Treatment for Brain Metastases
Key Points
Key Points
In the United States, it is estimated that between 8% and 10% of patients with cancer will develop brain metastases representing ~200,000 new patients with brain metastases every year.
The most likely primary cancers to seed brain metastases are melanoma, lung adenocarcinoma, and those from lung, breast, melanoma, renal, kidney, esophagus, and, head and neck.
This guideline was developed by a multi-disciplinary team of medical oncologists, neurosurgeons, neuro-oncologists and radiation oncologists, and it integrates the latest evidence supporting the use of surgery, radiation, and medical therapies for patients with CNS metastases.
Treatment
Treatmen...
...mendation 1.1Surgery may be offered fo...
...ecommendation 1.2Where surgery is con...
...on 1.3No recommendation can be made fo...
...tion 2.1Patients with symptomatic brain...
...mendation 2.2For patients with asy...
...tion 2.3 Osimertinib or icotinib may be offe...
...commendation 2.4Alectinib, brigatinib, or ceri...
...endation 2.5Pembrolizumab may be offe...
...2.6Ipilimumab plus nivolumab (for a...
...tion 2.7The combination of tucatinib, trastuz...
Recommendation 3.1Radiation therap...
...tion 3.2SRS alone (as opposed to WBRT...
...3.3SRS alone should be offered to patients w...
...n 3.4SRS, WBRT, and the combinatio...
...ecommendation 3.5Memantine and hippocamp...
...ommendation 3.6Radiation sensitizing ag...
...mmendation 4.1For patients who will rece...
...elieves that cancer clinical trials are vital t...