Antibiotic Use in Patients Undergoing Cholecystectomy for Gallbladder Disease

Authoring Organization

Publication Month/Year

May 6, 2022

Document Type


Country of Publication


Document Objectives

Manifestations of gallbladder disease range from intermittent abdominal pain (symptomatic cholelithiasis) to potentially life-threatening illness (gangrenous cholecystitis). Although surgical intervention to treat acute cholecystitis is well defined, the role of antibiotic administration before or after cholecystectomy to decrease morbidity or mortality is less clear. The Surgical Infection Society's Therapeutics and Guidelines Committee convened to develop guidelines for antibiotic use in patients undergoing cholecystectomy for gallbladder disease to prevent surgical site infection, other infection, hospital length of stay, or mortality.

Inclusion Criteria

Male, Female, Adult, Older adult

Health Care Settings

Hospital, Outpatient, Operating and recovery room

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Management, Prevention

Diseases/Conditions (MeSH)

D002763 - Cholecystectomy


infection prevention, Cholecystectomy, gallbladder disease, gallbladder

Source Citation

Colling KP, Besshoff KE, Forrester JD, Kendrick D, Mercier P, Huston JM. Surgical Infection Society Guidelines for Antibiotic Use in Patients Undergoing Cholecystectomy for Gallbladder Disease. Surg Infect (Larchmt). 2022 May;23(4):339-350. doi: 10.1089/sur.2021.207. Epub 2022 Mar 31. PMID: 35363086.