Consistent engagement with current medical literature enables clinicians to apply the latest evidence-based treatment and integrate research into clinical practice. This approach enhances patient outcomes by facilitating more effective and individualized care.
Today, we’re showcasing some of the latest hepatology-related articles published recently across medical journals. The topics in today’s rundown include hepatocellular carcinoma, liver transplant, and primary biliary cholangitis.
Hepatocellular Carcinoma Articles
The Combined Therapeutic Effect of Lenvatinib and ADI-PEG 20 in Advanced Hepatocellular Carcinoma: A Case Report
- In Vivo
- July 2026
- Description: Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality, with resistance to systemic therapies limiting outcomes. Arginine depletion with ADI-PEG 20 may enhance the efficacy of tyrosine kinase inhibitors (TKIs) such as lenvatinib.
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Efficacy and Long-Term Outcomes of Direct-Acting Antivirals in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
- Gut and Liver
- June 2026
- Description: The role of direct-acting antivirals (DAAs) in patients with hepatocellular carcinoma (HCC) remains uncertain due to conflicting data on virologic efficacy and long-term outcomes. This meta-analysis investigated studies reporting the sustained virologic response (SVR), recurrence, and overall survival in patients with HCC treated with DAAs.
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Selective Internal Radiotherapy vs. Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Systematic Review
- HPB
- June 2026
- Description: Hepatocellular carcinoma (HCC) is the most common primary liver tumor, with transarterial chemoembolization (TACE) and selective internal radiotherapy (SIRT) as main therapeutic options for patients with intermediate-stage HCC. This review compares TACE and SIRT outcomes in unresectable HCC.
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Liver Transplant Articles
Total Robotic Liver Transplant Using Whole Graft with Variant Donor Arterial and Biliary Anatomy
- American Journal of Transplantation
- June 2026
- Description: Robotic liver transplantation (RLT) is a novel and rapidly evolving approach in transplantation, representing perhaps the final frontier in robotic surgery. The technique offers the potential benefits of minimally invasive surgery for what is traditionally a maximally invasive, complex, and technically demanding operation. This report presents a successful case of a robotic recipient hepatectomy and implantation.
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Outcomes of Liver Transplant Versus Partial Hepatectomy for Perihilar Cholangiocarcinoma Patients Requiring Arterial Reconstruction
- Liver International
- June 2026
- Description: Liver resection (LR) and orthotopic liver transplantation (OLT) are therapeutic options for locally advanced perihilar cholangiocarcinoma (pCCA) requiring hepatic artery reconstruction (HAR). This study aimed to compare short‐ and long‐term outcomes of LR and OLT. Outcomes were major vascular complications, 90‐day mortality, overall survival (OS) and recurrence‐free survival (RFS).
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Liver Transplant Outcomes in Patients With Transjugular Intrahepatic Portosystemic Shunt: A Retrospective Cohort Study With Propensity Score Analysis
- Journal of Clinical and Experimental Hepatology
- May 2026
- Description: Transjugular intrahepatic portosystemic shunt (TIPS) is used to manage portal hypertension–related complications in patients awaiting liver transplantation. However, the role of pretransplant TIPS placement remains controversial. [The authors] conducted a retrospective, single-center cohort study to evaluate the impact of pretransplant TIPS on postoperative complications and in-hospital mortality.
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Primary Biliary Cholangitis Articles
The Emerging Role of PPARs in Primary Biliary Cholangitis
- Trends in Molecular Medicine
- June 2026
- Description: Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by autoimmune-mediated destruction of intrahepatic bile ducts, leading to fibrosis, cirrhosis, and liver failure. Ursodeoxycholic acid remains the first-line treatment, but up to 40% of patients respond inadequately and continue to experience fatigue and pruritus. This therapeutic gap has recently been addressed by the approval of two new drugs, elafibranor and seladelpar, which activate peroxisome proliferator-activated receptors (PPARs). This review explores recently unveiled molecular mechanisms underlying the effectiveness of PPAR-targeting drugs in PBC, focusing on their effects on cellular immune regulation, bile acid production and toxicity, and hepatic fibrosis.
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Prognostic Nutritional Index as a Predictor of Ursodeoxycholic Acid Response in Primary Biliary Cholangitis: A Retrospective Study
- BMC Gastroenterology
- June 2026
- Description: Primary Biliary Cholangitis (PBC) is an autoimmune hepatic disorder characterized by the progressive destruction of intrahepatic bile ducts. Ursodeoxycholic acid (UDCA) remains the primary treatment modality; however, a subset of patients exhibits non-responsiveness to UDCA therapy. The objective of this study is to investigate the association between the Prognostic Nutritional Index and UDCA treatment non-responsiveness in individuals diagnosed with PBC.
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Bezafibrate for Primary Biliary Cholangitis: a Number Needed to Treat Analysis
- JHEP Reports: Innovation in Hepatology
- June 2026
- Description: The clinical benefit of bezafibrate (BZF) in primary biliary cholangitis (PBC) has not been extensively reported in absolute measures. [The authors] assessed the number needed to treat (NNT) with BZF to prevent liver transplantation (LT) or (liver-related) death among people with PBC.
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