Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

Recruitment Status
RECRUITING
(See Contacts and Locations)Verified April 2026 by Bristol-Myers Squibb
Sponsor
Bristol-Myers Squibb
Information Provided by (Responsible Party)
Bristol-Myers Squibb
Clinicaltrials.gov Identifier
NCT07116967
Other Study ID Numbers:
IM011-1130
First Submitted
August 3, 2025
First Posted
August 11, 2025
Last Update Posted
May 6, 2026
Last Verified
April 2026

ClinicalTrials.gov processed this data on May 2026. Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

Condition or DiseaseIntervention/Treatment
Plaque Psoriasis
Drug: DeucravacitinibDrug: Ustekinumab

Study Design

Study TypeInterventional
Actual Enrollment3040 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingNone (Open Label)
Primary PurposeTreatment
Official TitleA Phase 3b/4 Multi-center, Randomized, Open-label, Long-term Safety Study of Deucravacitinib in Comparison to Ustekinumab in Participants With Moderate-to-Severe Plaque Psoriasis
Study Start DateSeptember 21, 2025
Actual Primary Completion Date4yrs 8mos from now
Actual Study Completion Date4yrs 8mos from now

Groups and Cohorts

Group/CohortIntervention/Treatment
Arm A
Drug: Deucravacitinib
Specified dose on specified days
Arm B
Drug: Ustekinumab
Specified dose on specified days

Outcome Measures

Primary Outcome Measures
  1. Composite cardiovascular adjudicated 3-point major adverse cardiovascular event (MACE) plus coronary revascularization
    MACE defined as non-fatal myocardial infarction \[MI\], nonfatal stroke, and cardiovascular death
Secondary Outcome Measures
  1. Number of participants with non-fatal MI
  2. Number of participants with non-fatal stroke
  3. Death due to cardiovascular events
  4. Number of participants with coronary revascularization
  5. Number of participants with 3-point MACE (non-fatal MI, non-fatal stroke, and cardiovascular death)
  6. Number of participants with pulmonary embolism (PE)
  7. Number of participants with deep vein thrombosis (DVT)
  8. Number of participants with composite venous thromboembolism (VTE)
    PE, DVT and retinal vein occlusion
  9. Number of participants with arterial thromboembolic events (including retinal artery occlusion)
  10. Number of participants with heart failure (HF) requiring hospitalization or urgent visit
  11. Number of participants with Malignancy excluding non-melanoma skin cancer (NMSC)
  12. Number of participants with NMSC
  13. Number of participants with opportunistic infections
    Opportunistic infections include tuberculosis and complicated herpes zoster (eg, disseminated herpes zoster, affecting more than 2 dermatomes, ophthalmic or meningoencephalopathic involvement, and other atypical presentations)
  14. Number of participants with Serious AEs (SAEs)
  15. All-cause mortality
  16. AEs leading to permanent treatment discontinuation
  17. Change from baseline in liver function test
  18. Change from baseline in fasting lipid panel

Eligibility Criteria

Ages Eligible for Study(Adult, Older Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersNo
Inclusion Criteria
Participants with moderate-to-severe plaque psoriasis: 1. Deemed by the Investigator to be a candidate for phototherapy or systemic treatment for psoriasis, including ustekinumab; 2. Have at least 1 of the following cardiovascular risk factors:
Current cigarette smoker
Diagnosis of hypertension
Diagnosis of hyperlipidemia
Diabetes mellitus type 1 or 2
History of one or more of the following cardiovascular events: Coronary intervention (PCI) or coronary artery bypass grafting (CABG), myocardial infarction (heart attack), cardiac arrest, hospitalization for unstable angina, acute coronary syndrome, stroke, or transient ischemic attack
Obesity
Family history of premature coronary heart disease or sudden death in a first-degree male relative younger than 55 years of age or in a first-degree female relative younger than 65 years of age.
Exclusion Criteria
Participants must not have recent history of 1 of the following cardiovascular events: MI, stroke, or coronary revascularization, or VTE within 90 days prior to Day 1.
Participants must not have unstable CVD, defined as a recent clinical cardiovascular event (eg, unstable angina, rapid atrial fibrillation), or a cardiac hospitalization (eg, pacemaker implantation, HF) within 90 days prior to Day 1.
Participants must not have evidence of active cancer or history of cancer (solid organ or hematologic malignancy including myelodysplastic syndrome) or lymphoproliferative disease within the previous 5 years (other than resected cutaneous basal cell or squamous cell carcinoma, or carcinoma of cervix in situ that has been treated with no evidence of recurrence).
Other protocol define inclusion/exclusion criteria apply.

Contacts and Locations

Sponsors and CollaboratorsBristol-Myers Squibb
Locations
Local Institution - 0088 | Birmingham Alabama, United States, 35249Medical Dermatology Specialists - Phoenix | Phoenix Arizona, United States, 85006-2722Saguaro Dermatology - Phoenix | Phoenix Arizona, United States, 85008Omni Dermatology | Phoenix Arizona, United States, 85018Alliance Dermatology | Phoenix Arizona, United States, 85032Local Institution - 0322 | Scottsdale Arizona, United States, 85254Local Institution - 0188 | Scottsdale Arizona, United States, 85255Scottsdale Clinical Trials | Scottsdale Arizona, United States, 85260Omni Dermatology | Tempe Arizona, United States, 85282Clinical Trials Institute of Northwest Arkansas | Fayetteville Arkansas, United States, 72703-6245Northwest Arkansas Clinical Trials Center (NWACTC), PLLC | Rogers Arkansas, United States, 72758California Dermatology & Clinical Research Institute | Encinitas California, United States, 92024-7700T. Joseph Raoof MD Inc | Encino California, United States, 91436First OC Dermatology - Fountain Valley | Fountain Valley California, United States, 92708Center For Dermatology Clinical Research, Inc. | Fremont California, United States, 94538Marvel Clinical Research | Huntington Beach California, United States, 92647Dermatology Research Associates - Howard Sofen, MD | Los Angeles California, United States, 90045Local Institution - 0192 | Los Angeles California, United States, 90056-1660Northridge Clinical Trials - Elite Clinical Network | Northridge California, United States, 91325Cura Clinical Research - Palmdale | Palmdale California, United States, 93551Pasadena Clinical Trials | Pasadena California, United States, 91101Empire Clinical Research - Pomona | Pomona California, United States, 91767Integrative Skin Science and Research | Sacramento California, United States, 95815UC Davis Dermatology Clinic | Sacramento California, United States, 95816Local Institution - 0078 | San Diego California, United States, 92123-1523Cura Clinical Research - Santa Clarita | Santa Clarita California, United States, 91355Clinical Science Institute | Santa Monica California, United States, 90404Advanced Dermatology and Skin Cancer Institute - Beverly Hills | Sherman Oaks California, United States, 91403Unison Clinical Trials | Sherman Oaks California, United States, 91403Golden State Dermatology - Ygnacio Valley Road | Walnut Creek California, United States, 94598-3335Local Institution - 0494 | Castle Rock Colorado, United States, 80109Local Institution - 0334 | Washington D.C. District of Columbia, United States, 20746Skin Care Research LLC (SCR) - Boca Raton | Boca Raton Florida, United States, 33486Driven Research LLC | Coral Gables Florida, United States, 33134Florida Academic Dermatology Center | Coral Gables Florida, United States, 33134Accel Research Sites - Maitland Clinical Research Unit | Maitland Florida, United States, 32751Miami Dermatology and Laser Research | Miami Florida, United States, 33133International GCC Research | Miami Florida, United States, 33135BioResearch Partner (BRP) - Miami | Miami Florida, United States, 33155Local Institution - 0029 | Miami Lakes Florida, United States, 33014Renstar Medical Research | Ocala Florida, United States, 34471LENUS Research | Sweetwater Florida, United States, 33172Local Institution - 0089 | Tampa Florida, United States, 33615Hamilton Dermatology (Atlanta Dermatology, Vein & Research Center, LLC) | Alpharetta Georgia, United States, 30022Local Institution - 0434 | Atlanta Georgia, United States, 30305Velocity Clinical Research, Savannah | Savannah Georgia, United States, 31406Local Institution - 0395 | Chicago Illinois, United States, 60614Endeavor Health Clinical Trials | Skokie Illinois, United States, 60077Deaconess Clinic Downtown | Evansville Indiana, United States, 47708Dawes Fretzin Clinical Research Group, LLC | Indianapolis Indiana, United States, 46250Southern Indiana Clinical trials | New Albany Indiana, United States, 47150Equity Medical - Bowling Green | Bowling Green Kentucky, United States, 42104Physician Skin Care, PLLC | Louisville Kentucky, United States, 40217Local Institution - 0030 | Owensboro Kentucky, United States, 42301Clinical Trials Management, LLC - Northshore Office | Covington Louisiana, United States, 70433Shondra L. Smith, MD - Dermatology and Advanced Aesthetics | Lake Charles Louisiana, United States, 70605Clinical Trials Management | Metairie Louisiana, United States, 70006Local Institution - 0069 | New Orleans Louisiana, United States, 70112Lawrence J. Green, MD. LLC | Rockville Maryland, United States, 20850U.S. Dermatology Partners Rockville | Rockville Maryland, United States, 20850Metro Boston Clinical Partners | Brighton Massachusetts, United States, 02135Kuchnir Dermatology & Dermatologic Surgery | Milford Massachusetts, United States, 01757Local Institution - 0287 | Quincy Massachusetts, United States, 02169-4339Oakland Hills Dermatology | Auburn Hills Michigan, United States, 48326-3396Michigan Center for Skin Care Research | Clinton Township Michigan, United States, 48038-1137Somerset Skin Centre | Troy Michigan, United States, 48084-5260Michigan Dermatology Institute - Waterford | Waterford Michigan, United States, 48328-3277Minnesota Clinical Study Center (MCSC) | New Brighton Minnesota, United States, 55112Local Institution - 0433 | Columbia Missouri, United States, 65201-6625Saint Louis University | St Louis Missouri, United States, 63110Local Institution - 0397 | Omaha Nebraska, United States, 68114-2508Local Institution - 0454 | Las Vegas Nevada, United States, 89145Las Vegas Clinical Trials, LLC | North Las Vegas Nevada, United States, 89030-7193Local Institution - 0097 | Portsmouth New Hampshire, United States, 03801StracSkin | Portsmouth New Hampshire, United States, 03801Local Institution - 0079 | Teaneck New Jersey, United States, 07666Local Institution - 0359 | Verona New Jersey, United States, 07044Forest Hills Dermatology Group | Kew Gardens New York, United States, 11415The Skin Center Dermatology Group | New City New York, United States, 10956-7153Local Institution - 0410 | New York New York, United States, 10029-6574Skin Search Rochester | Rochester New York, United States, 14623-1507Elyse S. Rafal, MD PC - Rafal Center for Dermatology & Cosmetic Surgery | Stony Brook New York, United States, 11790-2598Equity Medical - New York | The Bronx New York, United States, 10455Accellacare - Cary | Cary North Carolina, United States, 27518Local Institution - 0332 | Chapel Hill North Carolina, United States, 27516Local Institution - 0165 | Chapel Hill North Carolina, United States, 27517Local Institution - 0406 | Hickory North Carolina, United States, 28602Wilmington Dermatology Center-WDC Cosmetic and Research | Wilmington North Carolina, United States, 28405Local Institution - 0177 | Bexley Ohio, United States, 43209-2421Local Institution - 0392 | Canal Winchester Ohio, United States, 43110-2069Apex Clinical Research Center - Canton | Canton Ohio, United States, 44718Wright State Physicians | Fairborn Ohio, United States, 45324Dermatologists of Southwest Ohio | Mason Ohio, United States, 45040Apex Clinical Research Center | Mayfield Heights Ohio, United States, 44124Dermatology Partners Inc. - Medina Clinical Research | Medina Ohio, United States, 44256-9312Unity Clinical Research (UCR) | Oklahoma City Oklahoma, United States, 73118-2864Central Sooner Research (CSR) - Oklahoma City | Oklahoma City Oklahoma, United States, 73170Velocity Clinical Research, Medford | Medford Oregon, United States, 97504Oregon Medical Research Center | Portland Oregon, United States, 97201Oregon Dermatology and Research Center | Portland Oregon, United States, 97210Best Skin Research | Camp Hill Pennsylvania, United States, 17011-2308Local Institution - 0131 | Exton Pennsylvania, United States, 19341UPMC Department of Dermatology | Pittsburgh Pennsylvania, United States, 15213Palmetto Clinical Trial Services - Administrative Office | Anderson South Carolina, United States, 29621Local Institution - 0422 | Greenville South Carolina, United States, 29615Palmetto Clinical Trial Services - Administrative Office | Greenville South Carolina, United States, 29615Local Institution - 0418 | North Charleston South Carolina, United States, 29405Local Institution - 0084 | Rapid City South Dakota, United States, 57702-9208Local Institution - 0407 | Goodlettsville Tennessee, United States, 37072-2301Local Institution - 0338 | Hermitage Tennessee, United States, 37076International Clinical Research (IC Research) - Murfreesboro | Murfreesboro Tennessee, United States, 37130Local Institution - 0408 | Nashville Tennessee, United States, 37205Arlington Center for Dermatology | Arlington Texas, United States, 76011Studies in Dermatology, LLC | Cypress Texas, United States, 77429Modern Research Associates, PLLC | Dallas Texas, United States, 75231Local Institution - 0468 | Dallas Texas, United States, 75390Local Institution - 0500 | Houston Texas, United States, 77065Texas Dermatology and Laser Specialists | San Antonio Texas, United States, 78218Center For Clinical Studies | Webster Texas, United States, 77598Local Institution - 0333 | Norfolk Virginia, United States, 23502Frontier Dermatology | Mill Creek Washington, United States, 98012Premier Clinical Research | Spokane Washington, United States, 99202Consultorios Reumatológicos Pampa | C.a.b.a. Buenos Aires, Argentina, 1428Local Institution - 0429 | Buenos Aires Buenos Aires F.D., Argentina, C1060ABNInstituto de Neumonologia y Dermatologia | Buenos Aires Buenos Aires F.D., Argentina, C1425BEABuenos Aires Skin S.A | Buenos Aires C, Argentina, C1055AAOSTAT Research S.A. | Ciudad Autonoma Buenos Aires C, Argentina, C1126AABPsoriahue | Ciudad Autonoma Buenos Aires C, Argentina, C1425DKGCEMEDIAB - Centro Medico Diabetologico | Ciudad Autónoma Buenos Aires C, Argentina, 1205Derma Internacional S.A. | Autonomous City of Buenos Aires , Argentina, 1199CONEXA Investigacion Clinica S.A. | Buenos Aires , Argentina, 1012Hospital De Clinicas - Jose De San Martin | Buenos Aires , Argentina, C1120AAFHospital Italiano de Buenos Aires | CABA , Argentina, 1199Instituto de Investigaciones Clínicas Córdoba S.A. | Córdoba , Argentina, X5000Viviana Parra Instituto Parra Dermatología | Mendoza , Argentina, 5500The Skin Hospital | Darlinghurst New South Wales, Australia, 2010St George Dermatology & Skin Cancer Centre | Kogarah New South Wales, Australia, 2217Local Institution - 0216 | Westmead New South Wales, Australia, 2145Local Institution - 0311 | Woolloongabba Queensland, Australia, 4102Veracity Clinical Research Pty Ltd. | Woolloongabba Queensland, Australia, 4102Skin Health Institute Inc. | Carlton Victoria, Australia, 3053Monash Medical Centre Clayton | Clayton Victoria, Australia, 3168Dr Rodney Sinclair Pty Ltd. | East Melbourne Victoria, Australia, 3002Local Institution - 0063 | Woluwe-Saint-Lambert BRU, Belgium, 1200Local Institution - 0243 | Maldegem Oost- Vlaanderen, Belgium, 9990Local Institution - 0239 | Ghent VOV, Belgium, 9000Local Institution - 0037 | Juiz de Fora Minas Gerais, Brazil, 36010-570Local Institution - 0416 | Curitiba Paraná, Brazil, 80230-130Local Institution - 0384 | Curitiba Paraná, Brazil, 80730-380Local Institution - 0385 | João Pessoa Paraíba, Brazil, 58040-020Local Institution - 0390 | Porto Alegre Rio Grande do Sul, Brazil, 90410-000Centro de Pesquisa Clínica da Associação Hospitalar Moinhos de Vento | Porto Alegre Rio Grande do Sul, Brazil, 90560-032Faculdade de Medicina da UNESP-Upeclin - Faculdade de Medicina de Botucatu - UNESP | Botucatu São Paulo, Brazil, 18618-686Local Institution - 0383 | Campinas São Paulo, Brazil, 13086-888Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) - HCFMRP | Ribeirão Preto São Paulo, Brazil, 14051-140Local Institution - 0400 | São José do Rio Preto São Paulo, Brazil, 15090-000Local Institution - 0490 | Vila Clementino São Paulo-SP, Brazil, 04038-002Local Institution - 0039 | São Paulo , Brazil, 01323-020Local Institution - 0450 | São Paulo , Brazil, 04075-000Local Institution - 0481 | Burgas , Bulgaria, 8000Local Institution - 0480 | Lovech , Bulgaria, 5500Local Institution - 0479 | Pleven , Bulgaria, 5800Local Institution - 0483 | Plovdiv , Bulgaria, 4000Local Institution - 0486 | Plovdiv , Bulgaria, 4000Local Institution - 0482 | Rousse , Bulgaria, 7002Local Institution - 0487 | Sofia , Bulgaria, 1404Local Institution - 0484 | Sofia , Bulgaria, 1527Local Institution - 0485 | Stara Zagora , Bulgaria, 6003Local Institution - 0126 | Calgary Alberta, Canada, T2G 1B1Dermatology Research Institute | Calgary Alberta, Canada, T2J 7E1Beacon Dermatology | Calgary Alberta, Canada, T3E 0B2Laser Rejuvenation Clinics Edmonton D.T. Inc. | Edmonton Alberta, Canada, T5J 3S9Stratica Dermatology | Edmonton Alberta, Canada, T5K 1X3Alberta Dermasurgery Centre | Edmonton Alberta, Canada, T6G 1C3Vida Clinic Research | Edmonton Alberta, Canada, T6H 4J8Interior Dermatology Centre | Kelowna British Columbia, Canada, V1W 4V5Skin Care West | Nanaimo British Columbia, Canada, V9V 1A3Local Institution - 0120 | Surrey British Columbia, Canada, V3R 6A7Enverus Medical Research | Surrey British Columbia, Canada, V3V 0C6Wiseman Dermatology Research Inc. | Winnipeg Manitoba, Canada, R3M 3Z4Dr Tracey Brown-Maher Dermatology Clinic and Research Centre | St. John's Newfoundland and Labrador, Canada, A1E 1V4CCA Medical Research | Ajax Ontario, Canada, L1S 7K8SimcoDerm Medical and Surgical Dermatology Center | Barrie Ontario, Canada, L4M 7G1Local Institution - 0005 | Hamilton Ontario, Canada, L8N 1Y2Centricity Research London Victoria Multispecialty | London Ontario, Canada, N6A 2C2Lovegrove Dermatology | London Ontario, Canada, N6A 5R9DermEffects | London Ontario, Canada, N6H 5L5Lynderm Research Inc. | Markham Ontario, Canada, L3P 1X3DermEdge | Mississauga Ontario, Canada, L4Y 4C5Ryan Clinical Research Inc | Newmarket Ontario, Canada, L3Y 5G8North Bay Dermatology Centre | North Bay Ontario, Canada, P1B 3Z7The Centre for Clinical Trials Inc. | Oakville Ontario, Canada, L6J 7W5JRB Research Inc. | Ottawa Ontario, Canada, K1K 4L2SKiN Centre for Dermatology | Peterborough Ontario, Canada, K9J 5K2The Centre for Dermatology | Richmond Hill Ontario, Canada, L4B 1A5North York Research Inc. | Toronto Ontario, Canada, M2N 3A6Toronto Research Centre | Toronto Ontario, Canada, M3H 5Y8Centre de Recherche Saint-Louis | Montreal Quebec, Canada, H1Y 3L1Centre de Recherche Saint-Louis | Sherbrooke Quebec, Canada, J1G 1X9Sima Recherche | Verdun Quebec, Canada, H4G 3E7Centre de Recherche Saint-Louis | Québec , Canada, G1W 4R4Centro Médico Skin Med | Santiago Santiago Metropolitan, Chile, 7580206Clinica Dermacross | Santiago Santiago Metropolitan, Chile, 7640881Centro Internacional de Estudios Clinicos | Santiago Santiago Metropolitan, Chile, 8420383Medical Skin Center | Viña del Mar Valparaiso, Chile, 2542577Local Institution - 0352 | Bengbu Anhui, China, 233017Local Institution - 0050 | Beijing Beijing Municipality, China, 100050Local Institution - 0140 | Beijing Beijing Municipality, China, 100191Local Institution - 0226 | Chongqing Chongqing Municipality, China, 630014Local Institution - 0049 | Fuzhou FJ, China, 350005Local Institution - 0353 | Guangzhou Guangdong, China, 510000Local Institution - 0129 | Shenzhen Guangdong, China, 518058Local Institution - 0438 | Shijiazhuang Hebei, China, 50000Local Institution - 0293 | Harbin Heilongjiang, China, 150081Local Institution - 0439 | Zhengzhou Henan, China, 450003Local Institution - 0047 | Wuhan Hubei, China, 430022Local Institution - 0046 | Wuhan Hubei, China, 430030Local Institution - 0414 | Wuhan Hubei, China, 430031Local Institution - 0356 | Zhenjiang Jiangsu, China, 210031Local Institution - 0417 | Changchun Jilin, China, 130021Local Institution - 0054 | Shenyang Liaoning, China, 110001Local Institution - 0504 | Xi'an Shaanxi, China, 710004Local Institution - 0055 | Taiyuan Shan1xi, China, 030001Local Institution - 0194 | Jinan Shandong, China, 250012Local Institution - 0108 | Jinan Shandong, China, 250022Local Institution - 0053 | Chengdu Sichuan Provience, China, 610041Local Institution - 0044 | Hangzhou Zhejiang, China, 310006Local Institution - 0277 | Hangzhou Zhejiang, China, 310009Local Institution - 0052 | Ningbo Zhejiang, China, 315010Local Institution - 0207 | Changsha Shi , China, 410011Local Institution - 0051 | Hangzhou , China, 310009Local Institution - 0401 | Nanjing , China, 210029Local Institution - 0386 | Shenzhen , China, 518052Local Institution - 0202 | Prague PR, Czechia, 100 34Local Institution - 0440 | Brno , Czechia, 656 91Local Institution - 0151 | Olomouc , Czechia, 779 00Local Institution - 0389 | Prague , Czechia, 110 00Local Institution - 0121 | Prague , Czechia, 130 00Local Institution - 0502 | Prague , Czechia, 16000Local Institution - 0150 | Ústí nad Labem , Czechia, 401 13Local Institution - 0196 | Copenhagen Capital Region, Denmark, 2400Local Institution - 0324 | Aarhus , Denmark, 8200Local Institution - 0290 | Hellerup , Denmark, 2900Local Institution - 0457 | Herlev , Denmark, 2730Local Institution - 0238 | Nantes , France, 44093Local Institution - 0153 | Nice , France, 06000Local Institution - 0217 | Rennes , France, 35000Local Institution - 0328 | Saint-Pierre (La Réunion) , France, 97448Local Institution - 0101 | Freiburg im Breisgau Baden-Wurttemberg, Germany, 79104Local Institution - 0127 | Langenau Baden-Wurttemberg, Germany, 89129Local Institution - 0299 | Mahlow Brandenburg, Germany, 15831Local Institution - 0117 | Witten Northwest, Germany, 58453Local Institution - 0237 | Mainz Rhineland-Palatinate, Germany, 55101Local Institution - 0245 | Quedlinburg Saint, Germany, 06484Local Institution - 0255 | Dresden Saxony, Germany, 01307Local Institution - 0382 | Leipzig Saxony, Germany, 04103Local Institution - 0340 | Kiel Schleswig-Holstein, Germany, 24148Local Institution - 0291 | Berlin State of Berlin, Germany, 10117Local Institution - 0476 | Berlin , Germany, 13086Local Institution - 0001 | Bramsche , Germany, 49565Local Institution - 0109 | Dresden , Germany, 01097Local Institution - 0200 | Erlangen , Germany, 91054Local Institution - 0130 | Frankfurt am Main , Germany, 60590Local Institution - 0473 | Friedrichshafen , Germany, 88045Local Institution - 0472 | Halle , Germany, 06108Local Institution - 0471 | Hamburg , Germany, 20095Local Institution - 0106 | Heidelberg , Germany, 69120Local Institution - 0115 | Mainz , Germany, 55128Local Institution - 0112 | Memmingen , Germany, 87700Local Institution - 0295 | Merzig , Germany, 66663Local Institution - 0260 | Tübingen , Germany, 72076Local Institution - 0206 | Szeged Csongrád megye, Hungary, 6720Local Institution - 0209 | Budapest , Hungary, 1033Local Institution - 0266 | Debrecen , Hungary, 4026Local Institution - 0220 | Debrecen , Hungary, 4027Local Institution - 0404 | Veszprém , Hungary, 8200Local Institution - 0269 | L’Aquila AQ, Italy, 67100Local Institution - 0305 | Modena MO, Italy, 41126Local Institution - 0307 | Bologna , Italy, 40138Local Institution - 0249 | Naples , Italy, 80131Local Institution - 0309 | Roma , Italy, 00168Nagoya City University Hospital | Nagoya-sh Aichi-ken, Japan, 467-8602Local Institution - 0451 | Toyoake Shi Aichi-ken, Japan, 4701192Local Institution - 0374 | Asahikawa-shi Hokkaido, Japan, 078-8510Local Institution - 0378 | Suita Osaka, Japan, 565-0871Local Institution - 0377 | Suita-shi Osaka, Japan, 565-0871Local Institution - 0452 | Ōtsu Shiga, Japan, 5202192St. Luke's International Hospital | Chūōku Tokyo-to, Japan, 104-8560Fukuoka University Hospital | Fukuoka , Japan, 8140180Local Institution - 0376 | Gifu , Japan, 501-1194Teikyo University Hospital | Itabashi-Ku , Japan, 173-8605Local Institution - 0375 | Kanazawa , Japan, 920-8641Local Institution - 0379 | Kurume, Fukuoka , Japan, 830-0011Local Institution - 0456 | Okayama , Japan, 700-8558Local Institution - 0380 | Sakaishi , Japan, 593-8324Local Institution - 0415 | Sakaishi , Japan, 593-8324Local Institution - 0467 | Mexicali Estado de Baja California, Mexico, 21100Local Institution - 0321 | Guadalajara Jalisco, Mexico, 44638Local Institution - 0470 | Zapopan Jalisco, Mexico, 45190Local Institution - 0113 | Monterrey Nuevo León, Mexico, 64460Local Institution - 0469 | Monterrey Nuevo León, Mexico, 64460Local Institution - 0118 | Mérida Yucatán, Mexico, 97070Local Institution - 0466 | Chihuahua City , Mexico, 31350Local Institution - 0465 | Mexico City , Mexico, 14080Local Institution - 0265 | Torun Kuyavian-Pomeranian Voivodeship, Poland, 87-100Local Institution - 0425 | Puławy Lublin Voivodeship, Poland, 24-100Local Institution - 0424 | Warsaw Masovian Voivodeship, Poland, 03-291Local Institution - 0252 | Rzeszów Podkarpackie Voivodeship, Poland, 35-055Local Institution - 0292 | Bialystok Podlaskie Voivodeship, Poland, 15-375Local Institution - 0195 | Katowice Silesian Voivodeship, Poland, 40-081Local Institution - 0423 | Olsztyn Warmian-Masurian Voivodeship, Poland, 10-117Local Institution - 0428 | Poznan Wielkopolska, Poland, 60-309Local Institution - 0296 | Bialystok , Poland, 15-351Local Institution - 0091 | Gdansk , Poland, 80-546Local Institution - 0444 | Gdynia , Poland, 81-338Local Institution - 0162 | Katowice , Poland, 40-040Local Institution - 0154 | Katowice , Poland, 40-611Local Institution - 0276 | Lodz , Poland, 90-265Local Institution - 0413 | Mikołów , Poland, 43-190Local Institution - 0421 | Skierniewice , Poland, 96-100Local Institution - 0308 | Warsaw , Poland, 02-951Local Institution - 0205 | Wroclaw , Poland, 51-685Local Institution - 0244 | Kielce Świętokrzyskie Voivodeship, Poland, 25-316Centro Reumatologico Caguas | Caguas , Puerto Rico, 00725Local Institution - 0405 | Craiova Dolj, Romania, 200440Local Institution - 0403 | Iași IS, Romania, 700401Local Institution - 0388 | Reghin MS, Romania, 545300Local Institution - 0441 | Timișoara Timiș County, Romania, 300757Local Institution - 0225 | Brasov , Romania, 500285Local Institution - 0412 | Bucharest , Romania, 011464Local Institution - 0402 | Bucharest , Romania, 020125Local Institution - 0398 | Constanța , Romania, 900591Local Institution - 0458 | Iași , Romania, 707020Local Institution - 0065 | Seongnam-si, Gyeonggi-do Gyeonggi-do, South Korea, 13496Local Institution - 0067 | Seongnam-si , South Korea, 13620Local Institution - 0060 | Seoul , South Korea, 03722Local Institution - 0337 | Las Palmas de Gran Canaria Las Palmas, Spain, 35019Local Institution - 0242 | Alcorcón Madrid, Spain, 28922Local Institution - 0445 | Málaga MA, Spain, 29016Local Institution - 0236 | Seville SE, Spain, 41009Local Institution - 0258 | Madrid , Spain, 28041Local Institution - 0211 | Lund M, Sweden, 222 22Local Institution - 0223 | Borås , Sweden, 506 30Kaohsiung Veterans General Hospital | Zuoying Dist Kaohsiung, Taiwan, 813414Chang Gung Medical Foundation - Kaohsiung Branch | Niaosong KHH, Taiwan, 83301National Taiwan University Hospital | Taipei , Taiwan, 100Mackay Memorial Hospital-Taipei Branch | Taipei , Taiwan, 10449Taipei Veterans General Hospital | Taipei , Taiwan, 11217Chang Gung Memorial Hospital (CGMH) - Linkou Branch | Taoyuan City , Taiwan, 33305Velocity Clinical Research - North London | London Greater London, United Kingdom, N3 2JUUniversity Hospital Southampton NHS Foundation Trust - Southampton General Hospital | Southampton Hampshire, United Kingdom, SO16 6YDBarts Health NHS Trust | London LND, United Kingdom, E11 1NRSalford Care Organisation | Salford SLF, United Kingdom, M6 8HDLocal Institution - 0499 | Bristol South West, United Kingdom, BS82RAVelocity Clinical Research, High Wycombe | High Wycombe , United Kingdom, HP11 2QWNHS Fife - Victoria Hospital | Kirkcaldy , United Kingdom, KY2 5AHGuy's and St Thomas' NHS Foundation Trust - Guy's Hospital | London , United Kingdom, SE1 9RT
Investigators
Study Director: Bristol-Myers Squibb, Bristol-Myers Squibb