Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk

Publication Date: July 31, 2019

Key Points

Key Points

Individuals should be screened for metabolic risk, in five categories:
  • Elevated waist circumference
  • Decreased high density lipoprotein (HDL) cholesterol
  • Elevated serum triglycerides
  • Elevated blood pressure
  • Elevated blood glucose
Three or more categories being abnormal should alert the clinician to a patient’s increased risk for atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM) (i.e., metabolic risk).

Endocrine Society (ES) recommends that providers measure waist circumference as part of the initial evaluation. (Note: However, that this does not replace the measurement of weight.)

Behavioral change should be the first-line therapy for prevention and should include changes to diet, increased exercise, and weight loss.

Persons identified as having metabolic risk should undergo risk scoring to identify the 10-year risk for ASCVD.

Diagnosis

...agnosis

...finitions and Dia...

...: In individuals aged 40–75 years in the offi...

...viduals aged 40–75 years in the office...

...tablish metabolic risk in the gener...

...In individuals previously diagnosed with predia...

...ds that all individuals at metabolic risk in the o...

...For individuals with elevated blood pressure...

...1. Criteria Proposed for Clinical Dia...

...w Chart for the Assessment and Treatm...

...e 2. Measuring Waist Circumference...

...2. Recommended Waist Thresholds to D...

...ions of Prediabetes (Intermediate Glycem...


Treatment

...atment

...le and Behavioral Therapy...

...dividuals at metabolic risk, ES recommends that...

...iduals at metabolic risk with excess weight (...

...n individuals at metabolic risk, ES re...

...iduals at metabolic risk, ES recommends presc...

...4. Effect of Lifestyle Components on Metab...

...ble 5. Components of Healthy Cardiovascul...

...trient Action Nutrient Action LDL-C...


...d Pharmacological Therapy...

...isk Assessment and Evaluation...

...In individuals identified as having metaboli...

...duals with low density lipoprotein-choleste...

Cholesterol Reduc...

...3: In individuals 40–75 years of age with LDL-C...

....4: In individuals 40–75 years of a...

....4.1: In individuals 40–75 years of age w...

...iduals 40–75 years of age without diabetes...

...In individuals with metabolic risk, without...

...: In individuals aged >75 years wit...

...iduals at metabolic risk who are taking statins...

....6: In individuals aged 40 years and older at m...

...le 7. Statin TherapyHaving trouble viewing table?...

...tment Recommendations and LDL-C Goals fo...

...ssure Reduction...

...n individuals with blood pressure...

...viduals without a history of ASCVD wi...

Reducing Progression to Type 2 Di...

...viduals with prediabetes, ES recommends pr...

...viduals with prediabetes who have...