Early Detection of Prostate Cancer

Publication Date: August 1, 2013
Last Updated: March 14, 2022

Guideline Statements

The Panel recommends against PSA screening in men under age 40 years. (Moderate, C)

The Panel does not recommend routine screening in men between ages 40 to 54 years at average risk. (Moderate, C)

For men ages 55 to 69 years the Panel recognizes that the decision to undergo PSA screening involves weighing the benefits of preventing prostate cancer mortality in 1 man for every 1,000 men screened over a decade against the known potential harms associated with screening and treatment. For this reason, the Panel strongly recommends shared decision-making for men age 55 to 69 years that are considering PSA screening and proceeding based on a man's values and preferences. (Strong, B)

To reduce the harms of screening, a routine screening interval of two years or more may be preferred over annual screening in those men who have participated in shared decision-making and decided on screening. As compared to annual screening, it is expected that screening intervals of two years preserve the majority of the benefits and reduce over diagnosis and false positives. (Conditional, C)

The Panel does not recommend routine PSA screening in men age 70 years or more, or any man with less than a 10 to 15 year life expectancy. (Moderate, C)

Recommendation Grading




Early Detection of Prostate Cancer

Authoring Organization

Publication Month/Year

August 1, 2013

Last Updated Month/Year

June 26, 2023

Supplemental Implementation Tools

Document Type


External Publication Status


Country of Publication


Document Objectives

The guideline purpose is to provide the urologist with a framework for the early detection of prostate cancer in asymptomatic average risk men.

Target Patient Population

Men at average risk for prostate cancer

Inclusion Criteria

Male, Adult

Health Care Settings


Intended Users

Nurse, nurse practitioner, physician, physician assistant


Assessment and screening, Prevention

Diseases/Conditions (MeSH)

D017430 - Prostate-Specific Antigen, D055088 - Early Detection of Cancer


prostatic neoplasms, early detection of cancer, prostatic cancer

Supplemental Methodology Resources

Methodology Supplement


Number of Source Documents
Literature Search Start Date
January 1, 2000
Literature Search End Date
November 21, 2022