Secondary Prevention of Cervical Cancer

Publication Date: September 26, 2022

Key Points

Key Points

  • ASCO published its first guideline on secondary prevention of cervical cancer in 2016. This guideline updates the previous. New and altered recommendations for 2022 are identified; others remain the same as in 2016.
  • Resource stratified guidelines provide recommendations given the level of resources in particular settings.
  • Human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing is recommended in all resource settings; visual inspection with acetic acid may be used in the basic setting.
  • Women who are human immunodeficiency virus (HIV)-positive should be screened for HPV after diagnosis and twice as many times throughout their lifetime as those in the general population.

Resource Settings

...esource Settings

...ource StratificationSetting Basic Core resou...


Screening/Triage/Management

...ening/Triage/Manage...

Maximal Sett...

...In maximal resource settings, cervical cancer sc...

...en who are ≥65 years of age who have had cons...

...esults of the HPV DNA test are positive, clini...

...lts are abnormal (i.e., ≥ atypical squam...

...HPV test results are positive at the repea...

...en who have received HPV and cytology...

...ults of the biopsy indicate that women have precu...

...r women receive treatment for precursor les...


...hanced Sett...

...n enhanced resource settings, cervica...

...are two consecutive negative screening test...

Women who are ≥65 years of age who hav...

...sults of the HPV DNA test are positive, clinic...

...ts are abnormal (i.e., ≥ASC-US or positive fo...

...st results are positive at the repe...

...lts of colposcopy and biopsy indicate that wom...

...women receive treatment for precu...


...mited Setting...

...2022: Cervical cancer screening wi...

...ex cytology (quality assured) and/or HPV genotypi...

...ual inspection with acetic acid (V...

...2022: If cytology triage results are abnormal...

...HPV genotyping or VIA or VAT triage re...

...results are positive at the repeat 12-month fol...

...linicians should offer ablation if the crit...

...r women receive treatment for precursor l...


...ic Setting

...ealth systems in basic settings should move to p...

...2022: If the results of available HPV testing are...

...22: If primary screening is VIA an...

...er women receive treatment for precursor lesi...


.... VIA versus VAT...


...Secondary Prevention of Cervical Cancer for Women...


...ondary Prevention of Cervical Cancer for Wome...


...igure 4. Secondary Prevention of Ce...


...condary Prevention of Cervical Cancer fo...


...O believes that cancer clinical trials are vita...