BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

Recruitment Status
RECRUITING
(See Contacts and Locations)Verified June 2026 by Pfizer
Sponsor
Pfizer
Information Provided by (Responsible Party)
Pfizer
Clinicaltrials.gov Identifier
NCT07160244
Other Study ID Numbers:
C1091009
First Submitted
August 13, 2025
First Posted
September 7, 2025
Last Update Posted
July 8, 2026
Last Verified
June 2026

ClinicalTrials.gov processed this data on July 2026. Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

Condition or DiseaseIntervention/Treatment
Healthy
Biological: Multivalent Group B streptococcus vaccineBiological: PlaceboBiological: Infanrix hexaBiological: Prevenar 20Biological: PediarixBiological: Prevnar 20Biological: Infanrix

Study Design

Study TypeInterventional
Actual Enrollment6000 participants
Design AllocationRandomized
Interventional ModelParallel Assignment
MaskingQuadruple
Primary PurposePrevention
Official TitleA PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A MULTIVALENT GROUP B STREPTOCOCCUS VACCINE IN HEALTHY PREGNANT WOMEN AND THEIR INFANTS
Study Start DateAugust 24, 2025
Actual Primary Completion Date2yrs 3mos from now
Actual Study Completion Date2yrs 7mos from now

Groups and Cohorts

Group/CohortIntervention/Treatment
GBS6
Multivalent group B streptococcus vaccine
Biological: Multivalent Group B streptococcus vaccine
Multivalent Group B streptococcus vaccine
Placebo
Placebo
Biological: Placebo
Saline Control
Infanrix hexa
Commercially available combination vaccine containing diphtheria, tetanus, pertussis (whooping cough), hepatitis B, poliomyelitis (polio), and Haemophilus influenzae type b (Hib)
Biological: Infanrix hexa
Vaccine administered in a subset of infant participants as per the national immunization schedule
Prevenar 20
Commercially available vaccine that protects against 20 strains of Streptococcus pneumoniae
Biological: Prevenar 20
Vaccine administered in a subset of infant participants as per the national immunization schedule
Pediarix
Commercially available combination vaccine containing diphtheria, tetanus, pertussis (whooping cough), hepatitis B, and polio
Biological: Pediarix
Vaccine administered in a subset of infant participants as per the national immunization schedule
Prevnar 20
Commercially available vaccine that protects against 20 strains of Streptococcus pneumoniae
Biological: Prevnar 20
Vaccine administered in a subset of infant participants as per the national immunization schedule
Infanrix
Commercially available combination vaccine containing diphtheria, tetanus, and pertussis
Biological: Infanrix
Vaccine administered in a subset of infant participants as per the national immunization schedule

Outcome Measures

Primary Outcome Measures
  1. The proportion of maternal participants reporting prespecified local reactions within 7 days following study intervention
  2. The proportion of maternal participants reporting prespecified systemic events within 7 days following study intervention
  3. The proportion of maternal participants reporting adverse events (AEs) through 1 month following study intervention
  4. The proportion of maternal participants reporting serious adverse events (SAEs) through 6 months after delivery
  5. The proportion of maternal participants reporting medically attended adverse events (MAAEs) through 6 months after delivery
  6. The proportion of maternal participants reporting adverse events of special interest (AESIs) through 6 months after delivery.
  7. The proportion of infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy reporting adverse events (AEs) from birth through 1 month of age
  8. The proportion of infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy reporting serious adverse events (SAEs) from birth through end of the study
  9. The proportion of infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy reporting medically attended adverse events (MAAEs) from birth through 6 months of age
  10. The proportion of infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy reporting adverse events of special interest (AESIs) from birth through end of study
  11. To measure the relative risk reduction in the proportion of infant participants at birth with GBS serotype-specific IgG antibody concentrations below predefined serotype-specific GBS late onset disease thresholds in the GBS6 group to the placebo group
  12. To measure the relative risk reduction in the proportion of infant participants at birth with GBS serotype-specific IgG antibody concentrations below predefined serotype-specific GBS early onset disease thresholds in the GBS6 group to the placebo group
  13. To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS late onset disease based on serotype specific anti-CPS IgG concentrations measured in infants at birth.
  14. To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS early onset disease based on serotype specific anti-CPS IgG concentrations measured in infants at birth.
Secondary Outcome Measures
  1. To measure GBS serotype-specific opsonophagocytic titers in infant participants at birth by geometric mean ratio between GBS6 group versus placebo group and by the difference in seroresponse rates between GBS6 group and placebo group
  2. To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS disease (all disease) caused by the 6 individual vaccine serotypes in infants when GBS6 is administered to healthy pregnant women.
  3. To describe anti-CPS IgG antibody levels in infant participants born to maternal participants vaccinated with GBS6.
  4. To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS LOD and EOD, separately, caused by the 6 individual vaccine serotypes (Ia, Ib, II, III, IV, and V) in infants when GBS6 is administered to healthy pregnant women.
  5. To measure GBS serotype-specific IgG by geometric mean concentration in maternal participants at 1 month after vaccination and at delivery.
  6. Compare the proportion of infants with anti-diphtheria toxoid and/or pneumococcal IgG responses at 1 month post-primary and toddler doses between GBS6 and placebo groups, including predefined IgG levels and geometric mean ratios.

Eligibility Criteria

Ages Eligible for Study(Child, Adult)
Sexes Eligible for StudyAll
Accepts Healthy VolunteersYes
Inclusion Criteria
Key Inclusion criteria- Maternal:
Healthy pregnant women ≤49 years of age who are between 24 0/7 and 36 0/7 weeks of gestation on the day of planned vaccination, with an uncomplicated, singleton pregnancy, and who have no known increased risk of complications.
Had a fetal anomaly ultrasound examination with no significant fetal abnormalities observed.
Documented negative human immunodeficiency virus (HIV) antibody test, syphilis test, and hepatitis B virus (HBV) surface antigen test during this pregnancy and prior to randomization.
Capable of giving personal signed informed consent.
Willing to give informed consent for her infant to participate in the study. Key
Exclusion Criteria
Key Inclusion criteria- Maternal:
Healthy pregnant women ≤49 years of age who are between 24 0/7 and 36 0/7 weeks of gestation on the day of planned vaccination, with an uncomplicated, singleton pregnancy, and who have no known increased risk of complications.
Had a fetal anomaly ultrasound examination with no significant fetal abnormalities observed.
Documented negative human immunodeficiency virus (HIV) antibody test, syphilis test, and hepatitis B virus (HBV) surface antigen test during this pregnancy and prior to randomization.
Capable of giving personal signed informed consent.
Willing to give informed consent for her infant to participate in the study. Key Exclusion criteria- Maternal:
Prepregnancy body mass index (BMI) of \>40 kg/m2.
Current pregnancy complications or abnormalities that may increase the risk associated with the participation in and completion of the study.
Prior pregnancy complications or abnormalities that, based on the investigator's judgment, may increase the risk associated with the participation in and completion of the study.
History of microbiologically proven invasive disease caused by GBS in the current pregnancy.
A known or suspected infection during the current pregnancy that may increase the risk of complications in pregnancy (eg, active tuberculosis, syphilis, primary genital herpes simplex, malaria). Key Inclusion criteria- Infant Participants \- Evidence of a signed and dated ICD signed by the parent(s)/legally authorized representative or legal guardian Key Exclusion Criteria - Infant Participants: \- Children or grandchildren who are direct descendants of investigator site staff or sponsor and sponsor delegate employees directly involved in the conduct of the study. Key Exclusion Criteria - Infant immunogenicity subset Participants: \- Children with a known or suspected contraindication to any vaccine administered in the infant vaccine immunogenicity subset. Refer to the study contact for further eligibility details

Contacts and Locations

Sponsors and CollaboratorsPfizer
Locations
Center for Research in Women's Health | Birmingham Alabama, United States, 35233Children's of Alabama | Birmingham Alabama, United States, 35233University of Alabama at Birmingham - School of Medicine | Birmingham Alabama, United States, 35233University of Alabama at Birmingham Women & Infants Center | Birmingham Alabama, United States, 35294SEC Clinical Research | Dothan Alabama, United States, 36305USA Health Allen Cox Building | Mobile Alabama, United States, 36604USA Health Children's and Women's Hospital | Mobile Alabama, United States, 36604USA Health Mitchell Cancer Institute | Mobile Alabama, United States, 36604USA Health Strada Patient Care Center | Mobile Alabama, United States, 36604ClinMed | Phoenix Arizona, United States, 85004Valleywise Comprehensive Health Center Women's Clinic | Phoenix Arizona, United States, 85008Valleywise Health Medical Center | Phoenix Arizona, United States, 85008Genesis OB/GYN | Tucson Arizona, United States, 85741Eclipse Clinical Research | Tucson Arizona, United States, 85745Antelope Valley Medical Center | Lancaster California, United States, 93534Chemidox Clinical Trials | Lancaster California, United States, 93534Loma Linda University Children's Hospital | Loma Linda California, United States, 92354Loma Linda University Health System | Loma Linda California, United States, 92354Loma Linda University Pediatrics Clinic | Loma Linda California, United States, 92354Lucile Packard Children's Hospital | Palo Alto California, United States, 94304Stanford Obstetrics Clinic | Palo Alto California, United States, 94304Stanford University Medical Center | Palo Alto California, United States, 94304Stanford University | Palo Alto California, United States, 94304Anschutz Health Sciences Building | Aurora Colorado, United States, 80045Children's Hospital Colorado | Aurora Colorado, United States, 80045CU Research Pharmacy | Aurora Colorado, United States, 80045University of Colorado AO1 | Aurora Colorado, United States, 80045University of Colorado Hospital Outpatient Pavilion | Aurora Colorado, United States, 80045University of Colorado Hospital | Aurora Colorado, United States, 80045University of Colorado Research II Building | Aurora Colorado, United States, 80045South Florida Clinical Research Institute - Margate | Margate Florida, United States, 33063Citadelle Clinical Research | North Miami Beach Florida, United States, 33162Emerald Coast OBGYN Clinical Research | Panama City Florida, United States, 32405HCA Florida Gulf Coast Hospital | Panama City Florida, United States, 32405Advanced Specialty Research | Boise Idaho, United States, 83702Express Lab | Garden City Idaho, United States, 83714Clinical Research Prime | Idaho Falls Idaho, United States, 83404Eastern Idaho Regional Medical Center | Idaho Falls Idaho, United States, 83404Mountain View Hospital | Idaho Falls Idaho, United States, 83404Madison Memorial Hospital | Rexburg Idaho, United States, 83440Accellacare - McFarland | Ames Iowa, United States, 50010Mary Greeley Medical Center | Ames Iowa, United States, 50010McFarland Clinic, PC | Ames Iowa, United States, 50010Velocity Clinical Research, Covington | Covington Louisiana, United States, 70433Ochsner Baptist Medical Center | New Orleans Louisiana, United States, 70115Center for Immunization Research | Baltimore Maryland, United States, 21205Center for Immunization Research | Baltimore Maryland, United States, 21224Johns Hopkins Bayview Medical Center | Baltimore Maryland, United States, 21224Gynecology and Obstetrics at Johns Hopkins Health Care and Surgery Center- White Marsh | Nottingham Maryland, United States, 21236Boston Medical Center | Boston Massachusetts, United States, 02118Washington University School of Medicine | St Louis Missouri, United States, 63110Boeson Research GTF | Great Falls Montana, United States, 59405Great Falls OBGYN Associates | Great Falls Montana, United States, 59405Origin Health GTF | Great Falls Montana, United States, 59405Blue Moose Pediatrics | Missoula Montana, United States, 59804Boeson Research MSO | Missoula Montana, United States, 59804Origin Health | Missoula Montana, United States, 59804CHI Health St Francis | Grand Island Nebraska, United States, 68803Grand Island Regional Medical Center | Grand Island Nebraska, United States, 68803Velocity Clinical Research, Grand Island | Grand Island Nebraska, United States, 68803Midwest Children's Health Research Center | Lincoln Nebraska, United States, 68504Midwest Children's Health Research Center | Lincoln Nebraska, United States, 68505Bryan Health | Lincoln Nebraska, United States, 68506Midwest Children's Health Research Institute | Lincoln Nebraska, United States, 68516Women's Health Care Center of Williamsburg | Lincoln Nebraska, United States, 68516Midwest Children's Health Research Center | Lincoln Nebraska, United States, 68522Velocity Clinical Research, Norfolk | Norfolk Nebraska, United States, 68701Cooper University Health Care | Camden New Jersey, United States, 08103Cooper University Health Care | Cherry Hill New Jersey, United States, 08034Family Health Center | New Brunswick New Jersey, United States, 08901Saint Peter's University Hospital | New Brunswick New Jersey, United States, 08901Cooper University Health Care | Sewell New Jersey, United States, 08080Stony Brook Medicine Clinical Research Center | East Setauket New York, United States, 11733New York-Presbyterian Queens | Flushing New York, United States, 11355Obstetrical Center | Fresh Meadows New York, United States, 11365ACGC Research, NYU Ambulatory Care Garden City | Garden City New York, United States, 11530NYU Langone Ambulatory Care Garden City | Garden City New York, United States, 11530Jackson Heights Family Health Center | Jackson Heights New York, United States, 11372NYU Langone Long Island, Clinical Research Center 3-002 (Admin only) | Mineola New York, United States, 11501Columbia University Irving Medical Center | New York New York, United States, 10032Weill Cornell Medicine - New York Presbyterian Hospital | New York New York, United States, 10065Stony Brook University | Stony Brook New York, United States, 11794Duke Vaccine and Trials Unit | Durham North Carolina, United States, 27703Duke University - Main Hospital and Clinics | Durham North Carolina, United States, 27705Duke University - Main Hospital and Clinics | Durham North Carolina, United States, 27710Cincinnati Children's Hospital Medical Center | Cincinnati Ohio, United States, 45206University of Cincinnati Physicians Midtown | Cincinnati Ohio, United States, 45213Hoxworth Center | Cincinnati Ohio, United States, 45219University of Cincinnati Medical Center | Cincinnati Ohio, United States, 45219Cincinnati Children's Hospital Medical Center | Cincinnati Ohio, United States, 45229University Hospitals | Cleveland Ohio, United States, 44106Cincinnati Children's Hospital Medical Center Liberty | Liberty Township Ohio, United States, 45044Cincinnati Children's Hospital Medical Center Mason | Mason Ohio, United States, 45040Senders Pediatrics | South Euclid Ohio, United States, 44121University of Cincinnati Medical Center West Chester | West Chester Ohio, United States, 45069University of Cincinnati Physicians | West Chester Ohio, United States, 45069UPMC Children's Hospital of Pittsburgh | Pittsburgh Pennsylvania, United States, 15213UPMC Magee Women's Hospital | Pittsburgh Pennsylvania, United States, 15213Tribe Clinical Research, LLC- Greer | Greer South Carolina, United States, 29650Tribe Clinical Research at Parkside Pediatrics Five Forks | Simpsonville South Carolina, United States, 29681Proactive Clinical Research LLC | Edinburg Texas, United States, 78539Memorial Hermann Memorial City Hospital | Houston Texas, United States, 77024The University of Texas Health Science Center at Houston | Houston Texas, United States, 77024Maximos Ob/Gyn | League City Texas, United States, 77573Dr. Ruben Aleman and Associates | McAllen Texas, United States, 78504University of Utah Madsen Health Center - Women's Health | Salt Lake City Utah, United States, 84112University of Utah | Salt Lake City Utah, United States, 84112University of Utah Clinical Neuroscience Center | Salt Lake City Utah, United States, 84132University of Utah Hospital | Salt Lake City Utah, United States, 84132Inova Fairfax Medical Campus | Falls Church Virginia, United States, 22042Sentara Leigh Hospital | Norfolk Virginia, United States, 23502The Group For Women - Kempsville Office | Norfolk Virginia, United States, 23502Tidewater Physicians for Women | Norfolk Virginia, United States, 23502Womens Care Center | Norfolk Virginia, United States, 23502Virginia Physicians For Women (VPFW) | North Chesterfield Virginia, United States, 23235Clinical Research Partners, LLC | Richmond Virginia, United States, 23226Seattle Childrens Research Institute | Seattle Washington, United States, 98101Seattle Childrens Hospital | Seattle Washington, United States, 98105UW Medical Center Northwest | Seattle Washington, United States, 98133UW Medical Center Montlake | Seattle Washington, United States, 98195Marshfield Medical Center - Marshfield-(Hospital) | Marshfield Wisconsin, United States, 54449Marshfield Medical Center - Marshfield | Marshfield Wisconsin, United States, 54449Fundación Respirar | Ciudad Autónoma de Buenos Aires Buenos Aires, Argentina, C1426ABPClinica Del Niño Y La Madre | Mar del Plata Buenos Aires, Argentina, 7600Clinica Privada del Sol S.A | Córdoba Córdoba Province, Argentina, X5000IIHClínica Mayo de Urgencias Médicas Cruz Blanca S.R.L | San Miguel de Tucumán Tucumán Province, Argentina, 4000Instituto de Maternidad y Ginecología Nuestra Señora de las Mercedes | San Miguel de Tucumán Tucumán Province, Argentina, 4000Centro de investigación Clínica OSECAC - Sede Jonas Salk | Buenos Aires , Argentina, 1044Equipo Ciencia | Buenos Aires , Argentina, C1428BNFHospital Público Materno Infantil | Salta , Argentina, 4400Centro de Pesquisa Clínica - Obras Sociais Irmã Dulce | Salvador Estado de Bahia, Brazil, 41680-430Centro de Estudos e Pesquisa em Molestias Infecciosas - CPCLIN/RN | Natal Rio Grande do Norte, Brazil, 59025050Universidade Federal de Santa Maria. | Santa Maria Rio Grande do Sul, Brazil, 97105-900Fundação Faculdade Regional de Medicina de São José do Rio Preto | São José do Rio Preto São Paulo, Brazil, 15090000Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo | São Paulo São Paulo, Brazil, Canadian Center for Vaccinology | Halifax Nova Scotia, Canada, B3K 6R8Kingston Health Sciences Centre - Kingston General Site | Kingston Ontario, Canada, K7L 2V7CHU de Quebec-Universite Laval-Centre hospitalier de l'Universite Laval et Centre mere-enfant Soleil | Québec Quebec, Canada, G1V 4G2FVR, Kokkolan rokotetutkimusklinikka | Kokkola Keski-Pohjanmaa, Finland, 67100FVR, Oulun rokotetutkimusklinikka | Oulu North Ostrobothnia, Finland, 90220FVR, Tampereen rokotetutkimusklinikka | Tampere Pirkanmaa, Finland, 33100FVR, Seinäjoen rokotetutkimusklinikka | Seinäjoki South Ostrobothnia, Finland, 60100FVR, Turun rokotetutkimusklinikka | Turku Southwest Finland, Finland, 20520MeVac - Meilahti Vaccine Research Center | Helsinki Uusimaa, Finland, 00290St.Mary's Hospital | Kurume Fukuoka, Japan, 830-8543Sendai City Hospital | Sendai Miyagi, Japan, 982-8502Beppu Medical Center | Beppu-shi Oita Prefecture, Japan, 874-0011Osaka Habikino Medical Center | Habikino Osaka, Japan, 583-8588Taniguchi Hospital | Izumisano Osaka, Japan, 598-0043Yamanashi Prefectural Central Hospital | Kofu Yamanashi, Japan, 400-8506Fukui Aiiku Hospital | Fukui , Japan, 910-0833Rakuwakai Otowa Hospital | Kyoto , Japan, 607-8062Shizuoka General Hospital | Shizuoka , Japan, 420-8527Panamerican Clinical Research Mexico S.A de C.V. Guadalajara. | Guadalajara Jalisco, Mexico, 44670Arké SMO S.A. de C.V. | Mexico City Mexico City, Mexico, 06700Hospital Universitario "Dr. Jose Eleuterio Gonzalez" | Monterrey Nuevo León, Mexico, 64460Unidad de Medicina Especializada SMA | San Juan del Río Querétaro, Mexico, 76800Arké SMO S.A de C.V | Veracruz , Mexico, 91900Jeroen Bosch Hospital | 's-Hertogenbosch North Brabant, Netherlands, 5223 GZDiakonessenhuis, locatie Utrecht | Utrecht , Netherlands, 3582 KEUMC Utrecht - Wilhelmina Kinderziekenhuis | Utrecht , Netherlands, 3584Josha Research | Bloemfontein Free State, South Africa, 9301REIMED Reiger Park | Boksburg Gauteng, South Africa, 1459Wits RHI Shandukani Research Centre | Johannesburg Gauteng, South Africa, 2001Setshaba Research Centre | Pretoria Gauteng, South Africa, 0152Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit | Soweto Gauteng, South Africa, 1864MRC Unit on Child And Adolescent Health | Cape Town Western Cape, South Africa, 7700Gugulethu Green Clinic | Cape Town Western Cape, South Africa, 7750Kangwon National University Hospital | Chuncheon Gangwon-do, South Korea, 24289Chonnam National University Hospital | Gwangju Kwangju-kwangyǒkshi, South Korea, 61469Seoul National University Hospital | Seoul Seoul-teukbyeolsi [seoul], South Korea, 03080Korea University Guro Hospital | Seoul Seoul-teukbyeolsi [seoul], South Korea, 08308Keimyung University Dongsan Hospital | Daegu Taegu-kwangyǒkshi, South Korea, 42601Kyung Hee University Hospital at Gangdong | Seoul , South Korea, 05278CHUS - Hospital Clinico Universitario | Santiago de Compostela A Coruña [LA Coruña], Spain, 15706Hospital Sant Joan de Déu | Esplugues de Llobregat Barcelona [barcelona], Spain, 08950Hospital Universitario Quironsalud Madrid | Pozuelo de Alarcón Madrid, Spain, 28223Hospital Universitario de Torrejón | Torrejón de Ardoz Madrid, Spain, 28850Hospital Universitario La Paz | Madrid Madrid, Comunidad de, Spain, 28046Hospital Universitario HM Puerta del Sur | Madrid Madrid, Comunidad de, Spain, 28938Hospital Antequera | Antequera , Spain, 29200Hospital Universitario La Zarzuela | Aravaca , Spain, 28023Hospital General Universitario Gregorio Marañon | Madrid , Spain, 28007Hospital Universitario 12 de Octubre | Madrid , Spain, 28041Hospital Quirónsalud Sagrado Corazón | Seville , Spain, 41013Instituto Hispalense de Pediatria- IHP1 | Seville , Spain, 41014Hsinchu Municipal Mackay Children's Hospital | Hsinchu Hsinchu, Taiwan, 30046Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung City , Taiwan, 80756National Taiwan University Hospital | Taipei , Taiwan, 10002Mackay Memorial Hospital | Taipei , Taiwan, 10449Chang Gung Medical Foundation-Linkou Branch | Taoyuan , Taiwan, 333University Hospitals Bristol NHS Foundation Trust | Bristol Bristol, CITY of, United Kingdom, BS1 3NUSt Michael's Hospital | Bristol Bristol, CITY of, United Kingdom, BS2 8EGBarnet Hospital | London England, United Kingdom, EN5 3DJSt. George's Hospital | London England, United Kingdom, SW17 0QTNorth Manchester General Hospital | Manchester England, United Kingdom, M8 5RB.The Royal Cornwall Hospital | Truro England, United Kingdom, TR1 3LJSouthampton General Hospital | Southampton Hampshire, United Kingdom, SO16 6YDSt Mary's Hospital (Manchester University NHS Foundation Trust) | Manchester Lancashire, United Kingdom, M13 9WLImperial College Healthcare NHS Foundation Trust - St Mary's Hospital | London London, CITY of, United Kingdom, W2 1NYThe John Radcliffe Hospital | Oxford Oxfordshire, United Kingdom, OX3 9DUThe Princess Royal Hospital | Shropshire Telford AND Wrekin, United Kingdom, TF1 6TFBristol Royal Hospital for Children | Bristol , United Kingdom, BS2 8BJBristol Royal Infirmary | Bristol , United Kingdom, BS2 8EXSt James's University Hospital | Leeds , United Kingdom, LS9 7TFRoyal Free Hospital | London , United Kingdom, NW32QGWythenshawe Hospital | Manchester , United Kingdom, M23 9LT
Investigators
Study Director: Pfizer CT.gov Call Center, Pfizer