagamihara Kanagawa, Japan, 252-0392Yokohama City University Hospital | Yokohama Kanagawa-shi, Japan, 236-0004Kanto Rosai Hospital | Kanagawa Kawasaki-shi, Japan, 211-8510Mie University Hospital | Tsu Mie-ken, Japan, 514-8507Okayama University Hospital | Okayama Okayama-shi, Japan, 700-8558Dermatology and Ophthalmology Kume Clinic | Sakai Osaka, Japan, 593-8324Osaka University Hospital | Suita Osaka, Japan, 565-0871Osaka Metropolitan University Hospital | Osaka Osaka-shi, Japan, 545-8586Nippon Life Hospital | Osaka Osaka-Shi, Japan, 550-0006Hokkaido University Hospital | Hokkaido Sapporo-shi, Japan, 060-8648Kindai University Hospital | Osaka Sayama-Shi, Japan, 589-8511Tokyo Medical University Hospital | Tokyo Shinjuku-Ku, Japan, 160-0023Nihon University Itabashi Hospital | tabashi City Tokyo, Japan, 173-8610Medical Corporation Jitai kai Tachikawa Dermatology Clinic | Tachikawa Tokyo, Japan, 190-0023Yamaguchi University Hospital | Ube Yamaguchi, Japan, 755-8505Semigallia Ltd | Kuldīga Kuldigas, Latvia, LV3301Riga 1st Hospital | Riga Riga, Latvia, LV1001SIA Veseliba un estetika | Riga Riga, Latvia, LV1009Smite Aija medical practice in dermatology venereology | Talsi Talsi, Latvia, LV3201Med Art clinic | Riga , Latvia, LV1003Veselibas Centrs 4 | Riga , Latvia, LV1003Veselibas Centrs 4 Filiale Dermatologijas Klinika | Riga , Latvia, LV1013Specderm | Podlaski Bialystok, Poland, 15 - 375Centrum Medyczne Pratia Bydgoszcz | Bydgoszcz Kuyavian-Pomeranian Voivodeship, Poland, 85-796Synexus Centrum Medyczne Osteomed Wroclaw | Wroclaw Lower Silesian Voivodeship, Poland, 50-381WroMedica | Wroclaw Lower Silesian Voivodeship, Poland, 51-685Centrum Medyczne dr Rajzer spolka zoo | Krakow Malopolska, Poland, 30-438Diamond Clinic | Krakow Malopolska, Poland, 31-559RCMed Oddział Sochaczew | Sochaczew Masovian Voivodeship, Poland, 96-500FutureMeds Warszawa Centrum | Warsaw Masovian Voivodeship, Poland, 00-215Clinical Best Solutions | Warsaw Masovian Voivodeship, Poland, 00-710MICS Medical Center Warsaw | Warsaw Masovian Voivodeship, Poland, 00-874High Med Przychodnia Specjalistyczna | Warsaw Masovian Voivodeship, Poland, 01-817Centrum Medyczne Evimed | Warsaw Masovian Voivodeship, Poland, 02-625Centrum Medyczne Reuma Park | Warsaw Masovian Voivodeship, Poland, 02-665RoyalDerm | Warsaw Mazowiecke, Poland, 02-962ClinicMed Daniluk Nowak SpK | Bialystok Podlaskie Voivodeship, Poland, 15-879AES Gdansk | Gdansk Pomeranian Voivodeship, Poland, 80-382Pratia Gdynia | Gdynia Pomeranian Voivodeship, Poland, 81-338Derm Art Institute | Gdynia Pomeranian Voivodeship, Poland, 81-415Synexus Sp zo o Oddzial w Gdyni | Gdynia Pomeranian Voivodeship, Poland, 81-537Centrum Badan Klinicznych PI House | Gdansk Poneranian, Poland, 80-546Pratia Katowice | Katowice Silesian Voivodeship, Poland, 40-018Centrum Medyczne Angelius Provita | Katowice Silesian Voivodeship, Poland, 40-611Research Solutions | Katowice Silesian Voivodeship, Poland, 40-748Laser Clinic | Szczecin West Pomeranian Voivodeship, Poland, 70-332Care Clinic Katowice | Katowice , Poland, 40-568Centrum Medyczne All Med Badania Kliniczne | Krakow , Poland, 30-033Pratia MCM Krakow | Krakow , Poland, 30-727Krakowskie Centrum Medyczne | Krakow , Poland, 31-501Luxderm | Lublin , Poland, 20-573Zanamed Medical Clinic Sp z o o | Lublin , Poland, 20-601Klinika Dermatologii Uniwersytecki Szpital Kliniczny im F Chopina | Rzeszów , Poland, 35-329Rheuma Medicus | Warsaw , Poland, 02-118MTZ Clinical Research Sp z o o | Warsaw , Poland, 02-172Centrum Medyczne Synexus Warszawa | Warsaw , Poland, 02-672Klinika Ambroziak Dermatologia Kliniczna | Warsaw , Poland, 02-953dermMedica | Wroclaw , Poland, 51-503Dermoklinika | Lodz Łódź Voivodeship, Poland, 90-436FutureMeds Lodz | Lodz Łódź Voivodeship, Poland, 91-363Velocity Clinical Research Skierniewice | Skierniewice Łódź Voivodeship, Poland, 96-100Hospital da Senhora da Oliveira | Guimarães Braga District, Portugal, 4835-044Hospital CUF Descobertas | Lisbon Lisbon District, Portugal, 1998-018Unidade Local de Saude Santo Antonio Hospital de Santo Antonio | Porto , Portugal, 4099-001Centro Reumatologico de Cagus | Caguas Puerto Rico, Puerto Rico, 00725Ponce Medical School Foundation Inc | Ponce Puerto Rico, Puerto Rico, 00716Clinical Research Puerto Rico | San Juan Puerto Rico, Puerto Rico, 00909GCM Medical Group PSC Hato Rey Site | San Juan , Puerto Rico, 00917Pusan National University Hospital | Seogu Busan, South Korea, 49241Chosun Universtiy Hospital | Gwangju Dong-gu, South Korea, 61453Hallym University Sacred Heart Hospital | Anyang-si Gyeonggi-do, South Korea, 14068Seoul National University Bundang Hospital | Seongnam-si Gyeonggi-do, South Korea, 13620Seoul National University Hospital | Seoul , South Korea, 3080Konkuk University Medical Center | Seoul , South Korea, 5030University General Hospital Dr Balmis | Alicante Alicante, Spain, 3010Hospital del Mar | Barcelona Barcelona, Spain, 8003Hospital Universitario La Paz | Madrid Madrid, Spain, 28046Hospital Clínico Universitario de Santiago de Compostela | A Coruña Santiago de Compostela, Spain, 15706Hospital de la Santa Creu i Sant Pau | Barcelona , Spain, 8041Hospital Germans Trias i Pujol | Barcelona , Spain, 8916Hospital de Manises | Manises , Spain, 46940

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Additional Relevant MeSH Terms

PsoriasisSkin Diseases, PapulosquamousSkin DiseasesSkin and Connective Tissue Diseases