Stage III Non-Small Cell Lung Cancer
Key Points
Key Points
- Stage III non-small cell lung cancer (NSCLC) represents one of the most heterogenous subgroups of lung cancer. Consequently, it is also the subgroup in which choice and sequence of multimodality treatment varies significantly among clinicians, with variations being observed across and within institutes.
- This guideline reviews the published evidence addressing diagnosis and management of stage III NSCLC and provides evidence-based guidance on the common clinical dilemmas that clinicians may have while evaluating a patient with suspected or known stage III NSCLC.
- Four randomized control trials (RCTs) published in 2022, 2023, and 2024, prompted an amendment to the 2021 guideline.
Diagnosis
Diagnosis
...luation and Stag...
...1.1For patients with suspected stage I...
...n 1.2Following evaluation with CT scan as per Reco...
...commendation 1.3For patients with suspected stage...
...mmendation 1.4For patients who require...
...tion 1.5For patients who require patholog...
...ndation 1.6For patients who have suspected or...
...PointBiopsy should generally be performed...
Surge...
...mendation 2.1For patients with stage IIIA (N2...
...mendation 2.2For selected patients w...
...ractice Points...
...h stage III NSCLC generally should not be...
...oncogenic driver alterations, availab...
...providers should consider enrollment...
Treatment
...eatmen...
...juvant Therapy...
...ndation 3.1Patients who are planned for...
...ation 3.2Patients with stage III NSCL...
...ion 3.3For patients with resectable superi...
...vant Therapy
...endation 4.1Patients with resected s...
...commendation 4.2Patients with resected stage II...
...mmendation 4.3For patients with completely resect...
Unresectable Di...
....1Patients with stage III NSCLC who are...
...ndation 5.2Concurrent chemotherapy delive...
...endation 5.3Patients with stage III NSCLC who are...
....4Patients with stage III NSCLC receiving concurre...
...ion 5.5Doses higher than 60 Gy and up to 70...
...endation 5.6Patients with stage III NSCLC recei...
...dation 5.7Patients with stage III NSCLC recei...
...ation 5.8(Update): Patients with unresectable s...
...Evaluation and Staging in Stage III NSCLC...
Figure 2. Management of Stage III NSCLCA...