Secondary Prevention of Cervical Cancer

Publication Date: September 26, 2022

Key Points

Key Points

  • ASCO published its first guideline on secondary prevention of cervical cancer in 2016. This guideline updates the previous. New and altered recommendations for 2022 are identified; others remain the same as in 2016.
  • Resource stratified guidelines provide recommendations given the level of resources in particular settings.
  • Human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing is recommended in all resource settings; visual inspection with acetic acid may be used in the basic setting.
  • Women who are human immunodeficiency virus (HIV)-positive should be screened for HPV after diagnosis and twice as many times throughout their lifetime as those in the general population.

Resource Settings

...Resource Settings...

...amework of Resource StratificationSet...


Screening/Triage/Management

...Screening/Tri...

...Maximal Setting...

New in 2022: In maximal resource settings, cer...

...e ≥65 years of age who have had consiste...

If the results of the HPV DNA test are...

...lts are abnormal (i.e., ≥ atypica...

...test results are positive at the re...

...n who have received HPV and cytology...

...the results of the biopsy indicate that women h...

...eceive treatment for precursor lesions, follow...


...Enhanced Set...

...enhanced resource settings, cervical canc...

...e are two consecutive negative screeni...

...o are ≥65 years of age who have had co...

...ts of the HPV DNA test are positive, clinicians sh...

...riage results are abnormal (i.e., ...

...t results are positive at the repeat 12-month fol...

If the results of colposcopy and biopsy indicate t...

...r women receive treatment for precursor lesions, f...


...Limited Setting...

...22: Cervical cancer screening with HPV DNA testing...

...reflex cytology (quality assured) and/or HPV g...

...inspection with acetic acid (VIA). ( CB , , L ,...

...w in 2022: If cytology triage results...

...If HPV genotyping or VIA or VAT tri...

...esults are positive at the repeat 12-month fol...

...linicians should offer ablation if the...

...fter women receive treatment for precurso...


...Basic Setting...

...: Health systems in basic settings should...

...n 2022: If the results of available...

...2022: If primary screening is VIA and...

...ceive treatment for precursor lesions,...


...gure 1. VIA versus V...


...re 2. Secondary Prevention of Cervical Cancer fo...


...ndary Prevention of Cervical Cancer for Women...


...e 4. Secondary Prevention of Cervical Cancer...


...Secondary Prevention of Cervical Cancer for Women...


ASCO believes that cancer clinical trials are v...