Diffuse Astrocytic and Oligodendroglial Tumors in Adults

Publication Date: December 13, 2021

Key Points

Key Points

  • Each year, more than 15,000 people in the United States are newly diagnosed with diffuse astrocytic and oligodendroglial tumors, including glioblastoma.
  • Recently, several systemic agents and a device have demonstrated improvements in survival when added to surgical and radiation therapies.
  • Genetic alterations, specifically Isocitrate Dehydrogenase 1 and 2 (IDH1 and IDH2), have become critical classification and prognostic biomarkers.

Treatment

...atment...

...mutant Astrocytic and Oligodendroglial Tumor...

...igodendroglioma, IDH-mutant, 1p/19q co-delet...

...n 1.1People with oligodendroglioma, IDH...

...s a reasonable alternative to PCV wh...

....2Within the group of people with oligodend...

...ma, IDH-mutant, 1p/19q co-deleted, CNS WHO grade...

...dation 1.3People with oligodendroglioma, IDH-m...

...e is a reasonable alternative to PCV when toxici...

...ocytoma, IDH-mutant, 1p/19q non-co...

...ommendation 1.4People with astrocytoma, IDH-muta...

...mmendation 1.5In astrocytoma, IDH-mutant, 1p/19q n...

...oma, IDH-mutant, 1p/19q non-codeleted, CNS WHO gr...

...on 1.6People with astrocytoma, IDH-mutant, 1p/19q...

...IDH-mutant, CNS WHO grade 4 (former IDH-mutant...

...ndation 1.7People with astrocytoma, IDH...

...a and Other IDH-wildtype Diffuse Glio...

...mendation 2.1People with astrocytom...

...mmendation 2.2Concurrent temozolomide and rad...

...ommendation 2.3Six months of adjuvant te...

...ndation 2.4Alternating electric field therapy...

...commendation 2.5Bevacizumab is NOT rec...

...ndation 2.6In people with glioblastoma, IDH-wild...

...endation 2.7In people with glioblasto...

...tion 2.8No recommendation for or again...

...ple with recurrent glioblastoma should...

...on 2.9No recommendation for or agains...

...use midline glioma should be referred for parti...


Table 1. Reasonable Doses and Schedules by Recommendation

...1. Reasonable Doses and Schedules...