Treatment for Brain Metastases
Key Points
Key Points
In the United States, it is estimated that between 8% and 10% of patients with cancer will develop brain metastases representing ~200,000 new patients with brain metastases every year.
The most likely primary cancers to seed brain metastases are melanoma, lung adenocarcinoma, and those from lung, breast, melanoma, renal, kidney, esophagus, and, head and neck.
This guideline was developed by a multi-disciplinary team of medical oncologists, neurosurgeons, neuro-oncologists and radiation oncologists, and it integrates the latest evidence supporting the use of surgery, radiation, and medical therapies for patients with CNS metastases.
Treatment
...Treatment...
Recommendation 1.1Surgery may be offered for pati...
...dation 1.2Where surgery is considered,...
...mendation 1.3No recommendation can b...
...ndation 2.1Patients with symptomatic b...
...endation 2.2For patients with asymptomatic b...
...2.3 Osimertinib or icotinib may be offered to pa...
...endation 2.4Alectinib, brigatinib, or ceritinib...
...2.5Pembrolizumab may be offered to patients...
...commendation 2.6Ipilimumab plus niv...
...2.7The combination of tucatinib, trastu...
...ommendation 3.1Radiation therapy should not...
...tion 3.2SRS alone (as opposed to WBRT or com...
...mmendation 3.3SRS alone should be offer...
...on 3.4SRS, WBRT, and the combination of SR...
...dation 3.5Memantine and hippocampal av...
....6Radiation sensitizing agents should...
Recommendation 4.1For patients who will receive...
...CO believes that cancer clinical t...