Management Issues For Women With Epilepsy-Focus On Pregnancy: Vitamin K, Folic Acid, Blood Levels, And Breastfeeding

Authoring Organization

Publication Month/Year

April 27, 2008

Document Type


External Publication Status


Country of Publication


Document Objectives

To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AEDs), risks of breastfeeding, and change in AED levels during pregnancy.

Inclusion Criteria

Female, Adult, Infant

Health Care Settings

Ambulatory, Hospital, Outpatient

Intended Users

Dietician nutritionist, nurse, nurse practitioner, physician, physician assistant



Diseases/Conditions (MeSH)

D011247 - Pregnancy, D004827 - Epilepsy


Breastfeeding, vitamins and breastfeeding, epilepsy, women with epilepsy, hemorrhagic disease

Source Citation

Practice Parameter update: Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. C. L. Harden, P. B. Pennell, B. S. Koppel, C. A. Hovinga, B. Gidal, K. J. Meador, J. Hopp, T. Y. Ting, W. A. Hauser, D. Thurman, P. W. Kaplan, J. N. Robinson, J. A. French, S. Wiebe, A. N. Wilner, B. Vazquez, L. Holmes, A. Krumholz, R. Finnell, P. O. Shafer, C. Le Guen. Neurology Jul 2009, 73 (2) 142-149; DOI: 10.1212/WNL.0b013e3181a6b325