Lower Anogenital Squamous Terminology (LAST) for HPV-Associated Lesions
Publication Date: June 28, 2012
Last Updated: March 14, 2022
Summary of Consensus Recommendations
Squamous Intraepithelial Lesions
A unified histopathological nomenclature with a single set of diagnostic terms is recommended for all HPV-associated preinvasive squamous lesions of the lower anogenital tract (LAT).
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A 2-tiered nomenclature is recommended for noninvasive HPV-associated squamous proliferations of the LAT, which may be further qualified with the appropriate –IN terminology.
–IN refers to the generic intraepithelial neoplasia terminology, without specifying the location. For a specific location, the appropriate complete term should be used. Thus for an –IN 3 lesion: cervix = CIN 3, vagina = VaIN 3, vulva = VIN 3, anus = AIN 3, perianus = PAIN 3, and penis = PeIN 3
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The recommended terminology for HPV-associated squamous lesions of the LAT is low-grade squamous intraepithelial lesion (LSIL) and highgrade squamous intraepithelial lesion (HSIL), which may be further classified by the applicable –IN subcategorization.
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Title
Lower Anogenital Squamous Terminology (LAST) for HPV-Associated Lesions
Authoring Organization
College of American Pathologists