Secondary Prevention of Cervical Cancer

Publication Date: September 26, 2022

Key Points

Key Points

  • ASCO published its first guideline on secondary prevention of cervical cancer in 2016. This guideline updates the previous. New and altered recommendations for 2022 are identified; others remain the same as in 2016.
  • Resource stratified guidelines provide recommendations given the level of resources in particular settings.
  • Human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing is recommended in all resource settings; visual inspection with acetic acid may be used in the basic setting.
  • Women who are human immunodeficiency virus (HIV)-positive should be screened for HPV after diagnosis and twice as many times throughout their lifetime as those in the general population.

Resource Settings

Resource Setti...

...rk of Resource StratificationSetting Basi...


Screening/Triage/Management

...ening/Triage/Manag...

Maximal Set...

...In maximal resource settings, cervical can...

...65 years of age who have had consistently negat...

...sults of the HPV DNA test are positi...

...riage results are abnormal (i.e., ≥...

...lts are positive at the repeat 12-month fo...

...ave received HPV and cytology co-testing triag...

...the results of the biopsy indicate th...

...r women receive treatment for precursor lesion...


...hanced Sett...

...ew in 2022: In enhanced resource sett...

...are two consecutive negative screening te...

...omen who are ≥65 years of age who have ha...

...ults of the HPV DNA test are positive, clini...

...esults are abnormal (i.e., ≥ASC-US or positive...

...test results are positive at the repeat 12-mo...

...esults of colposcopy and biopsy indicate that wome...

...er women receive treatment for precursor...


...ed Setting...

...Cervical cancer screening with HPV DNA...

...reflex cytology (quality assured) and/o...

...ith visual inspection with acetic acid (VIA). (...

...n 2022: If cytology triage results are abnor...

...in 2022: If HPV genotyping or VIA...

...test results are positive at the repeat 12-month...

...r treatment, clinicians should offer ablation if...

...receive treatment for precursor le...


...sic Settin...

New in 2022: Health systems in basic...

...in 2022: If the results of available HPV tes...

...If primary screening is VIA and resul...

...women receive treatment for precursor lesi...


...igure 1. VIA versus VA...


...2. Secondary Prevention of Cervica...


...ary Prevention of Cervical Cancer for...


...e 4. Secondary Prevention of Cervical Cancer f...


...econdary Prevention of Cervical Cancer f...


...es that cancer clinical trials are...