Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults

fever, (S/L)

elevated ESR or CRP, (S/L)

Concomitant bloodstream infection or infective endocarditis. (S/L)

In patients with normal and stable neurologic exam and stable hemodynamics, IDSA suggests holding empiric antimicrobial therapy until a microbiologic diagnosis is established. ( W/L )

In patients with hemodynamic instability, sepsis, septic shock, severe or progressive neurologic symptoms, IDSA suggests the initiation of empiric antimicrobial therapy in conjunction with an attempt at establishing a microbiologic diagnosis. ( W/L )

IDSA recommends a total duration of 6 weeks of parenteral or highly bioavailable oral antimicrobial therapy for most patients with bacterial NVO. ( S/L )

IDSA recommends a total duration of 3 months of antimicrobial therapy for most patients with NVO due to Brucella sp. ( S/M )