Rosacea: Pathogenesis and Therapeutic Correlates. Journal Abstract

Rosacea: Pathogenesis and Therapeutic Correlates.

Publication Date: 2024

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Authors

Ryan S Q Geng; Adrienn N Bourkas; Asfandyar Mufti; R Gary Sibbald

Abstract

OBJECTIVE

Rosacea is a chronic inflammatory condition of which there is no cure. The pathogenesis of rosacea is likely multifactorial, involving genetic and environmental contributions. Current understanding suggests that pro-inflammatory pathways involving cathelicidins and inflammasome complexes are central to rosacea pathogenesis. Common rosacea triggers modulate these pathways in a complex manner, which may contribute to the varying severity and clinical presentations of rosacea. Established and emerging rosacea treatments may owe their efficacy to their ability to target different players in these pro-inflammatory pathways. Improving our molecular understanding of rosacea will guide the development of new therapies and the use of combination therapies.

Source

Journal of cutaneous medicine and surgery

Pub Types(s)

Journal Article

Language

English

PubMed ID

38450615