Treatment for Brain Metastases
Key Points
Key Points
In the United States, it is estimated that between 8% and 10% of patients with cancer will develop brain metastases representing ~200,000 new patients with brain metastases every year.
The most likely primary cancers to seed brain metastases are melanoma, lung adenocarcinoma, and those from lung, breast, melanoma, renal, kidney, esophagus, and, head and neck.
This guideline was developed by a multi-disciplinary team of medical oncologists, neurosurgeons, neuro-oncologists and radiation oncologists, and it integrates the latest evidence supporting the use of surgery, radiation, and medical therapies for patients with CNS metastases.
Treatment
Treatm...
...tion 1.1Surgery may be offered for patients with...
...ion 1.2Where surgery is considered, n...
...1.3No recommendation can be made for or against...
...ion 2.1Patients with symptomatic brain metastas...
....2For patients with asymptomatic brain metast...
....3 Osimertinib or icotinib may be offer...
...2.4Alectinib, brigatinib, or ceritinib m...
...2.5Pembrolizumab may be offered to...
...n 2.6Ipilimumab plus nivolumab (for...
...mendation 2.7The combination of tucatinib, trast...
...dation 3.1Radiation therapy should not...
...ommendation 3.2SRS alone (as opposed to WBR...
...ation 3.3SRS alone should be offered to...
...on 3.4SRS, WBRT, and the combination o...
...ommendation 3.5Memantine and hippocamp...
...mmendation 3.6Radiation sensitizing ag...
...Recommendation 4.1For patients wh...
...eves that cancer clinical trials are vital to inf...