Secondary Prevention of Cervical Cancer

Publication Date: September 26, 2022

Key Points

Key Points

  • ASCO published its first guideline on secondary prevention of cervical cancer in 2016. This guideline updates the previous. New and altered recommendations for 2022 are identified; others remain the same as in 2016.
  • Resource stratified guidelines provide recommendations given the level of resources in particular settings.
  • Human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing is recommended in all resource settings; visual inspection with acetic acid may be used in the basic setting.
  • Women who are human immunodeficiency virus (HIV)-positive should be screened for HPV after diagnosis and twice as many times throughout their lifetime as those in the general population.

Resource Settings

Resource Setti...

...source StratificationSetting Basi...


Screening/Triage/Management

Screening/Triage/Manag...

...al Setting...

...In maximal resource settings, cervica...

...who are ≥65 years of age who have had consiste...

...of the HPV DNA test are positive, clin...

If triage results are abnormal (i.e., ≥ atypic...

...results are positive at the repeat 12-month follo...

...en who have received HPV and cytology co-testing t...

...sults of the biopsy indicate that wo...

...women receive treatment for precursor lesions, fo...


...nced Setting...

...n enhanced resource settings, cervical cancer s...

...are two consecutive negative screening test result...

...≥65 years of age who have had consistently negat...

...e results of the HPV DNA test are positive, clini...

...f triage results are abnormal (i.e., ≥ASC-U...

...est results are positive at the repeat 12-month...

...s of colposcopy and biopsy indicat...

...ter women receive treatment for precursor lesio...


...ited Setting...

...22: Cervical cancer screening with HPV...

...iage with reflex cytology (quality assured) a...

...ual inspection with acetic acid (VIA). ( CB , ,...

New in 2022: If cytology triage results are a...

...: If HPV genotyping or VIA or VAT triage res...

...ults are positive at the repeat 12-month follo...

...clinicians should offer ablation if t...

...er women receive treatment for pre...


...sic Setting...

...: Health systems in basic settings...

...022: If the results of available HPV testin...

...022: If primary screening is VIA and...

After women receive treatment for...


Figure 1. VIA versus...


...2. Secondary Prevention of Cervical Ca...


...gure 3. Secondary Prevention of Cer...


...4. Secondary Prevention of Cervical...


...ondary Prevention of Cervical Cancer for Wome...


...s that cancer clinical trials are vital...