Testosterone Therapy in Men With Hypogonadism

Endocrine Society (ES) recommends diagnosing hypogonadism in men with symptoms and signs of testosterone deficiency and unequivocally and consistently low serum total testosterone (TT) and/or free testosterone (FT) concentrations (when indicated). ( 1-M )

ES recommends against routine screening of men in the general population for hypogonadism. ( 1-L )

In men who have hypogonadism, ES recommends distinguishing between primary (testicular) and secondary (pituitary-hypothalamic) hypogonadism by measuring serum luteinizing hormone and follicle-stimulating hormone concentrations. ( 1-M )

In men with hypogonadism, ES suggests further evaluation to identify the etiology of hypothalamic, pituitary, and/or testicular dysfunction. ( 2-L )