Botulinum Neurotoxin for the Treatment of Blepharospasm, Cervical Dystonia, Adult Spasticity, and Headache

Authoring Organization

Publication Month/Year

April 1, 2016

Last Updated Month/Year

June 1, 2023

Supplemental Implementation Tools

Document Type


External Publication Status


Country of Publication


Document Objectives

To update the 2008 American Academy of Neurology (AAN) guidelines regarding botulinum neurotoxin for blepharospasm, cervical dystonia (CD), headache, and adult spasticity.

Inclusion Criteria

Female, Male, Adult, Older adult

Health Care Settings

Ambulatory, Operating and recovery room, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant



Diseases/Conditions (MeSH)

D006261 - Headache, D004421 - Dystonia, D009128 - Muscle Spasticity


headache, blepharospasm, dystonia, adult spasticity, neurotoxin

Source Citation

Practice guideline update summary: Botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache. Report of the Guideline Development Subcommittee of the American Academy of Neurology. David M. Simpson, Mark Hallett, Eric J. Ashman, Cynthia L. Comella, Mark W. Green, Gary S. Gronseth, Melissa J. Armstrong, David Gloss, Sonja Potrebic, Joseph Jankovic, Barbara P. Karp, Markus Naumann, Yuen T. So, Stuart A. Yablon. Neurology May 2016, 86 (19) 1818-1826; DOI: 10.1212/WNL.0000000000002560

Supplemental Methodology Resources

Data Supplement, Data Supplement, Data Supplement