Stage II Colon Cancer Adjuvant Therapy

Publication Date: December 20, 2021

Key Points

Key Points

  • An estimated 105,000 new cases of colon cancer were diagnosed in the United States in 2021, of which approximately 39% were localized.
  • Stage II cancers are characterized by a lack of metastatic spread or lymph node involvement, and the main treatment is surgical resection of the primary tumor.
  • Prognosis after resection is relatively favorable, with an estimated five-year disease-free survival rate of approximately 68–83% with surgery alone.
  • In order to eradicate micrometastatic disease following surgery, adjuvant therapy may be considered for patients with a high risk of recurrence, however, the extent to which established prognostic factors can predict response to treatment is not well defined.

Treatment

...eatment...

...1.1Adjuvant chemotherapy (ACT) should not routi...


...on 1.2ACT should not routinely be offered to patie...


...n 1.3ACT should be offered to patients...


....4ACT may be offered to patients with stage II...


...endation 2.1Adjuvant fluoropyrimidine-o...


...3.1There is insufficient evidence to routinel...


...mendation 4.1In patients who are candidat...