Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Recruitment Status: RECRUITING
(See Contacts and Locations)Verified April 2026 by Alnylam Pharmaceuticals
Sponsor: Alnylam Pharmaceuticals
Information Provided by (Responsible Party): Alnylam Pharmaceuticals

Clinicaltrials.gov Identifier: NCT07181109
Other Study ID Numbers:: ALN-AGT01-008

First Submitted: September 11, 2025
First Posted: September 17, 2025
Last Update Posted: May 13, 2026
Last Verified: April 2026

ClinicalTrials.gov processed this data on May 2026. Link to the current ClinicalTrials.gov record .

History of Changes

Study Details

Study Description

Condition or Disease	Intervention/Treatment
High Risk Cardiovascular DiseaseHypertensionHigh Cardiovascular Risk	Drug: ZilebesiranDrug: Placebo

Study Design

Study Type	Interventional
Actual Enrollment	11000 participants
Design Allocation	Randomized
Interventional Model	Parallel Assignment
Masking	Quadruple
Primary Purpose	Treatment
Official Title	ZENITH: A Phase 3 Global, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Zilebesiran in Addition to Standard of Care in Reducing Major Adverse Cardiovascular Events in Adult Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
Study Start Date	September 21, 2025
Actual Primary Completion Date	4yrs 4mos from now
Actual Study Completion Date	4yrs 4mos from now

Groups and Cohorts

Group/Cohort	Intervention/Treatment
Zilebesiran 300 mg Participants will be administered 300 mg zilebesiran subcutaneously (SC) once every 6 months as add-on therapy to their standard of care antihypertensive medications.	Drug: Zilebesiran Zilebesiran will be administered SC
Placebo Participants will be administered placebo SC once every 6 months as add-on therapy to their standard of care antihypertensive medications.	Drug: Placebo Placebo will be administered SC

Outcome Measures

Primary Outcome Measures

Time to First Occurrence of a Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, or Heart Failure (HF) Event (Hospitalization for HF or Urgent HF Visit)

Secondary Outcome Measures

Change from Baseline in Mean Seated Office Systolic Blood Pressure (SBP) at Month 6
Time to First Occurrence of a Composite Endpoint of CV Death, Nonfatal MI, or Nonfatal Stroke
Composite Endpoint of CV Death and Total (First and Subsequent) HF Events (Hospitalization for HF or Urgent HF Visit)
Time to First Occurrence of Composite Endpoint of CV death, Nonfatal MI, Nonfatal Stroke, or Coronary Revascularization
Time to All-cause Death

Eligibility Criteria

Ages Eligible for Study	(Adult, Older Adult)
Sexes Eligible for Study	All
Accepts Healthy Volunteers	No
Inclusion Criteria	Is 18 years or older for patients with established cardiovascular disease (CVD) Is 55 years or older for patients with high risk for CVD Has established CVD (defined as coronary, cerebrovascular, or peripheral artery disease) or high risk for CVD Has treated hypertension on stable therapy with at least 2 standard of care antihypertensive medications, one of which must be a thiazide, thiazide-like, or loop diuretic
Exclusion Criteria	Has known history of secondary hypertension Has symptomatic orthostatic hypotension Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>3×upper limit of normal (ULN) Has total serum bilirubin \>1.5×ULN Has international normalized ratio (INR) \>1.5 Has serum potassium \>4.8 mEq/L Has estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m\^2

Contacts and Locations

Sponsors and Collaborators	Alnylam Pharmaceuticals
Locations	Clinical Trial Site \| Birmingham Alabama, United States, 35205Clinical Trial Site \| Birmingham Alabama, United States, 35211Clinical Trial Site \| Fairhope Alabama, United States, 36532Clinical Trial Site \| Foley Alabama, United States, 36535Clinical Trial Site \| Huntsville Alabama, United States, 35801Clinical Trial Site \| Huntsville Alabama, United States, 35805Clinical Trial Site \| Sheffield Alabama, United States, 35660Clinical Trial Site \| Chandler Arizona, United States, 85224Clinical Trial Site \| Gilbert Arizona, United States, 85296Clinical Trial Site \| Glendale Arizona, United States, 85308Clinical Trial Site \| Mesa Arizona, United States, 85213Clinical Trial Site \| Phoenix Arizona, United States, 85015Clinical Trial Site \| Phoenix Arizona, United States, 85020Clinical Trial Site \| Sun City West Arizona, United States, 85375Clinical Trial Site \| Tempe Arizona, United States, 85283Clinical Trial Site \| Tucson Arizona, United States, 85715Clinical Trial Site \| Tucson Arizona, United States, 85741Clinical Trial Site \| Yuma Arizona, United States, 85364Clinical Trial Site \| Little Rock Arkansas, United States, 72204Clinical Trial Site \| Little Rock Arkansas, United States, 72205Clinical Trial Site \| Beverly Hills California, United States, 90211Clinical Trial Site \| Chula Vista California, United States, 91910Clinical Trial Site \| Covina California, United States, 91723Clinical Trial Site \| Escondido California, United States, 92025Clinical Trial Site \| Glendale California, United States, 91206Clinical Trial Site \| Huntington Beach California, United States, 92648Clinical Trial Site \| La Jolla California, United States, 92037Clinical Trial Site \| Lancaster California, United States, 93534Clinical Trial Site \| Long Beach California, United States, 90815Clinical Trial Site \| Lynwood California, United States, 90262Clinical Trial Site \| Newhall California, United States, 91321Clinical Trial Site \| Northridge California, United States, 91325Clinical Trial Site \| Pasadena California, United States, 91105Clinical Trial Site \| San Diego California, United States, 92111Clinical Trial Site \| San Dimas California, United States, 91773Clinical Trial Site \| San Ramon California, United States, 94583Clinical Trial Site \| Tarzana California, United States, 91356Clinical Trial Site \| Toluca Lake California, United States, 91602Clinical Trial Site \| Torrance California, United States, 90502Clinical Trial Site \| Tustin California, United States, 92780Clinical Trial Site \| Vista California, United States, 92081Clinical Trial Site \| Walnut Creek California, United States, 94598Clinical Trial Site \| Bridgeport Connecticut, United States, 06610Clinical Trial Site \| Waterbury Connecticut, United States, 06708Clinical Trial Site \| Boca Raton Florida, United States, 33434Clinical Trial Site \| Brandon Florida, United States, 33511Clinical Trial Site \| Fleming Island Florida, United States, 32003Clinical Trial Site \| Fort Lauderdale Florida, United States, 33308Clinical Trial Site \| Hialeah Florida, United States, 33012Clinical Trial Site \| Hollywood Florida, United States, 33024Clinical Trial Site \| Homestead Florida, United States, 33030Clinical Trial Site \| Jacksonville Florida, United States, 32205Clinical Trial Site \| Jacksonville Florida, United States, 32216Clinical Trial Site \| Jensen Beach Florida, United States, 34957Clinical Trial Site \| Leesburg Florida, United States, 34748Clinical Trial Site \| Melbourne Florida, United States, 32934Clinical Trial Site \| Miami Florida, United States, 33126Clinical Trial Site \| Miami Florida, United States, 33134Clinical Trial Site \| Miami Florida, United States, 33135Clinical Trial Site \| Miami Florida, United States, 33155Clinical Trial Site \| Miami Florida, United States, 33169Clinical Trial Site \| Miami Florida, United States, 33186Clinical Trial Site \| Orlando Florida, United States, 32825Clinical Trial Site \| Palm Springs Florida, United States, 33406Clinical Trial Site \| Tampa Florida, United States, 33615Clinical Trial Site \| Wellington Florida, United States, 33449Clinical Trial Site \| Winter Park Florida, United States, 32789Clinical Trial Site \| Atlanta Georgia, United States, 30342Clinical Trial Site \| Brunswick Georgia, United States, 31520Clinical Trial Site \| Columbus Georgia, United States, 31901Clinical Trial Site \| Columbus Georgia, United States, 31904Clinical Trial Site \| Conyers Georgia, United States, 30012Clinical Trial Site \| Conyers Georgia, United States, 30094Clinical Trial Site \| Fayetteville Georgia, United States, 30214Clinical Trial Site \| Hinesville Georgia, United States, 31313Clinical Trial Site \| Johns Creek Georgia, United States, 30024Clinical Trial Site \| Lawrenceville Georgia, United States, 30044Clinical Trial Site \| Macon Georgia, United States, 31201Clinical Trial Site \| Stonecrest Georgia, United States, 30038Clinical Trial Site \| Suwanee Georgia, United States, 30024Clinical Trial Site \| Thomasville Georgia, United States, 31792Clinical Trial Site \| Arlington Heights Illinois, United States, 60005Clinical Trial Site \| Chicago Illinois, United States, 60611Clinical Trial Site \| Chicago Illinois, United States, 60640Clinical Trial Site \| Hazel Crest Illinois, United States, 60429Clinical Trial Site \| Oak Brook Illinois, United States, 60523Clinical Trial Site \| Orland Park Illinois, United States, 60462Clinical Trial Site \| Springfield Illinois, United States, 62701Clinical Trial Site \| Tinley Park Illinois, United States, 60477Clinical Trial Site \| Avon Indiana, United States, 46123Clinical Trial Site \| Carmel Indiana, United States, 46290Clinical Trial Site \| Evansville Indiana, United States, 47714Clinical Trial Site \| Evansville Indiana, United States, 47715Clinical Trial Site \| Franklin Indiana, United States, 46131Clinical Trial Site \| Greenfield Indiana, United States, 46140Clinical Trial Site \| South Bend Indiana, United States, 46617Clinical Trial Site \| Valparaiso Indiana, United States, 46383Clinical Trial Site \| Hutchinson Kansas, United States, 67502Clinical Trial Site \| Topeka Kansas, United States, 66606Clinical Trial Site \| Wichita Kansas, United States, 67214Clinical Trial Site \| Wichita Kansas, United States, 67218Clinical Trial Site \| Bowling Green Kentucky, United States, 42101Clinical Trial Site \| Lexington Kentucky, United States, 40503Clinical Trial Site \| Versailles Kentucky, United States, 40383Clinical Trial Site \| Hammond Louisiana, United States, 70403Clinical Trial Site \| Lafayette Louisiana, United States, 70503Clinical Trial Site \| New Orleans Louisiana, United States, 70112Clinical Trial Site \| Opelousas Louisiana, United States, 70570Clinical Trial Site \| Shreveport Louisiana, United States, 71105Clinical Trial Site \| Slidell Louisiana, United States, 70458Clinical Trial Site \| Zachary Louisiana, United States, 70791Clinical Trial Site \| Baltimore Maryland, United States, 21215Clinical Trial Site \| Baltimore Maryland, United States, 21229Clinical Trial Site \| Beltsville Maryland, United States, 20705Clinical Trial Site \| Bowie Maryland, United States, 20715Clinical Trial Site \| Lanham Maryland, United States, 20706Clinical Trial Site \| Rockville Maryland, United States, 20850Clinical Trial Site \| Flint Michigan, United States, 48504Clinical Trial Site \| Petoskey Michigan, United States, 49770Clinical Trial Site \| Shelby Michigan, United States, 48315Clinical Trial Site \| Southfield Michigan, United States, 48075Clinical Trial Site \| Troy Michigan, United States, 48085Clinical Trial Site \| Troy Michigan, United States, 48098Clinical Trial Site \| Richfield Minnesota, United States, 55423Clinical Trial Site \| Saint Cloud Minnesota, United States, 56303Clinical Trial Site \| Jackson Mississippi, United States, 39216Clinical Trial Site \| Olive Branch Mississippi, United States, 38654Clinical Trial Site \| Port Gibson Mississippi, United States, 39150Clinical Trial Site \| Ridgeland Mississippi, United States, 39157Clinical Trial Site \| Tupelo Mississippi, United States, 38801Clinical Trial Site \| Kansas City Missouri, United States, 64108Clinical Trial Site \| Kansas City Missouri, United States, 64111Clinical Trial Site \| Kansas City Missouri, United States, 64151Clinical Trial Site \| St Louis Missouri, United States, 63136Clinical Trial Site \| St Louis Missouri, United States, 63141Clinical Trial Site \| Fremont Nebraska, United States, 68025Clinical Trial Site \| Omaha Nebraska, United States, 68114Clinical Trial Site \| Las Vegas Nevada, United States, 89102Clinical Trial Site \| Las Vegas Nevada, United States, 89121Clinical Trial Site \| Las Vegas Nevada, United States, 89148Clinical Trial Site \| Portsmouth New Hampshire, United States, 03801Clinical Trial Site \| Brick New Jersey, United States, 08724Clinical Trial Site \| Bridgewater New Jersey, United States, 08807Clinical Trial Site \| Flemington New Jersey, United States, 08822Clinical Trial Site \| Albuquerque New Mexico, United States, 87106Clinical Trial Site \| New Windsor New York, United States, 12553Clinical Trial Site \| North Massapequa New York, United States, 11758Clinical Trial Site \| Poughkeepsie New York, United States, 12601Clinical Trial Site \| Riverhead New York, United States, 11901Clinical Trial Site \| Rosedale New York, United States, 11422Clinical Trial Site \| Saratoga Springs New York, United States, 12866Clinical Trial Site \| The Bronx New York, United States, 10461Clinical Trial Site \| West Seneca New York, United States, 14224Clinical Trial Site \| Westfield New York, United States, 14787Clinical Trial Site \| Durham North Carolina, United States, 27704Clinical Trial Site \| Greenville North Carolina, United States, 27834Clinical Trial Site \| High Point North Carolina, United States, 27260Clinical Trial Site \| Jacksonville North Carolina, United States, 28546Clinical Trial Site \| Kings Mountain North Carolina, United States, 28086Clinical Trial Site \| Monroe North Carolina, United States, 28112Clinical Trial Site \| Statesville North Carolina, United States, 28625Clinical Trial Site \| Fargo North Dakota, United States, 58104Clinical Trial Site \| Beavercreek Ohio, United States, 45431Clinical Trial Site \| Cincinnati Ohio, United States, 45212Clinical Trial Site \| Cincinnati Ohio, United States, 45219Clinical Trial Site \| Columbus Ohio, United States, 43213Clinical Trial Site \| Dayton Ohio, United States, 45409Clinical Trial Site \| Dayton Ohio, United States, 45429Clinical Trial Site \| Lima Ohio, United States, 45801Clinical Trial Site \| Maumee Ohio, United States, 43537Clinical Trial Site \| Moraine Ohio, United States, 45439Clinical Trial Site \| Edmond Oklahoma, United States, 73013Clinical Trial Site \| Moore Oklahoma, United States, 73160Clinical Trial Site \| Norman Oklahoma, United States, 73069Clinical Trial Site \| Oklahoma City Oklahoma, United States, 73120Clinical Trial Site \| Camp Hill Pennsylvania, United States, 17701Clinical Trial Site \| Horsham Pennsylvania, United States, 19044Clinical Trial Site \| Linwood Pennsylvania, United States, 19061Clinical Trial Site \| Media Pennsylvania, United States, 19063Clinical Trial Site \| Uniontown Pennsylvania, United States, 15401Clinical Trial Site \| Columbia South Carolina, United States, 29205Clinical Trial Site \| Greenville South Carolina, United States, 29607Clinical Trial Site \| Greer South Carolina, United States, 29650Clinical Trial Site \| Sioux Falls South Dakota, United States, 57104Clinical Trial Site \| Chattanooga Tennessee, United States, 37404Clinical Trial Site \| Chattanooga Tennessee, United States, 37412Clinical Trial Site \| Knoxville Tennessee, United States, 37909Clinical Trial Site \| Knoxville Tennessee, United States, 37923Clinical Trial Site \| Allen Texas, United States, 75013Clinical Trial Site \| Amarillo Texas, United States, 79106Clinical Trial Site \| Amarillo Texas, United States, 79124Clinical Trial Site \| Arlington Texas, United States, 76012Clinical Trial Site \| Arlington Texas, United States, 76015Clinical Trial Site \| Austin Texas, United States, 78735Clinical Trial Site \| Austin Texas, United States, 78759Clinical Trial Site \| Beaumont Texas, United States, 77702Clinical Trial Site \| Carrollton Texas, United States, 75006Clinical Trial Site \| Dallas Texas, United States, 75226Clinical Trial Site \| Dallas Texas, United States, 75235Clinical Trial Site \| Dallas Texas, United States, 75246Clinical Trial Site \| Duncanville Texas, United States, 75137Clinical Trial Site \| El Paso Texas, United States, 79905Clinical Trial Site \| Euless Texas, United States, 76040Clinical Trial Site \| Houston Texas, United States, 77002Clinical Trial Site \| Houston Texas, United States, 77024Clinical Trial Site \| Houston Texas, United States, 77025Clinical Trial Site \| Houston Texas, United States, 77036Clinical Trial Site \| Houston Texas, United States, 77043Clinical Trial Site \| Houston Texas, United States, 77061Clinical Trial Site \| Houston Texas, United States, 77070Clinical Trial Site \| Houston Texas, United States, 77095Clinical Trial Site \| Houston Texas, United States, 77429Clinical Trial Site \| Humble Texas, United States, 77338Clinical Trial Site \| Katy Texas, United States, 77450Clinical Trial Site \| Kingwood Texas, United States, 77339Clinical Trial Site \| Laredo Texas, United States, 78041Clinical Trial Site \| McAllen Texas, United States, 78503Clinical Trial Site \| McKinney Texas, United States, 75069Clinical Trial Site \| McKinney Texas, United States, 75071Clinical Trial Site \| Mesquite Texas, United States, 75149Clinical Trial Site \| Missouri City Texas, United States, 77459Clinical Trial Site \| Paris Texas, United States, 75462Clinical Trial Site \| Pasadena Texas, United States, 77504Clinical Trial Site \| Plano Texas, United States, 75024Clinical Trial Site \| Port Arthur Texas, United States, 77642Clinical Trial Site \| San Antonio Texas, United States, 78220Clinical Trial Site \| San Antonio Texas, United States, 78229Clinical Trial Site \| San Antonio Texas, United States, 78231Clinical Trial Site \| San Antonio Texas, United States, 78258Clinical Trial Site \| Sherman Texas, United States, 75092Clinical Trial Site \| Sugar Land Texas, United States, 77479Clinical Trial Site \| Tomball Texas, United States, 77375Clinical Trial Site \| Waco Texas, United States, 76712Clinical Trial Site \| Bountiful Utah, United States, 84010Clinical Trial Site \| Bountiful Utah, United States, 84025Clinical Trial Site \| Layton Utah, United States, 84041Clinical Trial Site \| Arlington Virginia, United States, 22205Clinical Trial Site \| Danville Virginia, United States, 24541Clinical Trial Site \| Falls Church Virginia, United States, 22042Clinical Trial Site \| Manassas Virginia, United States, 20109Clinical Trial Site \| Newport News Virginia, United States, 23606Clinical Trial Site \| Norfolk Virginia, United States, 23502Clinical Trial Site \| Richmond Virginia, United States, 23219Clinical Trial Site \| Suffolk Virginia, United States, 23435Clinical Trial Site \| Winchester Virginia, United States, 22601Clinical Trial Site \| Bellevue Washington, United States, 98007Clinical Trial Site \| Kenosha Wisconsin, United States, 53144Clinical Trial Site \| Buenos Aires , Argentina, C1012AARClinical Trial Site \| Buenos Aires , Argentina, C1060ABNClinical Trial Site \| Buenos Aires , Argentina, C1128AAFClinical Trial Site \| Buenos Aires , Argentina, C1205EYGClinical Trial Site \| Buenos Aires , Argentina, C1405BCHClinical Trial Site \| Buenos Aires , Argentina, C1425AGCClinical Trial Site \| Buenos Aires , Argentina, C1430CKEClinical Trial Site \| Córdoba , Argentina, X5000AAWClinical Trial Site \| Córdoba , Argentina, X5003DCEClinical Trial Site \| Córdoba , Argentina, X5006CBIClinical Trial Site \| Córdoba , Argentina, X5006ICGClinical Trial Site \| Córdoba , Argentina, X5016KETClinical Trial Site \| Formosa , Argentina, P3600KGCClinical Trial Site \| Rosario , Argentina, S2000DEJClinical Trial Site \| Rosario , Argentina, S2000DTPClinical Trial Site \| Auchenflower , Australia, 4066Clinical Trial Site \| Brookvale , Australia, 2100Clinical Trial Site \| Castle Hill , Australia, 2154Clinical Trial Site \| Clayton , Australia, 3168Clinical Trial Site \| Concord , Australia, 2139Clinical Trial Site \| Gosford , Australia, 2250Clinical Trial Site \| Kogarah , Australia, 2217Clinical Trial Site \| Leabrook , Australia, 5068Clinical Trial Site \| Merewether , Australia, 2291Clinical Trial Site \| Milton , Australia, 4064Clinical Trial Site \| Sippy Downs , Australia, 4556Clinical Trial Site \| Southport , Australia, 4217Clinical Trial Site \| Tarragindi , Australia, 4121Clinical Trial Site \| Waitara , Australia, 2077Clinical Trial Site \| Braunau am Inn , Austria, 5280Clinical Trial Site \| Graz , Austria, 8036Clinical Trial Site \| Saint Stefan Ob Stainz , Austria, 8511Clinical Trial Site \| Vienna , Austria, 1060Clinical Trial Site \| Vienna , Austria, 1190Clinical Trial Site \| Vienna , Austria, 1210Clinical Trial Site \| Aalst , Belgium, 9300Clinical Trial Site \| Bonheiden , Belgium, 2820Clinical Trial Site \| Brasschaat , Belgium, 2930Clinical Trial Site \| Brussels , Belgium, 1000Clinical Trial Site \| Erpent , Belgium, 5101Clinical Trial Site \| Genk , Belgium, 3600Clinical Trial Site \| Ghent , Belgium, 9000Clinical Trial Site \| Hasselt , Belgium, 3500Clinical Trial Site \| Huy , Belgium, 4500Clinical Trial Site \| Ieper , Belgium, 8900Clinical Trial Site \| Kortrijk , Belgium, 8500Clinical Trial Site \| Leuven , Belgium, 3000Clinical Trial Site \| Liège , Belgium, 4000Clinical Trial Site \| Ronse , Belgium, 9600Clinical Trial Site \| Yvoir , Belgium, 5530Clinical Trial Site \| Aracaju , Brazil, 49055-210Clinical Trial Site \| Belo Horizonte , Brazil, 30150-320Clinical Trial Site \| Curitiba , Brazil, 80030-480Clinical Trial Site \| Fortaleza , Brazil, 60160-230Clinical Trial Site \| Fortaleza , Brazil, 60430-350Clinical Trial Site \| Joinville , Brazil, 89227-680Clinical Trial Site \| Porto Alegre , Brazil, 90430-001Clinical Trial Site \| Porto Alegre , Brazil, 90560-032Clinical Trial Site \| Porto Alegre , Brazil, 90610-000Clinical Trial Site \| Rio de Janeiro , Brazil, 20241-180Clinical Trial Site \| Salvador , Brazil, 40301-155Clinical Trial Site \| São José do Rio Preto , Brazil, 15090-000Clinical Trial Site \| São José dos Campos , Brazil, 12243-280Clinical Trial Site \| São Paulo , Brazil, 01228-000Clinical Trial Site \| Blagoevgrad , Bulgaria, 2700Clinical Trial Site \| Burgas , Bulgaria, 8000Clinical Trial Site \| Burgas , Bulgaria, 8000Clinical Trial Site \| Burgas , Bulgaria, 8008Clinical Trial Site \| Dimitrovgrad , Bulgaria, 6400Clinical Trial Site \| Haskovo , Bulgaria, 6300Clinical Trial Site \| Pleven , Bulgaria, 5800Clinical Trial Site \| Rousse , Bulgaria, 7003Clinical Trial Site \| Sofia , Bulgaria, 1000Clinical Trial Site \| Sofia , Bulgaria, 1404Clinical Trial Site \| Sofia , Bulgaria, 1431Clinical Trial Site \| Sofia , Bulgaria, 1510Clinical Trial Site \| Sofia , Bulgaria, 1574Clinical Trial Site \| Sofia , Bulgaria, 1582Clinical Trial Site \| Sofia , Bulgaria, 1680Clinical Trial Site \| Sofia , Bulgaria, 1700Clinical Trial Site \| Sofia , Bulgaria, 1756Clinical Trial Site \| Stara Zagora , Bulgaria, 6000Clinical Trial Site \| Veliko Tarnovo , Bulgaria, 5006Clinical Trial Site \| Brampton , Canada, L6S 0C6Clinical Trial Site \| Brampton , Canada, L6Z 4N5Clinical Trial Site \| Burlington , Canada, L7M 1K9Clinical Trial Site \| Cambridge , Canada, N1R 7R1Clinical Trial Site \| Chicoutimi , Canada, G7H 7K9Clinical Trial Site \| Etobicoke , Canada, M9R 4E1Clinical Trial Site \| Greater Sudbury , Canada, P3C 1S8Clinical Trial Site \| Laval , Canada, H7T 2P5Clinical Trial Site \| Lévis , Canada, G6W 0M5Clinical Trial Site \| London , Canada, N6A 5W9Clinical Trial Site \| Longueuil , Canada, J4H 4B9Clinical Trial Site \| Mirabel , Canada, J7J 2K8Clinical Trial Site \| Mississauga , Canada, L5K 2L3Clinical Trial Site \| Moncton , Canada, E1G 5C4Clinical Trial Site \| Montreal , Canada, H1M 1B1Clinical Trial Site \| Montreal , Canada, H1M 1L3Clinical Trial Site \| Peterborough , Canada, K9J 0B2Clinical Trial Site \| Québec , Canada, G1R 2J6Clinical Trial Site \| Sarnia , Canada, N7T 4X3Clinical Trial Site \| Scarborough , Canada, M1B 4Z8Clinical Trial Site \| Scarborough , Canada, M1B 5N1Clinical Trial Site \| Sherbrooke , Canada, 8193462887Clinical Trial Site \| Sydney , Canada, B1S 0K1Clinical Trial Site \| Toronto , Canada, M6N 1B5Clinical Trial Site \| Trois-Rivières , Canada, G9A 4P3Clinical Trial Site \| Independencia , Chile, 8380000Clinical Trial Site \| Santiago , Chile, 7500588Clinical Trial Site \| Santiago , Chile, 7500739Clinical Trial Site \| Santiago , Chile, 7770086Clinical Trial Site \| Santiago , Chile, 8900085Clinical Trial Site \| Valdivia , Chile, 5110683Clinical Trial Site \| Luoyang , China, 471002Clinical Trial Site \| Shanghai , China, 200032Clinical Trial Site \| Bílina , Czechia, 418 01Clinical Trial Site \| Brno , Czechia, 602 00Clinical Trial Site \| Brno , Czechia, 612 00Clinical Trial Site \| Chlumec nad Cidlinou , Czechia, 503 51Clinical Trial Site \| Hodonín , Czechia, 695 01Clinical Trial Site \| Krnov , Czechia, 794 01Clinical Trial Site \| Mariánské Lázně , Czechia, 353 01Clinical Trial Site \| Olomouc , Czechia, 779 00Clinical Trial Site \| Ostrava , Czechia, 700 30Clinical Trial Site \| Ostrava , Czechia, 702 00Clinical Trial Site \| Ostrava , Czechia, 708-52Clinical Trial Site \| Pardubice , Czechia, 532 03Clinical Trial Site \| Prague , Czechia, 101 00Clinical Trial Site \| Prague , Czechia, 120 00Clinical Trial Site \| Prague , Czechia, 140 59Clinical Trial Site \| Příbram , Czechia, 261 01Clinical Trial Site \| Slaný , Czechia, 274 01Clinical Trial Site \| Zlín , Czechia, 760 01Clinical Trial Site \| København S , Denmark, 02300Clinical Trial Site \| Auxerre , France, 89000Clinical Trial Site \| Bobigny , France, 93000Clinical Trial Site \| Nîmes , France, 30900Clinical Trial Site \| Paris , France, 75010Clinical Trial Site \| Pau , France, 64046Clinical Trial Site \| Poitiers , France, 86000Clinical Trial Site \| Saint-Herblain , France, 44093Clinical Trial Site \| Valenciennes , France, 59300Clinical Trial Site \| Ahaus , Germany, 48683Clinical Trial Site \| Altenburg , Germany, 04600Clinical Trial Site \| Bad Homburg , Germany, 61348Clinical Trial Site \| Berlin , Germany, 10629Clinical Trial Site \| Berlin , Germany, 10789Clinical Trial Site \| Berlin , Germany, 12203Clinical Trial Site \| Berlin , Germany, 13347Clinical Trial Site \| Bremen , Germany, 28277Clinical Trial Site \| Cologne , Germany, 51069Clinical Trial Site \| Dortmund , Germany, 44137Clinical Trial Site \| Dresden , Germany, 01099Clinical Trial Site \| Elsterwerda , Germany, 04910Clinical Trial Site \| Essen , Germany, 45355Clinical Trial Site \| Frankfurt am Main , Germany, 60590Clinical Trial Site \| Hamburg , Germany, 22763Clinical Trial Site \| Jerichow , Germany, 39319Clinical Trial Site \| Kaiserslautern , Germany, 67655Clinical Trial Site \| Langen , Germany, 63225Clinical Trial Site \| Leipzig , Germany, 04289Clinical Trial Site \| Mühldorf , Germany, 84453Clinical Trial Site \| Offenbach , Germany, 63065Clinical Trial Site \| Papenburg , Germany, 26871Clinical Trial Site \| Pirna , Germany, 01796Clinical Trial Site \| Stuhr , Germany, 28816Clinical Trial Site \| Villingen-Schwenningen , Germany, 78052Clinical Trial Site \| Wermsdorf , Germany, 04779Clinical Trial Site \| Zwenkau , Germany, 04442Clinical Trial Site \| Ampelokipoi , Greece, 115 26Clinical Trial Site \| Athens , Greece, 115 21Clinical Trial Site \| Athens , Greece, 115 27Clinical Trial Site \| Athens , Greece, 115 27Clinical Trial Site \| Chios , Greece, 82131Clinical Trial Site \| Heraklion , Greece, 714 09Clinical Trial Site \| Heraklion , Greece, 715 00Clinical Trial Site \| Ioannina , Greece, 454 45Clinical Trial Site \| Kalyftaki-N. Kifissia , Greece, 145 64Clinical Trial Site \| Kifissia , Greece, 145 61Clinical Trial Site \| Larissa , Greece, 411 10Clinical Trial Site \| Marousi , Greece, 151 23Clinical Trial Site \| N. Efkapria-Pavlos Melas , Greece, 564 03Clinical Trial Site \| Nea Ionia , Greece, 142 33Clinical Trial Site \| Nikaia , Greece, 184 54Clinical Trial Site \| Pátrai , Greece, 265 04Clinical Trial Site \| Pylaia , Greece, 570 01Clinical Trial Site \| Thessaloniki , Greece, 546 36Clinical Trial Site \| Thessaloniki , Greece, 546 42Clinical Trial Site \| Thessaloniki , Greece, 546 42Clinical Trial Site \| Voula , Greece, 166 73Clinical Trial Site \| Baja , Hungary, 6500Clinical Trial Site \| Balatonfüred , Hungary, 8230Clinical Trial Site \| Békéscsaba , Hungary, 5600Clinical Trial Site \| Budapest , Hungary, 1033Clinical Trial Site \| Gyöngyös , Hungary, 3200Clinical Trial Site \| Hódmezovásárhely , Hungary, 6800Clinical Trial Site \| Nyíregyháza , Hungary, 4400Clinical Trial Site \| Nyíregyháza , Hungary, 4405Clinical Trial Site \| Orosháza , Hungary, 5905Clinical Trial Site \| Szeged , Hungary, 6724Clinical Trial Site \| Zalaegerszeg , Hungary, 8900Clinical Trial Site \| Ancona , Italy, 60129Clinical Trial Site \| L’Aquila , Italy, 67100Clinical Trial Site \| Messina , Italy, 98125Clinical Trial Site \| Naples , Italy, 80131Clinical Trial Site \| Novara , Italy, 28100Clinical Trial Site \| Palermo , Italy, 90127Clinical Trial Site \| Pisa , Italy, 56124Clinical Trial Site \| Pozzilli , Italy, 86077Clinical Trial Site \| San Benedetto del Tronto , Italy, 63074Clinical Trial Site \| Terni , Italy, 5100Clinical Trial Site \| Bunkyō City , Japan, 113-8603Clinical Trial Site \| Chikushino-shi , Japan, 818-0058Clinical Trial Site \| Chūōku , Japan, 103-0027Clinical Trial Site \| Chūōku , Japan, 104-0044Clinical Trial Site \| Chūōku , Japan, 810-0066Clinical Trial Site \| Fukuoka , Japan, 812-8582Clinical Trial Site \| Fukuoka , Japan, 814-0180Clinical Trial Site \| Hachioji-Shi , Japan, 192-0918Clinical Trial Site \| Hachiōji , Japan, 193-0811Clinical Trial Site \| Hakodate-Shi , Japan, 040-8611Clinical Trial Site \| Hakodate-Shi , Japan, 041-0821Clinical Trial Site \| Himeji , Japan, 670-8560Clinical Trial Site \| Izumi , Japan, 594-0073Clinical Trial Site \| Kasuga , Japan, 816-0864Clinical Trial Site \| Kita-ku , Japan, 530-0052Clinical Trial Site \| Kusatsu , Japan, 525-8585Clinical Trial Site \| Minamiku , Japan, 861-4193Clinical Trial Site \| Minato , Japan, 108-0073Clinical Trial Site \| Nagaoka-Shi , Japan, 940-8621Clinical Trial Site \| Nagasaki , Japan, 850-0842Clinical Trial Site \| Okayama , Japan, 700-0804Clinical Trial Site \| Osaka , Japan, 530-0005Clinical Trial Site \| Osaka , Japan, 530-0012Clinical Trial Site \| Osaka , Japan, 532-0025Clinical Trial Site \| Osaka , Japan, 558-8558Clinical Trial Site \| Ōta-ku , Japan, 144-0051Clinical Trial Site \| Saku , Japan, 385-0051Clinical Trial Site \| Sakura-Shi , Japan, 285-0841Clinical Trial Site \| Sapporo , Japan, 003-0026Clinical Trial Site \| Sapporo , Japan, 062-8618Clinical Trial Site \| Sendai , Japan, 983-0039Clinical Trial Site \| Shimotsuke-shi , Japan, 329-0498Clinical Trial Site \| Shinagawa-Ku , Japan, 140-8522Clinical Trial Site \| Shinjuku-ku , Japan, 162-8666Clinical Trial Site \| Suita , Japan, 565-0871Clinical Trial Site \| Tamanashi , Japan, 865-0016Clinical Trial Site \| Yokohama , Japan, 236-0004Clinical Trial Site \| Yokosuka , Japan, 239-8567Clinical Trial Site \| 's-Hertogenbosch , Netherlands, 5223 GZClinical Trial Site \| Amersfoort , Netherlands, 3813 TZClinical Trial Site \| Ede , Netherlands, 6716 RPClinical Trial Site \| Goes , Netherlands, 4462 RAClinical Trial Site \| Hoogeveen , Netherlands, 7909 AAClinical Trial Site \| Hoorn , Netherlands, 1624 NPClinical Trial Site \| Utrecht , Netherlands, 3584 CXClinical Trial Site \| Auckland , New Zealand, 1023Clinical Trial Site \| Christchurch , New Zealand, 8011Clinical Trial Site \| Ebdentown , New Zealand, 5018Clinical Trial Site \| Hamilton , New Zealand, 3243Clinical Trial Site \| Silverdale , New Zealand, 0932Clinical Trial Site \| Takapuna , New Zealand, 0620Clinical Trial Site \| Wellington , New Zealand, 6021Clinical Trial Site \| Bydgoszcz , Poland, 85-092Clinical Trial Site \| Bydgoszcz , Poland, 85-605Clinical Trial Site \| Chrzanów , Poland, 32-500Clinical Trial Site \| Częstochowa , Poland, 42-202Clinical Trial Site \| Dębica , Poland, 39-200Clinical Trial Site \| Gdansk , Poland, 80-262Clinical Trial Site \| Gdansk , Poland, 80-382Clinical Trial Site \| Gdynia , Poland, 81-157Clinical Trial Site \| Giżycko , Poland, 11-500Clinical Trial Site \| Jaksice , Poland, 88-181Clinical Trial Site \| Katowice , Poland, 40-040Clinical Trial Site \| Katowice , Poland, 40-156Clinical Trial Site \| Katowice , Poland, 40-555Clinical Trial Site \| Katowice , Poland, 40-648Clinical Trial Site \| Katowice , Poland, 40-760Clinical Trial Site \| Kędzierzyn-Koźle , Poland, 47-200Clinical Trial Site \| Krakow , Poland, 31-501Clinical Trial Site \| Krakow , Poland, 31-721Clinical Trial Site \| Lodz , Poland, 90-127Clinical Trial Site \| Lodz , Poland, 90-302Clinical Trial Site \| Lodz , Poland, 91-363Clinical Trial Site \| Lublin , Poland, 20-068Clinical Trial Site \| Lublin , Poland, 20-412Clinical Trial Site \| Myszków , Poland, 42-300Clinical Trial Site \| Olsztyn , Poland, 10-165Clinical Trial Site \| Ostrowiec Świętokrzyski , Poland, 27-400Clinical Trial Site \| Piotrkow Trybunalski , Poland, 97-300Clinical Trial Site \| Poznan , Poland, 60-111Clinical Trial Site \| Ruda Śląska , Poland, 41-710Clinical Trial Site \| Rybnik , Poland, 44-203Clinical Trial Site \| Rzeszów , Poland, 35-055Clinical Trial Site \| Siedlce , Poland, 08-110Clinical Trial Site \| Skierniewice , Poland, 96-100Clinical Trial Site \| Sopot , Poland, 81-717Clinical Trial Site \| Staszów , Poland, 28-200Clinical Trial Site \| Świdnik , Poland, 21-040Clinical Trial Site \| Tarnów , Poland, 33-100Clinical Trial Site \| Torun , Poland, 87-100Clinical Trial Site \| Warsaw , Poland, 01-249Clinical Trial Site \| Warsaw , Poland, 02-097Clinical Trial Site \| Warsaw , Poland, 02-672Clinical Trial Site \| Warsaw , Poland, 02-677Clinical Trial Site \| Warsaw , Poland, 02-696Clinical Trial Site \| Warsaw , Poland, 02-758Clinical Trial Site \| Wroclaw , Poland, 53-034Clinical Trial Site \| Zamość , Poland, 22-400Clinical Trial Site \| Baixa Da Banheira , Portugal, 2835-127Clinical Trial Site \| Carnaxide , Portugal, 2790-134Clinical Trial Site \| Coimbra , Portugal, 3000-150Clinical Trial Site \| Coimbra , Portugal, 3004-561Clinical Trial Site \| Creixomil , Portugal, 4835-044Clinical Trial Site \| Leiria , Portugal, 2400-110Clinical Trial Site \| Lisbon , Portugal, 1500-048Clinical Trial Site \| Loures , Portugal, 2674-514Clinical Trial Site \| Ponte de Lima , Portugal, 4990-029Clinical Trial Site \| Riachos , Portugal, 2350-325Clinical Trial Site \| Santa Maria da Feira , Portugal, 4520-211Clinical Trial Site \| Senhora da Hora , Portugal, 4464-513Clinical Trial Site \| Baia Mare , Romania, 430124Clinical Trial Site \| Baia Mare , Romania, 430222Clinical Trial Site \| Brasov , Romania, 500091Clinical Trial Site \| Brasov , Romania, 500283Clinical Trial Site \| Bucharest , Romania, 021875Clinical Trial Site \| Bucharest , Romania, 022328Clinical Trial Site \| Iași , Romania, 700503Clinical Trial Site \| Iași , Romania, 700547Clinical Trial Site \| Oradea , Romania, 410469Clinical Trial Site \| Ploieşti , Romania, 100342Clinical Trial Site \| Satu Mare , Romania, 440192Clinical Trial Site \| Sibiu , Romania, 550371Clinical Trial Site \| Târgu Mureş , Romania, 540136Clinical Trial Site \| Timișoara , Romania, 300024Clinical Trial Site \| Timișoara , Romania, 300362Clinical Trial Site \| Belgrade , Serbia, 11000Clinical Trial Site \| Zaječar , Serbia, 19000Clinical Trial Site \| Bardejov , Slovakia, 085 01Clinical Trial Site \| Bratislava , Slovakia, 831 03Clinical Trial Site \| Bratislava , Slovakia, 833 05Clinical Trial Site \| Bratislava , Slovakia, 841 03Clinical Trial Site \| Brezno , Slovakia, 977 01Clinical Trial Site \| Ilava , Slovakia, 019 01Clinical Trial Site \| Košice , Slovakia, 040 01Clinical Trial Site \| Košice , Slovakia, 040 22Clinical Trial Site \| Lučenec , Slovakia, 984 01Clinical Trial Site \| Moldava nad Bodvou , Slovakia, 045 01Clinical Trial Site \| Nitra , Slovakia, 949 01Clinical Trial Site \| Nitra , Slovakia, 949 01Clinical Trial Site \| Prešov , Slovakia, 080 01Clinical Trial Site \| Stará Turá , Slovakia, 916 01Clinical Trial Site \| Vinica , Slovakia, 991 28Clinical Trial Site \| Belville , South Africa, 7530Clinical Trial Site \| Bloemfontein , South Africa, 9301Clinical Trial Site \| Bloemfontein , South Africa, 9321Clinical Trial Site \| Cape Town , South Africa, 7130Clinical Trial Site \| Cape Town , South Africa, 7500Clinical Trial Site \| Cape Town , South Africa, 7646Clinical Trial Site \| Chatsworth , South Africa, 4084Clinical Trial Site \| City of Johannesburg , South Africa, 1820Clinical Trial Site \| Durban , South Africa, 4001Clinical Trial Site \| Durban , South Africa, 4091Clinical Trial Site \| Durban , South Africa, 4170Clinical Trial Site \| Durban , South Africa, 4320Clinical Trial Site \| Ekurhuleni , South Africa, 1459Clinical Trial Site \| Ekurhuleni , South Africa, 1466Clinical Trial Site \| Ekurhuleni , South Africa, 1619Clinical Trial Site \| Gauteng , South Africa, 0157Clinical Trial Site \| Johannesburg , South Africa, 1818Clinical Trial Site \| Johannesburg , South Africa, 2157Clinical Trial Site \| Johannesburg , South Africa, 2192Clinical Trial Site \| Johannesburg , South Africa, 2196Clinical Trial Site \| KwaDukuza , South Africa, 4449Clinical Trial Site \| KwaZulu - Natal , South Africa, 4449Clinical Trial Site \| Mogale City , South Africa, 1739Clinical Trial Site \| Mossel Bay , South Africa, 6506Clinical Trial Site \| Nelson Mandela Bay , South Africa, 6001Clinical Trial Site \| Plettenberg Bay , South Africa, 6600Clinical Trial Site \| Pretoria , South Africa, 0002Clinical Trial Site \| Pretoria , South Africa, 0183Clinical Trial Site \| Pretoria , South Africa, 0186Clinical Trial Site \| Worcester , South Africa, 6850Clinical Trial Site \| Anyang-si , South Korea, 14068Clinical Trial Site \| Busan , South Korea, 47392Clinical Trial Site \| Changwon-si , South Korea, 51472Clinical Trial Site \| Cheongju-si , South Korea, 28644Clinical Trial Site \| Daejeon , South Korea, 35015Clinical Trial Site \| Goyang-si , South Korea, 10326Clinical Trial Site \| Gwangju , South Korea, 61453Clinical Trial Site \| Gwangmyeong , South Korea, 14353Clinical Trial Site \| Jeonju , South Korea, 54907Clinical Trial Site \| Seoul , South Korea, 02053Clinical Trial Site \| Seoul , South Korea, 02447Clinical Trial Site \| Seoul , South Korea, 02841Clinical Trial Site \| Seoul , South Korea, 04763Clinical Trial Site \| Seoul , South Korea, 05278Clinical Trial Site \| Seoul , South Korea, 05368Clinical Trial Site \| Seoul , South Korea, 07804Clinical Trial Site \| Wŏnju , South Korea, 26426Clinical Trial Site \| Alcalá de Henares , Spain, 28880Clinical Trial Site \| Antequera , Spain, 29200Clinical Trial Site \| Badajoz , Spain, 06006Clinical Trial Site \| Barcelona , Spain, 08023Clinical Trial Site \| Barcelona , Spain, 08025Clinical Trial Site \| Barcelona , Spain, 08025Clinical Trial Site \| Barcelona , Spain, 08035Clinical Trial Site \| Barcelona , Spain, 08036Clinical Trial Site \| Barcelona , Spain, 28002Clinical Trial Site \| Burjassot , Spain, 46100Clinical Trial Site \| Cadiz , Spain, 11650Clinical Trial Site \| Centelles , Spain, 08540Clinical Trial Site \| Córdoba , Spain, 14004Clinical Trial Site \| El Palmar , Spain, 30120Clinical Trial Site \| Figueres , Spain, 17600Clinical Trial Site \| Huelva , Spain, 21080Clinical Trial Site \| L'Hospitalet de Llobregat , Spain, 8907Clinical Trial Site \| Lugo , Spain, 27003Clinical Trial Site \| Madrid , Spain, 28003Clinical Trial Site \| Madrid , Spain, 28040Clinical Trial Site \| Madrid , Spain, 28040Clinical Trial Site \| Madrid , Spain, 28041Clinical Trial Site \| Marbella , Spain, 29603Clinical Trial Site \| Pamplona , Spain, 31008Clinical Trial Site \| Peralada , Spain, 17491Clinical Trial Site \| San Sebastián de los Reyes , Spain, 28702Clinical Trial Site \| Santiago de Compostela , Spain, 15702Clinical Trial Site \| Santiago de Compostela , Spain, 15706Clinical Trial Site \| Segovia , Spain, 40002Clinical Trial Site \| Seville , Spain, 41003Clinical Trial Site \| Seville , Spain, 41950Clinical Trial Site \| Torrejón de Ardoz , Spain, 28850Clinical Trial Site \| Valencia , Spain, 46010Clinical Trial Site \| Valencia , Spain, 46015Clinical Trial Site \| Valladolid , Spain, 47012Clinical Trial Site \| Vigo , Spain, 36213Clinical Trial Site \| Stockholm , Sweden, 117 27Clinical Trial Site \| Kaohsiung City , Taiwan, 82445Clinical Trial Site \| New Taipei City , Taiwan, 235041Clinical Trial Site \| Taipei , Taiwan, 10002Clinical Trial Site \| Taipei , Taiwan, 104Clinical Trial Site \| Taipei , Taiwan, 106Clinical Trial Site \| Taipei , Taiwan, 114202Clinical Trial Site \| Istanbul , Turkey (Türkiye), 34093Clinical Trial Site \| Izmir , Turkey (Türkiye), 35330Clinical Trial Site \| Sivas , Turkey (Türkiye), 58140Clinical Trial Site \| Ashburton , United Kingdom, TQ13 7APClinical Trial Site \| Belfast , United Kingdom, BT2 8BGClinical Trial Site \| Bellshill , United Kingdom, ML4 3NJClinical Trial Site \| Birmingham , United Kingdom, B15 2SQClinical Trial Site \| Birmingham , United Kingdom, B21 9RYClinical Trial Site \| Bristol , United Kingdom, BS2 8HWClinical Trial Site \| Bristol , United Kingdom, BS37 4AXClinical Trial Site \| Bury St Edmunds , United Kingdom, IP33 2QZClinical Trial Site \| Cambridge , United Kingdom, CB2 0QQClinical Trial Site \| Cardiff , United Kingdom, CF15 9SSClinical Trial Site \| Cardiff , United Kingdom, CF5 4ADClinical Trial Site \| Chichester , United Kingdom, PO19 6SEClinical Trial Site \| Corby , United Kingdom, NN17 2URClinical Trial Site \| Darlington , United Kingdom, DL3 6HXClinical Trial Site \| Dorchester , United Kingdom, DT1 2JYClinical Trial Site \| Ely , United Kingdom, CB7 5JDClinical Trial Site \| Fowey , United Kingdom, PL23 1DTClinical Trial Site \| Glasgow , United Kingdom, G20 7BEClinical Trial Site \| Heston , United Kingdom, TW5 9ERClinical Trial Site \| Honiton , United Kingdom, EX14 2NYClinical Trial Site \| Ilford , United Kingdom, IG1 4HPClinical Trial Site \| Isleworth , United Kingdom, TW7 6AFClinical Trial Site \| Leeds , United Kingdom, LS26 9AAClinical Trial Site \| Liskeard , United Kingdom, PL14 3XAClinical Trial Site \| Liverpool , United Kingdom, L24 7RBClinical Trial Site \| Liverpool , United Kingdom, L9 7ALClinical Trial Site \| London , United Kingdom, EC1A 7BEClinical Trial Site \| London , United Kingdom, SE6 4LFClinical Trial Site \| Luton , United Kingdom, LU4 0DZClinical Trial Site \| Manchester , United Kingdom, M27 8FFClinical Trial Site \| Metropolitan Borough of Wirral , United Kingdom, CH62 6EEClinical Trial Site \| Middlesbrough , United Kingdom, TS5 6HAClinical Trial Site \| Milton Keynes , United Kingdom, MK15 0DUClinical Trial Site \| Newquay , United Kingdom, TR7 1RUClinical Trial Site \| Northallerton , United Kingdom, DL7 8AWClinical Trial Site \| Penzance , United Kingdom, TR18 3DXClinical Trial Site \| Plymouth , United Kingdom, PL5 3JBClinical Trial Site \| Plympton , United Kingdom, PL7 1ADClinical Trial Site \| Poole , United Kingdom, BH16 5PWClinical Trial Site \| Redhill , United Kingdom, RH1 5RHClinical Trial Site \| Sale , United Kingdom, M33 4BRClinical Trial Site \| Swansea , United Kingdom, SA2 8QAClinical Trial Site \| Swindon , United Kingdom, SN3 6BBClinical Trial Site \| Teeside , United Kingdom, TS19 8PEClinical Trial Site \| Thetford , United Kingdom, IP24 1JDClinical Trial Site \| Torpoint , United Kingdom, PL11 2TBClinical Trial Site \| Wolverhampton , United Kingdom, WV9 5HBClinical Trial Site \| York , United Kingdom, YO24 2RQ
Investigators	Study Director: Medical Director, Alnylam Pharmaceuticals

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Additional Relevant MeSH Terms

HypertensionCardiovascular DiseasesVascular Diseases