The American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) recently wrapped up its 2025 annual conference. AAO-HNSF 2025 was held from October 11 through October 14 in Indianapolis, Indiana. With so much new research presented at the conference, we would like to take a moment to highlight some of it.
Today, we’re taking a look at some of the hundreds of posters presented at AAO-HNSF 2025, specifically posters focusing on rhinosinusitis. The posters presented at AAO-HNSF 2025 all depicted research on acute or chronic rhinosinusitis. The studies featured include a study on the intersection of metformin, Type 2 diabetes, and chronic rhinosinusitis, the efficacy of probiotics in managing chronic rhinosinusitis, and more.
2025 AAO-HNSF Posters on Rhinosinusitis
Adult Inpatient Acute Rhinosinusitis Management and Outcomes Stratified by Age and Sex
- Description: This study compared the management of male and female inpatients with acute rhinosinusitis within the following age cohorts: 18-40 years, 41-59 years, and 60 years and older.
- Conclusion: In a cohort of adult inpatients with acute rhinosinusitis, males had greater total charges, length of stay, and odds for intracranial complications. Males aged 60 years and older also had a greater number of procedures undergone than females in this age group.
Development of New-Onset Chronic Rhinosinusitis After COVID-19 Infection
- Description: This study evaluated the risk of new onset chronic rhinosinusitis after having COVID-19, using a large national database.
- Conclusion: Patients with COVID-19 had a higher risk for developing chronic rhinosinusitis compared to a control population.
- Description: This study assessed chronic rhinosinusitis management in Asian and Chinese patients compared to others and aimed to identify factors which may affect sinonasal outcomes.
- Conclusion: Researchers noted differences in chronic rhinosinusitis disease course in White patients compared to Asian and Chinese patients which may reflect a greater need for healthcare services for the latter group and subgroup respectively. This may be linked to barriers in access to care and can better inform the chronic rhinosinusitis management of these patient populations in the Boston Chinatown area and other similar communities.
- Description: Metformin is commonly prescribed for Type 2 Diabetes Mellitus (T2DM), although its effects on sinonasal mucosa are not fully understood. This study examines the impact of Metformin on the complications of chronic rhinosinusitis in T2DM patients.
- Conclusion: Research found that Metformin may mitigate severe chronic rhinosinusitis complications, such as the need for surgery, for patients with T2DM.
- Description: Body mass index (BMI) has been linked to differential postoperative outcomes in chronic rhinosinusitis. Short-term data suggest better outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) for patients with BMI < 30, while the reverse is observed in chronic rhinosinusitis without nasal polyps (CRSsNP). This study evaluated whether these BMI-associated trends persist in the long term.
- Conclusion: This study demonstrated sustained BMI-associated differences in postoperative outcomes for chronic rhinosinusitis patients. CRSwNP patients with BMI < 30 exhibit better long-term improvements in SNOT-22 scores compared to those with BMI ≥30, while the reverse is observed in CRSsNP patients.
Nasal Corticosteroids Delivery Methods in Chronic Rhinosinusitis with Polyps: A Systematic Review
- Description: This study evaluated and compared the efficacy and safety of different intranasal corticosteroid delivery methods for treating CRSwNP.
- Conclusion: Non-aqueous delivery methods, including nebulizers, aerosol sprays, and nasal drops offer a safe alternative to oral corticosteroids without systemic side effects. Patients using aqueous formulations should be advised on the importance of long-term adherence to achieve symptom improvement.
- Description: This study evaluated the efficacy of probiotics as adjunctive therapy for chronic rhinosinusitis management compared to placebo treatment.
- Conclusion: Probiotics demonstrated significant potential as adjunctive treatment for chronic rhinosinusitis by improving symptom severity and reducing inflammation.
- Description: This study aimed evaluated the roles of nasal allergy, serum and tissue eosinophils, and serum IgE levels in chronic rhinosinusitis patients undergoing functional endoscopic sinus surgery (FESS), focusing on their associations with preoperative disease severity and postoperative outcomes.
- Conclusion: Our results show that serum eosinophil count is valuable in assessing preoperative olfactory function. FESS provided effective improvements in olfactory outcomes in eosinophilic chronic rhinosinusitis patients. On the contrary, allergy testing and serum IgE levels were not reliable tools for chronic rhinosinusitis severity or outcomes.
- Description: The purpose of this study was to determine the effectiveness of endoscopic sinus surgery in a select group of patients with mild chronic rhinosinusitis with respect to sino-nasal specific symptoms.
- Conclusion: Endoscopic sinus surgery can provide significant relief of sino-nasal symptoms in selected chronic rhinosinusitis patients with minimally affected CT scans.
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