Today, we present a selection of recently published rheumatology-focused articles from U.S.-based and international medical journals. the articles have been categorized into three distinct focuses: arthritis, fibromyalgia, and systemic lupus erythematous.

Each of the nine included articles is accompanied by links to both a summarized overview and the full-text version. All articles highlighted in today's rundown were published within October of 2025.

Arthritis

Atherosclerotic Cardiovascular Disease and Mortality in a Cohort of Patients With Rheumatoid Arthritis: A Prospective Study Investigating Micrornas as Predictors of Atherosclerosis and Mortality

  • Frontiers in Immunology, October 2025
  • Description: Rheumatoid arthritis (RA) is a chronic autoimmune disorder associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD) that is not fully explained by traditional risk factors. This study investigated whether a novel microRNA (hsa-miR) panel could improve cardiovascular risk prediction and stratification in RA patients.
  • Summary
  • Full Text

Efficacy of DMARDs Therapy on the Disease Activity and Gene Expression Levels of FoxO1, FoxO3, Runx1, and Runx3 in Early Rheumatoid Arthritis Patients: A Pre-Post Interventional Study With Healthy Controls

  • Health Science Reports, October 2025
  • Description: This study assessed the plasma concentrations of the pro-inflammatory interleukin-6 (IL-6) cytokine and the anti-inflammatory cytokine interleukin-10 (IL-10), as well as the gene expression levels of FoxO1, FoxO3, Runx1, and Runx3, in the peripheral blood sample of the early rheumatoid arthritis (RA) patients treated with conventional disease-modifying antirheumatic drugs (DMARDs) for 6 months relative to normal subjects.
  • Summary
  • Full Text

Autoantibody Fine Specificity Restriction is Associated with Clinical Response in RA Treated with Abatacept and Methotrexate

  • Clinical Immunology, October 2025
  • Description: Anti-modified protein antibodies are central in rheumatoid arthritis (RA). We evaluated whether changes in fine specificities of anti-citrullinated protein antibodies and anti-CarP antibodies relate to clinical prognosis in RA patients treated with abatacept plus methotrexate.
  • Summary
  • Full Text

Fibromyalgia

Cortical Excitability and Analgesic Effects of Multisite Transcranial Direct Current Stimulation Targeting the Motor Cortex and Cerebellum in Fibromyalgia

  • Scientific Reports, October 2025
  • Description: This double-blind, sham-controlled randomized clinical trial investigated whether a single session of anodal-(a) transcranial direct current stimulation, applied over the primary motor cortex, cerebellum, or both, would reduce pain and increase corticospinal excitability more effectively than sham stimulation.
  • Summary
  • Full Text

Correlations Between the Central Sensitization Inventory and Measures of Endogenous Pain Modulation in Women with Fibromyalgia

  • Musculoskeletal Science & Practice, October 2025
  • Description: The Central Sensitization Inventory (CSI) is a self-report measure to identify key symptoms of human assumed central sensitization (HACS). However, research examining how the CSI relates to experimental pain measures in a population with predominant HACS is scarce.
  • Summary
  • Full Text

Endoplasmic Reticulum Stress and Oxidative Imbalance is the Missing Link in Fibromyalgia Pathophysiology

  • Scientific Reports, October 2025
  • Description: This study aimed to investigate the involvement of endoplasmic reticulum stress in fibromyalgia syndrome by evaluating key endoplasmic reticulum stress markers and oxidative stress parameters in patients with fibromyalgia syndrome.
  • Summary
  • Full Text
Systemic Lupus Erythematosus (SLE)

Administration of Belimumab Prior to Standard Immunosuppression in Patients with Early Active Lupus Hinders Accrual of New EULAR/ACR Criteria Within First 12 Months of Treatment

  • Lupus Science & Medicine, October 2025
  • Description: To evaluate the effect of early belimumab administration on disease progression in patients with early active SLE.
  • Summary
  • Full Text

Corneal Confocal Microscopy: A Novel Biomarker of Small Fibre Neuropathy in SLE

  • Lupus Science & Medicine, October 2025
  • Description: Small fibre neuropathy (SFN) is an under-recognised complication of SLE that contributes to chronic pain and reduced quality of life. We assessed the utility of corneal confocal microscopy (CCM) for identifying small fibre damage in SLE in relation to disease activity, neuropathic pain and quality of life.
  • Summary
  • Full Text

Single-Cell RNA Profiling of Blood CD4 T Cells Identifies Distinct Helper and Dysfunctional Regulatory Clusters in Children with SLE

  • Nature Immunology, October 2025
  • Description: To characterize the complexity of the CD4⁺ T cell compartment in patients with systemic lupus erythematosus (SLE), researchers performed single-cell RNA sequencing of sorted blood CD4⁺ T cells from pediatric patients and healthy donors.
  • Summary
  • Full Text

Look forward to more journal-focused topics in the coming weeks. 

Sign up for alerts and stay informed on the latest published articles and guidelines.

Copyright © 2025 Guideline Central, all rights reserved.