Stage III Non-Small Cell Lung Cancer
Key Points
Key Points
- Stage III non-small cell lung cancer (NSCLC) represents one of the most heterogenous subgroups of lung cancer. Consequently, it is also the subgroup in which choice and sequence of multimodality treatment varies significantly among clinicians, with variations being observed across and within institutes.
- This guideline reviews the published evidence addressing diagnosis and management of stage III NSCLC and provides evidence-based guidance on the common clinical dilemmas that clinicians may have while evaluating a patient with suspected or known stage III NSCLC.
- Three randomized control trials (RCTs) were published in 2022 and 2023 and prompted an amendment to the 2021 guideline.
Diagnosis
...Diagnosis...
...Evaluation a...
...ommendation 1.1For patients with suspe...
...1.2Following evaluation with CT scan as per Re...
...ndation 1.3For patients with suspected stage III N...
...endation 1.4For patients who require pat...
...commendation 1.5For patients who require...
...tion 1.6For patients who have suspe...
...Practice PointBiopsy should generall...
Treatment
...Surgery...
...commendation 2.1For patients with stage IIIA...
...dation 2.2(Update): Patients with stage III NSCL...
...Good Practice Points...
...h stage III NSCLC generally should not be exclud...
...of oncogenic driver alterations, avail...
...providers should consider enrollment on clinical t...
...Neoadjuvant Therapy...
...ation 3.1Patients who are planned for a multi...
...ecommendation 3.2(Update): Patients with stage I...
...ation 3.3For patients with resecta...
...Adjuvant Therapy...
...ecommendation 4.1Patients with resected st...
Recommendation 4.2(Update): Patient...
...mendation 4.3For patients with completely rese...
...Unresectable Disease...
...mendation 5.1Patients with stage III...
....2Concurrent chemotherapy delivered wit...
...n 5.3Patients with stage III NSCLC who a...
...endation 5.4Patients with stage III NSCLC receiv...
...mmendation 5.5Doses higher than 60...
...ecommendation 5.6Patients with stage III NSCLC...
...mendation 5.7Patients with stage III N...
...aluation and Staging in Stage III NS...
...igure 2. Management of Stage III NSCLC Arrows...