Radiation Therapy for IDH-Mutant Grade 2 and Grade 3 Diffuse Glioma

Publication Date: May 31, 2022
Last Updated: July 5, 2022

Indication and timing for RT

Oligodendroglioma, IDH-mutant and 1p/19q codeleted

For patients with oligodendroglioma, IDH-mutant, 1p/19q codeleted, WHO grade 2, <4 to 6 cm tumor, with gross total resection (defined as <1 cm residual tumor on MRI) and age <40 years, close surveillance alone is recommended. (Strong, Low)
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Optimal dose of RT and target volume based on risk stratification

For patients with oligodendroglioma, IDH-mutant, 1p/19q codeleted, WHO grade 2 and astrocytoma, IDH-mutant, WHO grade 2, a total prescribed dose of 4500 to 5400 cGy in 180 cGy daily fractions is recommended. (Strong, High)
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Overview

Title

Radiation Therapy for IDH-Mutant Grade 2 and Grade 3 Diffuse Glioma

Authoring Organization