Last updated March 14, 2022

Tuberculosis Screening, Testing, and Treatment of U.S. Health Care Personnel


Baseline (preplacement) screening and testing

TB screening of all HCP, including a symptom evaluation and test (IGRA or TST) for those without documented prior TB disease or LTBI; individual TB risk assessment.

Postexposure screening and testing

Symptom evaluation for all HCP when an exposure is recognized. For HCP with a baseline negative TB test and no prior TB disease or LTBI, perform a test (IGRA or TST) when the exposure is identified. If that test is negative, do another test 8–10 weeks after the last exposure.

Serial screening and testing for HCP without LTBI

Not routinely recommended; can consider for selected HCP groups; recommend annual TB education for all HCP, including information about TB exposure risks for all HCP.

Evaluation and treatment of positive test results

Treatment is encouraged for all HCP with untreated LTBI, unless medically contraindicated.

IGRA = interferon-gamma release assay; LTBI = latent tuberculosis infection; TST = tuberculin skin test.

Recommendation Grading



Tuberculosis Screening, Testing, and Treatment of U.S. Health Care Personnel

Authoring Organization

Publication Month/Year

May 17, 2019

Document Type


External Publication Status


Country of Publication


Inclusion Criteria

Female, Male, Adolescent, Adult, Child, Older adult

Health Care Settings

Emergency care, Hospital, Outpatient

Intended Users

Epidemiology infection prevention, nurse, nurse practitioner, physician, physician assistant


Assessment and screening, Prevention, Treatment

Diseases/Conditions (MeSH)

D014376 - Tuberculosis


tuberculosis, preventative care, Tuberculosis

Source Citation

Sosa LE, Njie GJ, Lobato MN, et al. Tuberculosis Screening, Testing, and Treatment of U.S. Health Care Personnel: Recommendations from the National Tuberculosis Controllers Association and CDC, 2019. MMWR Morb Mortal Wkly Rep 2019;68:439–443. DOI: icon


Number of Source Documents
Literature Search Start Date
January 1, 2006
Literature Search End Date
November 1, 2017