Treatment of Cushing's Syndrome

In patients with overt CS, the Endocrine Society (ES) recommends normalizing cortisol levels or action at its receptors to eliminate the signs and symptoms of CS and treating comorbidities associated with hypercortisolism. ( 1-M )

ES recommends against treatment to reduce cortisol levels or action if there is not an established diagnosis of CS. ( 1-VL )

ES suggests against treatments designed to normalize cortisol or its action when there is only borderline biochemical abnormality of the hypothalamic-pituitary-adrenal (HPA) axis without any specific signs of CS. The benefit of treating to normalize cortisol is not established in this setting. ( 2-VL )