Treatment for Brain Metastases

Last updated March 14, 2022

Key Points

Key Points

In the United States, it is estimated that between 8% and 10% of patients with cancer will develop brain metastases representing ~200,000 new patients with brain metastases every year.

The most likely primary cancers to seed brain metastases are melanoma, lung adenocarcinoma, and those from lung, breast, melanoma, renal, kidney, esophagus, and, head and neck.

This guideline was developed by a multi-disciplinary team of medical oncologists, neurosurgeons, neuro-oncologists and radiation oncologists, and it integrates the latest evidence supporting the use of surgery, radiation, and medical therapies for patients with CNS metastases.

Treatment

...Treatment...

...mmendation 1.1Surgery may be offere...


...ndation 1.2Where surgery is conside...


...commendation 1.3No recommendation can be made...


...mmendation 2.1Patients with symptomatic brai...


Recommendation 2.2For patients with asympto...


...commendation 2.3 Osimertinib or ico...


...ecommendation 2.4Alectinib, brigatinib, or ceritin...


...ecommendation 2.5Pembrolizumab may be offer...


...ion 2.6Ipilimumab plus nivolumab (for...


...dation 2.7The combination of tucatin...


...mendation 3.1Radiation therapy should not b...


...ation 3.2SRS alone (as opposed to...


...3.3SRS alone should be offered to...


...Recommendation 3.4SRS, WBRT, and the combin...


...3.5Memantine and hippocampal avoidance sho...


...ndation 3.6Radiation sensitizing agents sh...


...mendation 4.1For patients who will...


...O believes that cancer clinical trials a...