Document Overview

Document Title

Management of Patients with Non-ST-Elevation Acute Coronary Syndromes

Authoring Societies

American College of Cardiology

American Heart Association

Document Publication Date

Sep 22, 2014

Page Last Reviewed/Updated

May 5, 2026

Document Type

Guideline

Country of Publication

United States

Full Text Freely Available

Yes

Full Text Guideline

www.ahajournals.org/doi/10.1161/CIR.0000000000000134

Source Citation

Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR, Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014 Dec 23;64(24):e139-e228. doi: 10.1016/j.jacc.2014.09.017. Epub 2014 Sep 23. Erratum in: J Am Coll Cardiol. 2014 Dec 23;64(24):2713-4. Dosage error in article text. PMID: 25260718.

Supplemental Implementation Resources

• Slide Set
• Quick-Reference Guide
• Quick-Reference Guide
• Quick-Reference Guide
• Quick-Reference Guide
• Decision Aid

Document Scope, Criteria, and Use Cases

Document Objectives

Establish a contemporary CPG for the optimal management of patients with NSTE-ACS.

Scope

Assessment and Screening, Diagnosis, Management, Treatment

Diseases/Conditions (MeSH)

D054058 - Acute Coronary Syndrome

D054058 - Acute Coronary Syndrome

Keywords

DAPT, Dual antiplatelet therapy, NSTE-ACS, acute coronary syndrome, acute coronary syndromes, antiplatelet agents

Target Patient Population

Patients with Non-ST-Elevation Acute Coronary Syndromes (NSTE-ACS).

Inclusion Criteria

Male, Female, Adult, Older Adult

Health Care Settings

Ambulatory, Emergency Care, Hospital, Operating and Recovery Room

Intended Users

Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

PICO Questions

1. What is the likelihood that the symptoms and signs represent ACS?
2. What is the likelihood of adverse clinical outcome(s)?

Number of Source Documents

827

Literature Search End Date

Sunday, September 30, 2012

Includes peer/external review process?

Yes

Includes public comment process?

No

Methodologist involvement?

Yes

Patient involvement?

No

Includes multi-disciplinary group?

Yes

Includes systematic review?

Yes

Grades quality of strength of evidence?

Yes

Grades quality of strength of recommendation?

Yes

Discloses funding source?

Yes

Discloses conflicts of interest?

Yes

Includes benefits/harms analysis with recommendations?

Yes