Treatment of Metastatic Colorectal Cancer
Publication Date: October 17, 2022
Last Updated: May 30, 2023
Treatment
Recommendation 1.1
Doublet (folinic acid [leucovorin], fluorouracil, oxaliplatin [FOLFOX] or folinic acid [leucovorin], fluorouracil, irinotecan [FOLFIRI]) backbone chemotherapy (CT) should be offered as first-line therapy to patients with initially unresectable microsatellite stable (MSS) or proficient DNA mismatch repair (pMMR) mCRC. (EB, B, M, S)
Qualifying statement: Treatment with capecitabine plus oxaliplatin may be substituted for FOLFOX at the clinical discretion of the treating provider, and in shared decision-making with the patient.
1048203
Title
Treatment of Metastatic Colorectal Cancer
Authoring Organization
American Society of Clinical Oncology