Disorders of Hepatic and Mesenteric Circulation

Publication Date: December 31, 2019
Last Updated: March 14, 2022


Bleeding and thrombotic risk in liver disorders

1. We do not recommend fresh frozen plasma FFP to improve thrombin generation in patients with cirrhosis at conventional doses (10 mL/kg). If sufficient volume is given (1–2 L) to lower a significantly prolonged INR, volume expansion increases portal pressure and may trigger variceal hemorrhage. Thus in most situations, infusion of plasma prophylactically to decrease bleeding risk is futile and potentially risky. (Conditional (weak)  “We suggest”, Low)



Disorders of the Hepatic and Mesenteric Circulation

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