Radiation Therapy for Endometrial Cancer

Authoring Organization

Publication Month/Year

October 21, 2022

Document Type


Country of Publication


Document Objectives

With the results of several recently published clinical trials, this guideline informs on the use of adjuvant radiation therapy (RT) and systemic therapy in the treatment of endometrial cancer. Updated evidence-based recommendations provide indications for adjuvant RT and the associated techniques, the utilization and sequencing of adjuvant systemic therapies, as well as the impact of surgical staging techniques and molecular tumor profiling.

Inclusion Criteria

Female, Adult, Older adult

Health Care Settings

Ambulatory, Outpatient, Radiology services

Intended Users

Nurse, nurse practitioner, physician, physician assistant, radiology technologist


Treatment, Management

Diseases/Conditions (MeSH)

D016889 - Endometrial Neoplasms, D018269 - Carcinoma, Endometrioid


Adjuvant Radiation Therapy, endometrial cancer

Source Citation

Harkenrider MM, Abu-Rustum N, Albuquerque K, Bradfield L, Bradley K, Dolinar E, Doll CM, Elshaikh M, Frick MA, Gehrig PA, Han K, Hathout L, Jones E, Klopp A, Mourtada F, Suneja G, Wright AA, Yashar C, Erickson BA. Radiation Therapy for Endometrial Cancer: An ASTRO Clinical Practice Guideline. Pract Radiat Oncol. 2022 Oct 21:S1879-8500(22)00273-9. doi: 10.1016/j.prro.2022.09.002. Epub ahead of print. PMID: 36280107.