A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term

Primary Outcome Measures

1. Relative change in body weight
   Measured as percentage change.

Secondary Outcome Measures

1. Number of participants who achieve greater than or equals (≥) 20% weight reduction
   Measured as count of participants.
2. Number of participants who achieve ≥ 25% weight reduction
   Measured as count of participants.
3. Number of participants who achieve ≥ 30% weight reduction
   Measured as count of participants.
4. Number of participants who achieve normal body mass index (BMI) (18.5 kilograms per meter square (kg/m^2) less than or equal to (≤ ) BMI < 25 kg/m^2)
   Measured as count of participants.
5. Number of participants who achieve BMI < 30 kg/m^2
   Measured as count of participants.
6. Change in waist circumference
   Measured as centimeter (cm).
7. Change in systolic blood pressure
   Measured as millimeters of mercury (mmHg).
8. Ratio to baseline in C-reactive protein (CRP)
   Measured as ratio.
9. Ratio to baseline in lipids: non-high density lipoprotein (HDL) cholesterol
   Measured as ratio.
10. Ratio to baseline in lipids: triglycerides
    Measured as ratio.
11. Ratio to baseline in lipids: HDL
    Measured as ratio.
12. Change in impact of weight on quality of life-lite for clinical trials (IWQOL-Lite-CT) physical function score
    Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Physical function score ranges from 0 to 100, with higher scores indicating better levels of functioning.
13. Change in short form (SF)-36v2 physical function
    Measured as score on a scale. The SF-36v2 acute measures health-related quality of life (HRQOL). The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 United States general population has a mean of 50 and a standard deviation of 10. Physical functioning score ranges from 19.0-57.6, with higher scores indicating better functional health and well-being.
14. Change in IWQOL-Lite-CT physical function for subgroup with poor physical functioning at baseline (according to patient global impression of status [PGI-S])
    Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Physical function score ranges from 0 to 100, with higher scores indicating better levels of functioning. PGI-S at baseline is used to define the subgroup with &quot;poor&quot; physical function in IWQOL-Lite-CT.
15. Change in SF-36v2 physical function for subgroup with poor physical functioning at baseline (according to PGI-S)
    Measured as score on a scale. SF-36v2 acute measures HRQOL. The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 United States general population has a mean of 50 and a standard deviation of 10. Physical functioning score ranges from 19.0-57.6, with higher scores indicating better functional health and well-being. PGI-S at baseline is used to define the subgroup with &quot;poor&quot; physical function in SF-36V2.
16. Number of participants who achieve ≥ 5% weight reduction
    Measured as count of participants.
17. Number of participants who achieve ≥ 10% weight reduction
    Measured as count of participants.
18. Number of participants who achieve ≥ 15% weight reduction
    Measured as count of participants.
19. Change in waist to height ratio
    Measured as ratio.
20. Change in waist to hip ratio
    Measured as ratio.
21. Number of participants with reduction in weight category
    Measured as count of participants. Reduction in weight categories: underweight, BMI \&lt; 18.5 kg/m\^2; normal weight 18.5 kg/m\^2 &le; BMI \&lt; 25 kg/m\^2; overweight 25 kg/m\^2 &le; BMI \&lt; 30 kg/m\^2; obesity class I 30 kg/m\^2 &le; BMI \&lt; 35 kg/m\^2; obesity class II 35 kg/m\^2 &le; BMI \&lt; 40 kg/m\^2; obesity class III BMI &ge; 40 kg/m\^2.
22. Change in diastolic blood pressure
    Measured as mmHg.
23. Ratio to baseline in lipids: total cholesterol
    Measured as ratio.
24. Ratio to baseline in lipids: low-density lipoprotein (LDL) cholesterol
    Measured as ratio.
25. Ratio to baseline in lipids: very low-density lipoprotein (VLDL) cholesterol
    Measured as ratio.
26. Ratio to baseline in lipids: free fatty acids
    Measured as ratio.
27. Change in control of eating questionnaire (CoEQ): craving control score
    Measured as score on a scale. CoEQ is a 19-item multidimensional PRO that assesses the experience of hunger, satiety, and severity and type of food cravings. CoEQ consists of 4 subscales that measure craving control (5 items), positive mood (4 items), craving for sweet (4 items), craving for savoury food (4 items), and 2 single items that address hunger and satiety. Each item is evaluated on a 0-10 (i.e., 11-point) numeric rating scale. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control 0-50/5 = 0-10); Positive Mood (0-40/4 = 0-10); Craving Sweet (0-40/4 = 0-10); Craving Savoury food (0-40/4 = 0-10); single items that address hunger and satiety (0-10). For the craving control subscale, the subscale score is reversed so that a higher score represents a greater level of craving control.
28. Change in CoEQ: positive mood score
    Measured as score on a scale. CoEQ is a 19-item multidimensional PRO that assesses the experience of hunger, satiety, and severity and type of food cravings. CoEQ consists of 4 subscales that measure craving control (5 items), positive mood (4 items), craving for sweet (4 items), and craving for savoury food (4 items), and 2 single items that address hunger and satiety. Each item is evaluated on a 0-10 (i.e., 11-point) numeric rating scale. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control 0-50/5 = 0-10); Positive Mood (0-40/4 = 0-10); Craving Sweet (0-40/4 = 0-10); Craving Savoury food (0-40/4 = 0-10); single items that address hunger and satiety (0-10). For the Positive Mood subscale, item 6 &#039;How anxious have you felt?&#039; is reversed.
29. Change in CoEQ: craving for sweets score
    Measured as score on a scale. CoEQ is a 19-item multidimensional PRO that assesses the experience of hunger, satiety, and severity and type of food cravings. CoEQ consists of 4 subscales that measure craving control (5 items), positive mood (4 items), craving for sweet (4 items), craving for savoury food (4 items), and 2 single items that address hunger and satiety. Each item is evaluated on a 0-10 (i.e., 11-point) numeric rating scale. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control 0-50/5 = 0-10); Positive Mood (0-40/4 = 0-10); Craving Sweet (0-40/4 = 0-10); Craving Savoury food (0-40/4 = 0-10); single items that address hunger and satiety (0-10). For the craving sweets food subscale, higher score represents a greater level of craving.
30. Change in CoEQ: craving for savoury score
    Measured as score on a scale. CoEQ is a 19-item multidimensional PRO that assesses the experience of hunger, satiety, and severity and type of food cravings. CoEQ consists of 4 subscales that measure craving control (5 items), positive mood (4 items), craving for sweet (4 items), craving for savoury food (4 items), and 2 single items that address hunger and satiety. Each item is evaluated on a 0-10 (i.e., 11-point) numeric rating scale. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control 0-50/5 = 0-10); Positive Mood (0-40/4 = 0-10); Craving Sweet (0-40/4 = 0-10); Craving Savoury food (0-40/4 = 0-10); single items that address hunger and satiety (0-10). For the craving savoury food subscale, higher score represents a greater level of craving.
31. Change in CoEQ: hunger score
    Measured as score on a scale. CoEQ is a 19-item multidimensional PRO that assesses the experience of hunger, satiety, and severity and type of food cravings. CoEQ consists of 4 subscales that measure craving control (5 items), positive mood (4 items), craving for sweet (4 items), craving for savoury food (4 items), and 2 single items that address hunger and satiety. Each item is evaluated on a 0-10 (i.e., 11-point) numeric rating scale. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control 0-50/5 = 0-10); Positive Mood (0-40/4 = 0-10); Craving Sweet (0-40/4 = 0-10); Craving Savoury food (0-40/4 = 0-10); single items that address hunger and satiety (0-10). For the hunger subscale, higher score represents a greater level of craving.
32. Change in CoEQ: satiety score
    Measured as score points. CoEQ is a 19-item multidimensional PRO that assesses the experience of hunger, satiety, and severity and type of food cravings. CoEQ consists of 4 subscales that measure craving control (5 items), positive mood (4 items), craving for sweet (4 items), craving for savoury food (4 items), and 2 single items that address hunger and satiety. Each item is evaluated on a 0-10 (i.e., 11-point) numeric rating scale. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control 0-50/5 = 0-10); Positive Mood (0-40/4 = 0-10); Craving Sweet (0-40/4 = 0-10); Craving Savoury food (0-40/4 = 0-10); single items that address hunger and satiety (0-10). For the satiety subscale, higher score represents a greater level of craving.
33. Change in IWQOL-Lite-CT: physical score
    Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Physical score ranges from 0 to 100, with higher scores indicating better levels of functioning.
34. Change in IWQOL-Lite-CT: psychosocial score
    Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Psychosocial score ranges from 0 to 100, with higher scores indicating better levels of functioning.
35. Change in IWQOL-Lite-CT: total score
    Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Total score ranges from 0 to 100, with higher scores indicating better levels of functioning.
36. Change in SF-36v2 health survey acute: physical component summary score
    Measured as score on a scale. The SF-36v2 acute measures HRQOL. The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 United States general population has a mean of 50 and a standard deviation of 10. The physical component summary score ranges from 6.1-79.7, with higher scores indicating better functional health and well-being.
37. Change in SF-36v2 health survey acute: mental component summary
    Measured as score on a scale. The SF-36v2 acute measures HRQOL. The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 United States general population has a mean of 50 and a standard deviation of 10. The mental component summary score ranges from -3.8-78.7, with higher scores indicating better functional health and well-being.
38. Number of treatment emergent adverse events (TEAEs)
    Measured as count of events.
39. Number of treatment emergent serious adverse events (TESAEs)
    Measured as count of events.