Recommendations

Document Overview

Design and created by Guideline Central in participation with the American Association for the Study of Liver Diseases.

Diagnosis and Management of Hemochromatosis

American Association for the Study of Liver Diseases

Publication Date: Mar 1, 2011

Page Last Updated: May 5, 2026

Recommendation Grading

Strength of Recommendation		Level of Evidence
1 - Strong	Benefit clearly outweighs risk	A	High
2 - Weak	Benefits and risks are more closely matched and are more dependent on specific clinical scenarios	B	Moderate
2 - Weak		C	Low
G-U	Good Practice Statement - Ungraded
CS	Consensus Statement – Ungraded

Document Overview

Document Title: Diagnosis and Management of Hemochromatosis

Authoring Society: American Association for the Study of Liver Diseases

Document Publication Date: Mar 1, 2011

Page Last Reviewed/Updated: May 5, 2026

Document Type: Guideline

Country of Publication: United States

Full Text Freely Available: Yes

Full Text Guideline: aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.24330

Source Citation: https://doi.org/10.1002/hep.24330

Supplemental Implementation Resources

Algorithm

Document Scope, Criteria, and Use Cases

Document Objectives: These recommendations suggest preferred approaches to the diagnostic, therapeutic, and preventive aspects of care for hemochromatosis.

Scope: Assessment and Screening, Diagnosis, Management, Prevention, Treatment

Diseases/Conditions (MeSH)

D005820 - Genetic Testing

D008107 - Liver Diseases

D006432 - Hemochromatosis

D000071020 - Hemochromatosis Protein

D019190 - Iron Overload

D008107 - Liver Diseases

D005820 - Genetic Testing

D006432 - Hemochromatosis

D000071020 - Hemochromatosis Protein

D019190 - Iron Overload

Keywords: genetic, hemochromatosis, iron, liver disease

Target Patient Population: Patients with hemochromatosis

Inclusion Criteria: Female, Male, Adolescent, Adult, Older Adult

Health Care Settings: Ambulatory, Hospital, Outpatient

Intended Users: Nurse, Nurse Practitioner, Physician, Physician Assistant

Recommendation Development Processes & Methodology

Number of Source Documents: 95

Includes peer/external review process?: Yes

Includes public comment process?: No

Methodologist involvement?: Yes

Patient involvement?: No

Includes multi-disciplinary group?: Yes

Includes systematic review?: Yes

Grades quality of strength of evidence?: Yes

Grades quality of strength of recommendation?: Yes

Discloses funding source?: No

Discloses conflicts of interest?: No

Includes benefits/harms analysis with recommendations?: No

Diagnosis and Management of Hemochromatosis

Recommendations

Clinical Features

Diagnosis

Family Screening

Liver Biopsy

Role of Liver Biopsy in Non–HFE-related HH

Treatment of Hemochromatosis

Treatment of Secondary Iron Overload

General Population Screening

Recommendation Grading

Document Overview

Supplemental Implementation Resources

Document Scope, Criteria, and Use Cases

Recommendation Development Processes & Methodology