Oral and Topical Treatment of Painful Diabetic Polyneuropathy

Authoring Organization

Publication Month/Year

December 27, 2021

Last Updated Month/Year

February 12, 2024

Document Type


Country of Publication


Document Objectives

To review all of the available options to reduce pain in patients with diabetes, including oral, topical, and nonpharmacologic interventions.

Target Patient Population

Adults with diabetes and nerve pain

Target Provider Population

Neurologists, primary care providers, pain specialists, endocrinologists and other providers who manage patients with diabetes

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Ambulatory, Long term care

Intended Users

Diabetes educator, nurse, nurse practitioner, occupational therapist, physician, physician assistant


Treatment, Management

Diseases/Conditions (MeSH)

D011115 - Polyneuropathies, D003929 - Diabetic Neuropathies


diabetes, neuropathic pain, neuropathy, polyneuropathy, diabetic neuropathy, peripheral neuropathy, nerve pain


Number of Source Documents
Literature Search Start Date
January 1, 2008
Literature Search End Date
April 1, 2020