Primary Sclerosing Cholangitis

Publication Date: May 1, 2015
Last Updated: March 14, 2022

RECOMMENDATIONS

Diagnosis

MRCP is preferred over ERCP to establish a diagnosis of PSC. (Strong “We recommend”, Moderate)
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Liver biopsy is not necessary to make a diagnosis in patients with suspected PSC based on diagnostic cholangiographics findings. (Conditional (weak) “We suggest”, Low)
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Liver biopsy is recommended to make a diagnosis in patients with suspected small duct PSC or to exclude other conditions such as suspected overlap with autoimmune hepatitis. (Conditional (weak) “We suggest”, Moderate)
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Antimitochondrial autoantibody testing can help exclude primary biliary cirrhosis. (Conditional (weak) “We suggest”, Moderate)
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Patients with PSC should be tested at least once for elevated serum IgG4 levels. (Conditional (weak) “We suggest”, Moderate)
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Overview

Title

Primary Sclerosing Cholangitis

Authoring Organization

American College of Gastroenterology