Hypercalcemia of Malignancy in Adults
Key Points
Key Points
- Hypercalcemia of malignancy (HCM), a condition associated with high morbidity and mortality, is the most common metabolic complication of malignancies.
- All adults with HCM should receive treatment with denosumab (Dmab) or an intravenous (IV) bisphosphonate (BP).
- Adults with calcitriol-mediated HCM should first be treated with glucocorticoids, with the addition of Dmab or an IV BP if glucocorticoid therapy is insufficient.
Treatment
...eatment...
...n 1In adults with HCM, Endocrine Society (ES) rec...
...dation 2In adults with HCM, ES suggests tr...
...3In adults with severe HCM (serum calcium [SCa]>1...
...ion 4In adults with refractory/recurre...
...ation 5In adults with HCM from tumo...
...mendation 6In adult patients with hyperc...
...on 7In adult patients with hypercalcemia d...
...on 8In adult patients with hypercalcemia due...
...ctice Statements...
...1In adults with HCM, adequate hydr...
...with HCM, dental hygiene and oral...
...GPS 3In adults with HCM who receive an...
...s with HCM, renal function (creatinine...
UGPS 5In adults with HCM and renal insuffi...
...s with HCM, serum magnesium and phosphorous le...
...adults with HCM, clinical oncology cons...
...ts with hypercalcemia due to parat...
...le 1. Treatment Regimens for Hyperc...
...gested Workflow for the Management of Hy...
...ppendix A: Common Terminology Criteria...