A Study to Assess Zipalertinib Versus Placebo in Participants With Early Stage NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

Recruitment Status
ACTIVE, NOT RECRUITING
(See Contacts and Locations)Verified July 2026 by Taiho Oncology, Inc.
Sponsor
Taiho Oncology, Inc.
Information Provided by (Responsible Party)
Taiho Oncology, Inc.
Clinicaltrials.gov Identifier
NCT07128199
Other Study ID Numbers:
TAS6417-302
First Submitted
August 10, 2025
First Posted
August 16, 2025
Last Update Posted
August 25, 2026
Last Verified
July 2026

ClinicalTrials.gov processed this data on August 2026Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

This study will evaluate zipalertinib, a novel EGFR tyrosine kinase inhibitor (TKI) versus placebo in participants with resected early stage NSCLC harboring uncommon EGFRmt.

Approximately 360 participants will be randomized to:

Arm A: Zipalertinib twice daily (BID) monotherapy OR

Arm B: Placebo BID monotherapy.

An independent data monitoring committee (IDMC) will be established to monitor interim safety data.

Condition or DiseaseIntervention/Treatment
Lung CancerAdjuvantPost-surgicalEGFRExon 20Early Stage Lung CancerUncommon EGFR MutationsNSCLC, Early Stage
Drug: TAS6417Drug: Zipalertinib Matching-placebo

Study Design

Study TypeInterventional
Actual Enrollment360 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingDouble
Primary PurposeTreatment
Official TitleA Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Versus Placebo in Early Stage NSCLC Patients With Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)
Study Start DateDecember 21, 2025
Actual Primary Completion Date3yrs 3w from now
Actual Study Completion Date6yrs 3w from now

Groups and Cohorts

Group/CohortIntervention/Treatment
Zipalertinib
Participants will receive zipalertinib orally until the participant meets any of the treatment discontinuation criteria.
Drug: TAS6417
Oral tablets.
Placebo
Participants will receive zipalertinib matching-placebo, until the participant meets any of the treatment discontinuation criteria.
Drug: Zipalertinib Matching-placebo
Oral tablets.

Outcome Measures

Primary Outcome Measures
  1. Disease-free Survival (DFS) as Assessed by the Investigator
Secondary Outcome Measures
  1. Disease-free Survival Rate
  2. Overall Survival (OS)
  3. Overall Survival Rate
  4. DFS of Central Nervous System (cDFS)
  5. Number of Participants With Treatment Emergent Adverse Events (TEAEs) Graded According to the National Cancer Institute Common Terminology Criteria for Adverse Events Version 5.0 (CTCAE v5.0)
  6. Number of Participants with Clinically Significant Changes in Clinical Laboratory Parameters
  7. Number of Participants with Clinically Significant Changes in Vital Signs
  8. Number of Participants with Clinically Significant Changes in Electrocardiogram (ECG) Parameters
  9. Number of Participants With Change in Left Ventricular Ejection Fraction (LVEF) Evaluated Using Electrocardiography (ECHO) and Multigated Acquisition (MUGA) Scan
  10. Change in EuroQuality of Life-5 Dimensional 3-Level (EQ-5D-3L)
    EQ-5D-3L is a standardized measure of the participant's health-related quality of life (QoL). EQ-5D is a 5-item questionnaire that assesses 5 domains.
  11. Change From Baseline in European Organisation for Research and Treatment of Cancer - Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30) Scores
    EORTC QLQ-C30 is a 30-item participant self-report questionnaire composed of both multi-item and single scales, including a global health status/quality of life (GHS/QoL) scale.

Eligibility Criteria

Ages Eligible for Study(Adult, Older Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersNo
Inclusion Criteria
1. Histologically confirmed diagnosis of primary NSCLC on predominantly non-squamous histology. 2. Documented EGFRmt status as determined by local testing performed at a clinical laboratory improvement amendment (CLIA) certified (United States \[US\]) or accredited (outside of the US) local laboratory, defined as either one of the following EGFRmt: 1. exon20 insertion mutations (ex20ins) or 2. other uncommon, non-ex20ins EGFRmt (eg, G719X, L861Q, or S768I) exons 18-21 of the EGFR tyrosine kinase domain 3. Baseline imaging assessment of the brain (MRI \[preferred modality\] or CT scan) performed within 8 weeks prior to randomization must show no evidence of brain metastasis 4. Complete surgical resection of the primary NSCLC is mandatory with negative surgical margins and systematic lymph node sampling or dissection. 5. Complete recovery from surgery, including post-operative wound healing, and prior adjuvant chemotherapy (if applicable) at the time of randomization. Randomization timing is defined as follows: 1. For participants without prior adjuvant chemotherapy: 4 weeks and 12 weeks following surgery. 2. For participants with prior adjuvant chemotherapy: 4 weeks and 8 weeks after the last dose of adjuvant chemotherapy. 6. Eastern cooperative oncology group performance status (ECOG PS) of 0 or 1. 7. Pathologic (post-operative) Stage IB, IIA, IIB, or IIIA according to the AJCC 9th tumor nodes metastasis (TNM) staging system for lung cancer. In addition, participants with stage IIIB are eligible when regional lymph node involvement is N2. 8. Archival tumor tissue available for submission, with minimum quantity sufficient to evaluate EGFRmt status and, where possible, other biomarkers.
Exclusion Criteria
1. Is currently receiving an investigational drug in a clinical trial or participating in any other type of medical research. 2. Treatment with any of the following within the time frame specified: 1. Zipalertinib (TAS6417/CLN-081) or any other EGFR inhibitor at any time. 2. Pre-operative or post-operative or planned radiation therapy for the current lung cancer. 3. Any prior systemic anticancer therapy for NSCLC, including preoperative (neoadjuvant) chemotherapy, immunotherapy, or investigational therapy. (Exception: Participants who have received postoperative adjuvant platinum-based chemotherapy up to 4 cycles are permitted) 4. Major surgery (including primary tumor surgery, excluding placement of vascular access) within 4 weeks prior to the first dose of study treatment. 5. Treatment with an investigational drug within five half-lives of the compound or any of its related material, if known. 3. Has received only wedge resections (complete anatomic segmentectomy is acceptable). 4. Past medical history of interstitial lung disease (ILD)/pneumonitis, drug-induced ILD/pneumonitis or any evidence of clinically active ILD/pneumonitis. 5. Unable to swallow tablets or has any disease or condition that may significantly affect gastrointestinal (GI) absorption of zipalertinib (such as inflammatory bowel disease, malabsorption syndrome, or prior significant bowel resection). 6. Has a history of any other cancer except for any of the following: 1. Non-melanoma skin cancer treated with curative intent 2. Carcinoma in situ treated with curative intent 3. Other curatively treated cancer, with no evidence of disease for \>3 years following the end of treatment and, in the opinion of the treating physician, has no substantial risk of recurrence. 4. Concurrent malignancy of which natural history does not have the potential to interfere with the safety or efficacy assessment (eg, Gleason 6 prostate cancer) 7. Known history of hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) that is unstable or not controlled with treatment. 8. Active bleeding disorders. 9. Known hypersensitivity to the ingredients in zipalertinib/placebo or any drugs similar in structure or class.

Contacts and Locations

Sponsors and CollaboratorsTaiho Oncology, Inc.
Locations
Alaska Oncology and Hematology | Anchorage Alaska, United States, 99508City of Hope Comprehensive Cancer Center - Duarte | Duarte California, United States, 91010City of Hope Comprehensive Cancer Center Orange County Lennar Foundation Cancer Center | Irvine California, United States, 92618Scripps Clinic Torrey Pines | La Jolla California, United States, 92037Kaiser Permanente - Vallejo Medical Center | Vallejo California, United States, 94589Georgetown University School of Medicine | Washington D.C. District of Columbia, United States, 20007D&H Cancer Research Center - Margate | Margate Florida, United States, 33063Alpha Oncology Research | Orange City Florida, United States, 32763City of Hope - Atlanta | Newnan Georgia, United States, 30265University of Illinois Medical Center | Chicago Illinois, United States, 60612Profound Research LLC at Michigan Hematology and Oncology Consultants | Dearborn Michigan, United States, 48126Henry Ford Health System | Detroit Michigan, United States, 48202Memorial Sloan Kettering Cancer Center - Basking Ridge | Basking Ridge New Jersey, United States, 07920Memorial Sloan Kettering Cancer Center - Monmouth | Middletown New Jersey, United States, 07748Memorial Sloan Kettering Cancer Center - Bergen | Montvale New Jersey, United States, 07645Memorial Sloan Kettering Cancer Center - Commack | Commack New York, United States, 11725Memorial Sloan Kettering Cancer Center - Westchester | East White Plains New York, United States, 10604Long Island Jewish Medical Center | Lake Success New York, United States, 11042Perlmutter Cancer Center - 34th Street | New York New York, United States, 10016Memorial Sloan Kettering Cancer Center - New York | New York New York, United States, 10065Memorial Sloan Kettering Cancer Center - Nassau | Uniondale New York, United States, 11553Atrium Health Wake Forest Baptist - Comprehensive Cancer Center | Charlotte North Carolina, United States, 28204Durham Veterans Affairs Health Care System | Durham North Carolina, United States, 27705Gabrail Cancer and Research Center | Canton Ohio, United States, 44718Gibbs Cancer Center and Research Institute Spartanburg | Spartanburg South Carolina, United States, 29303Virginia Cancer Specialists - Arlington Office | Arlington Virginia, United States, 22201Virginia Cancer Specialists - Fairfax Office | Fairfax Virginia, United States, 22031Virginia Cancer Specialists - Bristow Office | Manassas Virginia, United States, 20110Virginia Cancer Specialists - Reston | Reston Virginia, United States, 20190Virginia Cancer Specialists - Woodbridge Office | Woodbridge Virginia, United States, 22191Instituto Argentino de Diagnóstico y Tratamiento | Ciudad Autónoma de Buenos Aires Buenos Aires, Argentina, C1122Centro de Investigación Pergamino SA | Pergamino Buenos Aires, Argentina, B2700KMPHospital Universitario Austral | Pilar Buenos Aires, Argentina, B1629AHJCEMAIC - Centro de Especialidades Médicas Ambulatorias e Investigación Clínica | Córdoba Córdoba Province, Argentina, X5008HHWBankstown-Lidcombe Hospital | Bankstown New South Wales, Australia, 2200GenesisCare - North Shore | St Leonards New South Wales, Australia, 2065Saint John of God - Subiaco Hospital | Subiaco Western Australia, Australia, 6008Universitair Ziekenhuis Antwerpen | Edegem Antwerpen, Belgium, 2650Algemeen Ziekenhuis Sint-Maarten | Mechelen Antwerpen, Belgium, 2800Universitair Ziekenhuis (UZ) Leuven - Campus Gasthuisberg | Leuven Flemish Brabant, Belgium, 3000NOHC - Núcleo de Oncologia e Hematologia do Ceará - José Lourenço | Fortaleza Ceará, Brazil, 60115-281Centro Regional Integrado de Oncologia | Fortaleza Ceará, Brazil, 60335-480Centro de Pesquisas Clínicas Em Oncologia - CPCO | Cachoeiro de Itapemirim Espírito Santo, Brazil, 29308-065Hospital Santa Rita | Vitória Espírito Santo, Brazil, 29043-260Núcleo de Oncologia da Bahia Ondina - NOB | Salvador Estado de Bahia, Brazil, 40170-110Oncoclinicas Oncovida - Brasilia | Brasília Federal District, Brazil, 70390-150Cetus Oncologia - Unidade Belo Horizonte | Belo Horizonte Minas Gerais, Brazil, 30110-022Cenantron Centro Avançado de Tratamento Oncológico | Belo Horizonte Minas Gerais, Brazil, 30130-090Centro Integrado de Oncologia de Curitiba (CIONC) | Curitiba Paraná, Brazil, 80810-050Instituto de Medicina Integral Professor Fernando Figueira | Recife Pernambuco, Brazil, 50070-902Centro de Pesquisa Vencer e Oncoclínica - Teresina | Teresina Piauí, Brazil, 64.049-200Instituto D'Or de Pesquisa e Ensino - Rio de Janeiro | Botafogo Rio de Janeiro, Brazil, 22281-100Liga Contra o Câncer - Centro Avançado de Oncologia | Natal Rio Grande do Norte, Brazil, 59062-000Clínica Viver | Centro Santa Maria Rio Grande do Sul, Brazil, 97015-450Hospital Bruno Born | Lajeado Rio Grande do Sul, Brazil, 95900-022Hospital São Vicente de Paulo | Passo Fundo Rio Grande do Sul, Brazil, 99010-090Irmandade da Santa Casa de Misericórdia Hospital - Porto Alegre | Porto Alegre Rio Grande do Sul, Brazil, 90050-170Irmandade da Santa Casa de Misericórdia Hospital - Porto Alegre | Porto Alegre Rio Grande do Sul, Brazil, 90440-010Hospital Mãe de Deus - Centro Integrado de Oncologia | Porto Alegre Rio Grande do Sul, Brazil, 91210-250Grupo ELORA | Florianópolis Santa Catarina, Brazil, 88020-210CHO Centro - Centro de Hematologia e Oncologia de Joinville | Joinville Santa Catarina, Brazil, 89201-260Fundação Pio XII - Hospital de Câncer de Barretos - Hospital de Amor | Barretos São Paulo, Brazil, 14784-400Hospital Amaral Carvalho | Jaú São Paulo, Brazil, 17210-180A Beneficência Portuguesa de São Paulo | São Paulo São Paulo, Brazil, 01323-001Instituto de Assistência Médica ao Servidor Público Estadual | São Paulo São Paulo, Brazil, 04039-004Instituto de Oncologia de Sorocaba | Sorocaba São Paulo, Brazil, 18030-005Cross Cancer Institute | Edmonton Alberta, Canada, T6G1Z2William Osler Health System - Brampton Civic Hospital | Brampton Ontario, Canada, L6R317London Health Sciences Centre | London Ontario, Canada, N6A 4G5Sunnybrook Health Sciences Centre - Bayview Campus | Toronto Ontario, Canada, M4N3M5Princess Margaret Cancer Centre | Toronto Ontario, Canada, M5G2M9Hôpital Saint-André | Bordeaux Aquitane, France, 33000Hôpital Louis Pradel | Bron Auvergne-Rhône-Alpes, France, 69500Hôpital de la Croix Rousse | Lyon Auvergne-Rhône-Alpes, France, 69004Centre Léon Bérard | Lyon Auvergne-Rhône-Alpes, France, 69008Centre Hospitalier Lyon-Sud | Pierre-Bénite Auvergne-Rhône-Alpes, France, 69495L'Hôpital Nord-Ouest (HNO) - Villefranche-sur-Saône | Villefranche-de-Rouergue Aveyron, France, 12200Hôpital Côte De Nacre | Caen Basse-Normandie, France, 14033Centre Hospitalier Universitaire de Nîmes | Nîmes Gard, France, 30029Hôpital Emile Muller | Mulhouse Grand Est, France, 8051Hôpital Pontchaillou | Rennes Ille-et-Vilaine, France, 35033Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec | Saint-Herblain Loire-Atlantique, France, 44800Centre Hospitalier Universitaire d'Angers | Angers Maine-et-Loire, France, 49 933CHU d Angers | Angers Maine-et-Loire, France, 49 933Institut de Cancérologie de l'Ouest - Angers | Angers Maine-et-Loire, France, 49055CHU de Nimes - Caremeau Nord | Nîmes Occitanie, France, 30029Hôpital Universitaire Pitié Salpêtrière | Paris Paris, France, 75013Centre Hospitalier Le Mans | Le Mans Pays de la Loire Region, France, 72037Hopital Prive du Confluet | Nantes Pays de la Loire Region, France, 44277Hôpital Privé du Confluent | Nantes Pays de la Loire Region, France, 44277Hopital Nord Ouest | Gleizé Rhône, France, 69 655Gustave Roussy | Villejuif Val-De-Marne, France, 94800Hôpital Ambroise-Paré | Boulogne-Billancourt Île-de-France Region, France, 92100Centre Hospitalier Intercommunal de Créteil | Créteil Île-de-France Region, France, 94000Groupe Hospitalier Paris Saint-Joseph | Paris Île-de-France Region, France, 75014Hôpital Bichat - Claude-Bernard | Paris Île-de-France Region, France, 75018SLK-Kliniken - Fachklinik Löwenstein | Löwenstein Baden-Wurttemberg, Germany, 74245Krankenhaus Nordwest | Frankfurt am Main Hesse, Germany, 60488Universitätsklinikum Gießen und Marburg - Gießen | Giessen Hesse, Germany, 35392Kliniken der Stadt Köln | Cologne North Rhine-Westphalia, Germany, 51067Saint Savvas Anticancer - Oncological Hospital of Athens | Athens Attica, Greece, 115 22General Hospital for Thoracic Diseases Sotiria | Athens Attica, Greece, 11527Metaxa Cancer Hospital of Piraeus | Athens Attica, Greece, 18537BioClinic Thessaloniki | Athens Central Macedonia, Greece, 54622Interbalkan Medical Center of Thessaloniki | Thessaloniki Central Macedonia, Greece, 57001Hong Kong Sanatorium and Hospital | Happy Valley , Hong Kong, Humanity & Health Clinical Trial Centre | Hong Kong , Hong Kong, Queen Mary Hospital - Hong Kong | Hong Kong , Hong Kong, Princess Margaret Hospital | Kowloon , Hong Kong, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo - Alessandria | Alessandria Alessandria, Italy, 15121Azienda Ospedaliero Universitaria Delle Marche | Ancona Ancona, Italy, 60126Azienda Socio Sanitaria Territoriale (ASST) Papa Giovanni XXIII | Bergamo Bergamo, Italy, 24127Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi | Bologna Bologna, Italy, 40138Azienda Ospedaliero Universitaria Policlinico Gaspare Rodolico - San Marco - Catania/ Presidio G. Rodolico | Catania Catania, Italy, 95125Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST | Meldola Forlì-Cesena, Italy, 47014Azienda Unita Sanitaria Locale toscana Nord Ovest | Livorno Livorno, Italy, 57124Azienda Unità Sanitaria Locale Toscana Nord Ovest | Livorno Livorno, Italy, 57124Azienda Socio Sanitaria Territoriale (ASST) di Bergamo Ovest | Legnano Milan, Italy, 20025Azienda Ospedaliera Complesso Ospedaliero San Giovanni - Addolorata | Milan Milan, Italy, 20132Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele | Milan Milan, Italy, 20132Fondazione IRCCS - Istituto Nazionale dei Tumori | Milan Milan, Italy, 20133Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda | Milan Milan, Italy, 20141Istituto Europeo di Oncologia | Milan Milan, Italy, 20141Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda | Milan Milan, Italy, 20162Azienda Ospedaliero - Universitaria di Modena | Modena Modena, Italy, 41124Ospedale del Mare | Naples Naples, Italy, 80147Fondazione IRCCS Policlinico San Matteo | Pavia Pavia, Italy, 27100Ospedale Santa Maria delle Croci di Ravenna | Lugo Ravenna, Italy, 48022Azienda Ospedaliera Complesso Ospedaliero San Giovanni - Addolorata | Roma Rome, Italy, 00184Azienda Ospedaliera Universitaria Senese - L'ospedale Santa Maria alle Scotte | Siena Siena, Italy, 53100Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia | Candiolo Torino, Italy, 10060Azienda Ospedaliero - Universitaria San Luigi Gonzaga | Orbassano Torino, Italy, 10043Ospedale P. Pederzoli - Casa di Cura Privata S.p.A. | Peschiera del Garda Verona, Italy, 37019Azienda Ospedaliera Universitaria Integrata Verona | Verona Verona, Italy, 37126Humanitas Gavazzeni | Bergamo , Italy, 24125Nagoya Univeristy Hospital | Nagoya Aichi-ken, Japan, 466-8560Aichi Cancer Center | Nagoya Aiti [Aichi], Japan, 464-8681Kurume University Hospital | Kurume-Shi Fukuoka, Japan, 830-0011Hiroshima University Hospital | Hiroshima Hirosima [Hiroshima], Japan, 734-8551Hokkaido Cancer Center | Sapporo Hokkaido, Japan, 003-0804National Hospital Organization Kyushu Cancer Center | Fukuoka Hukuoka [Fukuoka], Japan, 811-1395Hyogo Cancer Center | Akashi Hyōgo, Japan, 673-8558Kobe University Hospital | Kobe Hyōgo, Japan, 650-0017Kanagawa Cancer Center | Yokohama Kanagawa, Japan, 241-8515Tohoku University Hospital | Sendai Miyagi, Japan, 980-8574Nagasaki University Hospital | Nagasaki Nagasaki, Japan, 852-8501Kansai Medical University Hospital | Hirakata Osaka, Japan, 573-1191Osaka City General Hospital | Osaka Osaka, Japan, 534-0021Osaka Prefectural Hospital Organization - Osaka International Cancer Institute | Osaka Osaka, Japan, 541-8567Kindai University Hospital | Osakasayama-Shi Osaka, Japan, 589-8511Saitama Medical University - International Medical Center | Hidaka-Shi Saltama, Japan, 350-1298Shizuoka Cancer Center | Sunto-gun Sizuoka [Shizuoka], Japan, 411-8777National Cancer Center Hospital East | Kashiwa-shi Tiba [Chiba], Japan, 277-8577Cancer Institute Hospital of JFCR | Koto Tokyo, Japan, 135-8550Tokyo Medical University Hospital | Shinjuku-ku Tokyo, Japan, 160-0023National Cancer Center Hospital | Tokyo Tokyo, Japan, 104-0045Yamagata University Hospital | Yamagata Yamagata, Japan, 990-9585Okayama University Hospital | Okayama , Japan, 700-8558Hospital Raja Perempuan Zainab II | Kota Bharu Kelantan, Malaysia, 15586Hospital Kuala Lumpur | Kuala Lumpur Kuala Lumpur, Malaysia, 50586Hospital Pulau Pinang | Pulau Pinang Pulau Pinang, Malaysia, 10450Hospital Picaso | Petaling Jaya Selangor, Malaysia, 46300Sunway Medical Centre | Selangor Darul Ehsan , Malaysia, 47500Preparaciones Oncológicas S.C. | León Guanajuato, Mexico, 37178Centro Oncológico Alianza XXI | Mexico City Mexico City, Mexico, 06760Clínica Integral Internacional de Oncología S de RL de CV | Mirador Puebla, Mexico, 72530Ziekenhuis St Jansdal Harderwijk | Harderwijk Gelderland, Netherlands, 3844Radboud Universitair Medisch Centrum | Nijmegen Gelderland, Netherlands, 6525 GALeids Universitair Medisch Centrum (LUMC) | Leiden South Holland, Netherlands, 2333 ZAHospital Nacional Arzobispo Loayza | Lima Cercado Lima region, Peru, 15082Clínicas Oncosalud Sede Guardia Civil | San Borja Lima region, Peru, 15036Luis Alberto Vera Valdivia | San Borja Lima region, Peru, 15036IPOR - Instituto Peruano de Oncología & Radioterapia - Sede Principal | San Isidro Lima region, Peru, 15036Detecta Clínica | Surquillo Lima region, Peru, 15038Mruk-Med I Sp. z o.o. | Rzeszów Podkarpackie Voivodeship, Poland, 35-021Warmińsko-mazurskie Centrum Chorób Płuc w Olsztynie | Olsztyn Warmian-Masurian Voivodeship, Poland, 10-357Institutul Oncologic Bucuresti - Prof. Dr. Alexandru Trestioreanu | Bucharest Bucharest, Romania, 022328Monza Oncology Day Hospital | Bucharest Bucharest, Romania, 13823Centrul de Radioterapie Amethyst Cluj | Floreşti Cluj, Romania, 407280Ovidius Clinical Hospital | Ovidiu Constanța County, Romania, 905900Clinica MC Gral Ploiesti | Ploieşti Prahova, Romania, 100010Spitalul Județean de Urgență Satu Mare | Satu Mare Satu Mare County, Romania, 440192Oncocenter - Oncologie Clinica | Timișoara Timiș County, Romania, 300166Curie Oncology - Farrer - 10-05 | Singapore Central Singapore, Singapore, 217562P.H Feng Research Centre | Singapore Central Singapore, Singapore, 308433Tan Tock Seng Hospital | Singapore North East, Singapore, 308433National Cancer Centre Singapore | Singapore , Singapore, 168583Kyungpook National University Chilgok Hospital | Daegu Daegu Gwang'Yeogsi [Taegu-Kwangyokshi], South Korea, 41404Seoul National University Bundang Hospital | Seongnam-si Gyeonggi-do, South Korea, 13620Catholic University of Korea St. Vincent's Hospital | Suwon Gyeonggi-do, South Korea, 16247Ajou University Hospital | Suwon Gyeonggi-do, South Korea, 16499Chungbuk National University Hospital | Cheongju-si Gyeonggido [Kyonggi-do], South Korea, 28644National Cancer Center - Korea | Goyang-si Gyeonggido [Kyonggi-do], South Korea, 10408Keimyung University Dongsan Hospital | Daegu Gyeongsangbugdo [Kyongsangbuk-do], South Korea, 42601Kosin University Gospel Hospital | Pusan Gyeongsangnam-do, South Korea, 49267Pusan National University Yangsan Hospital | Yangsan Gyeongsangnam-do, South Korea, 50612Gyeongsang National University Hospital | Jinju Gyeongsangnamdo [Kyongsangnam-do], South Korea, 52727Inha University Hospital | Incheon Incheon Gwang'Yeogsi [Inch'On-Kwangyokshi], South Korea, 22332Chonnam National University Hwasun Hospital | Hwasun-gun Jeollanam-do, South Korea, 58128Jeonbuk National University Hospital | Jeonju Jeonrabugdo [Chollabuk-do], South Korea, 561-712Seoul Metropolitan Government Seoul National University Boramae Medical Center | Seoul Seoul, South Korea, 07061Korea University Anam Hospital | Seoul Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], South Korea, 02841Severance Hospital | Seoul Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], South Korea, 03722Konkuk University Medical Center | Seoul Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], South Korea, 05030The Catholic University of Korea - Seoul St. Mary's Hospital | Seoul Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], South Korea, 06591Korea University Guro Hospital | Seoul Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], South Korea, 08308Hanyang University Hospital | Seoul Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], South Korea, 4763Seoul National University Hospital | Seoul Seoul Teugbyeolsi, South Korea, 03080Hospital Universitario Son Espases | Palma de Mallorca Balearic Islands, Spain, 07120Institut Català d'Oncologia Badalona | Badalona Barcelona, Spain, 08916Instituto Oncológico Dr Rosell | Barcelona Barcelona, Spain, 08028Hospital Universitari Vall d'Hebrón | Barcelona Barcelona, Spain, 08035Hospital de la Santa Creu i Sant Pau | Barcelona Barcelona, Spain, 08041Hospital de Sabadell | Sabadell Barcelona, Spain, 08208Hospital Universitario Clínico San Cecilio PTS | Granada Granada, Spain, 18016Complejo Hospitalario Universitario Insular Materno Infantil | Las Palmas de Gran Canaria Las Palmas, Spain, 35016Hospital Universitario Lucus Augusti | Lugo Lugo, Spain, 27003MD Anderson Cancer Center Madrid | Madrid Madrid, Spain, 28033Hospital Universitario Fundación Jiménez Díaz | Madrid Madrid, Spain, 28040Hospital Universitario 12 de Octubre | Madrid Madrid, Spain, 28041Hospital Universitario Puerta de Hierro - Majadahonda | Majadahonda Madrid, Spain, 28222Hospital Quirónsalud Málaga | Málaga Málaga, Spain, 29004Hospital Universitario Virgen del Rocío | Seville Sevilla, Spain, 41013Hospital Universitari Sant Joan de Reus | Reus Tarragona, Spain, 43204Hospital Universitari i Politècnic La Fe | Valencia València, Spain, 46026Chulabhorn Hospital | Bang Kapi Bangkok, Thailand, 10240Faculty of Medicine Siriraj Hospital | Bangkoknoi Bangkok, Thailand, 10700King Chulalongkorn Memorial Hospital | Pathum Wan Bangkok, Thailand, 10330Lampang Cancer Hospital | Muang Changwat Lampang, Thailand, 10400Songklanagarind Hospital | Hat Yai Changwat Songkhla, Thailand, 90110Navamindradhiraj University - Faculty of Medicine Vajira Hospital | Bangkok Khet Dusit, Thailand, 10300Medical Park Seyhan Hastanesi | Adana Adana, Turkey (Türkiye), 01040T.C. Saglik Bakanligi Adana Sehir Egitim ve Arastirma Hastanesi | Adana Adana, Turkey (Türkiye), 01370Başkent Üniversitesi Adana Dr Turgut Noyan Uygulama ve Araştirma Merkezi | Yüreğir Adana, Turkey (Türkiye), 01250Memorial Ankara Hastanesi | Ankara Ankara, Turkey (Türkiye), 6520Liv Hospital Ankara | Ankara Ankara, Turkey (Türkiye), 6680Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve Arastirma Hastanesi | Etlik Ankara, Turkey (Türkiye), 06010Dicle Üniversitesi Tıp Fakültesi | Sur Diyarbakır, Turkey (Türkiye), 21280Trakya Üniversitesi Sağlık Araştırma ve Uygulama Merkezi | Edirne Edirne, Turkey (Türkiye), 22130Ozel Gaziantep Medical Point Hastanesi | Gaziantep Gaziantep, Turkey (Türkiye), 27584Gaziantep Universitesi - Şahinbey Araştırma ve Uygulama Hastanesi | Şehitkamil Gaziantep, Turkey (Türkiye), 27310Memorial Bahçelievler Hospital | Bahçelievler Istanbul, Turkey (Türkiye), 34180İstinye Üniversite Hastanesi Liv Hospital Bahcesehir | Esenyurt Istanbul, Turkey (Türkiye), 34517T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi | Istanbul Istanbul, Turkey (Türkiye), 34722İ.A.Ü. VM Medical Park Florya Hastanesi | Küçükçekmece Istanbul, Turkey (Türkiye), 34295Izmir Ekonomi Universitesi Medical Point Hastanesi | Izmir İzmir, Turkey (Türkiye), 35575Medicana International Izmir Hastanesi | Turgutlu Manisa, Turkey (Türkiye), 45400VM Medical Park Samsun Hastanesi | Atakum Samsun, Turkey (Türkiye), 55200The Christie NHS Foundation Trust | Manchester England, United Kingdom, M20 4BXNottingham University Hospitals NHS Trust | Nottingham England, United Kingdom, NG5 1PBTorbay and South Devon NHS Foundation Trust | Torquay England, United Kingdom, TQ27AAVelindre University NHS Trust | Cardiff Wales, United Kingdom, CF14 2TL