Today we’re showcasing some of the most recent hepatology-related articles posted recently across medical journals.

Prediction of Biological Evolution Following Blood Product Transfusion During Liver Transplantation: The Contribution of Machine Learning to Decision-Making

  • BMJ Health & Care Informatics, June 2025
  • Description: Liver transplantation is a complex procedure frequently requiring transfusion of blood products to manage coagulopathy and haemorrhage. This study aimed to develop machine learning models to predict the biological effects of blood product transfusions, assisting clinicians in selecting optimal therapeutic combinations.
  • Abstract
  • Full Text

Chimeric Antigen Receptor (CAR) T-cell Therapy: Engineering Immune Cells to Treat Liver Diseases

  • Journal of Hepatology, June 2025
  • Description: This review presents an overview of CAR technology's fundamental principles and achievements, focusing on CAR-T cell applications in hepatic viral infections, autoimmune liver disease, and hepatobiliary tumors. Emerging senolytic therapies that target senescent cells and hepatic fibrosis are highlighted alongside regulatory CAR-T cells that induce liver-specific immune tolerance in transplantation.
  • Abstract
  • Full Text

Algorithm-based Intraoperative Diagnosis of Liver Tumors Using Infrared Spectroscopy

  • Scientific Reports, June 2025
  • Description: This study assessed fiber-based attenuated total reflection infrared (ATR IR) spectroscopy combined with supervised machine learning for intraoperative liver tumor classification based on a holistic biochemical signature approach. Fresh liver tissue from 69 surgical patients was analyzed using a probe consisting of Ge ATR crystal and silver halide fibers.
  • Abstract
  • Full Text

Safety and Immunogenicity of the Measles-mumps-rubella vaccine in Immunocompromised Children with Inflammatory Bowel Disease, or After Liver Transplantation: An Observational Study

  • Vaccine, June 2025
  • Description: The objective was to monitor the immunogenicity and safety of attenuated live vaccines against measles, mumps and rubella (MMR) in children receiving immunosuppressive therapy. In this prospective multicenter observational study (DRKS00014569) 22 children and adolescents with incomplete MMR vaccination status were identified. Following individual assessment of vaccination readiness with stable immunosuppressive therapy in the last three months with no evidence of underlying disease activity, a risk-benefit assessment regarding vaccination with live-attenuated vaccines was performed.
  • Abstract
  • Full Text

Protocol to Study Ductal Progenitor-like Cells from the Adult Human Pancreas Using 3D Suspension and Methylcellulose-based Culture Systems

  • STAR Protocols, June 2025
  • Description: The article presents a protocol for studying ductal progenitor-like cells using a good manufacturing practice (GMP)-compatible 3D suspension culture system and a methylcellulose- and Matrigel-based 3D colony assay. The study describes steps for dispersing and cryopreserving human pancreatic cells and initiating and maintaining cultures. The article then details how to prepare ductal spheroids or colonies for downstream applications.
  • Abstract
  • Full Text

3D Imaging of Human Pancreas Suggests Islet Size and Endocrine Composition Influence Their Loss in Type 1 Diabetes

  • Research Square, June 2025
  • Description: Within the study, 3-dimensional (3D) analyses of pancreata from control persons without diabetes (ND) revealed heretofore under-appreciated frequencies (approximately 50%) of insulin-positive (INS+) glucagon-negative (GCG-) islets.
  • Abstract
  • Full Text

Decreased Proliferation of HepG2 Liver Cancer Cells in Vitro and Exhibited Proteomic Changes in Vivo in Subjects with Metabolic Syndrome and Metabolic Dysfunction-associated Steatotic Liver Disease Who Performed Four-week Dawn-to-dusk Dry Fasting

  • Clinical Proteomics, June 2025
  • Description: Four-week dawn-to-dusk dry fasting (DDDF) was previously shown to have a potent anti-inflammatory effect and induce an anti-tumorigenic proteome in the serum and peripheral blood mononuclear cells in patients without cancer. The goal was to determine if serum obtained from these patients without cancer who underwent 4-week DDDF had an anti-tumorigenic effect.
  • Abstract
  • Full Text

Look forward to more journal-focused topics in the coming weeks. Sign up for alerts and stay informed on the latest published articles and guidelines.

Copyright © 2025 Guideline Central, all rights reserved.