Prevention Of Stroke In Nonvalvular Atrial Fibrillation

Publication Date: February 23, 2014

Key Points

Key Points

  • The absolute risk of stroke varies 20-fold among AF patients according to age and associated vascular comorbidities. Current AHA2 guidelines use the CHADS stratification scheme.
  • The major risk of antithrombotic medications used to lower the incidence of AF-related stroke is bleeding.
  • For warfarin, this involves balancing a bleeding risk of 1% to 12% per year.
  • The advent of several new antithrombotic agents offers alternatives to warfarin and may lower the thromboembolic risk threshold for initiating therapy in patients with AF.

Diagnosis

...iagnosis

...able 1. Stroke Risk in Patients With Nonvalvula...


...re 1. Patterns of Atrial Fibrillat...


Treatment

...eatmen...

...rfarin (A)300167...

...igatran (B)300167...

...xaban (B)300167

rivaroxaban (B)300...


...and efficacy of combining dabigatran, ri...


...pirin, Clopidogrel & Wa...

...d-dose warfarin (target INR – 2....

...t therapy with aspirin is recommended for low...

...atients with AF deemed unsuitable f...

...r patients with ischemic stroke or TIA with parox...

...nts unable to take oral anticoagulants,...

...he combination of clopidogrel plus aspirin carr...


...abigatran

...useful as an alternative to warfarin for the p...

...150 mg twice daily is an efficacious a...

...e basis of pharmacokinetic data, the use o...

...ere are no data to support the use of dabigatra...


...pixaban...

...wice daily is an efficacious alternative to asp...

...ety and efficacy have not been established,...

...pixaban 5 mg twice daily is a relatively safe...

Although its safety and efficacy have not bee...

...ould NOT be used if the CrCI is...


Rivaroxab...

...ts with nonvalvular AF who are at m...

...n patients with renal impairment and nonvalvular...

...n should NOT be used if the CrCI is...


...gents Recommended for Stroke Prevention...


...revention of Stroke in Nonvalvular Atrial F...