Pharmacologic Management of Premature Ejaculation

Publication Date: December 31, 2009
Last Updated: March 14, 2022

Guideline Statements

  • The diagnosis of PE is based on sexual history alone. A detailed sexual history should be obtained from all patients with ejaculatory complaints.
  • In patients with concomitant PE and ED, the ED should be treated first.
  • The risks and benefits of all treatment options should be discussed with the patient prior to any intervention. Patient and partner satisfaction is the primary target outcome for the treatment of PE.
  • Premature ejaculation can be treated effectively with several serotonin reuptake inhibitors (SRIs) or with topical anesthetics. The optimal treatment choice should be based on both physician judgment and patient preference.

Recommendation Grading



Pharmacologic Management of Premature Ejaculation

Authoring Organization

Publication Month/Year

December 31, 2009

Last Updated Month/Year

January 4, 2024

Supplemental Implementation Tools

Document Type


External Publication Status


Country of Publication


Document Objectives

This clinical guideline discusses the evaluation and treatment of premature ejaculation. 

Inclusion Criteria

Male, Adult, Older adult

Health Care Settings

Ambulatory, Outpatient

Intended Users

Psychologist, nurse, nurse practitioner, physician, physician assistant


Assessment and screening, Management, Treatment

Diseases/Conditions (MeSH)

D061686 - Premature Ejaculation


Premature Ejaculation, sexual dysfunction, ejaculatory dysfunction


Number of Source Documents
Literature Search Start Date
December 9, 2019
Literature Search End Date
December 23, 2019