Hypercalcemia of Malignancy in Adults
Key Points
Key Points
- Hypercalcemia of malignancy (HCM), a condition associated with high morbidity and mortality, is the most common metabolic complication of malignancies.
- All adults with HCM should receive treatment with denosumab (Dmab) or an intravenous (IV) bisphosphonate (BP).
- Adults with calcitriol-mediated HCM should first be treated with glucocorticoids, with the addition of Dmab or an IV BP if glucocorticoid therapy is insufficient.
Treatment
Treatment
...1In adults with HCM, Endocrine Society (ES) recomm...
...ation 2In adults with HCM, ES suggests...
...mendation 3In adults with severe HCM (serum ca...
...4In adults with refractory/recurrent H...
...ommendation 5In adults with HCM from tumors assoc...
...ecommendation 6In adult patients with hypercal...
...mmendation 7In adult patients with hy...
...mmendation 8In adult patients with h...
...Practice Stateme...
...ults with HCM, adequate hydration with IV flui...
...with HCM, dental hygiene and oral health, inclu...
...with HCM who receive antiresorptive therapy, vi...
...with HCM, renal function (creatinine clearanc...
...S 5In adults with HCM and renal insufficie...
...ts with HCM, serum magnesium and phosph...
...n adults with HCM, clinical oncology consultat...
...n adults with hypercalcemia due to parathyro...
...le 1. Treatment Regimens for Hypercalcemia of M...
...Suggested Workflow for the Managemen...
...ndix A: Common Terminology Criteria for Adver...