Diagnostic Accuracy Of CSF 14-3-3 Protein In Sporadic Creutzfeldt-Jakob Disease

Authoring Organization

Publication Month/Year

October 2, 2012

Last Updated Month/Year

May 16, 2023

Supplemental Implementation Tools

Document Type


External Publication Status


Country of Publication


Document Objectives

To assess the available evidence for the diagnostic accuracy of CSF testing for protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD).

Inclusion Criteria

Female, Male, Adult, Older adult

Health Care Settings

Ambulatory, Hospice, Hospital, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Assessment and screening, Diagnosis, Management

Diseases/Conditions (MeSH)

D007562 - Creutzfeldt-Jakob Syndrome


Creutzfeldt-Jakob disease, subacute spongiform encephalopathy, CJD

Source Citation

Evidence-based guideline: Diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease. Report of the Guideline Development Subcommittee of the American Academy of Neurology. Taim Muayqil, Gary Gronseth, Richard Camicioli. Neurology Oct 2012, 79 (14) 1499-1506; DOI: 10.1212/WNL.0b013e31826d5fc3

Supplemental Methodology Resources

Data Supplement, Evidence Tables


Number of Source Documents
Literature Search Start Date
January 1, 1995
Literature Search End Date
January 1, 2011