Last updated March 14, 2022

Appropriate Use Criteria For Amyloid PET

Appropriate Indications

Patients with persistent or progressive unexplained mild cognitive impairment (MCI)

Patients satisfying core clinical criteria for possible Alzheimer’s disease (AD) (i.e., atypical clinical course or etiologically mixed presentation)

Patients with atypically young-onset dementia

Not Appropriate Indications

Patients with core clinical criteria for probable AD with typical age of onset

To determine dementia severity

Based solely on a positive family history of dementia or presence of APOE ε4

Patients with a cognitive complaint that is unconfirmed on clinical examination

In lieu of genotyping for suspected autosomal mutation carriers

The clinical use of amyloid positron emission tomography (PET) in asymptomatic individuals

Nonmedical usage -- e.g., legal-, disability-, and employment-related matters

Recommendation Grading



Appropriate Use Criteria For Amyloid PET

Authoring Organizations

Publication Month/Year

January 1, 2013

Document Type


External Publication Status


Country of Publication


Document Objectives

To provide guidance to dementia care practitioners, patients, and caregivers, the Alzheimer’s Association and the Society of Nuclear Medicine and Molecular Imaging convened the Amyloid Imaging Taskforce (AIT). The AIT considered a broad range of specific clinical scenarios in which amyloid PET could potentially be used appropriately. Peer-reviewed, published literature was searched to ascertain available evi- dence relevant to these scenarios, and the AIT developed a consensus of expert opinion. Although empirical evidence of impact on clinical outcomes is not yet available, a set of specific appropriate use criteria (AUC) were agreed on that define the types of patients and clinical circumstances in which amyloid PET could be used.

Inclusion Criteria

Female, Male, Adult, Older adult

Health Care Settings

Ambulatory, Outpatient

Intended Users

Nurse, nurse practitioner, physician, physician assistant


Assessment and screening, Diagnosis, Management

Diseases/Conditions (MeSH)

D000066492 - Cognitive Aging, D003072 - Cognition Disorders


dementia, mild cognitive impairment, Alzheimer disease, amyloidosis

Source Citation

Johnson KA, Minoshima S, Bohnen NI, et al. Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association. Alzheimers Dement. 2013;9(1):e‐16. doi:10.1016/j.jalz.2013.01.002