Secondary Prevention of Cervical Cancer

Publication Date: September 25, 2022

Key Points

Key Points

  • ASCO published its first guideline on secondary prevention of cervical cancer in 2016. This guideline updates the previous. New and altered recommendations for 2022 are identified; others remain the same as in 2016.
  • Resource stratified guidelines provide recommendations given the level of resources in particular settings.
  • Human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing is recommended in all resource settings; visual inspection with acetic acid may be used in the basic setting.
  • Women who are human immunodeficiency virus (HIV)-positive should be screened for HPV after diagnosis and twice as many times throughout their lifetime as those in the general population.

Resource Settings

...urce Settings...

...amework of Resource StratificationSett...


Screening/Triage/Management

...eening/Triage/Management...

Maximal Setti...

...in 2022: In maximal resource settings, cervical c...

...omen who are ≥65 years of age who have had cons...

...f the results of the HPV DNA test are positi...

...results are abnormal (i.e., ≥ atypical...

...sults are positive at the repeat 12-month follow...

...ho have received HPV and cytology co-tes...

...f the results of the biopsy indicate that women...

...ive treatment for precursor lesions, foll...


...ced Setting...

...in 2022: In enhanced resource settin...

...consecutive negative screening test resu...

...≥65 years of age who have had consisten...

...results of the HPV DNA test are positive, clinici...

If triage results are abnormal (i.e.,...

...st results are positive at the repeat...

...of colposcopy and biopsy indicate that wom...

...n receive treatment for precursor lesi...


Limited Set...

...vical cancer screening with HPV DNA testing shoul...

...riage with reflex cytology (quality...

...with visual inspection with aceti...

...f cytology triage results are abno...

...2022: If HPV genotyping or VIA or VAT tr...

...results are positive at the repeat 12-month...

..., clinicians should offer ablation if the criter...

...receive treatment for precursor lesions...


...ic Setting

...n 2022: Health systems in basic settings...

...n 2022: If the results of available HPV testi...

...n 2022: If primary screening is VIA and results a...

...n receive treatment for precursor lesion...


...1. VIA versus VAT...


...ure 2. Secondary Prevention of Cervical...


...dary Prevention of Cervical Cancer fo...


...gure 4. Secondary Prevention of Ce...


...dary Prevention of Cervical Cancer for Women Ag...


...that cancer clinical trials are v...