Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies

Publication Date: August 3, 2021
Last Updated: March 14, 2022

Summary of Recommendations

Clinical care providers should order both serum protein electrophoresis (SPEP) and serum free light chains (sFLC) for the initial detection of monoclonal immunoglobulin protein (M-protein) in all patients with suspected monoclonal gammopathies (MG). ( S )
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Overview

Title

Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies

Authoring Organizations

Association for Diagnostics & Laboratory Medicine

American Society for Clinical Pathology

College of American Pathologists