Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk

Publication Date: July 31, 2019

Key Points

Key Points

Individuals should be screened for metabolic risk, in five categories:
  • Elevated waist circumference
  • Decreased high density lipoprotein (HDL) cholesterol
  • Elevated serum triglycerides
  • Elevated blood pressure
  • Elevated blood glucose
Three or more categories being abnormal should alert the clinician to a patient’s increased risk for atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus (T2DM) (i.e., metabolic risk).

Endocrine Society (ES) recommends that providers measure waist circumference as part of the initial evaluation. (Note: However, that this does not replace the measurement of weight.)

Behavioral change should be the first-line therapy for prevention and should include changes to diet, increased exercise, and weight loss.

Persons identified as having metabolic risk should undergo risk scoring to identify the 10-year risk for ASCVD.

Diagnosis

...gnosis

...tions and Diagnosis...

...uals aged 40–75 years in the office set...

...viduals aged 40–75 years in the o...

...blish metabolic risk in the general popu...

...In individuals previously diagnosed with pr...

...ds that all individuals at metaboli...

...uals with elevated blood pressure >130 mmHg sy...

...Criteria Proposed for Clinical Diagnosis...

...ure 1. Flow Chart for the Assessment and...

...ring Waist Circumference According to NHAN...

...le 2. Recommended Waist Thresholds...

...initions of Prediabetes (Intermediate...


Treatment

...atment...

...estyle and Behavioral Therap...

...ndividuals at metabolic risk, ES recommends tha...

...: For individuals at metabolic risk...

...individuals at metabolic risk, ES...

...als at metabolic risk, ES recommends...

...of Lifestyle Components on Metabolic Parameters...

Table 5. Components of Healthy Car...

...t Action Nutrient Action LDL-C...


...dical and Pharmacological Therapy...

...Assessment and Evaluation...

...duals identified as having metabolic risk,...

...: In individuals with low density lipoprotein-ch...

...lesterol Reductio...

3.3: In individuals 40–75 years of age...

...individuals 40–75 years of age with...

...ndividuals 40–75 years of age with...

...iduals 40–75 years of age without diabetes a...

...duals with metabolic risk, without...

...dividuals aged >75 years without diabete...

....5: In individuals at metabolic risk...

...dividuals aged 40 years and older at metabolic ri...

...e 7. Statin TherapyHaving trouble viewing...

...ment Recommendations and LDL-C Goals fo...

...essure Reduction

...7: In individuals with blood pressur...

...duals without a history of ASCVD with metabolic...

...ression to Type 2 Diabetes...

....9: In individuals with prediabetes, ES...

...ividuals with prediabetes who have limitat...