Pharmacologic Management of Premature Ejaculation

Publication Date: December 31, 2009

Last Updated: March 14, 2022

Guideline Statements

The diagnosis of PE is based on sexual history alone. A detailed sexual history should be obtained from all patients with ejaculatory complaints.
In patients with concomitant PE and ED, the ED should be treated first.
The risks and benefits of all treatment options should be discussed with the patient prior to any intervention. Patient and partner satisfaction is the primary target outcome for the treatment of PE.
Premature ejaculation can be treated effectively with several serotonin reuptake inhibitors (SRIs) or with topical anesthetics. The optimal treatment choice should be based on both physician judgment and patient preference.